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Q8N752

- KC1AL_HUMAN

UniProt

Q8N752 - KC1AL_HUMAN

Protein

Casein kinase I isoform alpha-like

Gene

CSNK1A1L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (22 Jul 2008)
      Previous versions | rss
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    Functioni

    Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling By similarity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei46 – 461ATPPROSITE-ProRule annotation
    Active sitei136 – 1361Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi23 – 319ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Wnt signaling pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ8N752.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Casein kinase I isoform alpha-like (EC:2.7.11.1)
    Short name:
    CKI-alpha-like
    Alternative name(s):
    CK1
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:20289. CSNK1A1L.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134917108.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 337337Casein kinase I isoform alpha-likePRO_0000192830Add
    BLAST

    Proteomic databases

    MaxQBiQ8N752.
    PaxDbiQ8N752.
    PRIDEiQ8N752.

    PTM databases

    PhosphoSiteiQ8N752.

    Expressioni

    Gene expression databases

    BgeeiQ8N752.
    CleanExiHS_CSNK1A1L.
    GenevestigatoriQ8N752.

    Interactioni

    Protein-protein interaction databases

    BioGridi125755. 8 interactions.
    IntActiQ8N752. 5 interactions.
    STRINGi9606.ENSP00000369126.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N752.
    SMRiQ8N752. Positions 13-302.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini17 – 285269Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000182055.
    HOVERGENiHBG000176.
    InParanoidiQ8N752.
    KOiK08957.
    OMAiPYREDKH.
    OrthoDBiEOG7CZK5W.
    PhylomeDBiQ8N752.
    TreeFamiTF354246.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8N752-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTNNSGSKAE LVVGGKYKLV RKIGSGSFGD VYLGITTTNG EDVAVKLESQ    50
    KVKHPQLLYE SKLYTILQGG VGIPHMHWYG QEKDNNVLVM DLLGPSLEDL 100
    FNFCSRRFTM KTVLMLADQM ISRIEYVHTK NFLHRDIKPD NFLMGTGRHC 150
    NKLFLIDFGL AKKYRDNRTR QHIPYREDKH LIGTVRYASI NAHLGIEQSR 200
    RDDMESLGYV FMYFNRTSLP WQGLRAMTKK QKYEKISEKK MSTPVEVLCK 250
    GFPAEFAMYL NYCRGLRFEE VPDYMYLRQL FRILFRTLNH QYDYTFDWTM 300
    LKQKAAQQAA SSSGQGQQAQ TQTGKQTEKN KNNVKDN 337
    Length:337
    Mass (Da):39,086
    Last modified:July 22, 2008 - v2
    Checksum:i6110F854D739B142
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti225 – 2251R → K in AAH28723. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti5 – 51S → G.1 Publication
    Corresponds to variant rs56224973 [ dbSNP | Ensembl ].
    VAR_042074
    Natural varianti21 – 211R → Q in a colorectal cancer sample; somatic mutation. 1 Publication
    Corresponds to variant rs56158728 [ dbSNP | Ensembl ].
    VAR_036450
    Natural varianti21 – 211R → W.1 Publication
    Corresponds to variant rs56158728 [ dbSNP | Ensembl ].
    VAR_042075
    Natural varianti42 – 421D → E.1 Publication
    Corresponds to variant rs9576175 [ dbSNP | Ensembl ].
    VAR_042076
    Natural varianti170 – 1701R → S.1 Publication
    Corresponds to variant rs17773251 [ dbSNP | Ensembl ].
    VAR_034047
    Natural varianti177 – 1771E → K.1 Publication
    Corresponds to variant rs17054882 [ dbSNP | Ensembl ].
    VAR_042077
    Natural varianti220 – 2201P → L.1 Publication
    Corresponds to variant rs56252856 [ dbSNP | Ensembl ].
    VAR_042078
    Natural varianti230 – 2301K → N.1 Publication
    Corresponds to variant rs56252523 [ dbSNP | Ensembl ].
    VAR_042079
    Natural varianti257 – 2571A → T.1 Publication
    Corresponds to variant rs55895045 [ dbSNP | Ensembl ].
    VAR_042080

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL391383 Genomic DNA. Translation: CAI15195.1.
    CH471075 Genomic DNA. Translation: EAX08587.1.
    BC028723 mRNA. Translation: AAH28723.1.
    CCDSiCCDS9363.1.
    RefSeqiNP_660204.2. NM_145203.5.
    UniGeneiHs.512897.

    Genome annotation databases

    EnsembliENST00000379800; ENSP00000369126; ENSG00000180138.
    GeneIDi122011.
    KEGGihsa:122011.
    UCSCiuc001uwm.1. human.

    Polymorphism databases

    DMDMi212286065.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL391383 Genomic DNA. Translation: CAI15195.1 .
    CH471075 Genomic DNA. Translation: EAX08587.1 .
    BC028723 mRNA. Translation: AAH28723.1 .
    CCDSi CCDS9363.1.
    RefSeqi NP_660204.2. NM_145203.5.
    UniGenei Hs.512897.

    3D structure databases

    ProteinModelPortali Q8N752.
    SMRi Q8N752. Positions 13-302.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125755. 8 interactions.
    IntActi Q8N752. 5 interactions.
    STRINGi 9606.ENSP00000369126.

    Chemistry

    BindingDBi Q8N752.
    ChEMBLi CHEMBL5520.
    GuidetoPHARMACOLOGYi 1996.

    PTM databases

    PhosphoSitei Q8N752.

    Polymorphism databases

    DMDMi 212286065.

    Proteomic databases

    MaxQBi Q8N752.
    PaxDbi Q8N752.
    PRIDEi Q8N752.

    Protocols and materials databases

    DNASUi 122011.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000379800 ; ENSP00000369126 ; ENSG00000180138 .
    GeneIDi 122011.
    KEGGi hsa:122011.
    UCSCi uc001uwm.1. human.

    Organism-specific databases

    CTDi 122011.
    GeneCardsi GC13M037677.
    H-InvDB HIX0011244.
    HGNCi HGNC:20289. CSNK1A1L.
    neXtProti NX_Q8N752.
    PharmGKBi PA134917108.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000182055.
    HOVERGENi HBG000176.
    InParanoidi Q8N752.
    KOi K08957.
    OMAi PYREDKH.
    OrthoDBi EOG7CZK5W.
    PhylomeDBi Q8N752.
    TreeFami TF354246.

    Enzyme and pathway databases

    SignaLinki Q8N752.

    Miscellaneous databases

    GenomeRNAii 122011.
    NextBioi 80837.
    PROi Q8N752.

    Gene expression databases

    Bgeei Q8N752.
    CleanExi HS_CSNK1A1L.
    Genevestigatori Q8N752.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-42.
      Tissue: Testis.
    4. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-21.
    5. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLY-5; TRP-21; SER-170; LYS-177; LEU-220; ASN-230 AND THR-257.

    Entry informationi

    Entry nameiKC1AL_HUMAN
    AccessioniPrimary (citable) accession number: Q8N752
    Secondary accession number(s): Q5T2N2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3