ID   CLD22_HUMAN             Reviewed;         220 AA.
AC   Q8N7P3;
DT   14-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   29-MAR-2005, sequence version 3.
DT   27-MAR-2024, entry version 141.
DE   RecName: Full=Claudin-22;
GN   Name=CLDN22;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 18-220.
RC   TISSUE=Trachea;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
CC   -!- FUNCTION: Plays a major role in tight junction-specific obliteration of
CC       the intercellular space, through calcium-independent cell-adhesion
CC       activity. {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q8N7P3; Q8WTT0: CLEC4C; NbExp=3; IntAct=EBI-17766761, EBI-12913226;
CC       Q8N7P3; P25025: CXCR2; NbExp=3; IntAct=EBI-17766761, EBI-2835281;
CC       Q8N7P3; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-17766761, EBI-2820517;
CC       Q8N7P3; P35372-10: OPRM1; NbExp=3; IntAct=EBI-17766761, EBI-12807478;
CC       Q8N7P3; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-17766761, EBI-742688;
CC       Q8N7P3; P55061: TMBIM6; NbExp=3; IntAct=EBI-17766761, EBI-1045825;
CC       Q8N7P3; Q9NSU2-1: TREX1; NbExp=3; IntAct=EBI-17766761, EBI-16746122;
CC   -!- SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000250}. Cell
CC       membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the claudin family. {ECO:0000305}.
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DR   EMBL; AC093844; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK098064; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS43286.1; -.
DR   RefSeq; NP_001104789.1; NM_001111319.1.
DR   AlphaFoldDB; Q8N7P3; -.
DR   SMR; Q8N7P3; -.
DR   BioGRID; 119811; 7.
DR   IntAct; Q8N7P3; 7.
DR   STRING; 9606.ENSP00000318113; -.
DR   TCDB; 1.H.1.1.3; the claudin tight junction (claudin1) family.
DR   BioMuta; CLDN22; -.
DR   DMDM; 62298548; -.
DR   PaxDb; 9606-ENSP00000318113; -.
DR   Antibodypedia; 55709; 79 antibodies from 19 providers.
DR   DNASU; 53842; -.
DR   Ensembl; ENST00000323319.7; ENSP00000318113.5; ENSG00000177300.7.
DR   GeneID; 53842; -.
DR   KEGG; hsa:53842; -.
DR   MANE-Select; ENST00000323319.7; ENSP00000318113.5; NM_001111319.3; NP_001104789.1.
DR   UCSC; uc010isa.2; human.
DR   AGR; HGNC:2044; -.
DR   CTD; 53842; -.
DR   DisGeNET; 53842; -.
DR   GeneCards; CLDN22; -.
DR   HGNC; HGNC:2044; CLDN22.
DR   HPA; ENSG00000177300; Tissue enriched (salivary).
DR   MIM; 620566; gene.
DR   neXtProt; NX_Q8N7P3; -.
DR   OpenTargets; ENSG00000177300; -.
DR   PharmGKB; PA26570; -.
DR   VEuPathDB; HostDB:ENSG00000177300; -.
DR   eggNOG; ENOG502RSH3; Eukaryota.
DR   GeneTree; ENSGT00940000162234; -.
DR   HOGENOM; CLU_076370_1_2_1; -.
DR   InParanoid; Q8N7P3; -.
DR   OMA; QTQDHHQ; -.
DR   OrthoDB; 4058939at2759; -.
DR   PhylomeDB; Q8N7P3; -.
DR   TreeFam; TF331936; -.
DR   PathwayCommons; Q8N7P3; -.
DR   Reactome; R-HSA-420029; Tight junction interactions.
DR   SignaLink; Q8N7P3; -.
DR   BioGRID-ORCS; 53842; 17 hits in 1048 CRISPR screens.
DR   GeneWiki; CLDN22; -.
DR   GenomeRNAi; 53842; -.
DR   Pharos; Q8N7P3; Tdark.
DR   PRO; PR:Q8N7P3; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   RNAct; Q8N7P3; Protein.
DR   Bgee; ENSG00000177300; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 78 other cell types or tissues.
DR   GO; GO:0005923; C:bicellular tight junction; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0042802; F:identical protein binding; ISS:UniProtKB.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0070830; P:bicellular tight junction assembly; IBA:GO_Central.
DR   GO; GO:0016338; P:calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; ISS:UniProtKB.
DR   GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR   Gene3D; 1.20.140.150; -; 1.
DR   InterPro; IPR006187; Claudin.
DR   InterPro; IPR017974; Claudin_CS.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   PANTHER; PTHR12002; CLAUDIN; 1.
DR   PANTHER; PTHR12002:SF84; CLAUDIN-22; 1.
DR   Pfam; PF00822; PMP22_Claudin; 1.
DR   PRINTS; PR01077; CLAUDIN.
DR   PROSITE; PS01346; CLAUDIN; 1.
PE   1: Evidence at protein level;
KW   Cell junction; Cell membrane; Membrane; Reference proteome; Tight junction;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..220
FT                   /note="Claudin-22"
FT                   /id="PRO_0000144785"
FT   TOPO_DOM        1..10
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        11..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        31..81
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        103..117
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        118..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        139..164
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        165..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        186..220
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        111
FT                   /note="Q -> L (in Ref. 2; AK098064)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   220 AA;  24509 MW;  0DBB146E10EBE91D CRC64;
     MALVFRTVAQ LAGVSLSLLG WVLSCLTNYL PHWKNLNLDL NEMENWTMGL WQTCVIQEEV
     GMQCKDFDSF LALPAELRVS RILMFLSNGL GFLGLLVSGF GLDCLRIGES QRDLKRRLLI
     LGGILSWASG VTALVPVSWV AHKTVQEFWD ENVPDFVPRW EFGEALFLGW FAGLSLLLGG
     CLLHCAACSS HAPLASGHYA VAQTQDHHQE LETRNTNLKH
//