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Q8N7B6 (PACRL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
PACRG-like protein
Gene names
Name:PACRGL
Synonyms:C4orf28
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length248 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8N7B6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8N7B6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     203-229: Missing.
Isoform 3 (identifier: Q8N7B6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     70-167: Missing.
     203-229: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: Q8N7B6-4)

The sequence of this isoform differs from the canonical sequence as follows:
     70-122: Missing.
     204-248: LSKRLMDKKF...KIPTYCSICC → DPVQLMRFPR...IKIKISKGEP

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 248248PACRG-like protein
PRO_0000278243

Amino acid modifications

Modified residue11N-acetylmethionine Ref.4

Natural variations

Alternative sequence70 – 16798Missing in isoform 3.
VSP_043351
Alternative sequence70 – 12253Missing in isoform 4.
VSP_045095
Alternative sequence203 – 22927Missing in isoform 2 and isoform 3.
VSP_023206
Alternative sequence204 – 24845LSKRL…CSICC → DPVQLMRFPRPLLGLMICQK DPWNSGKLLLAVMVSYNTQK IKIKISKGEP in isoform 4.
VSP_045096

Experimental info

Sequence conflict1041W → R in BAC05381. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 20, 2007. Version 2.
Checksum: 01E1EB06F10E85F7

FASTA24827,152
        10         20         30         40         50         60 
MQKSEGSGGT QLKNRATGNY DQRTSSSTQL KHRNAVQGSK SSLSTSSPES ARKLHPRPSD 

        70         80         90        100        110        120 
KLNPKTINPF GEQSRVPSAF AAIYSKGGIP CRLVHGSVKH RLQWECPPES LSFDPLLITL 

       130        140        150        160        170        180 
AEGLRETKHP YTFVSKEGFR ELLLVKGAPE KAIPLLPRLI PVLKAALVHS DDEVFERGLN 

       190        200        210        220        230        240 
ALVQLSVVVG PSLNDHLKHL LTSLSKRLMD KKFKEPITSA LQKLEQHGGS GSLSIIKSKI 


PTYCSICC 

« Hide

Isoform 2 [UniParc].

Checksum: 2BB975BCBF8984DD
Show »

FASTA22124,100
Isoform 3 [UniParc].

Checksum: 9027DB129B1F8943
Show »

FASTA12313,285
Isoform 4 [UniParc].

Checksum: 89A783D4CDBD3B26
Show »

FASTA20022,059

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4).
Tissue: Brain and Testis.
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Placenta.
[4]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK098692 mRNA. Translation: BAC05381.1.
AK297556 mRNA. Translation: BAG59949.1.
AK315482 mRNA. Translation: BAG37866.1.
AK294077 mRNA. Translation: BAG57419.1.
AC097505 Genomic DNA. No translation available.
AC104065 Genomic DNA. Translation: AAY40910.1.
BC023002 mRNA. Translation: AAH23002.1.
RefSeqNP_001124199.1. NM_001130727.1.
NP_001245274.1. NM_001258345.1.
NP_001245275.1. NM_001258346.1.
NP_659485.1. NM_145048.3.
UniGeneHs.479298.

3D structure databases

ProteinModelPortalQ8N7B6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid126346. 1 interaction.
IntActQ8N7B6. 1 interaction.
STRING9606.ENSP00000295290.

PTM databases

PhosphoSiteQ8N7B6.

Polymorphism databases

DMDM126215685.

Proteomic databases

PaxDbQ8N7B6.
PeptideAtlasQ8N7B6.
PRIDEQ8N7B6.

Protocols and materials databases

DNASU133015.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000295290; ENSP00000295290; ENSG00000163138. [Q8N7B6-2]
ENST00000360916; ENSP00000354171; ENSG00000163138. [Q8N7B6-2]
ENST00000444671; ENSP00000415832; ENSG00000163138. [Q8N7B6-3]
ENST00000467997; ENSP00000423477; ENSG00000163138. [Q8N7B6-2]
ENST00000471979; ENSP00000423914; ENSG00000163138. [Q8N7B6-1]
ENST00000502374; ENSP00000425461; ENSG00000163138. [Q8N7B6-4]
ENST00000503585; ENSP00000423881; ENSG00000163138. [Q8N7B6-1]
ENST00000506702; ENSP00000423536; ENSG00000163138. [Q8N7B6-2]
ENST00000507634; ENSP00000425938; ENSG00000163138. [Q8N7B6-2]
ENST00000538990; ENSP00000438269; ENSG00000163138. [Q8N7B6-3]
GeneID133015.
KEGGhsa:133015.
UCSCuc003gpz.3. human. [Q8N7B6-2]
uc003gqa.3. human. [Q8N7B6-3]
uc010iek.3. human. [Q8N7B6-1]
uc011bxm.2. human.

Organism-specific databases

CTD133015.
GeneCardsGC04P020697.
HGNCHGNC:28442. PACRGL.
HPAHPA042137.
HPA054666.
neXtProtNX_Q8N7B6.
PharmGKBPA164724318.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG305954.
HOGENOMHOG000068031.
HOVERGENHBG102880.
InParanoidQ8N7B6.
OMAHRTTVQQ.
PhylomeDBQ8N7B6.
TreeFamTF321123.

Gene expression databases

ArrayExpressQ8N7B6.
BgeeQ8N7B6.
CleanExHS_PACRGL.
GenevestigatorQ8N7B6.

Family and domain databases

Gene3D1.25.10.10. 1 hit.
InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR019399. Parkin_co-regulated_protein.
[Graphical view]
PfamPF10274. ParcG. 1 hit.
[Graphical view]
SUPFAMSSF48371. SSF48371. 1 hit.
ProtoNetSearch...

Other

ChiTaRSPACRGL. human.
GenomeRNAi133015.
NextBio83175.
PROQ8N7B6.

Entry information

Entry namePACRL_HUMAN
AccessionPrimary (citable) accession number: Q8N7B6
Secondary accession number(s): B2RDB9 expand/collapse secondary AC list , B4DFF8, B4DMN7, Q8TBA8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 20, 2007
Last modified: March 19, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM