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Q8N7H5

- PAF1_HUMAN

UniProt

Q8N7H5 - PAF1_HUMAN

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Protein

RNA polymerase II-associated factor 1 homolog

Gene

PAF1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the RNF20/40 E3 ubiquitin-protein ligase complex. Involved in polyadenylation of mRNA precursors. Has oncogenic activity in vivo and in vitro.7 Publications

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. RNA polymerase II core binding Source: UniProtKB

GO - Biological processi

  1. cellular response to lipopolysaccharide Source: UniProtKB
  2. endodermal cell fate commitment Source: UniProtKB
  3. histone H2B ubiquitination Source: UniProtKB
  4. histone monoubiquitination Source: UniProtKB
  5. mRNA polyadenylation Source: UniProtKB
  6. negative regulation of myeloid cell differentiation Source: UniProtKB
  7. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  8. positive regulation of mRNA 3'-end processing Source: UniProtKB
  9. positive regulation of transcription elongation from RNA polymerase II promoter Source: UniProtKB
  10. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  11. stem cell maintenance Source: Ensembl
  12. transcription, DNA-templated Source: UniProtKB-KW
  13. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II-associated factor 1 homolog
Short name:
hPAF1
Alternative name(s):
Pancreatic differentiation protein 2
Gene namesi
Name:PAF1
Synonyms:PD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:25459. PAF1.

Subcellular locationi

Nucleus 1 Publication
Note: Punctuate distribution throughout the nucleus except in nucleoli and the perinuclear chromatin.

GO - Cellular componenti

  1. Cdc73/Paf1 complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

PharmGKBiPA142671206.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 531531RNA polymerase II-associated factor 1 homologPRO_0000326400Add
BLAST

Proteomic databases

MaxQBiQ8N7H5.
PaxDbiQ8N7H5.
PRIDEiQ8N7H5.

Expressioni

Gene expression databases

BgeeiQ8N7H5.
CleanExiHS_PAF1.
ExpressionAtlasiQ8N7H5. baseline and differential.
GenevestigatoriQ8N7H5.

Organism-specific databases

HPAiHPA041875.

Interactioni

Subunit structurei

Component of the PAF1 complex, which consists of CDC73, PAF1, LEO1, CTR9, RTF1 and WDR61. Interacts with POLR2A, TCEA1, TTC37, KMT2A/MLL1, SUPT5H, RNF20 and RNF40. Interacts with UBE2E1. Interacts with influenza A strain H3N2 NS1 protein; the interaction interferes with host cell gene transcription, specifically with that of antiviral genes.9 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CDC73Q6P1J925EBI-2607770,EBI-930143
CTR9Q6PD6222EBI-2607770,EBI-1019583
KMT2AQ031644EBI-2607770,EBI-591370
LEO1Q8WVC017EBI-2607770,EBI-932432
NS1B2BUF16EBI-2607770,EBI-4291940From a different organism.
POLR2AP249285EBI-2607770,EBI-295301
RTF1Q9254116EBI-2607770,EBI-1055239
TCEA1P231934EBI-2607770,EBI-2608271
TTC37Q6PGP72EBI-2607770,EBI-6083436
UBE2E1P519652EBI-2607770,EBI-348546

Protein-protein interaction databases

BioGridi120081. 44 interactions.
DIPiDIP-48673N.
IntActiQ8N7H5. 19 interactions.
STRINGi9606.ENSP00000221265.

Structurei

Secondary structure

1
531
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi172 – 18716
Beta strandi201 – 2066
Beta strandi211 – 2155
Beta strandi231 – 2344
Beta strandi238 – 2414
Helixi246 – 2494

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4M6TX-ray2.50A170-250[»]
ProteinModelPortaliQ8N7H5.
SMRiQ8N7H5. Positions 170-257.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili352 – 40049Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi358 – 45295Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the PAF1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG297168.
GeneTreeiENSGT00390000001474.
HOGENOMiHOG000115425.
HOVERGENiHBG053131.
InParanoidiQ8N7H5.
KOiK15174.
OMAiYEVLTEH.
PhylomeDBiQ8N7H5.
TreeFamiTF313642.

