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Protein

E3 ubiquitin-protein ligase CBLL2

Gene

CBLL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:20657603). May operate on tyrosine-phosphorylated SRC substrates (PubMed:22252131).2 Publications

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.1 Publication
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri57 – 97RING-typePROSITE-ProRule annotationAdd BLAST41
Zinc fingeri112 – 138C2H2-typePROSITE-ProRule annotationAdd BLAST27

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase CBLL2Curated (EC:2.3.2.271 Publication)
Alternative name(s):
Cbl proto-oncogene-like protein 2
RING-type E3 ubiquitin transferase ZNF645
Zinc finger protein 645
c-Cbl-like protein 2
Gene namesi
Name:CBLL2Imported
Synonyms:ZNF645
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000175809.5
HGNCiHGNC:26371 CBLL2
neXtProtiNX_Q8N7E2

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi158506
OpenTargetsiENSG00000175809
PharmGKBiPA134934025

Polymorphism and mutation databases

BioMutaiZNF645
DMDMi74759980

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000563161 – 425E3 ubiquitin-protein ligase CBLL2Add BLAST425

Proteomic databases

PaxDbiQ8N7E2
PeptideAtlasiQ8N7E2
PRIDEiQ8N7E2

PTM databases

iPTMnetiQ8N7E2
PhosphoSitePlusiQ8N7E2

Expressioni

Tissue specificityi

Exclusively expressed in testis and sperm, including spermatocytes, round and elongated spermatids, and Leydig cells.1 Publication

Gene expression databases

BgeeiENSG00000175809
CleanExiHS_ZNF645
GenevisibleiQ8N7E2 HS

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi127688, 6 interactors
IntActiQ8N7E2, 7 interactors
STRINGi9606.ENSP00000323348

Structurei

3D structure databases

ProteinModelPortaliQ8N7E2
SMRiQ8N7E2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni96 – 154HYB domainAdd BLAST59

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi254 – 343Pro-richAdd BLAST90

Domaini

The HYB domain forms a phosphotyrosine-binding pocket upon dimerization, and mediates as well the recognition of its flanking acidic amino acids.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri57 – 97RING-typePROSITE-ProRule annotationAdd BLAST41
Zinc fingeri112 – 138C2H2-typePROSITE-ProRule annotationAdd BLAST27

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2932 Eukaryota
ENOG410XQ6S LUCA
GeneTreeiENSGT00510000047522
HOGENOMiHOG000082498
HOVERGENiHBG057723
InParanoidiQ8N7E2
KOiK15714
OMAiPQFTENQ
OrthoDBiEOG091G0AJH
PhylomeDBiQ8N7E2
TreeFamiTF332910

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR013087 Znf_C2H2_type
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PROSITEiView protein in PROSITE
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8N7E2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKMPAGEQE CEYNKEGKYY SKGVKLVRKK KKIPGYRWGD IKINIIGEKD
60 70 80 90 100
DLPIHFCDKC DLPIKIYGRI IPCKHAFCYH CANLYDKVGY KVCPRCRYPV
110 120 130 140 150
LRIEAHKRGS VFMCSIVQQC KRTYLSQKSL QAHIKRRHKR ARKQVTSASL
160 170 180 190 200
EKVRPHIAPP QTEISDIPKR LQDRDHLSYI PPEQHTMVSL PSVQHMLQEQ
210 220 230 240 250
HNQPHKDIQA PPPELSLSLP FPIQWETVSI FTRKHGNLTV DHIQNNSDSG
260 270 280 290 300
AKKPTPPDYY PECQSQPAVS SPHHIIPQKQ HYAPPPSPSS PVNHQMPYPP
310 320 330 340 350
QDVVTPNSVR SQVPALTTTY DPSSGYIIVK VPPDMNSPPL RAPQSQNGNP
360 370 380 390 400
SASEFASHHY NLNILPQFTE NQETLSPQFT QTDAMDHRRW PAWKRLSPCP
410 420
PTRSPPPSTL HGRSHHSHQR RHRRY
Length:425
Mass (Da):48,785
Last modified:October 1, 2002 - v1
Checksum:i873C2802514CD9E5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti267P → L in ADI56589 (PubMed:20657603).Curated1
Sequence conflicti411H → Q in ADI56589 (PubMed:20657603).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030340166D → E2 PublicationsCorresponds to variant dbSNP:rs5951426Ensembl.1
Natural variantiVAR_030341287S → F. Corresponds to variant dbSNP:rs12860105Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ355336 mRNA Translation: ADI56589.1
AK098601 mRNA Translation: BAC05348.1
BX293560 Genomic DNA No translation available.
BC074910 mRNA Translation: AAH74910.1
BC126190 mRNA Translation: AAI26191.1
BC126192 mRNA Translation: AAI26193.1
CCDSiCCDS14205.1
RefSeqiNP_689790.1, NM_152577.3
UniGeneiHs.132485

Genome annotation databases

EnsembliENST00000323684; ENSP00000323348; ENSG00000175809
GeneIDi158506
KEGGihsa:158506
UCSCiuc004dai.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCBLL2_HUMAN
AccessioniPrimary (citable) accession number: Q8N7E2
Secondary accession number(s): A0AV29
, A0AV31, E3SBK4, Q6DJY9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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