Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Casein kinase I isoform alpha-like

Gene

CSNK1A1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei46 – 461ATPPROSITE-ProRule annotation
Active sitei136 – 1361Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi23 – 319ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Wnt signaling pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ8N752.

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase I isoform alpha-like (EC:2.7.11.1)
Short name:
CKI-alpha-like
Alternative name(s):
CK1
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:20289. CSNK1A1L.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134917108.

Polymorphism and mutation databases

BioMutaiCSNK1A1L.
DMDMi212286065.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 337336Casein kinase I isoform alpha-likePRO_0000192830Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei8 – 81N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ8N752.
PaxDbiQ8N752.
PRIDEiQ8N752.

PTM databases

PhosphoSiteiQ8N752.

Expressioni

Gene expression databases

BgeeiQ8N752.
CleanExiHS_CSNK1A1L.

Interactioni

Protein-protein interaction databases

BioGridi125755. 11 interactions.
IntActiQ8N752. 5 interactions.
STRINGi9606.ENSP00000369126.

Structurei

3D structure databases

ProteinModelPortaliQ8N752.
SMRiQ8N752. Positions 13-302.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 285269Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119040.
HOGENOMiHOG000182055.
HOVERGENiHBG000176.
InParanoidiQ8N752.
KOiK08957.
OMAiPYREDKH.
OrthoDBiEOG7CZK5W.
PhylomeDBiQ8N752.
TreeFamiTF354246.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N752-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNNSGSKAE LVVGGKYKLV RKIGSGSFGD VYLGITTTNG EDVAVKLESQ
60 70 80 90 100
KVKHPQLLYE SKLYTILQGG VGIPHMHWYG QEKDNNVLVM DLLGPSLEDL
110 120 130 140 150
FNFCSRRFTM KTVLMLADQM ISRIEYVHTK NFLHRDIKPD NFLMGTGRHC
160 170 180 190 200
NKLFLIDFGL AKKYRDNRTR QHIPYREDKH LIGTVRYASI NAHLGIEQSR
210 220 230 240 250
RDDMESLGYV FMYFNRTSLP WQGLRAMTKK QKYEKISEKK MSTPVEVLCK
260 270 280 290 300
GFPAEFAMYL NYCRGLRFEE VPDYMYLRQL FRILFRTLNH QYDYTFDWTM
310 320 330
LKQKAAQQAA SSSGQGQQAQ TQTGKQTEKN KNNVKDN
Length:337
Mass (Da):39,086
Last modified:July 22, 2008 - v2
Checksum:i6110F854D739B142
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti225 – 2251R → K in AAH28723 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti5 – 51S → G.1 Publication
Corresponds to variant rs56224973 [ dbSNP | Ensembl ].
VAR_042074
Natural varianti21 – 211R → Q in a colorectal cancer sample; somatic mutation. 1 Publication
Corresponds to variant rs56158728 [ dbSNP | Ensembl ].
VAR_036450
Natural varianti21 – 211R → W.1 Publication
Corresponds to variant rs56158728 [ dbSNP | Ensembl ].
VAR_042075
Natural varianti42 – 421D → E.1 Publication
Corresponds to variant rs9576175 [ dbSNP | Ensembl ].
VAR_042076
Natural varianti170 – 1701R → S.1 Publication
Corresponds to variant rs17773251 [ dbSNP | Ensembl ].
VAR_034047
Natural varianti177 – 1771E → K.1 Publication
Corresponds to variant rs17054882 [ dbSNP | Ensembl ].
VAR_042077
Natural varianti220 – 2201P → L.1 Publication
Corresponds to variant rs56252856 [ dbSNP | Ensembl ].
VAR_042078
Natural varianti230 – 2301K → N.1 Publication
Corresponds to variant rs56252523 [ dbSNP | Ensembl ].
VAR_042079
Natural varianti257 – 2571A → T.1 Publication
Corresponds to variant rs55895045 [ dbSNP | Ensembl ].
VAR_042080

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL391383 Genomic DNA. Translation: CAI15195.1.
CH471075 Genomic DNA. Translation: EAX08587.1.
BC028723 mRNA. Translation: AAH28723.1.
CCDSiCCDS9363.1.
RefSeqiNP_660204.2. NM_145203.5.
UniGeneiHs.512897.

Genome annotation databases

EnsembliENST00000379800; ENSP00000369126; ENSG00000180138.
GeneIDi122011.
KEGGihsa:122011.
UCSCiuc001uwm.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL391383 Genomic DNA. Translation: CAI15195.1.
CH471075 Genomic DNA. Translation: EAX08587.1.
BC028723 mRNA. Translation: AAH28723.1.
CCDSiCCDS9363.1.
RefSeqiNP_660204.2. NM_145203.5.
UniGeneiHs.512897.

3D structure databases

ProteinModelPortaliQ8N752.
SMRiQ8N752. Positions 13-302.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125755. 11 interactions.
IntActiQ8N752. 5 interactions.
STRINGi9606.ENSP00000369126.

Chemistry

BindingDBiQ8N752.
ChEMBLiCHEMBL5520.
GuidetoPHARMACOLOGYi1996.

PTM databases

PhosphoSiteiQ8N752.

Polymorphism and mutation databases

BioMutaiCSNK1A1L.
DMDMi212286065.

Proteomic databases

MaxQBiQ8N752.
PaxDbiQ8N752.
PRIDEiQ8N752.

Protocols and materials databases

DNASUi122011.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379800; ENSP00000369126; ENSG00000180138.
GeneIDi122011.
KEGGihsa:122011.
UCSCiuc001uwm.1. human.

Organism-specific databases

CTDi122011.
GeneCardsiGC13M037677.
H-InvDBHIX0011244.
HGNCiHGNC:20289. CSNK1A1L.
neXtProtiNX_Q8N752.
PharmGKBiPA134917108.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119040.
HOGENOMiHOG000182055.
HOVERGENiHBG000176.
InParanoidiQ8N752.
KOiK08957.
OMAiPYREDKH.
OrthoDBiEOG7CZK5W.
PhylomeDBiQ8N752.
TreeFamiTF354246.

Enzyme and pathway databases

SignaLinkiQ8N752.

Miscellaneous databases

GenomeRNAii122011.
NextBioi80837.
PROiQ8N752.

Gene expression databases

BgeeiQ8N752.
CleanExiHS_CSNK1A1L.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-42.
    Tissue: Testis.
  4. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-21.
  5. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLY-5; TRP-21; SER-170; LYS-177; LEU-220; ASN-230 AND THR-257.

Entry informationi

Entry nameiKC1AL_HUMAN
AccessioniPrimary (citable) accession number: Q8N752
Secondary accession number(s): Q5T2N2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: July 22, 2008
Last modified: July 22, 2015
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.