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Protein

Zinc finger protein 433

Gene

ZNF433

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri142 – 16423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri170 – 19223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri198 – 22023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri226 – 24823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri254 – 27623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri282 – 30423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri310 – 33223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri338 – 36023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri366 – 38823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri394 – 41623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri422 – 44423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri450 – 47223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri478 – 50023C2H2-type 13; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri506 – 52823C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri534 – 55623C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri562 – 58423C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri590 – 61223C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri618 – 64023C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri646 – 66823C2H2-type 19PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 433
Gene namesi
Name:ZNF433
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:20811. ZNF433.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134943717.

Polymorphism and mutation databases

BioMutaiZNF433.
DMDMi30173446.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 673673Zinc finger protein 433PRO_0000047581Add
BLAST

Proteomic databases

EPDiQ8N7K0.
PaxDbiQ8N7K0.
PRIDEiQ8N7K0.

PTM databases

PhosphoSiteiQ8N7K0.

Expressioni

Gene expression databases

BgeeiQ8N7K0.
CleanExiHS_ZNF433.
ExpressionAtlasiQ8N7K0. baseline and differential.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-5P603703EBI-10267553,EBI-10172150
KRTAP10-7P604093EBI-10267553,EBI-10172290
MDFIQ997503EBI-10267553,EBI-724076

Protein-protein interaction databases

BioGridi127846. 7 interactions.
IntActiQ8N7K0. 3 interactions.
STRINGi9606.ENSP00000339767.

Structurei

3D structure databases

ProteinModelPortaliQ8N7K0.
SMRiQ8N7K0. Positions 7-55, 95-673.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 8579KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 19 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri142 – 16423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri170 – 19223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri198 – 22023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri226 – 24823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri254 – 27623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri282 – 30423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri310 – 33223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri338 – 36023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri366 – 38823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri394 – 41623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri422 – 44423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri450 – 47223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri478 – 50023C2H2-type 13; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri506 – 52823C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri534 – 55623C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri562 – 58423C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri590 – 61223C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri618 – 64023C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri646 – 66823C2H2-type 19PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N7K0.
KOiK09228.
OMAiRYHGRTH.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8N7K0.
TreeFamiTF343410.

Family and domain databases

Gene3Di3.30.160.60. 19 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 18 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N7K0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMFQDSVAFE DVAVTFTQEE WALLDPSQKN LCRDVMQETF RNLASIGKKW
60 70 80 90 100
KPQNIYVEYE NLRRNLRIVG ERLFESKEGH QHGEILTQVP DDMLKKTTTG
110 120 130 140 150
VKSCESSVYG EVGSAHSSLN RHIRDDTGHK AYEYQEYGQK PYKCKYCKKP
160 170 180 190 200
FNCLSSVQTH ERAHSGRKLY VCEECGKTFI SHSNLQRHRI MHRGDGPYKC
210 220 230 240 250
KFCGKALMFL SLYLIHKRTH TGEKPYQCKQ CGKAFSHSSS LRIHERTHTG
260 270 280 290 300
EKPYKCNECG KAFHSSTCLH AHKRTHTGEK PYECKQCGKA FSSSHSFQIH
310 320 330 340 350
ERTHTGEKPY ECKECGKAFK CPSSVRRHER THSRKKPYEC KHCGKVLSYL
360 370 380 390 400
TSFQNHLGMH TGEISHKCKI CGKAFYSPSS LQTHEKTHTG EKPYKCNQCG
410 420 430 440 450
KAFNSSSSFR YHERTHTGEK PYECKQCGKA FRSASLLQTH GRTHTGEKPY
460 470 480 490 500
ACKECGKPFS NFSFFQIHER MHREEKPYEC KGYGKTFSLP SLFHRHERTH
510 520 530 540 550
TGGKTYECKQ CGRSFNCSSS FRYHGRTHTG EKPYECKQCG KAFRSASQLQ
560 570 580 590 600
IHGRTHTGEK PYECKQCGKA FGSASHLQMH GRTHTGEKPY ECKQCGKSFG
610 620 630 640 650
CASRLQMHGR THTGEKPYKC KQCGKAFGCP SNLRRHGRTH TGEKPYKCNQ
660 670
CGKVFRCSSQ LQVHGRAHCI DTP
Length:673
Mass (Da):77,243
Last modified:October 1, 2002 - v1
Checksum:i8C8B1B6D272D08FC
GO
Isoform 2 (identifier: Q8N7K0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: Missing.

