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Q8N729

- NPW_HUMAN

UniProt

Q8N729 - NPW_HUMAN

Protein

Neuropeptide W

Gene

NPW

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress By similarity. NPW23 activates GPR7 and GPR8 more efficiently than NPW30.By similarity

    GO - Molecular functioni

    1. protein binding Source: HGNC

    GO - Biological processi

    1. feeding behavior Source: HGNC
    2. G-protein coupled receptor signaling pathway Source: HGNC
    3. neuropeptide signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Neuropeptide

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuropeptide W
    Alternative name(s):
    Preproprotein L8
    Short name:
    hPPL8
    Cleaved into the following 2 chains:
    Neuropeptide W-23
    Short name:
    NPW23
    Short name:
    hL8
    Neuropeptide W-30
    Short name:
    NPW30
    Short name:
    hL8C
    Gene namesi
    Name:NPW
    Synonyms:PPL8, PPNPW
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:30509. NPW.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671248.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3232Sequence AnalysisAdd
    BLAST
    Peptidei33 – 6230Neuropeptide W-30PRO_0000019843Add
    BLAST
    Peptidei33 – 5523Neuropeptide W-23PRO_0000019844Add
    BLAST
    Propeptidei65 – 165101Sequence AnalysisPRO_0000019845Add
    BLAST

    Keywords - PTMi

    Cleavage on pair of basic residues

    Proteomic databases

    PaxDbiQ8N729.
    PRIDEiQ8N729.

    PTM databases

    PhosphoSiteiQ8N729.

    Expressioni

    Tissue specificityi

    Detected at high levels in the substantia nigra, fetal kidney and trachea; at lower levels in testis, uterus, ovary and placenta. Not detectable in many regions of the central nervous system. Also detected at high levels in lymphoblastic leukemia and colorectal adenocarcinoma.

    Gene expression databases

    ArrayExpressiQ8N729.
    BgeeiQ8N729.
    CleanExiHS_NPW.
    GenevestigatoriQ8N729.

    Interactioni

    Protein-protein interaction databases

    BioGridi129692. 1 interaction.
    STRINGi9606.ENSP00000330070.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N729.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the neuropeptide B/W family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG42832.
    HOGENOMiHOG000113846.
    InParanoidiQ8N729.
    PhylomeDBiQ8N729.
    TreeFamiTF333179.

    Family and domain databases

    InterProiIPR013297. Neuropept_BW_pre.
    IPR013299. Neuropept_W_pre.
    [Graphical view]
    PfamiPF15180. NPBW. 1 hit.
    [Graphical view]
    PRINTSiPR01888. NROPEPTIDEBW.
    PR01890. PPNRPEPTIDEW.
    ProDomiPD601995. Neuropept_W_pre. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8N729-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAWRPGERGA PASRPRLALL LLLLLLPLPS GAWYKHVASP RYHTVGRAAG    50
    LLMGLRRSPY LWRRALRAAA GPLARDTLSP EPAAREAPLL LPSWVQELWE 100
    TRRRSSQAGI PVRAPRSPRA PEPALEPESL DFSGAGQRLR RDVSRPAVDP 150
    AANRLGLPCL APGPF 165
    Length:165
    Mass (Da):18,048
    Last modified:July 25, 2003 - v2
    Checksum:iF426AF4B7FB6E604
    GO

    Sequence cautioni

    The sequence BAC07172.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti149 – 1491D → A.
    Corresponds to variant rs2286472 [ dbSNP | Ensembl ].
    VAR_050292

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB084276 mRNA. Translation: BAC07172.1. Different initiation.
    CCDSiCCDS42102.1.
    RefSeqiNP_001092926.2. NM_001099456.2.
    UniGeneiHs.233533.

    Genome annotation databases

    EnsembliENST00000329610; ENSP00000330070; ENSG00000183971.
    GeneIDi283869.
    KEGGihsa:283869.
    UCSCiuc002coh.4. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB084276 mRNA. Translation: BAC07172.1 . Different initiation.
    CCDSi CCDS42102.1.
    RefSeqi NP_001092926.2. NM_001099456.2.
    UniGenei Hs.233533.

    3D structure databases

    ProteinModelPortali Q8N729.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 129692. 1 interaction.
    STRINGi 9606.ENSP00000330070.

    PTM databases

    PhosphoSitei Q8N729.

    Proteomic databases

    PaxDbi Q8N729.
    PRIDEi Q8N729.

    Protocols and materials databases

    DNASUi 283869.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000329610 ; ENSP00000330070 ; ENSG00000183971 .
    GeneIDi 283869.
    KEGGi hsa:283869.
    UCSCi uc002coh.4. human.

    Organism-specific databases

    CTDi 283869.
    GeneCardsi GC16P002059.
    H-InvDB HIX0038533.
    HGNCi HGNC:30509. NPW.
    MIMi 607997. gene.
    neXtProti NX_Q8N729.
    PharmGKBi PA142671248.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42832.
    HOGENOMi HOG000113846.
    InParanoidi Q8N729.
    PhylomeDBi Q8N729.
    TreeFami TF333179.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii NPW.
    NextBioi 94311.
    PROi Q8N729.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8N729.
    Bgeei Q8N729.
    CleanExi HS_NPW.
    Genevestigatori Q8N729.

    Family and domain databases

    InterProi IPR013297. Neuropept_BW_pre.
    IPR013299. Neuropept_W_pre.
    [Graphical view ]
    Pfami PF15180. NPBW. 1 hit.
    [Graphical view ]
    PRINTSi PR01888. NROPEPTIDEBW.
    PR01890. PPNRPEPTIDEW.
    ProDomi PD601995. Neuropept_W_pre. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8."
      Shimomura Y., Harada M., Goto M., Sugo T., Matsumoto Y., Abe M., Watanabe T., Asami T., Kitada C., Mori M., Onda H., Fujino M.
      J. Biol. Chem. 277:35826-35832(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, SYNTHESIS OF NPW23 AND NPW30.
    2. "Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8."
      Brezillon S., Lannoy V., Franssen J.-D., Le Poul E., Dupriez V., Lucchetti J., Detheux M., Parmentier M.
      J. Biol. Chem. 278:776-783(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.

    Entry informationi

    Entry nameiNPW_HUMAN
    AccessioniPrimary (citable) accession number: Q8N729
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2003
    Last sequence update: July 25, 2003
    Last modified: October 1, 2014
    This is version 80 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3