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Protein

Killer cell immunoglobulin-like receptor 3DL3

Gene

KIR3DL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor on natural killer cells. May inhibit the activity of NK cells thus preventing cell lysis.1 Publication

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell immunoglobulin-like receptor 3DL3
Alternative name(s):
CD158 antigen-like family member Z
Killer cell inhibitory receptor 1
CD_antigen: CD158z
Gene namesi
Name:KIR3DL3
Synonyms:CD158Z, KIR3DL7, KIRC1
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:16312. KIR3DL3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 322ExtracellularSequence analysisAdd BLAST297
Transmembranei323 – 343HelicalSequence analysisAdd BLAST21
Topological domaini344 – 410CytoplasmicSequence analysisAdd BLAST67

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi100132285.
115653.
3804.
PharmGKBiPA134887375.

Polymorphism and mutation databases

BioMutaiKIR3DL3.
DMDMi269849611.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000001509126 – 410Killer cell immunoglobulin-like receptor 3DL3Sequence analysisAdd BLAST385

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 95Curated
Disulfide bondi144 ↔ 195By similarity
Glycosylationi179N-linked (GlcNAc...) asparagineCurated1
Glycosylationi239N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi244 ↔ 293By similarity
Glycosylationi273N-linked (GlcNAc...) asparagineCurated1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8N743.
PeptideAtlasiQ8N743.
PRIDEiQ8N743.

PTM databases

PhosphoSitePlusiQ8N743.

Expressioni

Gene expression databases

CleanExiHS_KIR3DL3.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000291860.

Structurei

3D structure databases

ProteinModelPortaliQ8N743.
SMRiQ8N743.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 97Ig-like C2-type 1CuratedAdd BLAST56
Domaini137 – 197Ig-like C2-type 2CuratedAdd BLAST61
Domaini237 – 295Ig-like C2-type 3CuratedAdd BLAST59

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JAMM. Eukaryota.
ENOG410ZT7K. LUCA.
HOVERGENiHBG074353.
InParanoidiQ8N743.
OrthoDBiEOG091G0APE.
PhylomeDBiQ8N743.
TreeFamiTF352669.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
PfamiView protein in Pfam
PF00047. ig. 2 hits.
SMARTiView protein in SMART
SM00409. IG. 3 hits.
SM00408. IGc2. 1 hit.
SUPFAMiSSF48726. SSF48726. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N743-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLMVVSMAC VGFFLLEGPW PHVGGQDKPF LSAWPGTVVS EGQHVTLQCR
60 70 80 90 100
SRLGFNEFSL SKEDGMPVPE LYNRIFRNSF LMGPVTPAHA GTYRCCSSHP
110 120 130 140 150
HSPTGWSAPS NPVVIMVTGV HRKPSLLAHP GPLVKSGETV ILQCWSDVRF
160 170 180 190 200
ERFLLHREGI TEDPLRLVGQ LHDAGSQVNY SMGPMTPALA GTYRCFGSVT
210 220 230 240 250
HLPYELSAPS DPLDIVVVGL YGKPSLSAQP GPTVQAGENV TLSCSSRSLF
260 270 280 290 300
DIYHLSREAE AGELRLTAVL RVNGTFQANF PLGPVTHGGN YRCFGSFRAL
310 320 330 340 350
PHAWSDPSDP LPVSVTGNSR HLHVLIGTSV VIIPFAILLF FLLHRWCANK
360 370 380 390 400
KNAVVMDQEP AGNRTVNRED SDEQDPQEVT YAQLNHCVFT QRKITRPSQR
410
PKTPPTDTSV
Length:410
Mass (Da):44,928
Last modified:November 24, 2009 - v2
Checksum:iD1C4D06DE8FEF35E
GO

