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Protein

Casein kinase I isoform alpha-like

Gene

CSNK1A1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei46ATPPROSITE-ProRule annotation1
Active sitei136Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi23 – 31ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Wnt signaling pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS11453-MONOMER.
SignaLinkiQ8N752.
SIGNORiQ8N752.

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase I isoform alpha-like (EC:2.7.11.1)
Short name:
CKI-alpha-like
Alternative name(s):
CK1
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:20289. CSNK1A1L.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000180138.
PharmGKBiPA134917108.

Chemistry databases

ChEMBLiCHEMBL5520.
GuidetoPHARMACOLOGYi1996.

Polymorphism and mutation databases

BioMutaiCSNK1A1L.
DMDMi212286065.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001928302 – 337Casein kinase I isoform alpha-likeAdd BLAST336

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8N752.
MaxQBiQ8N752.
PaxDbiQ8N752.
PeptideAtlasiQ8N752.
PRIDEiQ8N752.

PTM databases

iPTMnetiQ8N752.
PhosphoSitePlusiQ8N752.

Expressioni

Gene expression databases

BgeeiENSG00000180138.
CleanExiHS_CSNK1A1L.

Interactioni

Protein-protein interaction databases

BioGridi125755. 12 interactors.
IntActiQ8N752. 6 interactors.
STRINGi9606.ENSP00000369126.

Chemistry databases

BindingDBiQ8N752.

Structurei

3D structure databases

ProteinModelPortaliQ8N752.
SMRiQ8N752.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 285Protein kinasePROSITE-ProRule annotationAdd BLAST269

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1164. Eukaryota.
ENOG410XPGP. LUCA.
GeneTreeiENSGT00760000119040.
HOGENOMiHOG000182055.
HOVERGENiHBG000176.
InParanoidiQ8N752.
KOiK08957.
OMAiPYREDKH.
OrthoDBiEOG091G0AFG.
PhylomeDBiQ8N752.
TreeFamiTF354246.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N752-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNNSGSKAE LVVGGKYKLV RKIGSGSFGD VYLGITTTNG EDVAVKLESQ
60 70 80 90 100
KVKHPQLLYE SKLYTILQGG VGIPHMHWYG QEKDNNVLVM DLLGPSLEDL
110 120 130 140 150
FNFCSRRFTM KTVLMLADQM ISRIEYVHTK NFLHRDIKPD NFLMGTGRHC
160 170 180 190 200
NKLFLIDFGL AKKYRDNRTR QHIPYREDKH LIGTVRYASI NAHLGIEQSR
210 220 230 240 250
RDDMESLGYV FMYFNRTSLP WQGLRAMTKK QKYEKISEKK MSTPVEVLCK
260 270 280 290 300
GFPAEFAMYL NYCRGLRFEE VPDYMYLRQL FRILFRTLNH QYDYTFDWTM
310 320 330
LKQKAAQQAA SSSGQGQQAQ TQTGKQTEKN KNNVKDN
Length:337
Mass (Da):39,086
Last modified:July 22, 2008 - v2
Checksum:i6110F854D739B142
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti225R → K in AAH28723 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0420745S → G.1 PublicationCorresponds to variant rs56224973dbSNPEnsembl.1
Natural variantiVAR_03645021R → Q in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs56158728dbSNPEnsembl.1
Natural variantiVAR_04207521R → W.1 PublicationCorresponds to variant rs56158728dbSNPEnsembl.1
Natural variantiVAR_04207642D → E.1 PublicationCorresponds to variant rs9576175dbSNPEnsembl.1
Natural variantiVAR_034047170R → S.1 PublicationCorresponds to variant rs17773251dbSNPEnsembl.1
Natural variantiVAR_042077177E → K.1 PublicationCorresponds to variant rs17054882dbSNPEnsembl.1
Natural variantiVAR_042078220P → L.1 PublicationCorresponds to variant rs56252856dbSNPEnsembl.1
Natural variantiVAR_042079230K → N.1 PublicationCorresponds to variant rs56252523dbSNPEnsembl.1
Natural variantiVAR_042080257A → T.1 PublicationCorresponds to variant rs55895045dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL391383 Genomic DNA. Translation: CAI15195.1.
CH471075 Genomic DNA. Translation: EAX08587.1.
BC028723 mRNA. Translation: AAH28723.1.
CCDSiCCDS9363.1.
RefSeqiNP_660204.2. NM_145203.5.
UniGeneiHs.512897.

Genome annotation databases

EnsembliENST00000379800; ENSP00000369126; ENSG00000180138.
GeneIDi122011.
KEGGihsa:122011.
UCSCiuc001uwm.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL391383 Genomic DNA. Translation: CAI15195.1.
CH471075 Genomic DNA. Translation: EAX08587.1.
BC028723 mRNA. Translation: AAH28723.1.
CCDSiCCDS9363.1.
RefSeqiNP_660204.2. NM_145203.5.
UniGeneiHs.512897.

3D structure databases

ProteinModelPortaliQ8N752.
SMRiQ8N752.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125755. 12 interactors.
IntActiQ8N752. 6 interactors.
STRINGi9606.ENSP00000369126.

Chemistry databases

BindingDBiQ8N752.
ChEMBLiCHEMBL5520.
GuidetoPHARMACOLOGYi1996.

PTM databases

iPTMnetiQ8N752.
PhosphoSitePlusiQ8N752.

Polymorphism and mutation databases

BioMutaiCSNK1A1L.
DMDMi212286065.

Proteomic databases

EPDiQ8N752.
MaxQBiQ8N752.
PaxDbiQ8N752.
PeptideAtlasiQ8N752.
PRIDEiQ8N752.

Protocols and materials databases

DNASUi122011.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379800; ENSP00000369126; ENSG00000180138.
GeneIDi122011.
KEGGihsa:122011.
UCSCiuc001uwm.2. human.

Organism-specific databases

CTDi122011.
GeneCardsiCSNK1A1L.
H-InvDBHIX0011244.
HGNCiHGNC:20289. CSNK1A1L.
neXtProtiNX_Q8N752.
OpenTargetsiENSG00000180138.
PharmGKBiPA134917108.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1164. Eukaryota.
ENOG410XPGP. LUCA.
GeneTreeiENSGT00760000119040.
HOGENOMiHOG000182055.
HOVERGENiHBG000176.
InParanoidiQ8N752.
KOiK08957.
OMAiPYREDKH.
OrthoDBiEOG091G0AFG.
PhylomeDBiQ8N752.
TreeFamiTF354246.

Enzyme and pathway databases

BioCyciZFISH:HS11453-MONOMER.
SignaLinkiQ8N752.
SIGNORiQ8N752.

Miscellaneous databases

GenomeRNAii122011.
PROiQ8N752.

Gene expression databases

BgeeiENSG00000180138.
CleanExiHS_CSNK1A1L.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKC1AL_HUMAN
AccessioniPrimary (citable) accession number: Q8N752
Secondary accession number(s): Q5T2N2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: July 22, 2008
Last modified: November 2, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.