Q8N743 (KI3L3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Killer cell immunoglobulin-like receptor 3DL3

Alternative name(s):
CD158 antigen-like family member Z
Killer cell inhibitory receptor 1
CD_antigen=CD158z

Gene names

Name:	KIR3DL3
Synonyms:	CD158Z, KIR3DL7, KIRC1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	410 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor on natural killer cells. May inhibit the activity of NK cells thus preventing cell lysis. Ref.2
Subcellular location	Cell membrane; Single-pass type I membrane protein.
Polymorphism	Various different KIR3DL3 alleles are known: KIR3DL3*00101, KIR3DL3*00102, KIR3DL3*00103, KIR3DL3*00201, KIR3DL3*00202, KIR3DL3*00203, KIR3DL3*00204, KIR3DL3*00205, KIR3DL3*00206, KIR3DL3*00207, KIR3DL3*0030101 KIR3DL3*0030102, KIR3DL3*00401, KIR3DL3*00402, KIR3DL3*005, KIR3DL3*00601, KIR3DL3*00602, KIR3DL3*007, KIR3DL3*00801, KIR3DL3*00802, KIR3DL3*00901, KIR3DL3*00902, KIR3DL3*010, KIR3DL3*01101, KIR3DL3*01102, KIR3DL3*012, KIR3DL3*01301, KIR3DL3*01302, KIR3DL3*01303, KIR3DL3*01304, KIR3DL3*01305, KIR3DL3*01306, KIR3DL3*01307, KIR3DL3*01401, KIR3DL3*01402, KIR3DL3*01403, KIR3DL3*01404, KIR3DL3*01405, KIR3DL3*015 KIR3DL3*016, KIR3DL3*017, KIR3DL3*018, KIR3DL3*019, KIR3DL3*020, KIR3DL3*021, KIR3DL3*022, KIR3DL3*023, KIR3DL3*024, KIR3DL3*025, KIR3DL3*026, KIR3DL3*027, KIR3DL3*028, KIR3DL3*029, KIR3DL3*030 and KIR3DL3*031. The sequence shown corresponds to the alleles KIR3DL3*002.
Sequence similarities	Belongs to the immunoglobulin superfamily. Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Chain	26 – 410	385	Killer cell immunoglobulin-like receptor 3DL3		PRO_0000015091
Regions
	Topological domain	26 – 322	297	Extracellular Potential
	Transmembrane	323 – 343	21	Helical; Potential
	Topological domain	344 – 410	67	Cytoplasmic Potential
	Domain	42 – 97	56	Ig-like C2-type 1
	Domain	137 – 197	61	Ig-like C2-type 2
	Domain	237 – 295	59	Ig-like C2-type 3
Amino acid modifications
	Glycosylation	179	1	N-linked (GlcNAc...) Potential
	Glycosylation	239	1	N-linked (GlcNAc...) Potential
	Glycosylation	273	1	N-linked (GlcNAc...) Potential
	Disulfide bond	49 ↔ 95		Potential
	Disulfide bond	144 ↔ 195		Potential
	Disulfide bond	244 ↔ 293		Potential
Natural variations
	Natural variant	52	1	R → H in allele KIR3DL3*00401, allele KIR3DL3*00402, allele KIR3DL3*00801, allele KIR3DL3*00802 and allele KIR3DL3*026. Ref.2 Corresponds to variant rs11575927 [ dbSNP | Ensembl ].		VAR_060610
	Natural variant	56	1	N → K in allele KIR3DL3*00601, allele KIR3DL3*00602, allele KIR3DL3*01501 and allele KIR3DL3*01601.		VAR_060611
	Natural variant	77	1	R → W in allele KIR3DL3*010 and allele KIR3DL3*028. Corresponds to variant rs2075732 [ dbSNP | Ensembl ].		VAR_060612
	Natural variant	149	1	R → S in allele KIR3DL3*00601, allele KIR3DL3*00602, allele KIR3DL3*01501 and allele KIR3DL3*01601. Corresponds to variant rs62132665 [ dbSNP | Ensembl ].		VAR_060613
	Natural variant	152	1	R → H in allele KIR3DL3*007, allele KIR3DL3*030 and allele KIR3DL3*031.		VAR_060614
	Natural variant	168	1	V → I in allele KIR3DL3*00101, allele KIR3DL3*00102, allele KIR3DL3*00103, allele KIR3DL3*0030101, allele KIR3DL3*00901, allele KIR3DL3*00902, allele KIR3DL3*010 and allele KIR3DL3*028. Ref.1 Corresponds to variant rs270790 [ dbSNP | Ensembl ].		VAR_019426
	Natural variant	231	1	G → D in allele KIR3DL3*005.		VAR_060615
	Natural variant	290	1	N → T in allele KIR3DL3*00601, allele KIR3DL3*00602, allele KIR3DL3*01101, allele KIR3DL3*01102, allele KIR3DL3*01501, allele KIR3DL3*01601 and allele KIR3DL3*017. Ref.6 Corresponds to variant rs2302422 [ dbSNP | Ensembl ].		VAR_060616
	Natural variant	321	1	H → N in allele KIR3DL3*00101, allele KIR3DL3*00102, allele KIR3DL3*00103, allele KIR3DL3*00601, allele KIR3DL3*00602, allele KIR3DL3*01302, allele KIR3DL3*01305, allele KIR3DL3*01306, allele KIR3DL3*01307, allele KIR3DL3*017 and allele KIR3DL3*026. Ref.1		VAR_060617
	Natural variant	321	1	H → Y in allele KIR3DL3*00101, allele KIR3DL3*0030101, allele KIR3DL3*00401, allele KIR3DL3*00402, allele KIR3DL3*007, allele KIR3DL3*01404, allele KIR3DL3*01405, allele KIR3DL3*01601 and allele KIR3DL3*028. Ref.2 Corresponds to variant rs602444 [ dbSNP | Ensembl ].		VAR_060618
	Natural variant	324	1	V → A in allele KIR3DL3*0030101, allele KIR3DL3*00401, allele KIR3DL3*00402, allele KIR3DL3*007, allele KIR3DL3*01404, allele KIR3DL3*01405, allele KIR3DL3*01601 and allele KIR3DL3*028. Corresponds to variant rs662386 [ dbSNP | Ensembl ].		VAR_060366
	Natural variant	324	1	V → D in allele KIR3DL3*029.		VAR_060619
	Natural variant	348	1	A → P in allele KIR3DL3*027, allele KIR3DL3*029 and allele KIR3DL3*031. Corresponds to variant rs16985907 [ dbSNP | Ensembl ].		VAR_056092
	Natural variant	373	1	E → D in allele KIR3DL3*027, allele KIR3DL3*029 and allele KIR3DL3*031.		VAR_060620

