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Q8N7B6

- PACRL_HUMAN

UniProt

Q8N7B6 - PACRL_HUMAN

Protein

PACRG-like protein

Gene

PACRGL

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 2 (20 Feb 2007)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    PACRG-like protein
    Gene namesi
    Name:PACRGL
    Synonyms:C4orf28
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:28442. PACRGL.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164724318.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 248248PACRG-like proteinPRO_0000278243Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ8N7B6.
    PaxDbiQ8N7B6.
    PeptideAtlasiQ8N7B6.
    PRIDEiQ8N7B6.

    PTM databases

    PhosphoSiteiQ8N7B6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8N7B6.
    BgeeiQ8N7B6.
    CleanExiHS_PACRGL.
    GenevestigatoriQ8N7B6.

    Organism-specific databases

    HPAiHPA042137.
    HPA054666.

    Interactioni

    Protein-protein interaction databases

    BioGridi126346. 1 interaction.
    IntActiQ8N7B6. 1 interaction.
    STRINGi9606.ENSP00000295290.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N7B6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG305954.
    HOGENOMiHOG000068031.
    HOVERGENiHBG102880.
    InParanoidiQ8N7B6.
    OMAiHRTTVQQ.
    PhylomeDBiQ8N7B6.
    TreeFamiTF321123.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR019399. Parkin_co-regulated_protein.
    [Graphical view]
    PfamiPF10274. ParcG. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N7B6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQKSEGSGGT QLKNRATGNY DQRTSSSTQL KHRNAVQGSK SSLSTSSPES    50
    ARKLHPRPSD KLNPKTINPF GEQSRVPSAF AAIYSKGGIP CRLVHGSVKH 100
    RLQWECPPES LSFDPLLITL AEGLRETKHP YTFVSKEGFR ELLLVKGAPE 150
    KAIPLLPRLI PVLKAALVHS DDEVFERGLN ALVQLSVVVG PSLNDHLKHL 200
    LTSLSKRLMD KKFKEPITSA LQKLEQHGGS GSLSIIKSKI PTYCSICC 248
    Length:248
    Mass (Da):27,152
    Last modified:February 20, 2007 - v2
    Checksum:i01E1EB06F10E85F7
    GO
    Isoform 2 (identifier: Q8N7B6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         203-229: Missing.

    Show »
    Length:221
    Mass (Da):24,100
    Checksum:i2BB975BCBF8984DD
    GO
    Isoform 3 (identifier: Q8N7B6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         70-167: Missing.
         203-229: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:123
    Mass (Da):13,285
    Checksum:i9027DB129B1F8943
    GO
    Isoform 4 (identifier: Q8N7B6-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         70-122: Missing.
         204-248: LSKRLMDKKF...KIPTYCSICC → DPVQLMRFPR...IKIKISKGEP

    Show »
    Length:200
    Mass (Da):22,059
    Checksum:i89A783D4CDBD3B26
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti104 – 1041W → R in BAC05381. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei70 – 16798Missing in isoform 3. 1 PublicationVSP_043351Add
    BLAST
    Alternative sequencei70 – 12253Missing in isoform 4. 1 PublicationVSP_045095Add
    BLAST
    Alternative sequencei203 – 22927Missing in isoform 2 and isoform 3. 2 PublicationsVSP_023206Add
    BLAST
    Alternative sequencei204 – 24845LSKRL…CSICC → DPVQLMRFPRPLLGLMICQK DPWNSGKLLLAVMVSYNTQK IKIKISKGEP in isoform 4. 1 PublicationVSP_045096Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK098692 mRNA. Translation: BAC05381.1.
    AK297556 mRNA. Translation: BAG59949.1.
    AK315482 mRNA. Translation: BAG37866.1.
    AK294077 mRNA. Translation: BAG57419.1.
    AC097505 Genomic DNA. No translation available.
    AC104065 Genomic DNA. Translation: AAY40910.1.
    BC023002 mRNA. Translation: AAH23002.1.
    CCDSiCCDS3427.1. [Q8N7B6-2]
    CCDS47034.1. [Q8N7B6-3]
    CCDS58895.1. [Q8N7B6-1]
    CCDS58896.1. [Q8N7B6-4]
    RefSeqiNP_001124199.1. NM_001130727.1. [Q8N7B6-3]
    NP_001245274.1. NM_001258345.1. [Q8N7B6-1]
    NP_001245275.1. NM_001258346.1. [Q8N7B6-4]
    NP_659485.1. NM_145048.3. [Q8N7B6-2]
    XP_006714003.1. XM_006713940.1. [Q8N7B6-1]
    XP_006714004.1. XM_006713941.1. [Q8N7B6-1]
    XP_006714005.1. XM_006713942.1. [Q8N7B6-1]
    XP_006714006.1. XM_006713943.1. [Q8N7B6-1]
    XP_006714007.1. XM_006713944.1. [Q8N7B6-1]
    XP_006714008.1. XM_006713945.1. [Q8N7B6-1]
    XP_006714009.1. XM_006713946.1. [Q8N7B6-1]
    XP_006714010.1. XM_006713947.1. [Q8N7B6-1]
    XP_006714011.1. XM_006713948.1. [Q8N7B6-1]
    XP_006714012.1. XM_006713949.1. [Q8N7B6-1]
    XP_006714014.1. XM_006713951.1. [Q8N7B6-2]
    UniGeneiHs.479298.

    Genome annotation databases

    EnsembliENST00000295290; ENSP00000295290; ENSG00000163138. [Q8N7B6-2]
    ENST00000360916; ENSP00000354171; ENSG00000163138. [Q8N7B6-2]
    ENST00000444671; ENSP00000415832; ENSG00000163138. [Q8N7B6-3]
    ENST00000467997; ENSP00000423477; ENSG00000163138. [Q8N7B6-2]
    ENST00000471979; ENSP00000423914; ENSG00000163138. [Q8N7B6-1]
    ENST00000502374; ENSP00000425461; ENSG00000163138. [Q8N7B6-4]
    ENST00000503585; ENSP00000423881; ENSG00000163138. [Q8N7B6-1]
    ENST00000506702; ENSP00000423536; ENSG00000163138. [Q8N7B6-2]
    ENST00000507634; ENSP00000425938; ENSG00000163138. [Q8N7B6-2]
    GeneIDi133015.
    KEGGihsa:133015.
    UCSCiuc003gpz.3. human. [Q8N7B6-2]
    uc003gqa.3. human. [Q8N7B6-3]
    uc010iek.3. human. [Q8N7B6-1]
    uc011bxm.2. human.

    Polymorphism databases

    DMDMi126215685.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK098692 mRNA. Translation: BAC05381.1 .
    AK297556 mRNA. Translation: BAG59949.1 .
    AK315482 mRNA. Translation: BAG37866.1 .
    AK294077 mRNA. Translation: BAG57419.1 .
    AC097505 Genomic DNA. No translation available.
    AC104065 Genomic DNA. Translation: AAY40910.1 .
    BC023002 mRNA. Translation: AAH23002.1 .
    CCDSi CCDS3427.1. [Q8N7B6-2 ]
    CCDS47034.1. [Q8N7B6-3 ]
    CCDS58895.1. [Q8N7B6-1 ]
    CCDS58896.1. [Q8N7B6-4 ]
    RefSeqi NP_001124199.1. NM_001130727.1. [Q8N7B6-3 ]
    NP_001245274.1. NM_001258345.1. [Q8N7B6-1 ]
    NP_001245275.1. NM_001258346.1. [Q8N7B6-4 ]
    NP_659485.1. NM_145048.3. [Q8N7B6-2 ]
    XP_006714003.1. XM_006713940.1. [Q8N7B6-1 ]
    XP_006714004.1. XM_006713941.1. [Q8N7B6-1 ]
    XP_006714005.1. XM_006713942.1. [Q8N7B6-1 ]
    XP_006714006.1. XM_006713943.1. [Q8N7B6-1 ]
    XP_006714007.1. XM_006713944.1. [Q8N7B6-1 ]
    XP_006714008.1. XM_006713945.1. [Q8N7B6-1 ]
    XP_006714009.1. XM_006713946.1. [Q8N7B6-1 ]
    XP_006714010.1. XM_006713947.1. [Q8N7B6-1 ]
    XP_006714011.1. XM_006713948.1. [Q8N7B6-1 ]
    XP_006714012.1. XM_006713949.1. [Q8N7B6-1 ]
    XP_006714014.1. XM_006713951.1. [Q8N7B6-2 ]
    UniGenei Hs.479298.

    3D structure databases

    ProteinModelPortali Q8N7B6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126346. 1 interaction.
    IntActi Q8N7B6. 1 interaction.
    STRINGi 9606.ENSP00000295290.

    PTM databases

    PhosphoSitei Q8N7B6.

    Polymorphism databases

    DMDMi 126215685.

    Proteomic databases

    MaxQBi Q8N7B6.
    PaxDbi Q8N7B6.
    PeptideAtlasi Q8N7B6.
    PRIDEi Q8N7B6.

    Protocols and materials databases

    DNASUi 133015.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000295290 ; ENSP00000295290 ; ENSG00000163138 . [Q8N7B6-2 ]
    ENST00000360916 ; ENSP00000354171 ; ENSG00000163138 . [Q8N7B6-2 ]
    ENST00000444671 ; ENSP00000415832 ; ENSG00000163138 . [Q8N7B6-3 ]
    ENST00000467997 ; ENSP00000423477 ; ENSG00000163138 . [Q8N7B6-2 ]
    ENST00000471979 ; ENSP00000423914 ; ENSG00000163138 . [Q8N7B6-1 ]
    ENST00000502374 ; ENSP00000425461 ; ENSG00000163138 . [Q8N7B6-4 ]
    ENST00000503585 ; ENSP00000423881 ; ENSG00000163138 . [Q8N7B6-1 ]
    ENST00000506702 ; ENSP00000423536 ; ENSG00000163138 . [Q8N7B6-2 ]
    ENST00000507634 ; ENSP00000425938 ; ENSG00000163138 . [Q8N7B6-2 ]
    GeneIDi 133015.
    KEGGi hsa:133015.
    UCSCi uc003gpz.3. human. [Q8N7B6-2 ]
    uc003gqa.3. human. [Q8N7B6-3 ]
    uc010iek.3. human. [Q8N7B6-1 ]
    uc011bxm.2. human.

    Organism-specific databases

    CTDi 133015.
    GeneCardsi GC04P020697.
    HGNCi HGNC:28442. PACRGL.
    HPAi HPA042137.
    HPA054666.
    neXtProti NX_Q8N7B6.
    PharmGKBi PA164724318.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG305954.
    HOGENOMi HOG000068031.
    HOVERGENi HBG102880.
    InParanoidi Q8N7B6.
    OMAi HRTTVQQ.
    PhylomeDBi Q8N7B6.
    TreeFami TF321123.

    Miscellaneous databases

    ChiTaRSi PACRGL. human.
    GenomeRNAii 133015.
    NextBioi 83175.
    PROi Q8N7B6.

    Gene expression databases

    ArrayExpressi Q8N7B6.
    Bgeei Q8N7B6.
    CleanExi HS_PACRGL.
    Genevestigatori Q8N7B6.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR019399. Parkin_co-regulated_protein.
    [Graphical view ]
    Pfami PF10274. ParcG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4).
      Tissue: Brain and Testis.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Placenta.
    4. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPACRL_HUMAN
    AccessioniPrimary (citable) accession number: Q8N7B6
    Secondary accession number(s): B2RDB9
    , B4DFF8, B4DMN7, Q8TBA8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 20, 2007
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 85 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM

    External Data

    Dasty 3