Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Claudin-22

Gene

CLDN22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177300-MONOMER.
ReactomeiR-HSA-420029. Tight junction interactions.

Protein family/group databases

TCDBi1.H.1.1.3. the claudin tight junction (claudin1) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-22
Gene namesi
Name:CLDN22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:2044. CLDN22.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 30HelicalSequence analysisAdd BLAST20
Topological domaini31 – 81ExtracellularSequence analysisAdd BLAST51
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 117CytoplasmicSequence analysisAdd BLAST15
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Topological domaini139 – 164ExtracellularSequence analysisAdd BLAST26
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Topological domaini186 – 220CytoplasmicSequence analysisAdd BLAST35

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000177300.
PharmGKBiPA26570.

Polymorphism and mutation databases

BioMutaiCLDN22.
DMDMi62298548.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447851 – 220Claudin-22Add BLAST220

Proteomic databases

PaxDbiQ8N7P3.
PRIDEiQ8N7P3.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000318113.

Structurei

3D structure databases

ProteinModelPortaliQ8N7P3.
SMRiQ8N7P3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410INS5. Eukaryota.
ENOG4111QE3. LUCA.
GeneTreeiENSGT00760000119222.
HOGENOMiHOG000220937.
HOVERGENiHBG104065.
InParanoidiQ8N7P3.
KOiK06087.
OMAiLETRNTN.
OrthoDBiEOG091G0QQ0.
PhylomeDBiQ8N7P3.
TreeFamiTF331936.

Family and domain databases

InterProiIPR006187. Claudin.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N7P3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALVFRTVAQ LAGVSLSLLG WVLSCLTNYL PHWKNLNLDL NEMENWTMGL
60 70 80 90 100
WQTCVIQEEV GMQCKDFDSF LALPAELRVS RILMFLSNGL GFLGLLVSGF
110 120 130 140 150
GLDCLRIGES QRDLKRRLLI LGGILSWASG VTALVPVSWV AHKTVQEFWD
160 170 180 190 200
ENVPDFVPRW EFGEALFLGW FAGLSLLLGG CLLHCAACSS HAPLASGHYA
210 220
VAQTQDHHQE LETRNTNLKH
Length:220
Mass (Da):24,509
Last modified:March 29, 2005 - v3
Checksum:i0DBB146E10EBE91D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti111Q → L in AK098064 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093844 Genomic DNA. No translation available.
AK098064 mRNA. No translation available.
CCDSiCCDS43286.1.
RefSeqiNP_001104789.1. NM_001111319.1.
UniGeneiHs.333179.

Genome annotation databases

EnsembliENST00000323319; ENSP00000318113; ENSG00000177300.
GeneIDi53842.
KEGGihsa:53842.
UCSCiuc010isa.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093844 Genomic DNA. No translation available.
AK098064 mRNA. No translation available.
CCDSiCCDS43286.1.
RefSeqiNP_001104789.1. NM_001111319.1.
UniGeneiHs.333179.

3D structure databases

ProteinModelPortaliQ8N7P3.
SMRiQ8N7P3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000318113.

Protein family/group databases

TCDBi1.H.1.1.3. the claudin tight junction (claudin1) family.

Polymorphism and mutation databases

BioMutaiCLDN22.
DMDMi62298548.

Proteomic databases

PaxDbiQ8N7P3.
PRIDEiQ8N7P3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323319; ENSP00000318113; ENSG00000177300.
GeneIDi53842.
KEGGihsa:53842.
UCSCiuc010isa.2. human.

Organism-specific databases

CTDi53842.
GeneCardsiCLDN22.
HGNCiHGNC:2044. CLDN22.
neXtProtiNX_Q8N7P3.
OpenTargetsiENSG00000177300.
PharmGKBiPA26570.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INS5. Eukaryota.
ENOG4111QE3. LUCA.
GeneTreeiENSGT00760000119222.
HOGENOMiHOG000220937.
HOVERGENiHBG104065.
InParanoidiQ8N7P3.
KOiK06087.
OMAiLETRNTN.
OrthoDBiEOG091G0QQ0.
PhylomeDBiQ8N7P3.
TreeFamiTF331936.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177300-MONOMER.
ReactomeiR-HSA-420029. Tight junction interactions.

Miscellaneous databases

GeneWikiiCLDN22.
GenomeRNAii53842.
PROiQ8N7P3.

Family and domain databases

InterProiIPR006187. Claudin.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLD22_HUMAN
AccessioniPrimary (citable) accession number: Q8N7P3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: March 29, 2005
Last modified: November 2, 2016
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.