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Protein

Transmembrane protein 217

Gene

TMEM217

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 217
Gene namesi
Name:TMEM217
Synonyms:C6orf128
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21238. TMEM217.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3321HelicalSequence analysisAdd
BLAST
Transmembranei67 – 8721HelicalSequence analysisAdd
BLAST
Transmembranei94 – 11421HelicalSequence analysisAdd
BLAST
Transmembranei129 – 14921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162406568.

Polymorphism and mutation databases

BioMutaiTMEM217.
DMDMi68565216.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 229229Transmembrane protein 217PRO_0000089528Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi39 – 391N-linked (GlcNAc...)Sequence analysis
Glycosylationi156 – 1561N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8N7C4.
PRIDEiQ8N7C4.

Expressioni

Gene expression databases

BgeeiQ8N7C4.
CleanExiHS_TMEM217.
GenevisibleiQ8N7C4. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000338164.

Structurei

3D structure databases

ProteinModelPortaliQ8N7C4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IX9G. Eukaryota.
ENOG410YZ2V. LUCA.
GeneTreeiENSGT00730000111479.
HOGENOMiHOG000121780.
HOVERGENiHBG081110.
InParanoidiQ8N7C4.
OMAiWFGLVSR.
OrthoDBiEOG7XSTG4.
PhylomeDBiQ8N7C4.
TreeFamiTF338544.

Family and domain databases

InterProiIPR027862. DUF4534.
[Graphical view]
PfamiPF15049. DUF4534. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N7C4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKQQQWCGMT AKMGTVLSGV FTIMAVDMYL IFEQKHLGNG SCTEITPKYR
60 70 80 90 100
GASNIINNFI ICWSFKIVLF LSFITILISC FLLYSVYAQI FRGLVIYIVW
110 120 130 140 150
IFFYETANVV IQILTNNDFD IKEVRIMRWF GLVSRTVMHC FWMFFVINYA
160 170 180 190 200
HITYKNRSQG NIISYKRRIS TAEILHSRNK RLSISSGFSG SHLESQYFER
210 220
QSFHTSIFTC LSPVPSSAPS TCRYTIDVC
Note: No experimental confirmation available.
Length:229
Mass (Da):26,582
Last modified:October 1, 2002 - v1
Checksum:iB469BABA66AA99D7
GO
Isoform 2 (identifier: Q8N7C4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     202-211: SFHTSIFTCL → RRCSGKTSIK
     212-229: Missing.

Note: No experimental confirmation available.
Show »
Length:211
Mass (Da):24,697
Checksum:iC9014F4455AF0423
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei202 – 21110SFHTSIFTCL → RRCSGKTSIK in isoform 2. 1 PublicationVSP_014386
Alternative sequencei212 – 22918Missing in isoform 2. 1 PublicationVSP_014387Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098666 mRNA. Translation: BAC05371.1.
AL353579 Genomic DNA. Translation: CAI20317.1.
BC026012 mRNA. Translation: AAH26012.1.
CCDSiCCDS4831.1. [Q8N7C4-1]
CCDS69102.1. [Q8N7C4-2]
RefSeqiNP_001273330.1. NM_001286401.1. [Q8N7C4-2]
NP_660359.2. NM_145316.3. [Q8N7C4-1]
XP_011512668.1. XM_011514366.1. [Q8N7C4-1]
UniGeneiHs.520101.

Genome annotation databases

EnsembliENST00000336655; ENSP00000338164; ENSG00000172738. [Q8N7C4-1]
ENST00000356757; ENSP00000349198; ENSG00000172738. [Q8N7C4-2]
GeneIDi221468.
KEGGihsa:221468.
UCSCiuc003onl.5. human. [Q8N7C4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098666 mRNA. Translation: BAC05371.1.
AL353579 Genomic DNA. Translation: CAI20317.1.
BC026012 mRNA. Translation: AAH26012.1.
CCDSiCCDS4831.1. [Q8N7C4-1]
CCDS69102.1. [Q8N7C4-2]
RefSeqiNP_001273330.1. NM_001286401.1. [Q8N7C4-2]
NP_660359.2. NM_145316.3. [Q8N7C4-1]
XP_011512668.1. XM_011514366.1. [Q8N7C4-1]
UniGeneiHs.520101.

3D structure databases

ProteinModelPortaliQ8N7C4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000338164.

Polymorphism and mutation databases

BioMutaiTMEM217.
DMDMi68565216.

Proteomic databases

PaxDbiQ8N7C4.
PRIDEiQ8N7C4.

Protocols and materials databases

DNASUi221468.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336655; ENSP00000338164; ENSG00000172738. [Q8N7C4-1]
ENST00000356757; ENSP00000349198; ENSG00000172738. [Q8N7C4-2]
GeneIDi221468.
KEGGihsa:221468.
UCSCiuc003onl.5. human. [Q8N7C4-1]

Organism-specific databases

CTDi221468.
GeneCardsiTMEM217.
HGNCiHGNC:21238. TMEM217.
neXtProtiNX_Q8N7C4.
PharmGKBiPA162406568.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IX9G. Eukaryota.
ENOG410YZ2V. LUCA.
GeneTreeiENSGT00730000111479.
HOGENOMiHOG000121780.
HOVERGENiHBG081110.
InParanoidiQ8N7C4.
OMAiWFGLVSR.
OrthoDBiEOG7XSTG4.
PhylomeDBiQ8N7C4.
TreeFamiTF338544.

Miscellaneous databases

GenomeRNAii221468.
PROiQ8N7C4.

Gene expression databases

BgeeiQ8N7C4.
CleanExiHS_TMEM217.
GenevisibleiQ8N7C4. HS.

Family and domain databases

InterProiIPR027862. DUF4534.
[Graphical view]
PfamiPF15049. DUF4534. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.

Entry informationi

Entry nameiTM217_HUMAN
AccessioniPrimary (citable) accession number: Q8N7C4
Secondary accession number(s): Q8TC54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.