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Q8N7G0 (PO5F2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
POU domain, class 5, transcription factor 2
Alternative name(s):
Sperm 1 POU domain transcription factor
Short name=SPRM-1
Gene names
Name:POU5F2
Synonyms:SPRM1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length328 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor that binds preferentially to the octamer motif (5'-ATGTTAAT-3'). May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell By similarity.

Subcellular location

Nucleus By similarity.

Tissue specificity

Expressed in skeletal and cardiac muscles, brain, heart and lung. Little or no detectable expression found in pancreas, kidney, liver or placenta. Ref.4

Sequence similarities

Belongs to the POU transcription factor family. Class-5 subfamily.

Contains 1 homeobox DNA-binding domain.

Contains 1 POU-specific domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranscription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: Ensembl

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 328328POU domain, class 5, transcription factor 2
PRO_0000100756

Regions

Domain118 – 19275POU-specific
DNA binding210 – 26960Homeobox

Experimental info

Sequence conflict21A → D in AAH29532. Ref.2
Sequence conflict2291F → L in CAE46012. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q8N7G0 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: DD90D7153E69A3ED

FASTA32836,051
        10         20         30         40         50         60 
MAGHRPSNHF CPLPGSGGGG PRGPMPLRVD TLTWLSTQAA PGRVMVWPAV RPGICPGPDV 

        70         80         90        100        110        120 
WRIPLGPLPH EFRGWIAPCR PRLGASEAGD WLRRPSEGAL PGPYIALRSI PKLPPPEDIS 

       130        140        150        160        170        180 
GILKELQQLA KELRQKRLSL GYSQADVGIA VGALFGKVLS QTTICRFEAQ QLSVANMWKL 

       190        200        210        220        230        240 
RPLLKKWLKE VEAENLLGLC KMEMILQQSG KWRRASRERR IGNSLEKFFQ RCPKPTPQQI 

       250        260        270        280        290        300 
SHIAGCLQLQ KDVVRVWFYN RSKMGSRPTN DASPREIVGT AGPPCPGAPV CFHLGLGLPV 

       310        320 
DIPHYTRLYS AGVAHSSAPA TTLGLLRF 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 148-328.
Tissue: Uterus.
[4]"A human POU domain gene, mPOU, is expressed in developing brain and specific adult tissues."
Wey E., Lyons G.E., Schaefer B.W.
Eur. J. Biochem. 220:753-762(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 168-254, TISSUE SPECIFICITY.
Tissue: Skeletal muscle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK098546 mRNA. Translation: BAC05328.1.
BC029532 mRNA. Translation: AAH29532.2.
BX641019 mRNA. Translation: CAE46012.1.
Z21965 mRNA. Translation: CAA79976.1.
RefSeqNP_694948.1. NM_153216.1.
UniGeneHs.678995.

3D structure databases

ProteinModelPortalQ8N7G0.
SMRQ8N7G0. Positions 124-267.
ModBaseSearch...
MobiDBSearch...

Polymorphism databases

DMDM28201897.

Proteomic databases

PRIDEQ8N7G0.

Protocols and materials databases

DNASU134187.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000510627; ENSP00000464890; ENSG00000248483.
GeneID134187.
KEGGhsa:134187.
UCSCuc003kkl.1. human.

Organism-specific databases

CTD134187.
GeneCardsGC05M093102.
HGNCHGNC:26367. POU5F2.
neXtProtNX_Q8N7G0.
PharmGKBPA162399970.
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG057998.
OMAMEMILQQ.
OrthoDBEOG7MKW6H.
PhylomeDBQ8N7G0.

Gene expression databases

BgeeQ8N7G0.
CleanExHS_POU5F2.
GenevestigatorQ8N7G0.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSPR00028. POUDOMAIN.
SMARTSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEPS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi134187.
NextBio83332.
PROQ8N7G0.

Entry information

Entry namePO5F2_HUMAN
AccessionPrimary (citable) accession number: Q8N7G0
Secondary accession number(s): Q15169, Q6MZL7, Q8N748
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM