Q8N729 (NPW_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neuropeptide W

Alternative name(s):
Preproprotein L8
Short name=hPPL8

Cleaved into the following 2 chains:

1. Neuropeptide W-23
   Short name=NPW23
   Short name=hL8
2. Neuropeptide W-30
   Short name=NPW30
   Short name=hL8C

Gene names

Name:	NPW
Synonyms:	PPL8, PPNPW

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	165 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress By similarity. NPW23 activates GPR7 and GPR8 more efficiently than NPW30.
Subcellular location	Secreted.
Tissue specificity	Detected at high levels in the substantia nigra, fetal kidney and trachea; at lower levels in testis, uterus, ovary and placenta. Not detectable in many regions of the central nervous system. Also detected at high levels in lymphoblastic leukemia and colorectal adenocarcinoma.
Sequence similarities	Belongs to the neuropeptide B/W family.
Sequence caution	The sequence BAC07172.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Neuropeptide
PTM	Cleavage on pair of basic residues
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway Inferred from direct assay Ref.2. Source: HGNC feeding behavior Inferred from direct assay PubMed 12959997. Source: HGNC neuropeptide signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Traceable author statement. Source: Reactome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 32	32	Potential
	Peptide	33 – 62	30	Neuropeptide W-30		PRO_0000019843
	Peptide	33 – 55	23	Neuropeptide W-23		PRO_0000019844
	Propeptide	65 – 165	101	Potential		PRO_0000019845
Natural variations
	Natural variant	149	1	D → A. Corresponds to variant rs2286472 [ dbSNP | Ensembl ].		VAR_050292

Sequences

	Sequence		Length	Mass (Da)
	Q8N729 [UniParc]. Last modified July 25, 2003. Version 2. Checksum: F426AF4B7FB6E604	FASTA	165	18,048
	10 20 30 40 50 60 MAWRPGERGA PASRPRLALL LLLLLLPLPS GAWYKHVASP RYHTVGRAAG LLMGLRRSPY 70 80 90 100 110 120 LWRRALRAAA GPLARDTLSP EPAAREAPLL LPSWVQELWE TRRRSSQAGI PVRAPRSPRA 130 140 150 160 PEPALEPESL DFSGAGQRLR RDVSRPAVDP AANRLGLPCL APGPF

References

[1]	"Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8." Shimomura Y., Harada M., Goto M., Sugo T., Matsumoto Y., Abe M., Watanabe T., Asami T., Kitada C., Mori M., Onda H., Fujino M. J. Biol. Chem. 277:35826-35832(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, SYNTHESIS OF NPW23 AND NPW30.
[2]	"Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8." Brezillon S., Lannoy V., Franssen J.-D., Le Poul E., Dupriez V., Lucchetti J., Detheux M., Parmentier M. J. Biol. Chem. 278:776-783(2003) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB084276 mRNA. Translation: BAC07172.1. Different initiation.
IPI	IPI00853190.
RefSeq	NP_001092926.2. NM_001099456.2.
UniGene	Hs.233533.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000330070.
PTM databases
PhosphoSite	Q8N729.
Proteomic databases
PaxDb	Q8N729.
PRIDE	Q8N729.
Protocols and materials databases
DNASU	283869.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000329610; ENSP00000330070; ENSG00000183971.
GeneID	283869.
KEGG	hsa:283869.
UCSC	uc002coh.4. human.
Organism-specific databases
CTD	283869.
GeneCards	GC16P002059.
H-InvDB	HIX0038533.
HGNC	HGNC:30509. NPW.
MIM	607997. gene.
neXtProt	NX_Q8N729.
PharmGKB	PA142671248.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG42832.
HOGENOM	HOG000113846.
InParanoid	Q8N729.
OrthoDB	EOG4X6C9W.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	Q8N729.
Bgee	Q8N729.
CleanEx	HS_NPW.
Genevestigator	Q8N729.
GermOnline	ENSG00000183971. Homo sapiens.
Family and domain databases
InterPro	IPR013297. Neuropept_BW_pre. IPR013299. Neuropept_W_pre. [Graphical view]
PRINTS	PR01888. NROPEPTIDEBW. PR01890. PPNRPEPTIDEW.
ProDom	PD601995. Neuropept_W_pre. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...
Other
NextBio	94311.
SOURCE	Search...

Entry information

Entry name

NPW_HUMAN

Accession

Primary (citable) accession number: Q8N729

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2003
Last sequence update:	July 25, 2003
Last modified:	April 3, 2013
This is version 70 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.