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Q8N7P1 (PLD5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Inactive phospholipase D5

Short name=Inactive PLD 5
Alternative name(s):
Inactive choline phosphatase 5
Inactive phosphatidylcholine-hydrolyzing phospholipase D5
PLDc
Gene names
Name:PLD5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length536 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the phospholipase D family.

Contains 2 PLD phosphodiesterase domains.

Caution

In contrast to other members of the family, it lacks the conserved active sites, suggesting that it has no phospholipase activity.

Sequence caution

The sequence AAI01374.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAI01375.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAI01376.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainRepeat
Transmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncatalytic activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8N7P1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8N7P1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: MEIRQHEWLS...LSEKNCQNKC → MRMDSQKKIAKINVGK
Note: No experimental confirmation available.
Isoform 3 (identifier: Q8N7P1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-208: Missing.
Isoform 4 (identifier: Q8N7P1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-62: Missing.
     63-63: H → M

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 536536Inactive phospholipase D5
PRO_0000288606

Regions

Transmembrane69 – 8921Helical; Potential
Domain215 – 24228PLD phosphodiesterase 1
Domain434 – 46027PLD phosphodiesterase 2

Amino acid modifications

Glycosylation1211N-linked (GlcNAc...) Potential
Glycosylation3021N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1 – 208208Missing in isoform 3.
VSP_025724
Alternative sequence1 – 108108MEIRQ…CQNKC → MRMDSQKKIAKINVGK in isoform 2.
VSP_025725
Alternative sequence1 – 6262Missing in isoform 4.
VSP_025726
Alternative sequence631H → M in isoform 4.
VSP_025727

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 29, 2007. Version 2.
Checksum: 2FC94D6AB4A19934

FASTA53661,312
        10         20         30         40         50         60 
MEIRQHEWLS ASPHEGFEQM RLKSRPKEPS PSLTRVGANF YSSVKQQDYS ASVWLRRKDK 

        70         80         90        100        110        120 
LEHSQQKCIV IFALVCCFAI LVALIFSAVD IMGEDEDGLS EKNCQNKCRI ALVENIPEGL 

       130        140        150        160        170        180 
NYSENAPFHL SLFQGWMNLL NMAKKSVDIV SSHWDLNHTH PSACQGQRLF EKLLQLTSQN 

       190        200        210        220        230        240 
IEIKLVSDVT ADSKVLEALK LKGAEVTYMN MTAYNKGRLQ SSFWIVDKQH VYIGSAGLDW 

       250        260        270        280        290        300 
QSLGQMKELG VIFYNCSCLV LDLQRIFALY SSLKFKSRVP QTWSKRLYGV YDNEKKLQLQ 

       310        320        330        340        350        360 
LNETKSQAFV SNSPKLFCPK NRSFDIDAIY SVIDDAKQYV YIAVMDYLPI SSTSTKRTYW 

       370        380        390        400        410        420 
PDLDAKIREA LVLRSVRVRL LLSFWKETDP LTFNFISSLK AICTEIANCS LKVKFFDLER 

       430        440        450        460        470        480 
ENACATKEQK NHTFPRLNRN KYMVTDGAAY IGNFDWVGND FTQNAGTGLV INQADVRNNR 

       490        500        510        520        530 
SIIKQLKDVF ERDWYSPYAK TLQPTKQPNC SSLFKLKPLS NKTATDDTGG KDPRNV 

« Hide

Isoform 2 [UniParc].

Checksum: 71582866A7BE84DC
Show »

FASTA44450,795
Isoform 3 [UniParc].

Checksum: 38A06E30E98C3D57
Show »

FASTA32837,736
Isoform 4 [UniParc].

Checksum: D8B8CBD3D9DB4436
Show »

FASTA47453,990

References

« Hide 'large scale' references
[1]Li X., Xie Y., Mao Y.
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4).
Tissue: Brain, Corpus callosum and Trachea.
[3]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 46-536 (ISOFORM 1).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY461578 mRNA. Translation: AAS91020.1.
AK091691 mRNA. Translation: BAC03722.1.
AK098092 mRNA. Translation: BAC05230.1.
AK295421 mRNA. Translation: BAH12060.1.
AL591686, AL360271, AL583845 Genomic DNA. Translation: CAI15726.1.
AL591686 Genomic DNA. Translation: CAI15727.1.
AL360271, AL583845, AL591686 Genomic DNA. Translation: CAI14984.1.
AL583845, AL360271, AL591686 Genomic DNA. Translation: CAH71339.1.
AL445704 Genomic DNA. No translation available.
BC101373 mRNA. Translation: AAI01374.1. Different initiation.
BC101374 mRNA. Translation: AAI01375.1. Different initiation.
BC101375 mRNA. Translation: AAI01376.1. Different initiation.
CCDSCCDS1621.2. [Q8N7P1-1]
CCDS55692.1. [Q8N7P1-4]
RefSeqNP_001182740.1. NM_001195811.1. [Q8N7P1-4]
NP_001182741.1. NM_001195812.1. [Q8N7P1-3]
NP_689879.2. NM_152666.2. [Q8N7P1-1]
XP_006711815.1. XM_006711752.1. [Q8N7P1-1]
UniGeneHs.672452.

3D structure databases

ProteinModelPortalQ8N7P1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid128302. 1 interaction.
STRING9606.ENSP00000355503.

PTM databases

PhosphoSiteQ8N7P1.

Polymorphism databases

DMDM152112223.

Proteomic databases

PaxDbQ8N7P1.
PRIDEQ8N7P1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000427495; ENSP00000401285; ENSG00000180287. [Q8N7P1-4]
ENST00000442594; ENSP00000414188; ENSG00000180287. [Q8N7P1-2]
ENST00000536534; ENSP00000440896; ENSG00000180287. [Q8N7P1-1]
GeneID200150.
KEGGhsa:200150.
UCSCuc001hzl.4. human. [Q8N7P1-4]
uc001hzm.4. human. [Q8N7P1-1]
uc001hzo.2. human. [Q8N7P1-2]

Organism-specific databases

CTD200150.
GeneCardsGC01M242251.
HGNCHGNC:26879. PLD5.
HPAHPA028389.
neXtProtNX_Q8N7P1.
PharmGKBPA142671168.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG70733.
HOGENOMHOG000293407.
HOVERGENHBG108266.
InParanoidQ8N7P1.
KOK16861.
OMAHTFPRLN.
PhylomeDBQ8N7P1.
TreeFamTF313378.

Gene expression databases

ArrayExpressQ8N7P1.
BgeeQ8N7P1.
CleanExHS_PLD5.
GenevestigatorQ8N7P1.

Family and domain databases

InterProIPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
SMARTSM00155. PLDc. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiPLD5.
GenomeRNAi200150.
NextBio89842.
PROQ8N7P1.

Entry information

Entry namePLD5_HUMAN
AccessionPrimary (citable) accession number: Q8N7P1
Secondary accession number(s): A1KXV0 expand/collapse secondary AC list , B7Z324, Q494U9, Q8NB22
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: July 9, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM