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Q8N743 (KI3L3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Killer cell immunoglobulin-like receptor 3DL3
Alternative name(s):
CD158 antigen-like family member Z
Killer cell inhibitory receptor 1
CD_antigen=CD158z
Gene names
Name:KIR3DL3
Synonyms:CD158Z, KIR3DL7, KIRC1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length410 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor on natural killer cells. May inhibit the activity of NK cells thus preventing cell lysis. Ref.2

Subcellular location

Cell membrane; Single-pass type I membrane protein.

Polymorphism

Various different KIR3DL3 alleles are known: KIR3DL3*00101, KIR3DL3*00102, KIR3DL3*00103, KIR3DL3*00201, KIR3DL3*00202, KIR3DL3*00203, KIR3DL3*00204, KIR3DL3*00205, KIR3DL3*00206, KIR3DL3*00207, KIR3DL3*0030101 KIR3DL3*0030102, KIR3DL3*00401, KIR3DL3*00402, KIR3DL3*005, KIR3DL3*00601, KIR3DL3*00602, KIR3DL3*007, KIR3DL3*00801, KIR3DL3*00802, KIR3DL3*00901, KIR3DL3*00902, KIR3DL3*010, KIR3DL3*01101, KIR3DL3*01102, KIR3DL3*012, KIR3DL3*01301, KIR3DL3*01302, KIR3DL3*01303, KIR3DL3*01304, KIR3DL3*01305, KIR3DL3*01306, KIR3DL3*01307, KIR3DL3*01401, KIR3DL3*01402, KIR3DL3*01403, KIR3DL3*01404, KIR3DL3*01405, KIR3DL3*015 KIR3DL3*016, KIR3DL3*017, KIR3DL3*018, KIR3DL3*019, KIR3DL3*020, KIR3DL3*021, KIR3DL3*022, KIR3DL3*023, KIR3DL3*024, KIR3DL3*025, KIR3DL3*026, KIR3DL3*027, KIR3DL3*028, KIR3DL3*029, KIR3DL3*030 and KIR3DL3*031. The sequence shown corresponds to the alleles KIR3DL3*002.

Sequence similarities

Belongs to the immunoglobulin superfamily.

Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainImmunoglobulin domain
Repeat
Signal
Transmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 410385Killer cell immunoglobulin-like receptor 3DL3
PRO_0000015091

Regions

Topological domain26 – 322297Extracellular Potential
Transmembrane323 – 34321Helical; Potential
Topological domain344 – 41067Cytoplasmic Potential
Domain42 – 9756Ig-like C2-type 1
Domain137 – 19761Ig-like C2-type 2
Domain237 – 29559Ig-like C2-type 3

Amino acid modifications

Glycosylation1791N-linked (GlcNAc...) Potential
Glycosylation2391N-linked (GlcNAc...) Potential
Glycosylation2731N-linked (GlcNAc...) Potential
Disulfide bond49 ↔ 95 Potential
Disulfide bond144 ↔ 195 Potential
Disulfide bond244 ↔ 293 Potential

Natural variations

Natural variant521R → H in allele KIR3DL3*00401, allele KIR3DL3*00402, allele KIR3DL3*00801, allele KIR3DL3*00802 and allele KIR3DL3*026. Ref.2
Corresponds to variant rs11575927 [ dbSNP | Ensembl ].
VAR_060610
Natural variant561N → K in allele KIR3DL3*00601, allele KIR3DL3*00602, allele KIR3DL3*01501 and allele KIR3DL3*01601.
VAR_060611
Natural variant771R → W in allele KIR3DL3*010 and allele KIR3DL3*028.
Corresponds to variant rs2075732 [ dbSNP | Ensembl ].
VAR_060612
Natural variant1491R → S in allele KIR3DL3*00601, allele KIR3DL3*00602, allele KIR3DL3*01501 and allele KIR3DL3*01601.
Corresponds to variant rs62132665 [ dbSNP | Ensembl ].
VAR_060613
Natural variant1521R → H in allele KIR3DL3*007, allele KIR3DL3*030 and allele KIR3DL3*031.
VAR_060614
Natural variant1681V → I in allele KIR3DL3*00101, allele KIR3DL3*00102, allele KIR3DL3*00103, allele KIR3DL3*0030101, allele KIR3DL3*00901, allele KIR3DL3*00902, allele KIR3DL3*010 and allele KIR3DL3*028. Ref.1
Corresponds to variant rs270790 [ dbSNP | Ensembl ].
VAR_019426
Natural variant2311G → D in allele KIR3DL3*005.
VAR_060615
Natural variant2901N → T in allele KIR3DL3*00601, allele KIR3DL3*00602, allele KIR3DL3*01101, allele KIR3DL3*01102, allele KIR3DL3*01501, allele KIR3DL3*01601 and allele KIR3DL3*017. Ref.6
Corresponds to variant rs2302422 [ dbSNP | Ensembl ].
VAR_060616
Natural variant3211H → N in allele KIR3DL3*00101, allele KIR3DL3*00102, allele KIR3DL3*00103, allele KIR3DL3*00601, allele KIR3DL3*00602, allele KIR3DL3*01302, allele KIR3DL3*01305, allele KIR3DL3*01306, allele KIR3DL3*01307, allele KIR3DL3*017 and allele KIR3DL3*026. Ref.1
Corresponds to variant rs77241525 [ dbSNP | Ensembl ].
VAR_060617
Natural variant3211H → Y in allele KIR3DL3*00101, allele KIR3DL3*0030101, allele KIR3DL3*00401, allele KIR3DL3*00402, allele KIR3DL3*007, allele KIR3DL3*01404, allele KIR3DL3*01405, allele KIR3DL3*01601 and allele KIR3DL3*028. Ref.2
Corresponds to variant rs602444 [ dbSNP | Ensembl ].
VAR_060618
Natural variant3241V → A in allele KIR3DL3*0030101, allele KIR3DL3*00401, allele KIR3DL3*00402, allele KIR3DL3*007, allele KIR3DL3*01404, allele KIR3DL3*01405, allele KIR3DL3*01601 and allele KIR3DL3*028.
Corresponds to variant rs662386 [ dbSNP | Ensembl ].
VAR_060366
Natural variant3241V → D in allele KIR3DL3*029.
VAR_060619
Natural variant3481A → P in allele KIR3DL3*027, allele KIR3DL3*029 and allele KIR3DL3*031.
Corresponds to variant rs16985907 [ dbSNP | Ensembl ].
VAR_056092
Natural variant3731E → D in allele KIR3DL3*027, allele KIR3DL3*029 and allele KIR3DL3*031.
VAR_060620

Sequences

Sequence LengthMass (Da)Tools
Q8N743 [UniParc].

Last modified November 24, 2009. Version 2.
Checksum: D1C4D06DE8FEF35E

FASTA41044,928
        10         20         30         40         50         60 
MSLMVVSMAC VGFFLLEGPW PHVGGQDKPF LSAWPGTVVS EGQHVTLQCR SRLGFNEFSL 

        70         80         90        100        110        120 
SKEDGMPVPE LYNRIFRNSF LMGPVTPAHA GTYRCCSSHP HSPTGWSAPS NPVVIMVTGV 

       130        140        150        160        170        180 
HRKPSLLAHP GPLVKSGETV ILQCWSDVRF ERFLLHREGI TEDPLRLVGQ LHDAGSQVNY 

       190        200        210        220        230        240 
SMGPMTPALA GTYRCFGSVT HLPYELSAPS DPLDIVVVGL YGKPSLSAQP GPTVQAGENV 

       250        260        270        280        290        300 
TLSCSSRSLF DIYHLSREAE AGELRLTAVL RVNGTFQANF PLGPVTHGGN YRCFGSFRAL 

       310        320        330        340        350        360 
PHAWSDPSDP LPVSVTGNSR HLHVLIGTSV VIIPFAILLF FLLHRWCANK KNAVVMDQEP 

       370        380        390        400        410 
AGNRTVNRED SDEQDPQEVT YAQLNHCVFT QRKITRPSQR PKTPPTDTSV 

« Hide

References

« Hide 'large scale' references
[1]"Isotypic variation of novel immunoglobulin-like transcript/killer cell inhibitory receptor loci in the leukocyte receptor complex."
Torkar M., Norgate Z., Colonna M., Trowsdale J., Wilson M.J.
Eur. J. Immunol. 28:3959-3967(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE KIR3DL3*00101), VARIANTS ILE-168 AND ASN-321.
[2]"Inhibition of natural killer cell activation signals by killer cell immunoglobulin-like receptors (CD158)."
Long E.O., Barber D.F., Burshtyn D.N., Faure M., Peterson M., Rajagopalan S., Renard V., Sandusky M., Stebbins C.C., Wagtmann N., Watzl C.
Immunol. Rev. 181:223-233(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE KIR3DL3*00401), VARIANTS HIS-52 AND TYR-321, REVIEW.
Tissue: Peripheral blood.
[3]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"KIR3DL3 allelic diversity: six new alleles exhibit both conservative and non-conservative substitutions."
Steiner N.K., Hurley C.K.
Tissue Antigens 67:277-283(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 18-410 (ALLELES KIR3DL3*00101; KIR3DL3*00202; KIR3DL3*0030101; KIR3DL3*00402; KIR3DL3*005; KIR3DL3*00601; KIR3DL3*007; KIR3DL3*00801 AND KIR3DL3*00802).
[5]"Seventeen novel alleles add to the already extensive KIR3DL3 diversity."
Hou L., Chen M., Steiner N.K., Belle I., Turino C., Ng J., Hurley C.K.
Tissue Antigens 70:449-454(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 18-410 (ALLELES KIR3DL3*00101; KIR3DL3*00102; KIR3DL3*00103; KIR3DL3*00206; KIR3DL3*00207; KIR3DL3*0030101; KIR3DL3*00402; KIR3DL3*005; KIR3DL3*00602; KIR3DL3*007; KIR3DL3*00901; KIR3DL3*00902; KIR3DL3*010; KIR3DL3*01101; KIR3DL3*01102; KIR3DL3*01302; KIR3DL3*01305; KIR3DL3*01306; KIR3DL3*01307; KIR3DL3*01404; KIR3DL3*01405; KIR3DL3*01501; KIR3DL3*01601; KIR3DL3*017; KIR3DL3*026; KIR3DL3*027; KIR3DL3*028; KIR3DL3*029; KIR3DL3*030 AND KIR3DL3*031).
[6]"Natural killer immunoglobulin-like receptor (KIR) locus profiles in African and South Asian populations."
Norman P.J., Carrington C.V.F., Byng M., Maxwell L.D., Curran M.D., Stephens H.A.F., Chandanayingyong D., Verity D.H., Hameed K., Ramdath D.D., Vaughan R.W.
Genes Immun. 3:86-95(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 120-316, VARIANT THR-290.
+Additional computationally mapped references.

Web resources

IPD-KIR Database

KIR Allele Nomenclature

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF072410 expand/collapse EMBL AC list , AF072407, AF072408, AF072409 Genomic DNA. Translation: AAC99763.1.
AF352324 mRNA. Translation: AAK30258.1.
AC006293 Genomic DNA. Translation: AAD03159.1.
AL133414 Genomic DNA. Translation: CAC40702.1.
AY987937 Genomic DNA. Translation: ABC03227.1.
AY987938 Genomic DNA. Translation: ABC03228.1.
AY987939 Genomic DNA. Translation: ABC03229.1.
AY987940 Genomic DNA. Translation: ABC03230.1.
AY987941 Genomic DNA. Translation: ABC03231.1.
AY987942 Genomic DNA. Translation: ABC03232.1.
AY987943 Genomic DNA. Translation: ABC03233.1.
AH015397 Genomic DNA. Translation: ABC03234.1.
AH015396 Genomic DNA. Translation: ABC03226.1.
EF153459 Genomic DNA. Translation: ABM98078.1.
EF153460 Genomic DNA. Translation: ABM98079.1.
EF153461 Genomic DNA. Translation: ABM98080.1.
EF153462 Genomic DNA. Translation: ABM98081.1.
EF153463 Genomic DNA. Translation: ABM98082.1.
EF153464 Genomic DNA. Translation: ABM98083.1.
EF153465 Genomic DNA. Translation: ABM98084.1.
EF153466 Genomic DNA. Translation: ABM98085.1.
EF153467 Genomic DNA. Translation: ABM98086.1.
EF165005 Genomic DNA. Translation: ABM98087.1.
EF165006 Genomic DNA. Translation: ABM98088.1.
EF165007 Genomic DNA. Translation: ABM98089.1.
EF165008 Genomic DNA. Translation: ABM98090.1.
EF165009 Genomic DNA. Translation: ABM98091.1.
EF175456 Genomic DNA. Translation: ABM98092.1.
EF175457 Genomic DNA. Translation: ABM98093.1.
EF175458 Genomic DNA. Translation: ABM98094.1.
EF175459 Genomic DNA. Translation: ABM98095.1.
EF175460 Genomic DNA. Translation: ABM98096.1.
EF379094 Genomic DNA. Translation: ABM92653.1.
EF379095 Genomic DNA. Translation: ABM92654.1.
EF492034 Genomic DNA. Translation: ABS30929.1.
EF492035 Genomic DNA. Translation: ABS30930.1.
EF492036 Genomic DNA. Translation: ABS30931.1.
EF492037 Genomic DNA. Translation: ABS30932.1.
EF492038 Genomic DNA. Translation: ABS30933.1.
EF492039 Genomic DNA. Translation: ABS30934.1.
EF492040 Genomic DNA. Translation: ABS30935.1.
EF492041 Genomic DNA. Translation: ABS30936.1.
EF492042 Genomic DNA. Translation: ABS30937.1.
EF492043 Genomic DNA. Translation: ABS30938.1.
EF492044 Genomic DNA. Translation: ABS30939.1.
AH011562 Genomic DNA. Translation: AAM00023.1.
AY083462 Genomic DNA. Translation: AAM00024.1.
RefSeqNP_703144.2. NM_153443.3.
UniGeneHs.645224.

3D structure databases

ProteinModelPortalQ8N743.
SMRQ8N743. Positions 28-345.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8N743.

Polymorphism databases

DMDM269849611.

Proteomic databases

PaxDbQ8N743.
PRIDEQ8N743.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000291860; ENSP00000291860; ENSG00000242019.
ENST00000574960; ENSP00000459922; ENSG00000262335.
GeneID115653.
KEGGhsa:115653.
UCSCuc002qgu.1. human.

Organism-specific databases

CTD115653.
GeneCardsGC19P055270.
HGNCHGNC:16312. KIR3DL3.
MIM610095. gene.
neXtProtNX_Q8N743.
PharmGKBPA134887375.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG25862.
HOVERGENHBG074353.
InParanoidQ8N743.
KOK07980.
OMAEDRETED.
OrthoDBEOG7H792J.
PhylomeDBQ8N743.
TreeFamTF352669.

Gene expression databases

ArrayExpressQ8N743.
CleanExHS_KIR3DL3.
GenevestigatorQ8N743.

Family and domain databases

Gene3D2.60.40.10. 3 hits.
InterProIPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamPF00047. ig. 1 hit.
[Graphical view]
SMARTSM00409. IG. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiKIR3DL3.
NextBio20774190.
PROQ8N743.
SOURCESearch...

Entry information

Entry nameKI3L3_HUMAN
AccessionPrimary (citable) accession number: Q8N743
Secondary accession number(s): A9PL62 expand/collapse secondary AC list , A9PL64, A9PL65, A9PL66, A9PL67, A9PL68, A9PZV4, A9PZV7, A9PZV8, A9Q066, A9Q0R5, A9Q242, A9Q250, A9Q251, O95056, Q1X775, Q1X777, Q1X778, Q1X779, Q1X780, Q1X781, Q1X782, Q1X783, Q7Z7N4, Q8NHI2, Q8NHI3, Q9UEI4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: November 24, 2009
Last modified: March 19, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries