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Protein

Neuropeptide W

Gene

NPW

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By similarity). NPW23 activates GPR7 and GPR8 more efficiently than NPW30.By similarity

GO - Biological processi

  • feeding behavior Source: HGNC
  • G-protein coupled receptor signaling pathway Source: HGNC
  • neuropeptide signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide W
Alternative name(s):
Preproprotein L8
Short name:
hPPL8
Cleaved into the following 2 chains:
Neuropeptide W-23
Short name:
NPW23
Short name:
hL8
Neuropeptide W-30
Short name:
NPW30
Short name:
hL8C
Gene namesi
Name:NPW
Synonyms:PPL8, PPNPW
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:30509. NPW.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671248.

Polymorphism and mutation databases

BioMutaiNPW.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Sequence AnalysisAdd
BLAST
Peptidei33 – 6230Neuropeptide W-30PRO_0000019843Add
BLAST
Peptidei33 – 5523Neuropeptide W-23PRO_0000019844Add
BLAST
Propeptidei65 – 165101Sequence AnalysisPRO_0000019845Add
BLAST

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ8N729.
PRIDEiQ8N729.

PTM databases

PhosphoSiteiQ8N729.

Expressioni

Tissue specificityi

Detected at high levels in the substantia nigra, fetal kidney and trachea; at lower levels in testis, uterus, ovary and placenta. Not detectable in many regions of the central nervous system. Also detected at high levels in lymphoblastic leukemia and colorectal adenocarcinoma.

Gene expression databases

BgeeiQ8N729.
CleanExiHS_NPW.
ExpressionAtlasiQ8N729. baseline and differential.
GenevestigatoriQ8N729.

Interactioni

Protein-protein interaction databases

BioGridi129692. 1 interaction.
STRINGi9606.ENSP00000330070.

Structurei

3D structure databases

ProteinModelPortaliQ8N729.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the neuropeptide B/W family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42832.
HOGENOMiHOG000113846.
InParanoidiQ8N729.
PhylomeDBiQ8N729.
TreeFamiTF333179.

Family and domain databases

InterProiIPR013297. Neuropept_BW_pre.
IPR013299. Neuropept_W_pre.
[Graphical view]
PfamiPF15180. NPBW. 1 hit.
[Graphical view]
PRINTSiPR01888. NROPEPTIDEBW.
PR01890. PPNRPEPTIDEW.
ProDomiPD601995. Neuropept_W_pre. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N729-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWRPGERGA PASRPRLALL LLLLLLPLPS GAWYKHVASP RYHTVGRAAG
60 70 80 90 100
LLMGLRRSPY LWRRALRAAA GPLARDTLSP EPAAREAPLL LPSWVQELWE
110 120 130 140 150
TRRRSSQAGI PVRAPRSPRA PEPALEPESL DFSGAGQRLR RDVSRPAVDP
160
AANRLGLPCL APGPF
Length:165
Mass (Da):18,048
Last modified:July 25, 2003 - v2
Checksum:iF426AF4B7FB6E604
GO

Sequence cautioni

The sequence BAC07172.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti149 – 1491D → A.
Corresponds to variant rs2286472 [ dbSNP | Ensembl ].
VAR_050292

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB084276 mRNA. Translation: BAC07172.1. Different initiation.
CCDSiCCDS42102.1.
RefSeqiNP_001092926.2. NM_001099456.2.
UniGeneiHs.233533.

Genome annotation databases

EnsembliENST00000329610; ENSP00000330070; ENSG00000183971.
GeneIDi283869.
KEGGihsa:283869.
UCSCiuc002coh.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB084276 mRNA. Translation: BAC07172.1. Different initiation.
CCDSiCCDS42102.1.
RefSeqiNP_001092926.2. NM_001099456.2.
UniGeneiHs.233533.

3D structure databases

ProteinModelPortaliQ8N729.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129692. 1 interaction.
STRINGi9606.ENSP00000330070.

PTM databases

PhosphoSiteiQ8N729.

Polymorphism and mutation databases

BioMutaiNPW.

Proteomic databases

PaxDbiQ8N729.
PRIDEiQ8N729.

Protocols and materials databases

DNASUi283869.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329610; ENSP00000330070; ENSG00000183971.
GeneIDi283869.
KEGGihsa:283869.
UCSCiuc002coh.4. human.

Organism-specific databases

CTDi283869.
GeneCardsiGC16P002059.
H-InvDBHIX0038533.
HGNCiHGNC:30509. NPW.
MIMi607997. gene.
neXtProtiNX_Q8N729.
PharmGKBiPA142671248.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG42832.
HOGENOMiHOG000113846.
InParanoidiQ8N729.
PhylomeDBiQ8N729.
TreeFamiTF333179.

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikiiNPW.
NextBioi94311.
PROiQ8N729.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N729.
CleanExiHS_NPW.
ExpressionAtlasiQ8N729. baseline and differential.
GenevestigatoriQ8N729.

Family and domain databases

InterProiIPR013297. Neuropept_BW_pre.
IPR013299. Neuropept_W_pre.
[Graphical view]
PfamiPF15180. NPBW. 1 hit.
[Graphical view]
PRINTSiPR01888. NROPEPTIDEBW.
PR01890. PPNRPEPTIDEW.
ProDomiPD601995. Neuropept_W_pre. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

  1. "Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8."
    Shimomura Y., Harada M., Goto M., Sugo T., Matsumoto Y., Abe M., Watanabe T., Asami T., Kitada C., Mori M., Onda H., Fujino M.
    J. Biol. Chem. 277:35826-35832(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, SYNTHESIS OF NPW23 AND NPW30.
  2. "Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8."
    Brezillon S., Lannoy V., Franssen J.-D., Le Poul E., Dupriez V., Lucchetti J., Detheux M., Parmentier M.
    J. Biol. Chem. 278:776-783(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiNPW_HUMAN
AccessioniPrimary (citable) accession number: Q8N729
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: July 25, 2003
Last modified: April 29, 2015
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.