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Protein

Zinc finger protein 283

Gene

ZNF283

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri205 – 227C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri233 – 255C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri261 – 283C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri289 – 311C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri457 – 479C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri485 – 507C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri513 – 535C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri541 – 563C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri569 – 591C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri597 – 619C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176232-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 283
Alternative name(s):
Zinc finger protein HZF19
Gene namesi
Name:ZNF283
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13077. ZNF283.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167637.
PharmGKBiPA37653.

Polymorphism and mutation databases

BioMutaiZNF283.
DMDMi269849746.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475071 – 679Zinc finger protein 283Add BLAST679

Proteomic databases

PaxDbiQ8N7M2.
PeptideAtlasiQ8N7M2.
PRIDEiQ8N7M2.

PTM databases

iPTMnetiQ8N7M2.
PhosphoSitePlusiQ8N7M2.

Expressioni

Tissue specificityi

Detected in prostate, testis, and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000167637.
CleanExiHS_ZNF283.
ExpressionAtlasiQ8N7M2. baseline and differential.
GenevisibleiQ8N7M2. HS.

Interactioni

Protein-protein interaction databases

IntActiQ8N7M2. 1 interactor.
STRINGi9606.ENSP00000327314.

Structurei

3D structure databases

ProteinModelPortaliQ8N7M2.
SMRiQ8N7M2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 152KRABPROSITE-ProRule annotationAdd BLAST80

Sequence similaritiesi

Contains 15 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri205 – 227C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri233 – 255C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri261 – 283C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri289 – 311C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri457 – 479C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri485 – 507C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri513 – 535C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri541 – 563C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri569 – 591C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri597 – 619C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129704.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N7M2.
KOiK09228.
OMAiAFCWGYQ.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8N7M2.
TreeFamiTF341817.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 18 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 8 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N7M2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESRSVAQAG VQWCDLGSLQ APPPGFTLFS CLSLLSSWDY SSGFSGFCAS
60 70 80 90 100
PIEESHGALI SSCNSRTMTD GLVTFRDVAI DFSQEEWECL DPAQRDLYVD
110 120 130 140 150
VMLENYSNLV SLDLESKTYE TKKIFSENDI FEINFSQWEM KDKSKTLGLE
160 170 180 190 200
ASIFRNNWKC KSIFEGLKGH QEGYFSQMII SYEKIPSYRK SKSLTPHQRI
210 220 230 240 250
HNTEKSYVCK ECGKACSHGS KLVQHERTHT AEKHFECKEC GKNYLSAYQL
260 270 280 290 300
NVHQRFHTGE KPYECKECGK TFSWGSSLVK HERIHTGEKP YECKECGKAF
310 320 330 340 350
SRGYHLTQHQ KIHTGVKSYK CKECGKAFFW GSSLAKHEII HTGEKPYKCK
360 370 380 390 400
ECGKAFSRGY QLTQHQKIHT GKKPYECKIC GKAFCWGYQL TRHQIFHTGE
410 420 430 440 450
KPYECKECGK AFNCGSSLIQ HERIHTGEKP YECKECGKAF SRGYHLSQHQ
460 470 480 490 500
KIHTGEKPFE CKECGKAFSW GSSLVKHERV HTGEKSHECK ECGKTFCSGY
510 520 530 540 550
QLTRHQVFHT GEKPYECKEC GKAFNCGSSL VQHERIHTGE KPYECKECGK
560 570 580 590 600
AFSRGYHLTQ HQKIHTGEKP FKCKECGKAF SWGSSLVKHE RVHTNEKSYE
610 620 630 640 650
CKDCGKAFGS GYQLSVHQRF HTGEKLYQRK EFGKTFTCGS KLVHERTHSN
660 670
DKPYKYNECG EAFLWTTYSN EKIDTDETL
Length:679
Mass (Da):77,942
Last modified:November 24, 2009 - v4
Checksum:iADB64BFD18D49020
GO

Sequence cautioni

The sequence BAC05251 differs from that shown. Compared to the genome, the sequence lacks 6 bp for unexplained reasons.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti139 – 140Missing in BAG57956 (PubMed:14702039).Curated2
Sequence conflicti172E → R in AAS55109 (PubMed:7865130).Curated1
Sequence conflicti432E → K in AAS55109 (PubMed:7865130).Curated1
Sequence conflicti638C → H in BAC05251 (PubMed:14702039).Curated1
Sequence conflicti638C → H in BAG57956 (PubMed:14702039).Curated1
Sequence conflicti638C → H in AAS55109 (PubMed:7865130).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060605314T → I.2 PublicationsCorresponds to variant rs2195980dbSNPEnsembl.1
Natural variantiVAR_057416629R → H.Corresponds to variant rs1061768dbSNPEnsembl.1
Natural variantiVAR_060606638C → R.Corresponds to variant rs2356437dbSNPEnsembl.1
Natural variantiVAR_060607638C → Y.Corresponds to variant rs1061769dbSNPEnsembl.1
Natural variantiVAR_057417646R → I.Corresponds to variant rs10417624dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098175 mRNA. Translation: BAC05251.1. Sequence problems.
AK294852 mRNA. Translation: BAG57956.1.
AC011508 Genomic DNA. No translation available.
AY166784 mRNA. Translation: AAO45833.1.
AY500359 mRNA. Translation: AAS55109.1.
CCDSiCCDS46097.1.
RefSeqiNP_001284681.1. NM_001297752.1.
NP_862828.1. NM_181845.1.
XP_016882117.1. XM_017026628.1.
XP_016882118.1. XM_017026629.1.
XP_016882119.1. XM_017026630.1.
XP_016882120.1. XM_017026631.1.
UniGeneiHs.652513.

Genome annotation databases

EnsembliENST00000324461; ENSP00000327314; ENSG00000167637.
ENST00000618787; ENSP00000484852; ENSG00000167637.
GeneIDi284349.
KEGGihsa:284349.
UCSCiuc002oxr.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098175 mRNA. Translation: BAC05251.1. Sequence problems.
AK294852 mRNA. Translation: BAG57956.1.
AC011508 Genomic DNA. No translation available.
AY166784 mRNA. Translation: AAO45833.1.
AY500359 mRNA. Translation: AAS55109.1.
CCDSiCCDS46097.1.
RefSeqiNP_001284681.1. NM_001297752.1.
NP_862828.1. NM_181845.1.
XP_016882117.1. XM_017026628.1.
XP_016882118.1. XM_017026629.1.
XP_016882119.1. XM_017026630.1.
XP_016882120.1. XM_017026631.1.
UniGeneiHs.652513.

3D structure databases

ProteinModelPortaliQ8N7M2.
SMRiQ8N7M2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8N7M2. 1 interactor.
STRINGi9606.ENSP00000327314.

PTM databases

iPTMnetiQ8N7M2.
PhosphoSitePlusiQ8N7M2.

Polymorphism and mutation databases

BioMutaiZNF283.
DMDMi269849746.

Proteomic databases

PaxDbiQ8N7M2.
PeptideAtlasiQ8N7M2.
PRIDEiQ8N7M2.

Protocols and materials databases

DNASUi284349.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324461; ENSP00000327314; ENSG00000167637.
ENST00000618787; ENSP00000484852; ENSG00000167637.
GeneIDi284349.
KEGGihsa:284349.
UCSCiuc002oxr.5. human.

Organism-specific databases

CTDi284349.
GeneCardsiZNF283.
HGNCiHGNC:13077. ZNF283.
neXtProtiNX_Q8N7M2.
OpenTargetsiENSG00000167637.
PharmGKBiPA37653.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129704.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N7M2.
KOiK09228.
OMAiAFCWGYQ.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8N7M2.
TreeFamiTF341817.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176232-MONOMER.

Miscellaneous databases

ChiTaRSiZNF283. human.
GenomeRNAii284349.
PROiQ8N7M2.

Gene expression databases

BgeeiENSG00000167637.
CleanExiHS_ZNF283.
ExpressionAtlasiQ8N7M2. baseline and differential.
GenevisibleiQ8N7M2. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 18 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 8 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN283_HUMAN
AccessioniPrimary (citable) accession number: Q8N7M2
Secondary accession number(s): B4DGZ5
, B7WP04, Q6RFR9, Q86WM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: November 24, 2009
Last modified: November 30, 2016
This is version 128 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.