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Protein

Ubiquitin-like protein 4B

Gene

UBL4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Miscellaneous

May have arisen from retrotransposition of the X-linked UBL4A gene during mammalian evolution.

GO - Biological processi

  • positive regulation of protein targeting to mitochondrion Source: ParkinsonsUK-UCL

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-like protein 4B
Gene namesi
Name:UBL4B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:32309. UBL4B.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi164153.
OpenTargetsiENSG00000186150.
PharmGKBiPA142670661.

Polymorphism and mutation databases

BioMutaiUBL4B.
DMDMi74729219.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002637011 – 174Ubiquitin-like protein 4BAdd BLAST174

Proteomic databases

MaxQBiQ8N7F7.
PaxDbiQ8N7F7.
PeptideAtlasiQ8N7F7.
PRIDEiQ8N7F7.

Expressioni

Gene expression databases

BgeeiENSG00000186150.
CleanExiHS_UBL4B.
GenevisibleiQ8N7F7. HS.

Organism-specific databases

HPAiHPA031364.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi127890. 2 interactors.
IntActiQ8N7F7. 3 interactors.
STRINGi9606.ENSP00000334044.

Structurei

3D structure databases

ProteinModelPortaliQ8N7F7.
SMRiQ8N7F7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 76Ubiquitin-likePROSITE-ProRule annotationAdd BLAST76

Phylogenomic databases

eggNOGiKOG0001. Eukaryota.
COG5272. LUCA.
GeneTreeiENSGT00730000111022.
HOGENOMiHOG000006827.
HOVERGENiHBG072205.
InParanoidiQ8N7F7.
OMAiQHLLFRG.
OrthoDBiEOG091G0XVA.
PhylomeDBiQ8N7F7.
TreeFamiTF354228.

Family and domain databases

InterProiView protein in InterPro
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
PfamiView protein in Pfam
PF00240. ubiquitin. 1 hit.
SMARTiView protein in SMART
SM00213. UBQ. 1 hit.
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiView protein in PROSITE
PS50053. UBIQUITIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8N7F7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLTVKLLLG QRCSLKVSGQ ESVATLKRLV SRRLKVPEEQ QHLLFRGQLL
60 70 80 90 100
EDDKHLSDYC IGPNASINVI MQPLEKMALK EAHQPQTQPL WHQLGLVLAK
110 120 130 140 150
HFEPQDAKAV LQLLRQEHEE RLQKISLEHL EQLAQYLLAE EPHVEPAGER
160 170
ELEAKARPQS SCDMEEKEEA AADQ
Length:174
Mass (Da):19,909
Last modified:October 1, 2002 - v1
Checksum:iBC49D31A0357C1E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098556 mRNA. Translation: BAC05331.1.
BC058929 mRNA. Translation: AAH58929.1.
CCDSiCCDS820.1.
RefSeqiNP_981957.1. NM_203412.1.
UniGeneiHs.374027.

Genome annotation databases

EnsembliENST00000334179; ENSP00000334044; ENSG00000186150.
GeneIDi164153.
KEGGihsa:164153.
UCSCiuc001dzc.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098556 mRNA. Translation: BAC05331.1.
BC058929 mRNA. Translation: AAH58929.1.
CCDSiCCDS820.1.
RefSeqiNP_981957.1. NM_203412.1.
UniGeneiHs.374027.

3D structure databases

ProteinModelPortaliQ8N7F7.
SMRiQ8N7F7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127890. 2 interactors.
IntActiQ8N7F7. 3 interactors.
STRINGi9606.ENSP00000334044.

Polymorphism and mutation databases

BioMutaiUBL4B.
DMDMi74729219.

Proteomic databases

MaxQBiQ8N7F7.
PaxDbiQ8N7F7.
PeptideAtlasiQ8N7F7.
PRIDEiQ8N7F7.

Protocols and materials databases

DNASUi164153.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334179; ENSP00000334044; ENSG00000186150.
GeneIDi164153.
KEGGihsa:164153.
UCSCiuc001dzc.4. human.

Organism-specific databases

CTDi164153.
DisGeNETi164153.
GeneCardsiUBL4B.
HGNCiHGNC:32309. UBL4B.
HPAiHPA031364.
MIMi611127. gene.
neXtProtiNX_Q8N7F7.
OpenTargetsiENSG00000186150.
PharmGKBiPA142670661.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0001. Eukaryota.
COG5272. LUCA.
GeneTreeiENSGT00730000111022.
HOGENOMiHOG000006827.
HOVERGENiHBG072205.
InParanoidiQ8N7F7.
OMAiQHLLFRG.
OrthoDBiEOG091G0XVA.
PhylomeDBiQ8N7F7.
TreeFamiTF354228.

Miscellaneous databases

ChiTaRSiUBL4B. human.
GenomeRNAii164153.
PROiPR:Q8N7F7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186150.
CleanExiHS_UBL4B.
GenevisibleiQ8N7F7. HS.

Family and domain databases

InterProiView protein in InterPro
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
PfamiView protein in Pfam
PF00240. ubiquitin. 1 hit.
SMARTiView protein in SMART
SM00213. UBQ. 1 hit.
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiView protein in PROSITE
PS50053. UBIQUITIN_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUBL4B_HUMAN
AccessioniPrimary (citable) accession number: Q8N7F7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 1, 2002
Last modified: March 15, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.