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Q8N7P1

- PLD5_HUMAN

UniProt

Q8N7P1 - PLD5_HUMAN

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Protein

Inactive phospholipase D5

Gene

PLD5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. catalytic activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive phospholipase D5
Short name:
Inactive PLD 5
Alternative name(s):
Inactive choline phosphatase 5
Inactive phosphatidylcholine-hydrolyzing phospholipase D5
PLDc
Gene namesi
Name:PLD5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:26879. PLD5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei69 – 8921HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671168.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 536536Inactive phospholipase D5PRO_0000288606Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8N7P1.
PRIDEiQ8N7P1.

PTM databases

PhosphoSiteiQ8N7P1.

Expressioni

Gene expression databases

BgeeiQ8N7P1.
CleanExiHS_PLD5.
ExpressionAtlasiQ8N7P1. baseline and differential.
GenevestigatoriQ8N7P1.

Organism-specific databases

HPAiHPA028389.

Interactioni

Protein-protein interaction databases

BioGridi128302. 1 interaction.
STRINGi9606.ENSP00000355503.

Structurei

3D structure databases

ProteinModelPortaliQ8N7P1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini215 – 24228PLD phosphodiesterase 1Add
BLAST
Domaini434 – 46027PLD phosphodiesterase 2Add
BLAST

Sequence similaritiesi

Belongs to the phospholipase D family.Curated
Contains 2 PLD phosphodiesterase domains.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG70733.
GeneTreeiENSGT00390000009798.
HOGENOMiHOG000293407.
HOVERGENiHBG108266.
InParanoidiQ8N7P1.
KOiK16861.
OMAiHTFPRLN.
PhylomeDBiQ8N7P1.
TreeFamiTF313378.

Family and domain databases

InterProiIPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
SMARTiSM00155. PLDc. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N7P1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEIRQHEWLS ASPHEGFEQM RLKSRPKEPS PSLTRVGANF YSSVKQQDYS
60 70 80 90 100
ASVWLRRKDK LEHSQQKCIV IFALVCCFAI LVALIFSAVD IMGEDEDGLS
110 120 130 140 150
EKNCQNKCRI ALVENIPEGL NYSENAPFHL SLFQGWMNLL NMAKKSVDIV
160 170 180 190 200
SSHWDLNHTH PSACQGQRLF EKLLQLTSQN IEIKLVSDVT ADSKVLEALK
210 220 230 240 250
LKGAEVTYMN MTAYNKGRLQ SSFWIVDKQH VYIGSAGLDW QSLGQMKELG
260 270 280 290 300
VIFYNCSCLV LDLQRIFALY SSLKFKSRVP QTWSKRLYGV YDNEKKLQLQ
310 320 330 340 350
LNETKSQAFV SNSPKLFCPK NRSFDIDAIY SVIDDAKQYV YIAVMDYLPI
360 370 380 390 400
SSTSTKRTYW PDLDAKIREA LVLRSVRVRL LLSFWKETDP LTFNFISSLK
410 420 430 440 450
AICTEIANCS LKVKFFDLER ENACATKEQK NHTFPRLNRN KYMVTDGAAY
460 470 480 490 500
IGNFDWVGND FTQNAGTGLV INQADVRNNR SIIKQLKDVF ERDWYSPYAK
510 520 530
TLQPTKQPNC SSLFKLKPLS NKTATDDTGG KDPRNV
Length:536
Mass (Da):61,312
Last modified:May 29, 2007 - v2
Checksum:i2FC94D6AB4A19934
GO
Isoform 2 (identifier: Q8N7P1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: MEIRQHEWLS...LSEKNCQNKC → MRMDSQKKIAKINVGK

Note: No experimental confirmation available.

Show »
Length:444
Mass (Da):50,795
Checksum:i71582866A7BE84DC
GO
Isoform 3 (identifier: Q8N7P1-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-208: Missing.

Show »
Length:328
Mass (Da):37,736
Checksum:i38A06E30E98C3D57
GO
Isoform 4 (identifier: Q8N7P1-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-62: Missing.
     63-63: H → M

Show »
Length:474
Mass (Da):53,990
Checksum:iD8B8CBD3D9DB4436
GO

Sequence cautioni

The sequence AAI01374.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI01375.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI01376.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 208208Missing in isoform 3. 1 PublicationVSP_025724Add
BLAST
Alternative sequencei1 – 108108MEIRQ…CQNKC → MRMDSQKKIAKINVGK in isoform 2. 1 PublicationVSP_025725Add
BLAST
Alternative sequencei1 – 6262Missing in isoform 4. 2 PublicationsVSP_025726Add
BLAST
Alternative sequencei63 – 631H → M in isoform 4. 2 PublicationsVSP_025727

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY461578 mRNA. Translation: AAS91020.1.
AK091691 mRNA. Translation: BAC03722.1.
AK098092 mRNA. Translation: BAC05230.1.
AK295421 mRNA. Translation: BAH12060.1.
AL591686, AL360271, AL583845 Genomic DNA. Translation: CAI15726.1.
AL591686 Genomic DNA. Translation: CAI15727.1.
AL360271, AL583845, AL591686 Genomic DNA. Translation: CAI14984.1.
AL583845, AL360271, AL591686 Genomic DNA. Translation: CAH71339.1.
AL445704 Genomic DNA. No translation available.
BC101373 mRNA. Translation: AAI01374.1. Different initiation.
BC101374 mRNA. Translation: AAI01375.1. Different initiation.
BC101375 mRNA. Translation: AAI01376.1. Different initiation.
CCDSiCCDS1621.2. [Q8N7P1-1]
CCDS55692.1. [Q8N7P1-4]
RefSeqiNP_001182740.1. NM_001195811.1. [Q8N7P1-4]
NP_001182741.1. NM_001195812.1. [Q8N7P1-3]
NP_689879.2. NM_152666.2. [Q8N7P1-1]
XP_006711815.1. XM_006711752.1. [Q8N7P1-1]
UniGeneiHs.672452.

Genome annotation databases

EnsembliENST00000427495; ENSP00000401285; ENSG00000180287. [Q8N7P1-4]
ENST00000442594; ENSP00000414188; ENSG00000180287. [Q8N7P1-1]
ENST00000536534; ENSP00000440896; ENSG00000180287. [Q8N7P1-1]
GeneIDi200150.
KEGGihsa:200150.
UCSCiuc001hzl.4. human. [Q8N7P1-4]
uc001hzm.4. human. [Q8N7P1-1]
uc001hzo.2. human. [Q8N7P1-2]

Polymorphism databases

DMDMi152112223.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY461578 mRNA. Translation: AAS91020.1 .
AK091691 mRNA. Translation: BAC03722.1 .
AK098092 mRNA. Translation: BAC05230.1 .
AK295421 mRNA. Translation: BAH12060.1 .
AL591686 , AL360271 , AL583845 Genomic DNA. Translation: CAI15726.1 .
AL591686 Genomic DNA. Translation: CAI15727.1 .
AL360271 , AL583845 , AL591686 Genomic DNA. Translation: CAI14984.1 .
AL583845 , AL360271 , AL591686 Genomic DNA. Translation: CAH71339.1 .
AL445704 Genomic DNA. No translation available.
BC101373 mRNA. Translation: AAI01374.1 . Different initiation.
BC101374 mRNA. Translation: AAI01375.1 . Different initiation.
BC101375 mRNA. Translation: AAI01376.1 . Different initiation.
CCDSi CCDS1621.2. [Q8N7P1-1 ]
CCDS55692.1. [Q8N7P1-4 ]
RefSeqi NP_001182740.1. NM_001195811.1. [Q8N7P1-4 ]
NP_001182741.1. NM_001195812.1. [Q8N7P1-3 ]
NP_689879.2. NM_152666.2. [Q8N7P1-1 ]
XP_006711815.1. XM_006711752.1. [Q8N7P1-1 ]
UniGenei Hs.672452.

3D structure databases

ProteinModelPortali Q8N7P1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128302. 1 interaction.
STRINGi 9606.ENSP00000355503.

PTM databases

PhosphoSitei Q8N7P1.

Polymorphism databases

DMDMi 152112223.

Proteomic databases

PaxDbi Q8N7P1.
PRIDEi Q8N7P1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000427495 ; ENSP00000401285 ; ENSG00000180287 . [Q8N7P1-4 ]
ENST00000442594 ; ENSP00000414188 ; ENSG00000180287 . [Q8N7P1-1 ]
ENST00000536534 ; ENSP00000440896 ; ENSG00000180287 . [Q8N7P1-1 ]
GeneIDi 200150.
KEGGi hsa:200150.
UCSCi uc001hzl.4. human. [Q8N7P1-4 ]
uc001hzm.4. human. [Q8N7P1-1 ]
uc001hzo.2. human. [Q8N7P1-2 ]

Organism-specific databases

CTDi 200150.
GeneCardsi GC01M242251.
HGNCi HGNC:26879. PLD5.
HPAi HPA028389.
neXtProti NX_Q8N7P1.
PharmGKBi PA142671168.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG70733.
GeneTreei ENSGT00390000009798.
HOGENOMi HOG000293407.
HOVERGENi HBG108266.
InParanoidi Q8N7P1.
KOi K16861.
OMAi HTFPRLN.
PhylomeDBi Q8N7P1.
TreeFami TF313378.

Miscellaneous databases

ChiTaRSi PLD5. human.
GeneWikii PLD5.
GenomeRNAii 200150.
NextBioi 89842.
PROi Q8N7P1.

Gene expression databases

Bgeei Q8N7P1.
CleanExi HS_PLD5.
ExpressionAtlasi Q8N7P1. baseline and differential.
Genevestigatori Q8N7P1.

Family and domain databases

InterProi IPR001736. PLipase_D/transphosphatidylase.
[Graphical view ]
SMARTi SM00155. PLDc. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Li X., Xie Y., Mao Y.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4).
    Tissue: Brain, Corpus callosum and Trachea.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 46-536 (ISOFORM 1).

Entry informationi

Entry nameiPLD5_HUMAN
AccessioniPrimary (citable) accession number: Q8N7P1
Secondary accession number(s): A1KXV0
, B7Z324, Q494U9, Q8NB22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: November 26, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3