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Q8N7P1

- PLD5_HUMAN

UniProt

Q8N7P1 - PLD5_HUMAN

Protein

Inactive phospholipase D5

Gene

PLD5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (29 May 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. catalytic activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inactive phospholipase D5
    Short name:
    Inactive PLD 5
    Alternative name(s):
    Inactive choline phosphatase 5
    Inactive phosphatidylcholine-hydrolyzing phospholipase D5
    PLDc
    Gene namesi
    Name:PLD5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:26879. PLD5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671168.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 536536Inactive phospholipase D5PRO_0000288606Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8N7P1.
    PRIDEiQ8N7P1.

    PTM databases

    PhosphoSiteiQ8N7P1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8N7P1.
    BgeeiQ8N7P1.
    CleanExiHS_PLD5.
    GenevestigatoriQ8N7P1.

    Organism-specific databases

    HPAiHPA028389.

    Interactioni

    Protein-protein interaction databases

    BioGridi128302. 1 interaction.
    STRINGi9606.ENSP00000355503.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N7P1.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei69 – 8921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini215 – 24228PLD phosphodiesterase 1Add
    BLAST
    Domaini434 – 46027PLD phosphodiesterase 2Add
    BLAST

    Sequence similaritiesi

    Belongs to the phospholipase D family.Curated
    Contains 2 PLD phosphodiesterase domains.Curated

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG70733.
    HOGENOMiHOG000293407.
    HOVERGENiHBG108266.
    InParanoidiQ8N7P1.
    KOiK16861.
    OMAiHTFPRLN.
    PhylomeDBiQ8N7P1.
    TreeFamiTF313378.

    Family and domain databases

    InterProiIPR001736. PLipase_D/transphosphatidylase.
    [Graphical view]
    SMARTiSM00155. PLDc. 2 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N7P1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEIRQHEWLS ASPHEGFEQM RLKSRPKEPS PSLTRVGANF YSSVKQQDYS    50
    ASVWLRRKDK LEHSQQKCIV IFALVCCFAI LVALIFSAVD IMGEDEDGLS 100
    EKNCQNKCRI ALVENIPEGL NYSENAPFHL SLFQGWMNLL NMAKKSVDIV 150
    SSHWDLNHTH PSACQGQRLF EKLLQLTSQN IEIKLVSDVT ADSKVLEALK 200
    LKGAEVTYMN MTAYNKGRLQ SSFWIVDKQH VYIGSAGLDW QSLGQMKELG 250
    VIFYNCSCLV LDLQRIFALY SSLKFKSRVP QTWSKRLYGV YDNEKKLQLQ 300
    LNETKSQAFV SNSPKLFCPK NRSFDIDAIY SVIDDAKQYV YIAVMDYLPI 350
    SSTSTKRTYW PDLDAKIREA LVLRSVRVRL LLSFWKETDP LTFNFISSLK 400
    AICTEIANCS LKVKFFDLER ENACATKEQK NHTFPRLNRN KYMVTDGAAY 450
    IGNFDWVGND FTQNAGTGLV INQADVRNNR SIIKQLKDVF ERDWYSPYAK 500
    TLQPTKQPNC SSLFKLKPLS NKTATDDTGG KDPRNV 536
    Length:536
    Mass (Da):61,312
    Last modified:May 29, 2007 - v2
    Checksum:i2FC94D6AB4A19934
    GO
    Isoform 2 (identifier: Q8N7P1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-108: MEIRQHEWLS...LSEKNCQNKC → MRMDSQKKIAKINVGK

    Note: No experimental confirmation available.

    Show »
    Length:444
    Mass (Da):50,795
    Checksum:i71582866A7BE84DC
    GO
    Isoform 3 (identifier: Q8N7P1-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-208: Missing.

    Show »
    Length:328
    Mass (Da):37,736
    Checksum:i38A06E30E98C3D57
    GO
    Isoform 4 (identifier: Q8N7P1-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-62: Missing.
         63-63: H → M

    Show »
    Length:474
    Mass (Da):53,990
    Checksum:iD8B8CBD3D9DB4436
    GO

    Sequence cautioni

    The sequence AAI01374.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAI01375.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAI01376.1 differs from that shown. Reason: Erroneous initiation.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 208208Missing in isoform 3. 1 PublicationVSP_025724Add
    BLAST
    Alternative sequencei1 – 108108MEIRQ…CQNKC → MRMDSQKKIAKINVGK in isoform 2. 1 PublicationVSP_025725Add
    BLAST
    Alternative sequencei1 – 6262Missing in isoform 4. 2 PublicationsVSP_025726Add
    BLAST
    Alternative sequencei63 – 631H → M in isoform 4. 2 PublicationsVSP_025727

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY461578 mRNA. Translation: AAS91020.1.
    AK091691 mRNA. Translation: BAC03722.1.
    AK098092 mRNA. Translation: BAC05230.1.
    AK295421 mRNA. Translation: BAH12060.1.
    AL591686, AL360271, AL583845 Genomic DNA. Translation: CAI15726.1.
    AL591686 Genomic DNA. Translation: CAI15727.1.
    AL360271, AL583845, AL591686 Genomic DNA. Translation: CAI14984.1.
    AL583845, AL360271, AL591686 Genomic DNA. Translation: CAH71339.1.
    AL445704 Genomic DNA. No translation available.
    BC101373 mRNA. Translation: AAI01374.1. Different initiation.
    BC101374 mRNA. Translation: AAI01375.1. Different initiation.
    BC101375 mRNA. Translation: AAI01376.1. Different initiation.
    CCDSiCCDS1621.2. [Q8N7P1-1]
    CCDS55692.1. [Q8N7P1-4]
    RefSeqiNP_001182740.1. NM_001195811.1. [Q8N7P1-4]
    NP_001182741.1. NM_001195812.1. [Q8N7P1-3]
    NP_689879.2. NM_152666.2. [Q8N7P1-1]
    XP_006711815.1. XM_006711752.1. [Q8N7P1-1]
    UniGeneiHs.672452.

    Genome annotation databases

    EnsembliENST00000427495; ENSP00000401285; ENSG00000180287. [Q8N7P1-4]
    ENST00000442594; ENSP00000414188; ENSG00000180287. [Q8N7P1-2]
    ENST00000536534; ENSP00000440896; ENSG00000180287. [Q8N7P1-1]
    GeneIDi200150.
    KEGGihsa:200150.
    UCSCiuc001hzl.4. human. [Q8N7P1-4]
    uc001hzm.4. human. [Q8N7P1-1]
    uc001hzo.2. human. [Q8N7P1-2]

    Polymorphism databases

    DMDMi152112223.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY461578 mRNA. Translation: AAS91020.1 .
    AK091691 mRNA. Translation: BAC03722.1 .
    AK098092 mRNA. Translation: BAC05230.1 .
    AK295421 mRNA. Translation: BAH12060.1 .
    AL591686 , AL360271 , AL583845 Genomic DNA. Translation: CAI15726.1 .
    AL591686 Genomic DNA. Translation: CAI15727.1 .
    AL360271 , AL583845 , AL591686 Genomic DNA. Translation: CAI14984.1 .
    AL583845 , AL360271 , AL591686 Genomic DNA. Translation: CAH71339.1 .
    AL445704 Genomic DNA. No translation available.
    BC101373 mRNA. Translation: AAI01374.1 . Different initiation.
    BC101374 mRNA. Translation: AAI01375.1 . Different initiation.
    BC101375 mRNA. Translation: AAI01376.1 . Different initiation.
    CCDSi CCDS1621.2. [Q8N7P1-1 ]
    CCDS55692.1. [Q8N7P1-4 ]
    RefSeqi NP_001182740.1. NM_001195811.1. [Q8N7P1-4 ]
    NP_001182741.1. NM_001195812.1. [Q8N7P1-3 ]
    NP_689879.2. NM_152666.2. [Q8N7P1-1 ]
    XP_006711815.1. XM_006711752.1. [Q8N7P1-1 ]
    UniGenei Hs.672452.

    3D structure databases

    ProteinModelPortali Q8N7P1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128302. 1 interaction.
    STRINGi 9606.ENSP00000355503.

    PTM databases

    PhosphoSitei Q8N7P1.

    Polymorphism databases

    DMDMi 152112223.

    Proteomic databases

    PaxDbi Q8N7P1.
    PRIDEi Q8N7P1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000427495 ; ENSP00000401285 ; ENSG00000180287 . [Q8N7P1-4 ]
    ENST00000442594 ; ENSP00000414188 ; ENSG00000180287 . [Q8N7P1-2 ]
    ENST00000536534 ; ENSP00000440896 ; ENSG00000180287 . [Q8N7P1-1 ]
    GeneIDi 200150.
    KEGGi hsa:200150.
    UCSCi uc001hzl.4. human. [Q8N7P1-4 ]
    uc001hzm.4. human. [Q8N7P1-1 ]
    uc001hzo.2. human. [Q8N7P1-2 ]

    Organism-specific databases

    CTDi 200150.
    GeneCardsi GC01M242251.
    HGNCi HGNC:26879. PLD5.
    HPAi HPA028389.
    neXtProti NX_Q8N7P1.
    PharmGKBi PA142671168.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG70733.
    HOGENOMi HOG000293407.
    HOVERGENi HBG108266.
    InParanoidi Q8N7P1.
    KOi K16861.
    OMAi HTFPRLN.
    PhylomeDBi Q8N7P1.
    TreeFami TF313378.

    Miscellaneous databases

    GeneWikii PLD5.
    GenomeRNAii 200150.
    NextBioi 89842.
    PROi Q8N7P1.

    Gene expression databases

    ArrayExpressi Q8N7P1.
    Bgeei Q8N7P1.
    CleanExi HS_PLD5.
    Genevestigatori Q8N7P1.

    Family and domain databases

    InterProi IPR001736. PLipase_D/transphosphatidylase.
    [Graphical view ]
    SMARTi SM00155. PLDc. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Li X., Xie Y., Mao Y.
      Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4).
      Tissue: Brain, Corpus callosum and Trachea.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 46-536 (ISOFORM 1).

    Entry informationi

    Entry nameiPLD5_HUMAN
    AccessioniPrimary (citable) accession number: Q8N7P1
    Secondary accession number(s): A1KXV0
    , B7Z324, Q494U9, Q8NB22
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3