Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Claudin-22

Gene

CLDN22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

  1. identical protein binding Source: UniProtKB
  2. structural molecule activity Source: InterPro

GO - Biological processi

  1. calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
  2. cell-cell junction organization Source: Reactome
  3. cell junction assembly Source: Reactome
  4. tight junction assembly Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_19373. Tight junction interactions.

Protein family/group databases

TCDBi1.H.1.1.3. the claudin tight junction (claudin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-22
Gene namesi
Name:CLDN22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:2044. CLDN22.

Subcellular locationi

  1. Cell junctiontight junction By similarity
  2. Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010CytoplasmicSequence Analysis
Transmembranei11 – 3020HelicalSequence AnalysisAdd
BLAST
Topological domaini31 – 8151ExtracellularSequence AnalysisAdd
BLAST
Transmembranei82 – 10221HelicalSequence AnalysisAdd
BLAST
Topological domaini103 – 11715CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei118 – 13821HelicalSequence AnalysisAdd
BLAST
Topological domaini139 – 16426ExtracellularSequence AnalysisAdd
BLAST
Transmembranei165 – 18521HelicalSequence AnalysisAdd
BLAST
Topological domaini186 – 22035CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
  3. tight junction Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26570.

Polymorphism and mutation databases

BioMutaiCLDN22.
DMDMi62298548.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 220220Claudin-22PRO_0000144785Add
BLAST

Proteomic databases

PRIDEiQ8N7P3.

Expressioni

Gene expression databases

BgeeiQ8N7P3.
GenevestigatoriQ8N7P3.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000318113.

Structurei

3D structure databases

ProteinModelPortaliQ8N7P3.
SMRiQ8N7P3. Positions 50-189.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40943.
GeneTreeiENSGT00760000119222.
HOGENOMiHOG000220937.
HOVERGENiHBG104065.
InParanoidiQ8N7P3.
KOiK06087.
OMAiLETRNTN.
OrthoDBiEOG7VMP6V.
PhylomeDBiQ8N7P3.
TreeFamiTF331936.

Family and domain databases

InterProiIPR006187. Claudin.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01077. CLAUDIN.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N7P3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALVFRTVAQ LAGVSLSLLG WVLSCLTNYL PHWKNLNLDL NEMENWTMGL
60 70 80 90 100
WQTCVIQEEV GMQCKDFDSF LALPAELRVS RILMFLSNGL GFLGLLVSGF
110 120 130 140 150
GLDCLRIGES QRDLKRRLLI LGGILSWASG VTALVPVSWV AHKTVQEFWD
160 170 180 190 200
ENVPDFVPRW EFGEALFLGW FAGLSLLLGG CLLHCAACSS HAPLASGHYA
210 220
VAQTQDHHQE LETRNTNLKH
Length:220
Mass (Da):24,509
Last modified:March 29, 2005 - v3
Checksum:i0DBB146E10EBE91D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti111 – 1111Q → L in AK098064 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093844 Genomic DNA. No translation available.
AK098064 mRNA. No translation available.
CCDSiCCDS43286.1.
RefSeqiNP_001104789.1. NM_001111319.1.
UniGeneiHs.333179.

Genome annotation databases

EnsembliENST00000323319; ENSP00000318113; ENSG00000177300.
GeneIDi53842.
KEGGihsa:53842.
UCSCiuc010isa.1. human.

Polymorphism and mutation databases

BioMutaiCLDN22.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093844 Genomic DNA. No translation available.
AK098064 mRNA. No translation available.
CCDSiCCDS43286.1.
RefSeqiNP_001104789.1. NM_001111319.1.
UniGeneiHs.333179.

3D structure databases

ProteinModelPortaliQ8N7P3.
SMRiQ8N7P3. Positions 50-189.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000318113.

Protein family/group databases

TCDBi1.H.1.1.3. the claudin tight junction (claudin) family.

Polymorphism and mutation databases

BioMutaiCLDN22.
DMDMi62298548.

Proteomic databases

PRIDEiQ8N7P3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323319; ENSP00000318113; ENSG00000177300.
GeneIDi53842.
KEGGihsa:53842.
UCSCiuc010isa.1. human.

Organism-specific databases

CTDi53842.
GeneCardsiGC04M184239.
HGNCiHGNC:2044. CLDN22.
neXtProtiNX_Q8N7P3.
PharmGKBiPA26570.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG40943.
GeneTreeiENSGT00760000119222.
HOGENOMiHOG000220937.
HOVERGENiHBG104065.
InParanoidiQ8N7P3.
KOiK06087.
OMAiLETRNTN.
OrthoDBiEOG7VMP6V.
PhylomeDBiQ8N7P3.
TreeFamiTF331936.

Enzyme and pathway databases

ReactomeiREACT_19373. Tight junction interactions.

Miscellaneous databases

GeneWikiiCLDN22.
GenomeRNAii53842.
NextBioi56202.
PROiQ8N7P3.

Gene expression databases

BgeeiQ8N7P3.
GenevestigatoriQ8N7P3.

Family and domain databases

InterProiIPR006187. Claudin.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01077. CLAUDIN.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 18-220.
    Tissue: Trachea.

Entry informationi

Entry nameiCLD22_HUMAN
AccessioniPrimary (citable) accession number: Q8N7P3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: March 29, 2005
Last modified: April 29, 2015
This is version 94 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.