Family and domain databases

InterProiIPR007133. RNA_pol_II-assoc_Paf1.
[Graphical view]
PANTHERiPTHR23188. PTHR23188. 1 hit.
PfamiPF03985. Paf1. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N7H5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPTIQTQAQ REDGHRPNSH RTLPERSGVV CRVKYCNSLP DIPFDPKFIT
60 70 80 90 100
YPFDQNRFVQ YKATSLEKQH KHDLLTEPDL GVTIDLINPD TYRIDPNVLL
110 120 130 140 150
DPADEKLLEE EIQAPTSSKR SQQHAKVVPW MRKTEYISTE FNRYGISNEK
160 170 180 190 200
PEVKIGVSVK QQFTEEEIYK DRDSQITAIE KTFEDAQKSI SQHYSKPRVT
210 220 230 240 250
PVEVMPVFPD FKMWINPCAQ VIFDSDPAPK DTSGAAALEM MSQAMIRGMM
260 270 280 290 300
DEEGNQFVAY FLPVEETLKK RKRDQEEEMD YAPDDVYDYK IAREYNWNVK
310 320 330 340 350
NKASKGYEEN YFFIFREGDG VYYNELETRV RLSKRRAKAG VQSGTNALLV
360 370 380 390 400
VKHRDMNEKE LEAQEARKAQ LENHEPEEEE EEEMETEEKE AGGSDEEQEK
410 420 430 440 450
GSSSEKEGSE DEHSGSESER EEGDRDEASD KSGSGEDESS EDEARAARDK
460 470 480 490 500
EEIFGSDADS EDDADSDDED RGQAQGGSDN DSDSGSNGGG QRSRSHSRSA
510 520 530
SPFPSGSEHS AQEDGSEAAA SDSSEADSDS D
Length:531
Mass (Da):59,976
Last modified:April 8, 2008 - v2
Checksum:i756F800AA64255D6
GO
Isoform 2 (identifier: Q8N7H5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     17-26: Missing.
     190-212: Missing.
     395-508: DEEQEKGSSS...SASPFPSGSE → VMLILRTMPT...QQSTFLVVCL

Note: No experimental confirmation available.

Show »
Length:485
Mass (Da):55,039
Checksum:i619FCF62CF34627D
GO
Isoform 3 (identifier: Q8N7H5-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     17-26: Missing.
     395-495: DEEQEKGSSS...SNGGGQRSRS → VMLILRTMPT...QQSTFLVVCL
     496-531: Missing.

Show »
Length:485
Mass (Da):55,473
Checksum:iE92BFB28CB9D655E
GO

Sequence cautioni

The sequence AAC25503.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence EAW56880.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence EAW56881.1 differs from that shown. Reason: Erroneous gene model prediction.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti58 – 581F → I in BAA92020. (PubMed:15057824)Curated
Sequence conflicti68 – 681K → R in BAC05305. (PubMed:15057824)Curated
Sequence conflicti152 – 1521E → G in BAA92020. (PubMed:15057824)Curated
Sequence conflicti378 – 3781E → G in BAA92020. (PubMed:15057824)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei17 – 2610Missing in isoform 2 and isoform 3. 1 PublicationVSP_032650
Alternative sequencei190 – 21223Missing in isoform 2. CuratedVSP_032651Add
BLAST
Alternative sequencei395 – 508114DEEQE…PSGSE → VMLILRTMPTLMMRTEDRPK VAVTMIQTAAAMGVASGAGA TAAAPVPSPVAASTRPRRMA VKLQLLIPVKLIVTVTESQG IQGWFRHHYCEQQSTFLVVC L in isoform 2. CuratedVSP_032652Add
BLAST
Alternative sequencei395 – 495101DEEQE…QRSRS → VMLILRTMPTLMMRTEDRPK VAVTMIQTAAAMGVASGAGA TAAAPVPSPVAASTRPRRMA VKLQLLIPVKLIVTVTESQG IQGWFRHHYCEQQSTFLVVC L in isoform 3. 1 PublicationVSP_055740Add
BLAST
Alternative sequencei496 – 53136Missing in isoform 3. 1 PublicationVSP_055741Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ401156 mRNA. Translation: CAC20564.1.
AK001985 mRNA. Translation: BAA92020.1.
AK098423 mRNA. Translation: BAC05305.1.
AC005239 Genomic DNA. Translation: AAC25503.1. Sequence problems.
CH471126 Genomic DNA. Translation: EAW56880.1. Sequence problems.
CH471126 Genomic DNA. Translation: EAW56881.1. Sequence problems.
CH471126 Genomic DNA. Translation: EAW56883.1.
BC000017 mRNA. Translation: AAH00017.1.
BC013402 mRNA. Translation: AAH13402.1.
CCDSiCCDS12533.1. [Q8N7H5-1]
CCDS59387.1. [Q8N7H5-3]
RefSeqiNP_001243755.1. NM_001256826.1. [Q8N7H5-3]
NP_061961.2. NM_019088.3. [Q8N7H5-1]
UniGeneiHs.466714.

Genome annotation databases

EnsembliENST00000221265; ENSP00000221265; ENSG00000006712. [Q8N7H5-1]
ENST00000595564; ENSP00000468874; ENSG00000006712. [Q8N7H5-3]
GeneIDi54623.
KEGGihsa:54623.
UCSCiuc002old.4. human. [Q8N7H5-1]

Polymorphism databases

DMDMi182670295.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ401156 mRNA. Translation: CAC20564.1 .
AK001985 mRNA. Translation: BAA92020.1 .
AK098423 mRNA. Translation: BAC05305.1 .
AC005239 Genomic DNA. Translation: AAC25503.1 . Sequence problems.
CH471126 Genomic DNA. Translation: EAW56880.1 . Sequence problems.
CH471126 Genomic DNA. Translation: EAW56881.1 . Sequence problems.
CH471126 Genomic DNA. Translation: EAW56883.1 .
BC000017 mRNA. Translation: AAH00017.1 .
BC013402 mRNA. Translation: AAH13402.1 .
CCDSi CCDS12533.1. [Q8N7H5-1 ]
CCDS59387.1. [Q8N7H5-3 ]
RefSeqi NP_001243755.1. NM_001256826.1. [Q8N7H5-3 ]
NP_061961.2. NM_019088.3. [Q8N7H5-1 ]
UniGenei Hs.466714.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4M6T X-ray 2.50 A 170-250 [» ]
ProteinModelPortali Q8N7H5.
SMRi Q8N7H5. Positions 170-257.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120081. 44 interactions.
DIPi DIP-48673N.
IntActi Q8N7H5. 19 interactions.
STRINGi 9606.ENSP00000221265.

Polymorphism databases

DMDMi 182670295.

Proteomic databases

MaxQBi Q8N7H5.
PaxDbi Q8N7H5.
PRIDEi Q8N7H5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000221265 ; ENSP00000221265 ; ENSG00000006712 . [Q8N7H5-1 ]
ENST00000595564 ; ENSP00000468874 ; ENSG00000006712 . [Q8N7H5-3 ]
GeneIDi 54623.
KEGGi hsa:54623.
UCSCi uc002old.4. human. [Q8N7H5-1 ]

Organism-specific databases

CTDi 54623.
GeneCardsi GC19M039876.
HGNCi HGNC:25459. PAF1.
HPAi HPA041875.
MIMi 610506. gene.
neXtProti NX_Q8N7H5.
PharmGKBi PA142671206.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG297168.
GeneTreei ENSGT00390000001474.
HOGENOMi HOG000115425.
HOVERGENi HBG053131.
InParanoidi Q8N7H5.
KOi K15174.
OMAi YEVLTEH.
PhylomeDBi Q8N7H5.
TreeFami TF313642.

