ID   ZN655_HUMAN             Reviewed;         491 AA.
AC   Q8N720; Q8IV00; Q8TA89; Q96EZ3; Q9BQ85;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 3.
DT   07-JUL-2009, entry version 56.
DE   RecName: Full=Zinc finger protein 655;
DE   AltName: Full=Vav-interacting Krueppel-like protein;
GN   Name=ZNF655; Synonyms=VIK;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND INTERACTION WITH VAV1 AND
RP   CDK4.
RX   PubMed=15558030; DOI=10.1038/sj.onc.1208043;
RA   Houlard M., Romero-Portillo F., Germani A., Depaux A.,
RA   Regnier-Ricard F., Gisselbrecht S., Varin-Blank N.;
RT   "Characterization of VIK-1: a new Vav-interacting Kruppel-like
RT   protein.";
RL   Oncogene 24:28-38(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=22737999; PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=22616434; PubMed=12690205; DOI=10.1126/science.1083423;
RA   Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA   Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA   Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA   Kanematsu E., Gentles S., Christopoulos C.C., Choufani S.,
RA   Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z.,
RA   Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C.,
RA   Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J.,
RA   Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F.,
RA   Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F.,
RA   Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H.,
RA   Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G.,
RA   Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P.,
RA   Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J.,
RA   Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F.,
RA   Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B.,
RA   Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA   Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W.,
RA   Mural R.J., Adams M.D., Tsui L.-C.;
RT   "Human chromosome 7: DNA sequence and biology.";
RL   Science 300:767-772(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP   ASP-52.
RC   TISSUE=Brain, Cervix, Pancreas, Placenta, and Skin;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12, PHOSPHORYLATION
RP   [LARGE SCALE ANALYSIS] AT SER-60 (ISOFORM 2), AND MASS SPECTROMETRY.
RX   PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA   Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA   Greff Z., Keri G., Stemmann O., Mann M.;
RT   "Kinase-selective enrichment enables quantitative phosphoproteomics of
RT   the kinome across the cell cycle.";
RL   Mol. Cell 31:438-448(2008).
RN   [7]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60 (ISOFORM 2), AND MASS
RP   SPECTROMETRY.
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBUNIT: Interacts with VAV1 and CDK4.
CC   -!- INTERACTION:
CC       P11802:CDK4; NbExp=2; IntAct=EBI-625509, EBI-295644;
CC       P15498:VAV1; NbExp=4; IntAct=EBI-625509, EBI-625518;
CC   -!- SUBCELLULAR LOCATION: Nucleus (Probable).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8N720-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8N720-2; Sequence=VSP_036030, VSP_036031;
CC         Note=Phosphorylated on Ser-60;
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 6 C2H2-type zinc fingers.
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DR   EMBL; AY099353; AAM33786.1; -; mRNA.
DR   EMBL; AC005020; AAS02017.1; -; Genomic_DNA.
DR   EMBL; CH236956; EAL23871.1; -; Genomic_DNA.
DR   EMBL; CH471091; EAW76650.1; -; Genomic_DNA.
DR   EMBL; BC000823; AAH00823.1; -; mRNA.
DR   EMBL; BC004288; AAH04288.1; -; mRNA.
DR   EMBL; BC007378; AAH07378.1; -; mRNA.
DR   EMBL; BC011816; AAH11816.1; -; mRNA.
DR   EMBL; BC024770; AAH24770.1; -; mRNA.
DR   EMBL; BC037407; AAH37407.1; -; mRNA.
DR   IPI; IPI00031606; -.
DR   IPI; IPI00292660; -.
DR   RefSeq; NP_001009960.1; -.
DR   RefSeq; NP_001078835.1; -.
DR   RefSeq; NP_001078836.1; -.
DR   RefSeq; NP_076966.1; -.
DR   RefSeq; NP_612503.1; -.
DR   UniGene; Hs.696221; -.
DR   HSSP; P08045; 1ZNF.
DR   IntAct; Q8N720; 8.
DR   PeptideAtlas; Q8N720; -.
DR   PRIDE; Q8N720; -.
DR   Ensembl; ENSG00000197343; Homo sapiens.
DR   GeneID; 79027; -.
DR   UCSC; uc003urh.1; human.
DR   GeneCards; GC07P098993; -.
DR   HGNC; HGNC:30899; ZNF655.
DR   PharmGKB; PA134883537; -.
DR   HOGENOM; Q8N720; -.
DR   HOVERGEN; Q8N720; -.
DR   OMA; Q8N720; RIHTKEN.
DR   NextBio; 67721; -.
DR   ArrayExpress; Q8N720; -.
DR   Bgee; Q8N720; -.
DR   CleanEx; HS_ZNF655; -.
DR   GermOnline; ENSG00000197343; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 4.
DR   Pfam; PF00096; zf-C2H2; 6.
DR   ProDom; PD000003; Znf_C2H2; 5.
DR   SMART; SM00355; ZnF_C2H2; 7.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 6.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE   1: Evidence at protein level;
KW   Alternative splicing; Complete proteome; DNA-binding; Metal-binding;
KW   Nucleus; