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Protein

Cancer/testis antigen family 45 member A4/A6

Gene

CT45A4

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Cancer/testis antigen family 45 member A4/A6
Alternative name(s):
Cancer/testis antigen 45-4/6
Cancer/testis antigen 45A4/45A6
Gene namesi
Name:CT45A4
Synonyms:CT45-4
AND
Name:CT45A6
Synonyms:CT45-6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:33269. CT45A4.
HGNC:33271. CT45A6.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164718204.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 189189Cancer/testis antigen family 45 member A4/A6PRO_0000308949Add
BLAST

Proteomic databases

MaxQBiQ8N7B7.
PaxDbiQ8N7B7.
PRIDEiQ8N7B7.

PTM databases

PhosphoSiteiQ8N7B7.

Expressioni

Tissue specificityi

Testis specific. Expressed in cancer cell lines.1 Publication

Gene expression databases

BgeeiQ8N7B7.
GenevestigatoriQ8N7B7.

Organism-specific databases

HPAiHPA044735.
HPA044757.
HPA046872.
HPA046987.

Structurei

3D structure databases

ProteinModelPortaliQ8N7B7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG125008.
HOGENOMiHOG000082503.
HOVERGENiHBG095520.
InParanoidiQ8N7B7.
OrthoDBiEOG73V6MH.
PhylomeDBiQ8N7B7.

Family and domain databases

InterProiIPR029307. INT_SG_DDX_CT_C.
[Graphical view]
PfamiPF15300. INT_SG_DDX_CT_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N7B7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDKTEKVAV DPETVFKRPR ECDSPSYQKR QRMALLARKQ GAGDSLIAGS
60 70 80 90 100
AMSKAKKLMT GHAIPPSQLD SQIDDFTGFS KDRMMQKPGS NAPVGGNVTS
110 120 130 140 150
SFSGDDLECR ETASSPKSQQ EINADIKRKL VKELRCVGQK YEKIFEMLEG
160 170 180
VQGPTAVRKR FFESIIKEAA RCMRRDFVKH LKKKLKRMI
Length:189
Mass (Da):21,245
Last modified:October 1, 2002 - v1
Checksum:i3C5E639CB3C02146
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY743712 mRNA. Translation: AAW66467.1.
AY743714 mRNA. Translation: AAW66469.1.
AK098689 mRNA. Translation: BAC05380.1.
AL590618 Genomic DNA. Translation: CAI41549.1.
AL590618 Genomic DNA. Translation: CAI41551.1.
RefSeqiNP_001017436.1. NM_001017436.1.
UniGeneiHs.568346.
Hs.632281.
Hs.676560.

Genome annotation databases

GeneIDi441520.
KEGGihsa:441520.
UCSCiuc004ezb.3. human.

Polymorphism databases

DMDMi74751086.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY743712 mRNA. Translation: AAW66467.1.
AY743714 mRNA. Translation: AAW66469.1.
AK098689 mRNA. Translation: BAC05380.1.
AL590618 Genomic DNA. Translation: CAI41549.1.
AL590618 Genomic DNA. Translation: CAI41551.1.
RefSeqiNP_001017436.1. NM_001017436.1.
UniGeneiHs.568346.
Hs.632281.
Hs.676560.

3D structure databases

ProteinModelPortaliQ8N7B7.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ8N7B7.

Polymorphism databases

DMDMi74751086.

Proteomic databases

MaxQBiQ8N7B7.
PaxDbiQ8N7B7.
PRIDEiQ8N7B7.

Protocols and materials databases

DNASUi441520.
541465.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi441520.
KEGGihsa:441520.
UCSCiuc004ezb.3. human.

Organism-specific databases

CTDi441520.
GeneCardsiGC0XM134926.
GC0XM134961.
HGNCiHGNC:33269. CT45A4.
HGNC:33271. CT45A6.
HPAiHPA044735.
HPA044757.
HPA046872.
HPA046987.
MIMi300795. gene.
300797. gene.
neXtProtiNX_Q8N7B7.
PharmGKBiPA164718204.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG125008.
HOGENOMiHOG000082503.
HOVERGENiHBG095520.
InParanoidiQ8N7B7.
OrthoDBiEOG73V6MH.
PhylomeDBiQ8N7B7.

Miscellaneous databases

ChiTaRSiCT45A4. human.
NextBioi110269.
PROiQ8N7B7.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N7B7.
GenevestigatoriQ8N7B7.

Family and domain databases

InterProiIPR029307. INT_SG_DDX_CT_C.
[Graphical view]
PfamiPF15300. INT_SG_DDX_CT_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, IDENTIFICATION AS A CANCER/TESTIS ANTIGEN.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCT454_HUMAN
AccessioniPrimary (citable) accession number: Q8N7B7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 1, 2002
Last modified: March 4, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.