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Q8N729 (NPW_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuropeptide W
Alternative name(s):
Preproprotein L8
Short name=hPPL8

Cleaved into the following 2 chains:

  1. Neuropeptide W-23
    Short name=NPW23
    Short name=hL8
  2. Neuropeptide W-30
    Short name=NPW30
    Short name=hL8C
Gene names
Name:NPW
Synonyms:PPL8, PPNPW
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length165 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress By similarity. NPW23 activates GPR7 and GPR8 more efficiently than NPW30.

Subcellular location

Secreted.

Tissue specificity

Detected at high levels in the substantia nigra, fetal kidney and trachea; at lower levels in testis, uterus, ovary and placenta. Not detectable in many regions of the central nervous system. Also detected at high levels in lymphoblastic leukemia and colorectal adenocarcinoma.

Sequence similarities

Belongs to the neuropeptide B/W family.

Sequence caution

The sequence BAC07172.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionNeuropeptide
   PTMCleavage on pair of basic residues
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Inferred from direct assay Ref.2. Source: HGNC

feeding behavior

Inferred from direct assay PubMed 12959997. Source: HGNC

neuropeptide signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Traceable author statement. Source: Reactome

   Molecular_functionprotein binding

Inferred from physical interaction Ref.2. Source: HGNC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3232 Potential
Peptide33 – 6230Neuropeptide W-30
PRO_0000019843
Peptide33 – 5523Neuropeptide W-23
PRO_0000019844
Propeptide65 – 165101 Potential
PRO_0000019845

Natural variations

Natural variant1491D → A.
Corresponds to variant rs2286472 [ dbSNP | Ensembl ].
VAR_050292

Sequences

Sequence LengthMass (Da)Tools
Q8N729 [UniParc].

Last modified July 25, 2003. Version 2.
Checksum: F426AF4B7FB6E604

FASTA16518,048
        10         20         30         40         50         60 
MAWRPGERGA PASRPRLALL LLLLLLPLPS GAWYKHVASP RYHTVGRAAG LLMGLRRSPY 

        70         80         90        100        110        120 
LWRRALRAAA GPLARDTLSP EPAAREAPLL LPSWVQELWE TRRRSSQAGI PVRAPRSPRA 

       130        140        150        160 
PEPALEPESL DFSGAGQRLR RDVSRPAVDP AANRLGLPCL APGPF 

« Hide

References

[1]"Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8."
Shimomura Y., Harada M., Goto M., Sugo T., Matsumoto Y., Abe M., Watanabe T., Asami T., Kitada C., Mori M., Onda H., Fujino M.
J. Biol. Chem. 277:35826-35832(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, SYNTHESIS OF NPW23 AND NPW30.
[2]"Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8."
Brezillon S., Lannoy V., Franssen J.-D., Le Poul E., Dupriez V., Lucchetti J., Detheux M., Parmentier M.
J. Biol. Chem. 278:776-783(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB084276 mRNA. Translation: BAC07172.1. Different initiation.
CCDSCCDS42102.1.
RefSeqNP_001092926.2. NM_001099456.2.
UniGeneHs.233533.

3D structure databases

ProteinModelPortalQ8N729.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid129692. 1 interaction.
STRING9606.ENSP00000330070.

PTM databases

PhosphoSiteQ8N729.

Proteomic databases

PaxDbQ8N729.
PRIDEQ8N729.

Protocols and materials databases

DNASU283869.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000329610; ENSP00000330070; ENSG00000183971.
GeneID283869.
KEGGhsa:283869.
UCSCuc002coh.4. human.

Organism-specific databases

CTD283869.
GeneCardsGC16P002059.
H-InvDBHIX0038533.
HGNCHGNC:30509. NPW.
MIM607997. gene.
neXtProtNX_Q8N729.
PharmGKBPA142671248.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42832.
HOGENOMHOG000113846.
InParanoidQ8N729.
PhylomeDBQ8N729.
TreeFamTF333179.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressQ8N729.
BgeeQ8N729.
CleanExHS_NPW.
GenevestigatorQ8N729.

Family and domain databases

InterProIPR013297. Neuropept_BW_pre.
IPR013299. Neuropept_W_pre.
[Graphical view]
PfamPF15180. NPBW. 1 hit.
[Graphical view]
PRINTSPR01888. NROPEPTIDEBW.
PR01890. PPNRPEPTIDEW.
ProDomPD601995. Neuropept_W_pre. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Other

GeneWikiNPW.
NextBio94311.
PROQ8N729.
SOURCESearch...

Entry information

Entry nameNPW_HUMAN
AccessionPrimary (citable) accession number: Q8N729
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: July 25, 2003
Last modified: July 9, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM