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Protein

Zinc finger protein 433

Gene

ZNF433

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri142 – 164C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri170 – 192C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri198 – 220C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri226 – 248C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri254 – 276C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri282 – 304C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 332C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri338 – 360C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri422 – 444C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri450 – 472C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri478 – 500C2H2-type 13; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri506 – 528C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri534 – 556C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri562 – 584C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri590 – 612C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri618 – 640C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri646 – 668C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 433
Gene namesi
Name:ZNF433
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000197647.11.
HGNCiHGNC:20811. ZNF433.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi163059.
OpenTargetsiENSG00000197647.
PharmGKBiPA134943717.

Polymorphism and mutation databases

BioMutaiZNF433.
DMDMi30173446.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475811 – 673Zinc finger protein 433Add BLAST673

Proteomic databases

MaxQBiQ8N7K0.
PaxDbiQ8N7K0.
PeptideAtlasiQ8N7K0.
PRIDEiQ8N7K0.

PTM databases

iPTMnetiQ8N7K0.
PhosphoSitePlusiQ8N7K0.

Expressioni

Gene expression databases

BgeeiENSG00000197647.
CleanExiHS_ZNF433.
ExpressionAtlasiQ8N7K0. baseline and differential.

Organism-specific databases

HPAiHPA073724.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi127846. 7 interactors.
IntActiQ8N7K0. 5 interactors.
STRINGi9606.ENSP00000339767.

Structurei

3D structure databases

ProteinModelPortaliQ8N7K0.
SMRiQ8N7K0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 85KRABPROSITE-ProRule annotationAdd BLAST79

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri142 – 164C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri170 – 192C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri198 – 220C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri226 – 248C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri254 – 276C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri282 – 304C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 332C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri338 – 360C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri422 – 444C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri450 – 472C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri478 – 500C2H2-type 13; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri506 – 528C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri534 – 556C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri562 – 584C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri590 – 612C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri618 – 640C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri646 – 668C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N7K0.
KOiK09228.
OMAiRYHGRTH.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8N7K0.
TreeFamiTF343410.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.40.10. 2 hits.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 10 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 18 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N7K0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMFQDSVAFE DVAVTFTQEE WALLDPSQKN LCRDVMQETF RNLASIGKKW
60 70 80 90 100
KPQNIYVEYE NLRRNLRIVG ERLFESKEGH QHGEILTQVP DDMLKKTTTG
110 120 130 140 150
VKSCESSVYG EVGSAHSSLN RHIRDDTGHK AYEYQEYGQK PYKCKYCKKP
160 170 180 190 200
FNCLSSVQTH ERAHSGRKLY VCEECGKTFI SHSNLQRHRI MHRGDGPYKC
210 220 230 240 250
KFCGKALMFL SLYLIHKRTH TGEKPYQCKQ CGKAFSHSSS LRIHERTHTG
260 270 280 290 300
EKPYKCNECG KAFHSSTCLH AHKRTHTGEK PYECKQCGKA FSSSHSFQIH
310 320 330 340 350
ERTHTGEKPY ECKECGKAFK CPSSVRRHER THSRKKPYEC KHCGKVLSYL
360 370 380 390 400
TSFQNHLGMH TGEISHKCKI CGKAFYSPSS LQTHEKTHTG EKPYKCNQCG
410 420 430 440 450
KAFNSSSSFR YHERTHTGEK PYECKQCGKA FRSASLLQTH GRTHTGEKPY
460 470 480 490 500
ACKECGKPFS NFSFFQIHER MHREEKPYEC KGYGKTFSLP SLFHRHERTH
510 520 530 540 550
TGGKTYECKQ CGRSFNCSSS FRYHGRTHTG EKPYECKQCG KAFRSASQLQ
560 570 580 590 600
IHGRTHTGEK PYECKQCGKA FGSASHLQMH GRTHTGEKPY ECKQCGKSFG
610 620 630 640 650
CASRLQMHGR THTGEKPYKC KQCGKAFGCP SNLRRHGRTH TGEKPYKCNQ
660 670
CGKVFRCSSQ LQVHGRAHCI DTP
Length:673
Mass (Da):77,243
Last modified:October 1, 2002 - v1
Checksum:i8C8B1B6D272D08FC
GO
Isoform 2 (identifier: Q8N7K0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: Missing.

Show »
Length:638
Mass (Da):73,196
Checksum:i4E05BFC8FB53F1FD
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0355231 – 35Missing in isoform 2. 1 PublicationAdd BLAST35

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098300 mRNA. Translation: BAC05279.1.
CH471106 Genomic DNA. Translation: EAW84254.1.
BC047412 mRNA. Translation: AAH47412.1.
CCDSiCCDS45983.1. [Q8N7K0-1]
CCDS77240.1. [Q8N7K0-2]
RefSeqiNP_001073880.1. NM_001080411.2. [Q8N7K0-1]
NP_001295275.1. NM_001308346.1.
NP_001295277.1. NM_001308348.1.
NP_001295280.1. NM_001308351.1. [Q8N7K0-2]
NP_001295284.1. NM_001308355.1. [Q8N7K0-2]
NP_001295286.1. NM_001308357.1. [Q8N7K0-2]
XP_006722724.1. XM_006722661.3. [Q8N7K0-2]
UniGeneiHs.667776.

Genome annotation databases

EnsembliENST00000344980; ENSP00000339767; ENSG00000197647. [Q8N7K0-1]
ENST00000419886; ENSP00000393416; ENSG00000197647. [Q8N7K0-2]
GeneIDi163059.
KEGGihsa:163059.
UCSCiuc002msy.2. human. [Q8N7K0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZN433_HUMAN
AccessioniPrimary (citable) accession number: Q8N7K0
Secondary accession number(s): Q86VX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: October 1, 2002
Last modified: September 27, 2017
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families