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Protein

Zinc finger protein 433

Gene

ZNF433

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri142 – 164C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri170 – 192C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri198 – 220C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri226 – 248C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri254 – 276C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri282 – 304C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 332C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri338 – 360C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri422 – 444C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri450 – 472C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri478 – 500C2H2-type 13; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri506 – 528C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri534 – 556C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri562 – 584C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri590 – 612C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri618 – 640C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri646 – 668C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 433
Gene namesi
Name:ZNF433
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000197647.11
HGNCiHGNC:20811 ZNF433
neXtProtiNX_Q8N7K0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi163059
OpenTargetsiENSG00000197647
PharmGKBiPA134943717

Polymorphism and mutation databases

BioMutaiZNF433
DMDMi30173446

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475811 – 673Zinc finger protein 433Add BLAST673

Proteomic databases

MaxQBiQ8N7K0
PaxDbiQ8N7K0
PeptideAtlasiQ8N7K0
PRIDEiQ8N7K0
ProteomicsDBi72301
72302 [Q8N7K0-2]

PTM databases

iPTMnetiQ8N7K0
PhosphoSitePlusiQ8N7K0

Expressioni

Gene expression databases

BgeeiENSG00000197647
CleanExiHS_ZNF433
ExpressionAtlasiQ8N7K0 baseline and differential

Organism-specific databases

HPAiHPA073724

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi127846, 7 interactors
IntActiQ8N7K0, 5 interactors
STRINGi9606.ENSP00000339767

Structurei

3D structure databases

ProteinModelPortaliQ8N7K0
SMRiQ8N7K0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 85KRABPROSITE-ProRule annotationAdd BLAST79

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri142 – 164C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri170 – 192C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri198 – 220C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri226 – 248C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri254 – 276C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri282 – 304C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 332C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri338 – 360C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri422 – 444C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri450 – 472C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri478 – 500C2H2-type 13; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri506 – 528C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri534 – 556C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri562 – 584C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri590 – 612C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri618 – 640C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri646 – 668C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119089
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8N7K0
KOiK09228
OMAiRYHGRTH
OrthoDBiEOG091G02KC
PhylomeDBiQ8N7K0
TreeFamiTF343410

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 19 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 18 hits
PS50157 ZINC_FINGER_C2H2_2, 19 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N7K0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMFQDSVAFE DVAVTFTQEE WALLDPSQKN LCRDVMQETF RNLASIGKKW
60 70 80 90 100
KPQNIYVEYE NLRRNLRIVG ERLFESKEGH QHGEILTQVP DDMLKKTTTG
110 120 130 140 150
VKSCESSVYG EVGSAHSSLN RHIRDDTGHK AYEYQEYGQK PYKCKYCKKP
160 170 180 190 200
FNCLSSVQTH ERAHSGRKLY VCEECGKTFI SHSNLQRHRI MHRGDGPYKC
210 220 230 240 250
KFCGKALMFL SLYLIHKRTH TGEKPYQCKQ CGKAFSHSSS LRIHERTHTG
260 270 280 290 300
EKPYKCNECG KAFHSSTCLH AHKRTHTGEK PYECKQCGKA FSSSHSFQIH
310 320 330 340 350
ERTHTGEKPY ECKECGKAFK CPSSVRRHER THSRKKPYEC KHCGKVLSYL
360 370 380 390 400
TSFQNHLGMH TGEISHKCKI CGKAFYSPSS LQTHEKTHTG EKPYKCNQCG
410 420 430 440 450
KAFNSSSSFR YHERTHTGEK PYECKQCGKA FRSASLLQTH GRTHTGEKPY
460 470 480 490 500
ACKECGKPFS NFSFFQIHER MHREEKPYEC KGYGKTFSLP SLFHRHERTH
510 520 530 540 550
TGGKTYECKQ CGRSFNCSSS FRYHGRTHTG EKPYECKQCG KAFRSASQLQ
560 570 580 590 600
IHGRTHTGEK PYECKQCGKA FGSASHLQMH GRTHTGEKPY ECKQCGKSFG
610 620 630 640 650
CASRLQMHGR THTGEKPYKC KQCGKAFGCP SNLRRHGRTH TGEKPYKCNQ
660 670
CGKVFRCSSQ LQVHGRAHCI DTP
Length:673
Mass (Da):77,243
Last modified:October 1, 2002 - v1
Checksum:i8C8B1B6D272D08FC
GO
Isoform 2 (identifier: Q8N7K0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: Missing.

Show »
Length:638
Mass (Da):73,196
Checksum:i4E05BFC8FB53F1FD
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0355231 – 35Missing in isoform 2. 1 PublicationAdd BLAST35

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098300 mRNA Translation: BAC05279.1
CH471106 Genomic DNA Translation: EAW84254.1
BC047412 mRNA Translation: AAH47412.1
CCDSiCCDS45983.1 [Q8N7K0-1]
CCDS77240.1 [Q8N7K0-2]
RefSeqiNP_001073880.1, NM_001080411.2 [Q8N7K0-1]
NP_001295275.1, NM_001308346.1
NP_001295277.1, NM_001308348.1
NP_001295280.1, NM_001308351.1 [Q8N7K0-2]
NP_001295284.1, NM_001308355.1 [Q8N7K0-2]
NP_001295286.1, NM_001308357.1 [Q8N7K0-2]
XP_006722724.1, XM_006722661.3 [Q8N7K0-2]
UniGeneiHs.667776

Genome annotation databases

EnsembliENST00000344980; ENSP00000339767; ENSG00000197647 [Q8N7K0-1]
ENST00000419886; ENSP00000393416; ENSG00000197647 [Q8N7K0-2]
GeneIDi163059
KEGGihsa:163059
UCSCiuc002msy.2 human [Q8N7K0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZN433_HUMAN
AccessioniPrimary (citable) accession number: Q8N7K0
Secondary accession number(s): Q86VX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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