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Q8N7G0

- PO5F2_HUMAN

UniProt

Q8N7G0 - PO5F2_HUMAN

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Protein

POU domain, class 5, transcription factor 2

Gene

POU5F2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Transcription factor that binds preferentially to the octamer motif (5'-ATGTTAAT-3'). May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi210 – 26960HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: Ensembl
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 5, transcription factor 2
Alternative name(s):
Sperm 1 POU domain transcription factor
Short name:
SPRM-1
Gene namesi
Name:POU5F2
Synonyms:SPRM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:26367. POU5F2.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162399970.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328POU domain, class 5, transcription factor 2PRO_0000100756Add
BLAST

Proteomic databases

PRIDEiQ8N7G0.

Expressioni

Tissue specificityi

Expressed in skeletal and cardiac muscles, brain, heart and lung. Little or no detectable expression found in pancreas, kidney, liver or placenta.1 Publication

Gene expression databases

BgeeiQ8N7G0.
CleanExiHS_POU5F2.
GenevestigatoriQ8N7G0.

Structurei

3D structure databases

ProteinModelPortaliQ8N7G0.
SMRiQ8N7G0. Positions 124-267.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini118 – 19275POU-specificPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 POU-specific domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

GeneTreeiENSGT00760000118935.
HOVERGENiHBG057998.
InParanoidiQ8N7G0.
OMAiMEMILQQ.
OrthoDBiEOG7MKW6H.
PhylomeDBiQ8N7G0.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N7G0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGHRPSNHF CPLPGSGGGG PRGPMPLRVD TLTWLSTQAA PGRVMVWPAV
60 70 80 90 100
RPGICPGPDV WRIPLGPLPH EFRGWIAPCR PRLGASEAGD WLRRPSEGAL
110 120 130 140 150
PGPYIALRSI PKLPPPEDIS GILKELQQLA KELRQKRLSL GYSQADVGIA
160 170 180 190 200
VGALFGKVLS QTTICRFEAQ QLSVANMWKL RPLLKKWLKE VEAENLLGLC
210 220 230 240 250
KMEMILQQSG KWRRASRERR IGNSLEKFFQ RCPKPTPQQI SHIAGCLQLQ
260 270 280 290 300
KDVVRVWFYN RSKMGSRPTN DASPREIVGT AGPPCPGAPV CFHLGLGLPV
310 320
DIPHYTRLYS AGVAHSSAPA TTLGLLRF
Length:328
Mass (Da):36,051
Last modified:October 1, 2002 - v1
Checksum:iDD90D7153E69A3ED
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21A → D in AAH29532. (PubMed:15489334)Curated
Sequence conflicti229 – 2291F → L in CAE46012. (PubMed:17974005)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK098546 mRNA. Translation: BAC05328.1.
BC029532 mRNA. Translation: AAH29532.2.
BX641019 mRNA. Translation: CAE46012.1.
Z21965 mRNA. Translation: CAA79976.1.
CCDSiCCDS59489.1.
RefSeqiNP_694948.1. NM_153216.1.
UniGeneiHs.678995.

Genome annotation databases

EnsembliENST00000510627; ENSP00000464890; ENSG00000248483.
GeneIDi134187.
KEGGihsa:134187.
UCSCiuc003kkl.1. human.

Polymorphism databases

DMDMi28201897.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK098546 mRNA. Translation: BAC05328.1 .
BC029532 mRNA. Translation: AAH29532.2 .
BX641019 mRNA. Translation: CAE46012.1 .
Z21965 mRNA. Translation: CAA79976.1 .
CCDSi CCDS59489.1.
RefSeqi NP_694948.1. NM_153216.1.
UniGenei Hs.678995.

3D structure databases

ProteinModelPortali Q8N7G0.
SMRi Q8N7G0. Positions 124-267.
ModBasei Search...
MobiDBi Search...

Polymorphism databases

DMDMi 28201897.

Proteomic databases

PRIDEi Q8N7G0.

Protocols and materials databases

DNASUi 134187.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000510627 ; ENSP00000464890 ; ENSG00000248483 .
GeneIDi 134187.
KEGGi hsa:134187.
UCSCi uc003kkl.1. human.

Organism-specific databases

CTDi 134187.
GeneCardsi GC05M093102.
HGNCi HGNC:26367. POU5F2.
neXtProti NX_Q8N7G0.
PharmGKBi PA162399970.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00760000118935.
HOVERGENi HBG057998.
InParanoidi Q8N7G0.
OMAi MEMILQQ.
OrthoDBi EOG7MKW6H.
PhylomeDBi Q8N7G0.

Miscellaneous databases

GenomeRNAii 134187.
NextBioi 83332.
PROi Q8N7G0.

Gene expression databases

Bgeei Q8N7G0.
CleanExi HS_POU5F2.
Genevestigatori Q8N7G0.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProi IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view ]
PRINTSi PR00028. POUDOMAIN.
SMARTi SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEi PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 148-328.
    Tissue: Uterus.
  4. "A human POU domain gene, mPOU, is expressed in developing brain and specific adult tissues."
    Wey E., Lyons G.E., Schaefer B.W.
    Eur. J. Biochem. 220:753-762(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 168-254, TISSUE SPECIFICITY.
    Tissue: Skeletal muscle.

Entry informationi

Entry nameiPO5F2_HUMAN
AccessioniPrimary (citable) accession number: Q8N7G0
Secondary accession number(s): Q15169, Q6MZL7, Q8N748
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3