Sequences

	Sequence		Length	Mass (Da)
	Q8N743 [UniParc]. Last modified November 24, 2009. Version 2. Checksum: D1C4D06DE8FEF35E	FASTA	410	44,928
	10 20 30 40 50 60 MSLMVVSMAC VGFFLLEGPW PHVGGQDKPF LSAWPGTVVS EGQHVTLQCR SRLGFNEFSL 70 80 90 100 110 120 SKEDGMPVPE LYNRIFRNSF LMGPVTPAHA GTYRCCSSHP HSPTGWSAPS NPVVIMVTGV 130 140 150 160 170 180 HRKPSLLAHP GPLVKSGETV ILQCWSDVRF ERFLLHREGI TEDPLRLVGQ LHDAGSQVNY 190 200 210 220 230 240 SMGPMTPALA GTYRCFGSVT HLPYELSAPS DPLDIVVVGL YGKPSLSAQP GPTVQAGENV 250 260 270 280 290 300 TLSCSSRSLF DIYHLSREAE AGELRLTAVL RVNGTFQANF PLGPVTHGGN YRCFGSFRAL 310 320 330 340 350 360 PHAWSDPSDP LPVSVTGNSR HLHVLIGTSV VIIPFAILLF FLLHRWCANK KNAVVMDQEP 370 380 390 400 410 AGNRTVNRED SDEQDPQEVT YAQLNHCVFT QRKITRPSQR PKTPPTDTSV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isotypic variation of novel immunoglobulin-like transcript/killer cell inhibitory receptor loci in the leukocyte receptor complex." Torkar M., Norgate Z., Colonna M., Trowsdale J., Wilson M.J. Eur. J. Immunol. 28:3959-3967(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE KIR3DL3*00101), VARIANTS ILE-168 AND ASN-321.
[2]	"Inhibition of natural killer cell activation signals by killer cell immunoglobulin-like receptors (CD158)." Long E.O., Barber D.F., Burshtyn D.N., Faure M., Peterson M., Rajagopalan S., Renard V., Sandusky M., Stebbins C.C., Wagtmann N., Watzl C. Immunol. Rev. 181:223-233(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE KIR3DL3*00401), VARIANTS HIS-52 AND TYR-321, REVIEW. Tissue: Peripheral blood.
[3]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"KIR3DL3 allelic diversity: six new alleles exhibit both conservative and non-conservative substitutions." Steiner N.K., Hurley C.K. Tissue Antigens 67:277-283(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 18-410 (ALLELES KIR3DL3*00101; KIR3DL3*00202; KIR3DL3*0030101; KIR3DL3*00402; KIR3DL3*005; KIR3DL3*00601; KIR3DL3*007; KIR3DL3*00801 AND KIR3DL3*00802).
[5]	"Seventeen novel alleles add to the already extensive KIR3DL3 diversity." Hou L., Chen M., Steiner N.K., Belle I., Turino C., Ng J., Hurley C.K. Tissue Antigens 70:449-454(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 18-410 (ALLELES KIR3DL3*00101; KIR3DL3*00102; KIR3DL3*00103; KIR3DL3*00206; KIR3DL3*00207; KIR3DL3*0030101; KIR3DL3*00402; KIR3DL3*005; KIR3DL3*00602; KIR3DL3*007; KIR3DL3*00901; KIR3DL3*00902; KIR3DL3*010; KIR3DL3*01101; KIR3DL3*01102; KIR3DL3*01302; KIR3DL3*01305; KIR3DL3*01306; KIR3DL3*01307; KIR3DL3*01404; KIR3DL3*01405; KIR3DL3*01501; KIR3DL3*01601; KIR3DL3*017; KIR3DL3*026; KIR3DL3*027; KIR3DL3*028; KIR3DL3*029; KIR3DL3*030 AND KIR3DL3*031).
[6]	"Natural killer immunoglobulin-like receptor (KIR) locus profiles in African and South Asian populations." Norman P.J., Carrington C.V.F., Byng M., Maxwell L.D., Curran M.D., Stephens H.A.F., Chandanayingyong D., Verity D.H., Hameed K., Ramdath D.D., Vaughan R.W. Genes Immun. 3:86-95(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 120-316, VARIANT THR-290.
+	Additional computationally mapped references.

Web resources

IPD-KIR Database

KIR Allele Nomenclature

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF072410 , AF072407, AF072408, AF072409 Genomic DNA. Translation: AAC99763.1. AF352324 mRNA. Translation: AAK30258.1. AC006293 Genomic DNA. Translation: AAD03159.1. AL133414 Genomic DNA. Translation: CAC40702.1. AY987937 Genomic DNA. Translation: ABC03227.1. AY987938 Genomic DNA. Translation: ABC03228.1. AY987939 Genomic DNA. Translation: ABC03229.1. AY987940 Genomic DNA. Translation: ABC03230.1. AY987941 Genomic DNA. Translation: ABC03231.1. AY987942 Genomic DNA. Translation: ABC03232.1. AY987943 Genomic DNA. Translation: ABC03233.1. AH015397 Genomic DNA. Translation: ABC03234.1. AH015396 Genomic DNA. Translation: ABC03226.1. EF153459 Genomic DNA. Translation: ABM98078.1. EF153460 Genomic DNA. Translation: ABM98079.1. EF153461 Genomic DNA. Translation: ABM98080.1. EF153462 Genomic DNA. Translation: ABM98081.1. EF153463 Genomic DNA. Translation: ABM98082.1. EF153464 Genomic DNA. Translation: ABM98083.1. EF153465 Genomic DNA. Translation: ABM98084.1. EF153466 Genomic DNA. Translation: ABM98085.1. EF153467 Genomic DNA. Translation: ABM98086.1. EF165005 Genomic DNA. Translation: ABM98087.1. EF165006 Genomic DNA. Translation: ABM98088.1. EF165007 Genomic DNA. Translation: ABM98089.1. EF165008 Genomic DNA. Translation: ABM98090.1. EF165009 Genomic DNA. Translation: ABM98091.1. EF175456 Genomic DNA. Translation: ABM98092.1. EF175457 Genomic DNA. Translation: ABM98093.1. EF175458 Genomic DNA. Translation: ABM98094.1. EF175459 Genomic DNA. Translation: ABM98095.1. EF175460 Genomic DNA. Translation: ABM98096.1. EF379094 Genomic DNA. Translation: ABM92653.1. EF379095 Genomic DNA. Translation: ABM92654.1. EF492034 Genomic DNA. Translation: ABS30929.1. EF492035 Genomic DNA. Translation: ABS30930.1. EF492036 Genomic DNA. Translation: ABS30931.1. EF492037 Genomic DNA. Translation: ABS30932.1. EF492038 Genomic DNA. Translation: ABS30933.1. EF492039 Genomic DNA. Translation: ABS30934.1. EF492040 Genomic DNA. Translation: ABS30935.1. EF492041 Genomic DNA. Translation: ABS30936.1. EF492042 Genomic DNA. Translation: ABS30937.1. EF492043 Genomic DNA. Translation: ABS30938.1. EF492044 Genomic DNA. Translation: ABS30939.1. AH011562 Genomic DNA. Translation: AAM00023.1. AY083462 Genomic DNA. Translation: AAM00024.1.
IPI	IPI00410313.
RefSeq	NP_703144.2. NM_153443.3. XP_003119153.1. XM_003119105.3.
UniGene	Hs.512572. Hs.645224.
3D structure databases
ProteinModelPortal	Q8N743.
SMR	Q8N743. Positions 28-345.
ModBase	Search...
PTM databases
PhosphoSite	Q8N743.
Polymorphism databases
DMDM	269849611.
Proteomic databases
PaxDb	Q8N743.
PRIDE	Q8N743.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000291860; ENSP00000291860; ENSG00000242019. ENST00000574960; ENSP00000459922; ENSG00000262335.
GeneID	100133046. 115653.
KEGG	hsa:100133046. hsa:115653.
UCSC	uc002qgu.1. human.
Organism-specific databases
CTD	115653.
GeneCards	GC19P055259.
HGNC	HGNC:16312. KIR3DL3.
MIM	610095. gene.
neXtProt	NX_Q8N743.
PharmGKB	PA134887375.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG25862.
HOVERGEN	HBG074353.
InParanoid	Q8N743.
KO	K07980.
OMA	FRNSFLM.
OrthoDB	EOG4RJG1X.
PhylomeDB	Q8N743.
Gene expression databases
ArrayExpress	Q8N743.
CleanEx	HS_KIR3DL3.
Genevestigator	Q8N743.
GermOnline	ENSG00000125498. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 3 hits.
InterPro	IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR013151. Immunoglobulin. [Graphical view]
Pfam	PF00047. ig. 1 hit. [Graphical view]
SMART	SM00409. IG. 3 hits. [Graphical view]
PROSITE	PS50835. IG_LIKE. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	20774190.
SOURCE	Search...

Entry information

Entry name

KI3L3_HUMAN

Accession

Primary (citable) accession number: Q8N743
Secondary accession number(s): A9PL62 , A9PL64, A9PL65, A9PL66, A9PL67, A9PL68, A9PZV4, A9PZV7, A9PZV8, A9Q066, A9Q0R5, A9Q242, A9Q250, A9Q251, O95056, Q1X775, Q1X777, Q1X778, Q1X779, Q1X780, Q1X781, Q1X782, Q1X783, Q7Z7N4, Q8NHI2, Q8NHI3, Q9UEI4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	November 24, 2009
Last modified:	May 1, 2013
This is version 105 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.