Show »
Length:638
Mass (Da):73,196
Checksum:i4E05BFC8FB53F1FD
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3535Missing in isoform 2. 1 PublicationVSP_035523Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098300 mRNA. Translation: BAC05279.1.
CH471106 Genomic DNA. Translation: EAW84254.1.
BC047412 mRNA. Translation: AAH47412.1.
CCDSiCCDS45983.1. [Q8N7K0-1]
CCDS77240.1. [Q8N7K0-2]
RefSeqiNP_001073880.1. NM_001080411.2. [Q8N7K0-1]
NP_001295275.1. NM_001308346.1.
NP_001295277.1. NM_001308348.1.
NP_001295280.1. NM_001308351.1. [Q8N7K0-2]
NP_001295284.1. NM_001308355.1. [Q8N7K0-2]
NP_001295286.1. NM_001308357.1. [Q8N7K0-2]
XP_006722724.1. XM_006722661.2. [Q8N7K0-2]
UniGeneiHs.667776.

Genome annotation databases

EnsembliENST00000344980; ENSP00000339767; ENSG00000197647. [Q8N7K0-1]
ENST00000419886; ENSP00000393416; ENSG00000197647. [Q8N7K0-2]
GeneIDi163059.
KEGGihsa:163059.
UCSCiuc002msy.2. human. [Q8N7K0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098300 mRNA. Translation: BAC05279.1.
CH471106 Genomic DNA. Translation: EAW84254.1.
BC047412 mRNA. Translation: AAH47412.1.
CCDSiCCDS45983.1. [Q8N7K0-1]
CCDS77240.1. [Q8N7K0-2]
RefSeqiNP_001073880.1. NM_001080411.2. [Q8N7K0-1]
NP_001295275.1. NM_001308346.1.
NP_001295277.1. NM_001308348.1.
NP_001295280.1. NM_001308351.1. [Q8N7K0-2]
NP_001295284.1. NM_001308355.1. [Q8N7K0-2]
NP_001295286.1. NM_001308357.1. [Q8N7K0-2]
XP_006722724.1. XM_006722661.2. [Q8N7K0-2]
UniGeneiHs.667776.

3D structure databases

ProteinModelPortaliQ8N7K0.
SMRiQ8N7K0. Positions 7-55, 95-673.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127846. 7 interactions.
IntActiQ8N7K0. 3 interactions.
STRINGi9606.ENSP00000339767.

PTM databases

PhosphoSiteiQ8N7K0.

Polymorphism and mutation databases

BioMutaiZNF433.
DMDMi30173446.

Proteomic databases

EPDiQ8N7K0.
PaxDbiQ8N7K0.
PRIDEiQ8N7K0.

Protocols and materials databases

DNASUi163059.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344980; ENSP00000339767; ENSG00000197647. [Q8N7K0-1]
ENST00000419886; ENSP00000393416; ENSG00000197647. [Q8N7K0-2]
GeneIDi163059.
KEGGihsa:163059.
UCSCiuc002msy.2. human. [Q8N7K0-1]

Organism-specific databases

CTDi163059.
GeneCardsiZNF433.
HGNCiHGNC:20811. ZNF433.
neXtProtiNX_Q8N7K0.
PharmGKBiPA134943717.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N7K0.
KOiK09228.
OMAiRYHGRTH.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8N7K0.
TreeFamiTF343410.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii163059.
NextBioi88284.
PROiQ8N7K0.

Gene expression databases

BgeeiQ8N7K0.
CleanExiHS_ZNF433.
ExpressionAtlasiQ8N7K0. baseline and differential.

Family and domain databases

Gene3Di3.30.160.60. 19 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 18 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Uterus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.

Entry informationi

Entry nameiZN433_HUMAN
AccessioniPrimary (citable) accession number: Q8N7K0
Secondary accession number(s): Q86VX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: October 1, 2002
Last modified: May 11, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.