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Protein

PACRG-like protein

Gene

PACRGL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
PACRG-like protein
Gene namesi
Name:PACRGL
Synonyms:C4orf28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:28442. PACRGL.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164724318.

Polymorphism and mutation databases

BioMutaiPACRGL.
DMDMi126215685.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 248248PACRG-like proteinPRO_0000278243Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ8N7B6.
PaxDbiQ8N7B6.
PeptideAtlasiQ8N7B6.
PRIDEiQ8N7B6.

PTM databases

PhosphoSiteiQ8N7B6.

Expressioni

Gene expression databases

BgeeiQ8N7B6.
CleanExiHS_PACRGL.
ExpressionAtlasiQ8N7B6. baseline and differential.
GenevisibleiQ8N7B6. HS.

Organism-specific databases

HPAiHPA042137.
HPA054666.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MYOGP151733EBI-3925298,EBI-3906629
RCN3Q96D153EBI-3925298,EBI-746283

Protein-protein interaction databases

BioGridi126346. 3 interactions.
IntActiQ8N7B6. 5 interactions.
STRINGi9606.ENSP00000295290.

Structurei

3D structure databases

ProteinModelPortaliQ8N7B6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG305954.
GeneTreeiENSGT00530000063549.
HOGENOMiHOG000068031.
HOVERGENiHBG102880.
InParanoidiQ8N7B6.
OMAiPKTIDPF.
PhylomeDBiQ8N7B6.
TreeFamiTF321123.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR019399. Parkin_co-regulated_protein.
[Graphical view]
PfamiPF10274. ParcG. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N7B6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQKSEGSGGT QLKNRATGNY DQRTSSSTQL KHRNAVQGSK SSLSTSSPES
60 70 80 90 100
ARKLHPRPSD KLNPKTINPF GEQSRVPSAF AAIYSKGGIP CRLVHGSVKH
110 120 130 140 150
RLQWECPPES LSFDPLLITL AEGLRETKHP YTFVSKEGFR ELLLVKGAPE
160 170 180 190 200
KAIPLLPRLI PVLKAALVHS DDEVFERGLN ALVQLSVVVG PSLNDHLKHL
210 220 230 240
LTSLSKRLMD KKFKEPITSA LQKLEQHGGS GSLSIIKSKI PTYCSICC
Length:248
Mass (Da):27,152
Last modified:February 20, 2007 - v2
Checksum:i01E1EB06F10E85F7
GO
Isoform 2 (identifier: Q8N7B6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     203-229: Missing.

Show »
Length:221
Mass (Da):24,100
Checksum:i2BB975BCBF8984DD
GO
Isoform 3 (identifier: Q8N7B6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     70-167: Missing.
     203-229: Missing.

Note: No experimental confirmation available.
Show »
Length:123
Mass (Da):13,285
Checksum:i9027DB129B1F8943
GO
Isoform 4 (identifier: Q8N7B6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     70-122: Missing.
     204-248: LSKRLMDKKF...KIPTYCSICC → DPVQLMRFPR...IKIKISKGEP

Show »
Length:200
Mass (Da):22,059
Checksum:i89A783D4CDBD3B26
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti104 – 1041W → R in BAC05381 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei70 – 16798Missing in isoform 3. 1 PublicationVSP_043351Add
BLAST
Alternative sequencei70 – 12253Missing in isoform 4. 1 PublicationVSP_045095Add
BLAST
Alternative sequencei203 – 22927Missing in isoform 2 and isoform 3. 2 PublicationsVSP_023206Add
BLAST
Alternative sequencei204 – 24845LSKRL…CSICC → DPVQLMRFPRPLLGLMICQK DPWNSGKLLLAVMVSYNTQK IKIKISKGEP in isoform 4. 1 PublicationVSP_045096Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098692 mRNA. Translation: BAC05381.1.
AK297556 mRNA. Translation: BAG59949.1.
AK315482 mRNA. Translation: BAG37866.1.
AK294077 mRNA. Translation: BAG57419.1.
AC097505 Genomic DNA. No translation available.
AC104065 Genomic DNA. Translation: AAY40910.1.
BC023002 mRNA. Translation: AAH23002.1.
CCDSiCCDS3427.1. [Q8N7B6-2]
CCDS47034.1. [Q8N7B6-3]
CCDS58895.1. [Q8N7B6-1]
CCDS58896.1. [Q8N7B6-4]
RefSeqiNP_001124199.1. NM_001130727.1. [Q8N7B6-3]
NP_001245274.1. NM_001258345.1. [Q8N7B6-1]
NP_001245275.1. NM_001258346.1. [Q8N7B6-4]
NP_659485.1. NM_145048.3. [Q8N7B6-2]
UniGeneiHs.479298.

Genome annotation databases

EnsembliENST00000295290; ENSP00000295290; ENSG00000163138. [Q8N7B6-2]
ENST00000360916; ENSP00000354171; ENSG00000163138. [Q8N7B6-2]
ENST00000444671; ENSP00000415832; ENSG00000163138. [Q8N7B6-3]
ENST00000467997; ENSP00000423477; ENSG00000163138. [Q8N7B6-2]
ENST00000471979; ENSP00000423914; ENSG00000163138. [Q8N7B6-1]
ENST00000502374; ENSP00000425461; ENSG00000163138. [Q8N7B6-4]
ENST00000503585; ENSP00000423881; ENSG00000163138. [Q8N7B6-1]
ENST00000506702; ENSP00000423536; ENSG00000163138. [Q8N7B6-2]
ENST00000507634; ENSP00000425938; ENSG00000163138. [Q8N7B6-2]
GeneIDi133015.
KEGGihsa:133015.
UCSCiuc003gpz.3. human. [Q8N7B6-2]
uc003gqa.3. human. [Q8N7B6-3]
uc010iek.3. human. [Q8N7B6-1]
uc011bxm.2. human.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098692 mRNA. Translation: BAC05381.1.
AK297556 mRNA. Translation: BAG59949.1.
AK315482 mRNA. Translation: BAG37866.1.
AK294077 mRNA. Translation: BAG57419.1.
AC097505 Genomic DNA. No translation available.
AC104065 Genomic DNA. Translation: AAY40910.1.
BC023002 mRNA. Translation: AAH23002.1.
CCDSiCCDS3427.1. [Q8N7B6-2]
CCDS47034.1. [Q8N7B6-3]
CCDS58895.1. [Q8N7B6-1]
CCDS58896.1. [Q8N7B6-4]
RefSeqiNP_001124199.1. NM_001130727.1. [Q8N7B6-3]
NP_001245274.1. NM_001258345.1. [Q8N7B6-1]
NP_001245275.1. NM_001258346.1. [Q8N7B6-4]
NP_659485.1. NM_145048.3. [Q8N7B6-2]
UniGeneiHs.479298.

3D structure databases

ProteinModelPortaliQ8N7B6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126346. 3 interactions.
IntActiQ8N7B6. 5 interactions.
STRINGi9606.ENSP00000295290.

PTM databases

PhosphoSiteiQ8N7B6.

Polymorphism and mutation databases

BioMutaiPACRGL.
DMDMi126215685.

Proteomic databases

MaxQBiQ8N7B6.
PaxDbiQ8N7B6.
PeptideAtlasiQ8N7B6.
PRIDEiQ8N7B6.

Protocols and materials databases

DNASUi133015.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295290; ENSP00000295290; ENSG00000163138. [Q8N7B6-2]
ENST00000360916; ENSP00000354171; ENSG00000163138. [Q8N7B6-2]
ENST00000444671; ENSP00000415832; ENSG00000163138. [Q8N7B6-3]
ENST00000467997; ENSP00000423477; ENSG00000163138. [Q8N7B6-2]
ENST00000471979; ENSP00000423914; ENSG00000163138. [Q8N7B6-1]
ENST00000502374; ENSP00000425461; ENSG00000163138. [Q8N7B6-4]
ENST00000503585; ENSP00000423881; ENSG00000163138. [Q8N7B6-1]
ENST00000506702; ENSP00000423536; ENSG00000163138. [Q8N7B6-2]
ENST00000507634; ENSP00000425938; ENSG00000163138. [Q8N7B6-2]
GeneIDi133015.
KEGGihsa:133015.
UCSCiuc003gpz.3. human. [Q8N7B6-2]
uc003gqa.3. human. [Q8N7B6-3]
uc010iek.3. human. [Q8N7B6-1]
uc011bxm.2. human.

Organism-specific databases

CTDi133015.
GeneCardsiGC04P020697.
HGNCiHGNC:28442. PACRGL.
HPAiHPA042137.
HPA054666.
neXtProtiNX_Q8N7B6.
PharmGKBiPA164724318.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG305954.
GeneTreeiENSGT00530000063549.
HOGENOMiHOG000068031.
HOVERGENiHBG102880.
InParanoidiQ8N7B6.
OMAiPKTIDPF.
PhylomeDBiQ8N7B6.
TreeFamiTF321123.

Miscellaneous databases

ChiTaRSiPACRGL. human.
GenomeRNAii133015.
NextBioi83175.
PROiQ8N7B6.

Gene expression databases

BgeeiQ8N7B6.
CleanExiHS_PACRGL.
ExpressionAtlasiQ8N7B6. baseline and differential.
GenevisibleiQ8N7B6. HS.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR019399. Parkin_co-regulated_protein.
[Graphical view]
PfamiPF10274. ParcG. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4).
    Tissue: Brain and Testis.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Placenta.
  4. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPACRL_HUMAN
AccessioniPrimary (citable) accession number: Q8N7B6
Secondary accession number(s): B2RDB9
, B4DFF8, B4DMN7, Q8TBA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 20, 2007
Last modified: June 24, 2015
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.