Polymorphismi

Various different KIR3DL3 alleles are known: KIR3DL3*00101, KIR3DL3*00102, KIR3DL3*00103, KIR3DL3*00201, KIR3DL3*00202, KIR3DL3*00203, KIR3DL3*00204, KIR3DL3*00205, KIR3DL3*00206, KIR3DL3*00207, KIR3DL3*0030101 KIR3DL3*0030102, KIR3DL3*00401, KIR3DL3*00402, KIR3DL3*005, KIR3DL3*00601, KIR3DL3*00602, KIR3DL3*007, KIR3DL3*00801, KIR3DL3*00802, KIR3DL3*00901, KIR3DL3*00902, KIR3DL3*010, KIR3DL3*01101, KIR3DL3*01102, KIR3DL3*012, KIR3DL3*01301, KIR3DL3*01302, KIR3DL3*01303, KIR3DL3*01304, KIR3DL3*01305, KIR3DL3*01306, KIR3DL3*01307, KIR3DL3*01401, KIR3DL3*01402, KIR3DL3*01403, KIR3DL3*01404, KIR3DL3*01405, KIR3DL3*015 KIR3DL3*016, KIR3DL3*017, KIR3DL3*018, KIR3DL3*019, KIR3DL3*020, KIR3DL3*021, KIR3DL3*022, KIR3DL3*023, KIR3DL3*024, KIR3DL3*025, KIR3DL3*026, KIR3DL3*027, KIR3DL3*028, KIR3DL3*029, KIR3DL3*030 and KIR3DL3*031. The sequence shown corresponds to the alleles KIR3DL3*002.4 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06061052R → H in allele KIR3DL3*00401, allele KIR3DL3*00402, allele KIR3DL3*00801, allele KIR3DL3*00802 and allele KIR3DL3*026. 1 PublicationCorresponds to variant dbSNP:rs113988102Ensembl.1
Natural variantiVAR_06061156N → K in allele KIR3DL3*00601, allele KIR3DL3*00602, allele KIR3DL3*01501 and allele KIR3DL3*01601. Corresponds to variant dbSNP:rs2075731Ensembl.1
Natural variantiVAR_06061277R → W in allele KIR3DL3*010 and allele KIR3DL3*028. Corresponds to variant dbSNP:rs202170060Ensembl.1
Natural variantiVAR_060613149R → S in allele KIR3DL3*00601, allele KIR3DL3*00602, allele KIR3DL3*01501 and allele KIR3DL3*01601. Corresponds to variant dbSNP:rs62132665Ensembl.1
Natural variantiVAR_060614152R → H in allele KIR3DL3*007, allele KIR3DL3*030 and allele KIR3DL3*031. Corresponds to variant dbSNP:rs199609975Ensembl.1
Natural variantiVAR_019426168V → I in allele KIR3DL3*00101, allele KIR3DL3*00102, allele KIR3DL3*00103, allele KIR3DL3*0030101, allele KIR3DL3*00901, allele KIR3DL3*00902, allele KIR3DL3*010 and allele KIR3DL3*028. 1 PublicationCorresponds to variant dbSNP:rs270790Ensembl.1
Natural variantiVAR_060615231G → D in allele KIR3DL3*005. Corresponds to variant dbSNP:rs778109676Ensembl.1
Natural variantiVAR_060616290N → T in allele KIR3DL3*00601, allele KIR3DL3*00602, allele KIR3DL3*01101, allele KIR3DL3*01102, allele KIR3DL3*01501, allele KIR3DL3*01601 and allele KIR3DL3*017. 1 PublicationCorresponds to variant dbSNP:rs2302422Ensembl.1
Natural variantiVAR_060617321H → N in allele KIR3DL3*00101, allele KIR3DL3*00102, allele KIR3DL3*00103, allele KIR3DL3*00601, allele KIR3DL3*00602, allele KIR3DL3*01302, allele KIR3DL3*01305, allele KIR3DL3*01306, allele KIR3DL3*01307, allele KIR3DL3*017 and allele KIR3DL3*026. 1 PublicationCorresponds to variant dbSNP:rs602444Ensembl.1
Natural variantiVAR_060618321H → Y in allele KIR3DL3*00101, allele KIR3DL3*0030101, allele KIR3DL3*00401, allele KIR3DL3*00402, allele KIR3DL3*007, allele KIR3DL3*01404, allele KIR3DL3*01405, allele KIR3DL3*01601 and allele KIR3DL3*028. 1 PublicationCorresponds to variant dbSNP:rs602444Ensembl.1
Natural variantiVAR_060366324V → A in allele KIR3DL3*0030101, allele KIR3DL3*00401, allele KIR3DL3*00402, allele KIR3DL3*007, allele KIR3DL3*01404, allele KIR3DL3*01405, allele KIR3DL3*01601 and allele KIR3DL3*028. Corresponds to variant dbSNP:rs662386Ensembl.1
Natural variantiVAR_060619324V → D in allele KIR3DL3*029. Corresponds to variant dbSNP:rs662386Ensembl.1
Natural variantiVAR_056092348A → P in allele KIR3DL3*027, allele KIR3DL3*029 and allele KIR3DL3*031. Corresponds to variant dbSNP:rs16985907Ensembl.1
Natural variantiVAR_060620373E → D in allele KIR3DL3*027, allele KIR3DL3*029 and allele KIR3DL3*031. Corresponds to variant dbSNP:rs199554226Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072410
, AF072407, AF072408, AF072409 Genomic DNA. Translation: AAC99763.1.
AF352324 mRNA. Translation: AAK30258.1.
AC006293 Genomic DNA. Translation: AAD03159.1.
AL133414 Genomic DNA. Translation: CAC40702.1.
AY987937 Genomic DNA. Translation: ABC03227.1.
AY987938 Genomic DNA. Translation: ABC03228.1.
AY987939 Genomic DNA. Translation: ABC03229.1.
AY987940 Genomic DNA. Translation: ABC03230.1.
AY987941 Genomic DNA. Translation: ABC03231.1.
AY987942 Genomic DNA. Translation: ABC03232.1.
AY987943 Genomic DNA. Translation: ABC03233.1.
AH015397 Genomic DNA. Translation: ABC03234.1.
AH015396 Genomic DNA. Translation: ABC03226.1.
EF153459 Genomic DNA. Translation: ABM98078.1.
EF153460 Genomic DNA. Translation: ABM98079.1.
EF153461 Genomic DNA. Translation: ABM98080.1.
EF153462 Genomic DNA. Translation: ABM98081.1.
EF153463 Genomic DNA. Translation: ABM98082.1.
EF153464 Genomic DNA. Translation: ABM98083.1.
EF153465 Genomic DNA. Translation: ABM98084.1.
EF153466 Genomic DNA. Translation: ABM98085.1.
EF153467 Genomic DNA. Translation: ABM98086.1.
EF165005 Genomic DNA. Translation: ABM98087.1.
EF165006 Genomic DNA. Translation: ABM98088.1.
EF165007 Genomic DNA. Translation: ABM98089.1.
EF165008 Genomic DNA. Translation: ABM98090.1.
EF165009 Genomic DNA. Translation: ABM98091.1.
EF175456 Genomic DNA. Translation: ABM98092.1.
EF175457 Genomic DNA. Translation: ABM98093.1.
EF175458 Genomic DNA. Translation: ABM98094.1.
EF175459 Genomic DNA. Translation: ABM98095.1.
EF175460 Genomic DNA. Translation: ABM98096.1.
EF379094 Genomic DNA. Translation: ABM92653.1.
EF379095 Genomic DNA. Translation: ABM92654.1.
EF492034 Genomic DNA. Translation: ABS30929.1.
EF492035 Genomic DNA. Translation: ABS30930.1.
EF492036 Genomic DNA. Translation: ABS30931.1.
EF492037 Genomic DNA. Translation: ABS30932.1.
EF492038 Genomic DNA. Translation: ABS30933.1.
EF492039 Genomic DNA. Translation: ABS30934.1.
EF492040 Genomic DNA. Translation: ABS30935.1.
EF492041 Genomic DNA. Translation: ABS30936.1.
EF492042 Genomic DNA. Translation: ABS30937.1.
EF492043 Genomic DNA. Translation: ABS30938.1.
EF492044 Genomic DNA. Translation: ABS30939.1.
AH011562 Genomic DNA. Translation: AAM00023.1.
AY083462 Genomic DNA. Translation: AAM00024.1.
CCDSiCCDS12903.1.
UniGeneiHs.645224.

Genome annotation databases

EnsembliENST00000613010; ENSP00000482580; ENSG00000274639.
ENST00000614568; ENSP00000478200; ENSG00000276196.
UCSCiuc032msg.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKI3L3_HUMAN
AccessioniPrimary (citable) accession number: Q8N743
Secondary accession number(s): A9PL62
, A9PL64, A9PL65, A9PL66, A9PL67, A9PL68, A9PZV4, A9PZV7, A9PZV8, A9Q066, A9Q0R5, A9Q242, A9Q250, A9Q251, O95056, Q1X775, Q1X777, Q1X778, Q1X779, Q1X780, Q1X781, Q1X782, Q1X783, Q7Z7N4, Q8NHI2, Q8NHI3, Q9UEI4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: November 24, 2009
Last modified: June 7, 2017
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families