Q8N7B6 (PACRL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
PACRG-like protein

Gene names

Name:	PACRGL
Synonyms:	C4orf28

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	248 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8N7B6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8N7B6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     203-229: Missing.

Isoform 3 (identifier: Q8N7B6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     70-167: Missing.
     203-229: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q8N7B6-4)

The sequence of this isoform differs from the canonical sequence as follows:
     70-122: Missing.
     204-248: LSKRLMDKKF...KIPTYCSICC → DPVQLMRFPR...IKIKISKGEP

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 248	248	PACRG-like protein		PRO_0000278243
Amino acid modifications
	Modified residue	47	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	70 – 167	98	Missing in isoform 3.		VSP_043351
	Alternative sequence	70 – 122	53	Missing in isoform 4.		VSP_045095
	Alternative sequence	203 – 229	27	Missing in isoform 2 and isoform 3.		VSP_023206
	Alternative sequence	204 – 248	45	LSKRL…CSICC → DPVQLMRFPRPLLGLMICQK DPWNSGKLLLAVMVSYNTQK IKIKISKGEP in isoform 4.		VSP_045096
Experimental info
	Sequence conflict	104	1	W → R in BAC05381. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 20, 2007. Version 2. Checksum: 01E1EB06F10E85F7	FASTA	248	27,152
	10 20 30 40 50 60 MQKSEGSGGT QLKNRATGNY DQRTSSSTQL KHRNAVQGSK SSLSTSSPES ARKLHPRPSD 70 80 90 100 110 120 KLNPKTINPF GEQSRVPSAF AAIYSKGGIP CRLVHGSVKH RLQWECPPES LSFDPLLITL 130 140 150 160 170 180 AEGLRETKHP YTFVSKEGFR ELLLVKGAPE KAIPLLPRLI PVLKAALVHS DDEVFERGLN 190 200 210 220 230 240 ALVQLSVVVG PSLNDHLKHL LTSLSKRLMD KKFKEPITSA LQKLEQHGGS GSLSIIKSKI PTYCSICC
	Isoform 2 [UniParc]. Checksum: 2BB975BCBF8984DD	FASTA	221	24,100
	10 20 30 40 50 60 MQKSEGSGGT QLKNRATGNY DQRTSSSTQL KHRNAVQGSK SSLSTSSPES ARKLHPRPSD 70 80 90 100 110 120 KLNPKTINPF GEQSRVPSAF AAIYSKGGIP CRLVHGSVKH RLQWECPPES LSFDPLLITL 130 140 150 160 170 180 AEGLRETKHP YTFVSKEGFR ELLLVKGAPE KAIPLLPRLI PVLKAALVHS DDEVFERGLN 190 200 210 220 ALVQLSVVVG PSLNDHLKHL LTSGSLSIIK SKIPTYCSIC C
	Isoform 3 [UniParc]. Checksum: 9027DB129B1F8943	FASTA	123	13,285
	10 20 30 40 50 60 MQKSEGSGGT QLKNRATGNY DQRTSSSTQL KHRNAVQGSK SSLSTSSPES ARKLHPRPSD 70 80 90 100 110 120 KLNPKTINPV HSDDEVFERG LNALVQLSVV VGPSLNDHLK HLLTSGSLSI IKSKIPTYCS ICC
	Isoform 4 [UniParc]. Checksum: 89A783D4CDBD3B26	FASTA	200	22,059
	10 20 30 40 50 60 MQKSEGSGGT QLKNRATGNY DQRTSSSTQL KHRNAVQGSK SSLSTSSPES ARKLHPRPSD 70 80 90 100 110 120 KLNPKTINPG LRETKHPYTF VSKEGFRELL LVKGAPEKAI PLLPRLIPVL KAALVHSDDE 130 140 150 160 170 180 VFERGLNALV QLSVVVGPSL NDHLKHLLTS DPVQLMRFPR PLLGLMICQK DPWNSGKLLL 190 200 AVMVSYNTQK IKIKISKGEP

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4). Tissue: Brain and Testis.
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Placenta.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK098692 mRNA. Translation: BAC05381.1. AK297556 mRNA. Translation: BAG59949.1. AK315482 mRNA. Translation: BAG37866.1. AK294077 mRNA. Translation: BAG57419.1. AC097505 Genomic DNA. No translation available. AC104065 Genomic DNA. Translation: AAY40910.1. BC023002 mRNA. Translation: AAH23002.1.
IPI	IPI00297683. IPI00478060. IPI00909252.
RefSeq	NP_001124199.1. NM_001130727.1. NP_001245274.1. NM_001258345.1. NP_001245275.1. NM_001258346.1. NP_659485.1. NM_145048.3.
UniGene	Hs.479298.
3D structure databases
ProteinModelPortal	Q8N7B6.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8N7B6. 1 interaction.
STRING	9606.ENSP00000295290.
PTM databases
PhosphoSite	Q8N7B6.
Polymorphism databases
DMDM	126215685.
Proteomic databases
PaxDb	Q8N7B6.
PeptideAtlas	Q8N7B6.
PRIDE	Q8N7B6.
Protocols and materials databases
DNASU	133015.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000295290; ENSP00000295290; ENSG00000163138. ENST00000360916; ENSP00000354171; ENSG00000163138. ENST00000444671; ENSP00000415832; ENSG00000163138. ENST00000467997; ENSP00000423477; ENSG00000163138. ENST00000502374; ENSP00000425461; ENSG00000163138. ENST00000503585; ENSP00000423881; ENSG00000163138. ENST00000506702; ENSP00000423536; ENSG00000163138. ENST00000507634; ENSP00000425938; ENSG00000163138. ENST00000538990; ENSP00000438269; ENSG00000163138.
GeneID	133015.
KEGG	hsa:133015.
UCSC	uc003gpz.3. human. uc010iek.3. human.
Organism-specific databases
CTD	133015.
GeneCards	GC04P020697.
HGNC	HGNC:28442. PACRGL.
HPA	HPA042137.
neXtProt	NX_Q8N7B6.
PharmGKB	PA164724318.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG305954.
HOGENOM	HOG000068031.
HOVERGEN	HBG102880.
InParanoid	Q8N7B6.
OMA	KSECHGG.
PhylomeDB	Q8N7B6.
Gene expression databases
ArrayExpress	Q8N7B6.
Bgee	Q8N7B6.
CleanEx	HS_PACRGL.
Genevestigator	Q8N7B6.
Family and domain databases
Gene3D	1.25.10.10. 1 hit.
InterPro	IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR019399. Parkin_co-regulated_protein. [Graphical view]
Pfam	PF10274. ParcG. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	PACRGL. human.
GenomeRNAi	133015.
NextBio	83175.

Entry information

Entry name

PACRL_HUMAN

Accession

Primary (citable) accession number: Q8N7B6
Secondary accession number(s): B2RDB9 , B4DFF8, B4DMN7, Q8TBA8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
Last sequence update:	February 20, 2007
Last modified:	April 3, 2013
This is version 75 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.