Miscellaneous databases

ChiTaRSi PAF1. human.
GenomeRNAii 54623.
NextBioi 57158.
PROi Q8N7H5.
SOURCEi Search...

Gene expression databases

Bgeei Q8N7H5.
CleanExi HS_PAF1.
ExpressionAtlasi Q8N7H5. baseline and differential.
Genevestigatori Q8N7H5.

Family and domain databases

InterProi IPR007133. RNA_pol_II-assoc_Paf1.
[Graphical view ]
PANTHERi PTHR23188. PTHR23188. 1 hit.
Pfami PF03985. Paf1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human homologue of the RNA polymerase II-associated factor 1 (hPaf1), localized on the 19q13 amplicon, is associated with tumorigenesis."
    Moniaux N., Nemos C., Schmied B.M., Chauhan S.C., Deb S., Morikane K., Choudhury A., Vanlith M., Sutherlin M., Sikela J.M., Hollingsworth M.A., Batra S.K.
    Oncogene 25:3247-3257(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, INTERACTION WITH POLR2A, FUNCTION.
    Tissue: Fetal pancreas.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Placenta.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Muscle and Placenta.
  6. "The human PAF complex coordinates transcription with events downstream of RNA synthesis."
    Zhu B., Mandal S.S., Pham A.D., Zheng Y., Erdjument-Bromage H., Batra S.K., Tempst P., Reinberg D.
    Genes Dev. 19:1668-1673(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TTC37.
  7. "Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation."
    Zhu B., Zheng Y., Pham A.-D., Mandal S.S., Erdjument-Bromage H., Tempst P., Reinberg D.
    Mol. Cell 20:601-611(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UBE2E1.
  8. "The HRPT2 tumor suppressor gene product parafibromin associates with human PAF1 and RNA polymerase II."
    Yart A., Gstaiger M., Wirbelauer C., Pecnik M., Anastasiou D., Hess D., Krek W.
    Mol. Cell. Biol. 25:5052-5060(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CDC73 AND POLR2A.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "RAD6-mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells."
    Kim J., Guermah M., McGinty R.K., Lee J.S., Tang Z., Milne T.A., Shilatifard A., Muir T.W., Roeder R.G.
    Cell 137:459-471(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE PAF1 COMPLEX, INTERACTION WITH RNF20 AND RNF40.
  11. "DSIF, the Paf1 complex, and Tat-SF1 have nonredundant, cooperative roles in RNA polymerase II elongation."
    Chen Y., Yamaguchi Y., Tsugeno Y., Yamamoto J., Yamada T., Nakamura M., Hisatake K., Handa H.
    Genes Dev. 23:2765-2777(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE PAF1 COMPLEX, FUNCTION OF THE PAF1 COMPLEX, INTERACTION WITH SUPT5H.
  12. "The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis."
    Muntean A.G., Tan J., Sitwala K., Huang Y., Bronstein J., Connelly J.A., Basrur V., Elenitoba-Johnson K.S., Hess J.L.
    Cancer Cell 17:609-621(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE PAF1 COMPLEX, INTERACTION WITH KMT2A.
  13. "The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS."
    Kim J., Guermah M., Roeder R.G.
    Cell 140:491-503(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE PAF1 COMPLEX, COMPOSITION OF THE PAF1 COMPLEX, FUNCTION OF THE PAF1 COMPLEX, INTERACTION WITH TCEA1.
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "Transcriptional activators enhance polyadenylation of mRNA precursors."
    Nagaike T., Logan C., Hotta I., Rozenblatt-Rosen O., Meyerson M., Manley J.L.
    Mol. Cell 41:409-418(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, FUNCTION OF THE PAF1 COMPLEX.
  17. Cited for: FUNCTION OF THE PAF1 COMPLEX, INTERACTION WITH INFLUENZA A NS1 PROTEIN.
  18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPAF1_HUMAN
AccessioniPrimary (citable) accession number: Q8N7H5
Secondary accession number(s): M0QX35
, O75239, Q9H166, Q9NUU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: October 29, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3