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Q8N7G0

- PO5F2_HUMAN

UniProt

Q8N7G0 - PO5F2_HUMAN

Protein

POU domain, class 5, transcription factor 2

Gene

POU5F2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Transcription factor that binds preferentially to the octamer motif (5'-ATGTTAAT-3'). May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi210 – 26960HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: Ensembl
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    POU domain, class 5, transcription factor 2
    Alternative name(s):
    Sperm 1 POU domain transcription factor
    Short name:
    SPRM-1
    Gene namesi
    Name:POU5F2
    Synonyms:SPRM1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:26367. POU5F2.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162399970.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 328328POU domain, class 5, transcription factor 2PRO_0000100756Add
    BLAST

    Proteomic databases

    PRIDEiQ8N7G0.

    Expressioni

    Tissue specificityi

    Expressed in skeletal and cardiac muscles, brain, heart and lung. Little or no detectable expression found in pancreas, kidney, liver or placenta.1 Publication

    Gene expression databases

    BgeeiQ8N7G0.
    CleanExiHS_POU5F2.
    GenevestigatoriQ8N7G0.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N7G0.
    SMRiQ8N7G0. Positions 124-267.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini118 – 19275POU-specificPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 POU-specific domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    HOVERGENiHBG057998.
    OMAiMEMILQQ.
    OrthoDBiEOG7MKW6H.
    PhylomeDBiQ8N7G0.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PRINTSiPR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8N7G0-1 [UniParc]FASTAAdd to Basket

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    MAGHRPSNHF CPLPGSGGGG PRGPMPLRVD TLTWLSTQAA PGRVMVWPAV    50
    RPGICPGPDV WRIPLGPLPH EFRGWIAPCR PRLGASEAGD WLRRPSEGAL 100
    PGPYIALRSI PKLPPPEDIS GILKELQQLA KELRQKRLSL GYSQADVGIA 150
    VGALFGKVLS QTTICRFEAQ QLSVANMWKL RPLLKKWLKE VEAENLLGLC 200
    KMEMILQQSG KWRRASRERR IGNSLEKFFQ RCPKPTPQQI SHIAGCLQLQ 250
    KDVVRVWFYN RSKMGSRPTN DASPREIVGT AGPPCPGAPV CFHLGLGLPV 300
    DIPHYTRLYS AGVAHSSAPA TTLGLLRF 328
    Length:328
    Mass (Da):36,051
    Last modified:October 1, 2002 - v1
    Checksum:iDD90D7153E69A3ED
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2 – 21A → D in AAH29532. (PubMed:15489334)Curated
    Sequence conflicti229 – 2291F → L in CAE46012. (PubMed:17974005)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK098546 mRNA. Translation: BAC05328.1.
    BC029532 mRNA. Translation: AAH29532.2.
    BX641019 mRNA. Translation: CAE46012.1.
    Z21965 mRNA. Translation: CAA79976.1.
    CCDSiCCDS59489.1.
    RefSeqiNP_694948.1. NM_153216.1.
    UniGeneiHs.678995.

    Genome annotation databases

    EnsembliENST00000510627; ENSP00000464890; ENSG00000248483.
    GeneIDi134187.
    KEGGihsa:134187.
    UCSCiuc003kkl.1. human.

    Polymorphism databases

    DMDMi28201897.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK098546 mRNA. Translation: BAC05328.1 .
    BC029532 mRNA. Translation: AAH29532.2 .
    BX641019 mRNA. Translation: CAE46012.1 .
    Z21965 mRNA. Translation: CAA79976.1 .
    CCDSi CCDS59489.1.
    RefSeqi NP_694948.1. NM_153216.1.
    UniGenei Hs.678995.

    3D structure databases

    ProteinModelPortali Q8N7G0.
    SMRi Q8N7G0. Positions 124-267.
    ModBasei Search...
    MobiDBi Search...

    Polymorphism databases

    DMDMi 28201897.

    Proteomic databases

    PRIDEi Q8N7G0.

    Protocols and materials databases

    DNASUi 134187.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000510627 ; ENSP00000464890 ; ENSG00000248483 .
    GeneIDi 134187.
    KEGGi hsa:134187.
    UCSCi uc003kkl.1. human.

    Organism-specific databases

    CTDi 134187.
    GeneCardsi GC05M093102.
    HGNCi HGNC:26367. POU5F2.
    neXtProti NX_Q8N7G0.
    PharmGKBi PA162399970.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG057998.
    OMAi MEMILQQ.
    OrthoDBi EOG7MKW6H.
    PhylomeDBi Q8N7G0.

    Miscellaneous databases

    GenomeRNAii 134187.
    NextBioi 83332.
    PROi Q8N7G0.

    Gene expression databases

    Bgeei Q8N7G0.
    CleanExi HS_POU5F2.
    Genevestigatori Q8N7G0.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PRINTSi PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 148-328.
      Tissue: Uterus.
    4. "A human POU domain gene, mPOU, is expressed in developing brain and specific adult tissues."
      Wey E., Lyons G.E., Schaefer B.W.
      Eur. J. Biochem. 220:753-762(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 168-254, TISSUE SPECIFICITY.
      Tissue: Skeletal muscle.

    Entry informationi

    Entry nameiPO5F2_HUMAN
    AccessioniPrimary (citable) accession number: Q8N7G0
    Secondary accession number(s): Q15169, Q6MZL7, Q8N748
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3