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Protein

POU domain, class 5, transcription factor 2

Gene

POU5F2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor that binds preferentially to the octamer motif (5'-ATGTTAAT-3'). May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi210 – 269HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:G66-31174-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 5, transcription factor 2
Alternative name(s):
Sperm 1 POU domain transcription factor
Short name:
SPRM-1
Gene namesi
Name:POU5F2
Synonyms:SPRM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:26367. POU5F2.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000248483.
PharmGKBiPA162399970.

Polymorphism and mutation databases

BioMutaiPOU5F2.
DMDMi28201897.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001007561 – 328POU domain, class 5, transcription factor 2Add BLAST328

Proteomic databases

EPDiQ8N7G0.
PaxDbiQ8N7G0.
PRIDEiQ8N7G0.

PTM databases

iPTMnetiQ8N7G0.
PhosphoSitePlusiQ8N7G0.

Expressioni

Tissue specificityi

Expressed in skeletal and cardiac muscles, brain, heart and lung. Little or no detectable expression found in pancreas, kidney, liver or placenta.1 Publication

Gene expression databases

BgeeiENSG00000248483.
CleanExiHS_POU5F2.
GenevisibleiQ8N7G0. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000464890.

Structurei

3D structure databases

ProteinModelPortaliQ8N7G0.
SMRiQ8N7G0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini118 – 192POU-specificPROSITE-ProRule annotationAdd BLAST75

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 POU-specific domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG3802. Eukaryota.
ENOG410XQ7X. LUCA.
GeneTreeiENSGT00760000118935.
HOVERGENiHBG057998.
InParanoidiQ8N7G0.
OMAiCKMEMIL.
OrthoDBiEOG091G0ICI.
PhylomeDBiQ8N7G0.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_dom.
IPR015585. POU_dom_5.
[Graphical view]
PANTHERiPTHR11636:SF14. PTHR11636:SF14. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N7G0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGHRPSNHF CPLPGSGGGG PRGPMPLRVD TLTWLSTQAA PGRVMVWPAV
60 70 80 90 100
RPGICPGPDV WRIPLGPLPH EFRGWIAPCR PRLGASEAGD WLRRPSEGAL
110 120 130 140 150
PGPYIALRSI PKLPPPEDIS GILKELQQLA KELRQKRLSL GYSQADVGIA
160 170 180 190 200
VGALFGKVLS QTTICRFEAQ QLSVANMWKL RPLLKKWLKE VEAENLLGLC
210 220 230 240 250
KMEMILQQSG KWRRASRERR IGNSLEKFFQ RCPKPTPQQI SHIAGCLQLQ
260 270 280 290 300
KDVVRVWFYN RSKMGSRPTN DASPREIVGT AGPPCPGAPV CFHLGLGLPV
310 320
DIPHYTRLYS AGVAHSSAPA TTLGLLRF
Length:328
Mass (Da):36,051
Last modified:October 1, 2002 - v1
Checksum:iDD90D7153E69A3ED
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2A → D in AAH29532 (PubMed:15489334).Curated1
Sequence conflicti229F → L in CAE46012 (PubMed:17974005).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098546 mRNA. Translation: BAC05328.1.
BC029532 mRNA. Translation: AAH29532.2.
BX641019 mRNA. Translation: CAE46012.1.
Z21965 mRNA. Translation: CAA79976.1.
CCDSiCCDS59489.1.
RefSeqiNP_694948.1. NM_153216.1.
UniGeneiHs.678995.

Genome annotation databases

EnsembliENST00000606183; ENSP00000489796; ENSG00000248483.
GeneIDi134187.
KEGGihsa:134187.
UCSCiuc003kkl.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098546 mRNA. Translation: BAC05328.1.
BC029532 mRNA. Translation: AAH29532.2.
BX641019 mRNA. Translation: CAE46012.1.
Z21965 mRNA. Translation: CAA79976.1.
CCDSiCCDS59489.1.
RefSeqiNP_694948.1. NM_153216.1.
UniGeneiHs.678995.

3D structure databases

ProteinModelPortaliQ8N7G0.
SMRiQ8N7G0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000464890.

PTM databases

iPTMnetiQ8N7G0.
PhosphoSitePlusiQ8N7G0.

Polymorphism and mutation databases

BioMutaiPOU5F2.
DMDMi28201897.

Proteomic databases

EPDiQ8N7G0.
PaxDbiQ8N7G0.
PRIDEiQ8N7G0.

Protocols and materials databases

DNASUi134187.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000606183; ENSP00000489796; ENSG00000248483.
GeneIDi134187.
KEGGihsa:134187.
UCSCiuc003kkl.2. human.

Organism-specific databases

CTDi134187.
GeneCardsiPOU5F2.
HGNCiHGNC:26367. POU5F2.
neXtProtiNX_Q8N7G0.
OpenTargetsiENSG00000248483.
PharmGKBiPA162399970.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3802. Eukaryota.
ENOG410XQ7X. LUCA.
GeneTreeiENSGT00760000118935.
HOVERGENiHBG057998.
InParanoidiQ8N7G0.
OMAiCKMEMIL.
OrthoDBiEOG091G0ICI.
PhylomeDBiQ8N7G0.

Enzyme and pathway databases

BioCyciZFISH:G66-31174-MONOMER.

Miscellaneous databases

GenomeRNAii134187.
PROiQ8N7G0.

Gene expression databases

BgeeiENSG00000248483.
CleanExiHS_POU5F2.
GenevisibleiQ8N7G0. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_dom.
IPR015585. POU_dom_5.
[Graphical view]
PANTHERiPTHR11636:SF14. PTHR11636:SF14. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPO5F2_HUMAN
AccessioniPrimary (citable) accession number: Q8N7G0
Secondary accession number(s): Q15169, Q6MZL7, Q8N748
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.