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Protein

Zinc finger protein 283

Gene

ZNF283

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri205 – 22723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri233 – 25523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri261 – 28323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri289 – 31123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri317 – 33923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri345 – 36723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri373 – 39523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri401 – 42323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri429 – 45123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri457 – 47923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri485 – 50723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri513 – 53523C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri541 – 56323C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri569 – 59123C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri597 – 61923C2H2-type 15PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 283
Alternative name(s):
Zinc finger protein HZF19
Gene namesi
Name:ZNF283
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13077. ZNF283.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37653.

Polymorphism and mutation databases

BioMutaiZNF283.
DMDMi269849746.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 679679Zinc finger protein 283PRO_0000047507Add
BLAST

Proteomic databases

MaxQBiQ8N7M2.
PaxDbiQ8N7M2.
PeptideAtlasiQ8N7M2.
PRIDEiQ8N7M2.

PTM databases

iPTMnetiQ8N7M2.
PhosphoSiteiQ8N7M2.

Expressioni

Tissue specificityi

Detected in prostate, testis, and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000167637.
CleanExiHS_ZNF283.
ExpressionAtlasiQ8N7M2. baseline and differential.
GenevisibleiQ8N7M2. HS.

Interactioni

Protein-protein interaction databases

IntActiQ8N7M2. 1 interaction.
STRINGi9606.ENSP00000327314.

Structurei

3D structure databases

ProteinModelPortaliQ8N7M2.
SMRiQ8N7M2. Positions 187-663.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini73 – 15280KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 15 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri205 – 22723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri233 – 25523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri261 – 28323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri289 – 31123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri317 – 33923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri345 – 36723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri373 – 39523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri401 – 42323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri429 – 45123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri457 – 47923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri485 – 50723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri513 – 53523C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri541 – 56323C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri569 – 59123C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri597 – 61923C2H2-type 15PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129704.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N7M2.
KOiK09228.
OMAiAFCWGYQ.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8N7M2.
TreeFamiTF341817.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 17 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 8 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N7M2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESRSVAQAG VQWCDLGSLQ APPPGFTLFS CLSLLSSWDY SSGFSGFCAS
60 70 80 90 100
PIEESHGALI SSCNSRTMTD GLVTFRDVAI DFSQEEWECL DPAQRDLYVD
110 120 130 140 150
VMLENYSNLV SLDLESKTYE TKKIFSENDI FEINFSQWEM KDKSKTLGLE
160 170 180 190 200
ASIFRNNWKC KSIFEGLKGH QEGYFSQMII SYEKIPSYRK SKSLTPHQRI
210 220 230 240 250
HNTEKSYVCK ECGKACSHGS KLVQHERTHT AEKHFECKEC GKNYLSAYQL
260 270 280 290 300
NVHQRFHTGE KPYECKECGK TFSWGSSLVK HERIHTGEKP YECKECGKAF
310 320 330 340 350
SRGYHLTQHQ KIHTGVKSYK CKECGKAFFW GSSLAKHEII HTGEKPYKCK
360 370 380 390 400
ECGKAFSRGY QLTQHQKIHT GKKPYECKIC GKAFCWGYQL TRHQIFHTGE
410 420 430 440 450
KPYECKECGK AFNCGSSLIQ HERIHTGEKP YECKECGKAF SRGYHLSQHQ
460 470 480 490 500
KIHTGEKPFE CKECGKAFSW GSSLVKHERV HTGEKSHECK ECGKTFCSGY
510 520 530 540 550
QLTRHQVFHT GEKPYECKEC GKAFNCGSSL VQHERIHTGE KPYECKECGK
560 570 580 590 600
AFSRGYHLTQ HQKIHTGEKP FKCKECGKAF SWGSSLVKHE RVHTNEKSYE
610 620 630 640 650
CKDCGKAFGS GYQLSVHQRF HTGEKLYQRK EFGKTFTCGS KLVHERTHSN
660 670
DKPYKYNECG EAFLWTTYSN EKIDTDETL
Length:679
Mass (Da):77,942
Last modified:November 24, 2009 - v4
Checksum:iADB64BFD18D49020
GO

Sequence cautioni

The sequence BAC05251 differs from that shown.Compared to the genome, the sequence lacks 6 bp for unexplained reasons.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti139 – 1402Missing in BAG57956 (PubMed:14702039).Curated
Sequence conflicti172 – 1721E → R in AAS55109 (PubMed:7865130).Curated
Sequence conflicti432 – 4321E → K in AAS55109 (PubMed:7865130).Curated
Sequence conflicti638 – 6381C → H in BAC05251 (PubMed:14702039).Curated
Sequence conflicti638 – 6381C → H in BAG57956 (PubMed:14702039).Curated
Sequence conflicti638 – 6381C → H in AAS55109 (PubMed:7865130).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti314 – 3141T → I.2 Publications
Corresponds to variant rs2195980 [ dbSNP | Ensembl ].
VAR_060605
Natural varianti629 – 6291R → H.
Corresponds to variant rs1061768 [ dbSNP | Ensembl ].
VAR_057416
Natural varianti638 – 6381C → R.
Corresponds to variant rs2356437 [ dbSNP | Ensembl ].
VAR_060606
Natural varianti638 – 6381C → Y.
Corresponds to variant rs1061769 [ dbSNP | Ensembl ].
VAR_060607
Natural varianti646 – 6461R → I.
Corresponds to variant rs10417624 [ dbSNP | Ensembl ].
VAR_057417

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098175 mRNA. Translation: BAC05251.1. Sequence problems.
AK294852 mRNA. Translation: BAG57956.1.
AC011508 Genomic DNA. No translation available.
AY166784 mRNA. Translation: AAO45833.1.
AY500359 mRNA. Translation: AAS55109.1.
CCDSiCCDS46097.1.
RefSeqiNP_001284681.1. NM_001297752.1.
NP_862828.1. NM_181845.1.
UniGeneiHs.652513.

Genome annotation databases

EnsembliENST00000324461; ENSP00000327314; ENSG00000167637.
ENST00000618787; ENSP00000484852; ENSG00000167637.
GeneIDi284349.
KEGGihsa:284349.
UCSCiuc002oxr.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098175 mRNA. Translation: BAC05251.1. Sequence problems.
AK294852 mRNA. Translation: BAG57956.1.
AC011508 Genomic DNA. No translation available.
AY166784 mRNA. Translation: AAO45833.1.
AY500359 mRNA. Translation: AAS55109.1.
CCDSiCCDS46097.1.
RefSeqiNP_001284681.1. NM_001297752.1.
NP_862828.1. NM_181845.1.
UniGeneiHs.652513.

3D structure databases

ProteinModelPortaliQ8N7M2.
SMRiQ8N7M2. Positions 187-663.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8N7M2. 1 interaction.
STRINGi9606.ENSP00000327314.

PTM databases

iPTMnetiQ8N7M2.
PhosphoSiteiQ8N7M2.

Polymorphism and mutation databases

BioMutaiZNF283.
DMDMi269849746.

Proteomic databases

MaxQBiQ8N7M2.
PaxDbiQ8N7M2.
PeptideAtlasiQ8N7M2.
PRIDEiQ8N7M2.

Protocols and materials databases

DNASUi284349.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324461; ENSP00000327314; ENSG00000167637.
ENST00000618787; ENSP00000484852; ENSG00000167637.
GeneIDi284349.
KEGGihsa:284349.
UCSCiuc002oxr.5. human.

Organism-specific databases

CTDi284349.
GeneCardsiZNF283.
HGNCiHGNC:13077. ZNF283.
neXtProtiNX_Q8N7M2.
PharmGKBiPA37653.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129704.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N7M2.
KOiK09228.
OMAiAFCWGYQ.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8N7M2.
TreeFamiTF341817.

Miscellaneous databases

ChiTaRSiZNF283. human.
GenomeRNAii284349.
PROiQ8N7M2.

Gene expression databases

BgeeiENSG00000167637.
CleanExiHS_ZNF283.
ExpressionAtlasiQ8N7M2. baseline and differential.
GenevisibleiQ8N7M2. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 17 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 8 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN283_HUMAN
AccessioniPrimary (citable) accession number: Q8N7M2
Secondary accession number(s): B4DGZ5
, B7WP04, Q6RFR9, Q86WM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: November 24, 2009
Last modified: September 7, 2016
This is version 125 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.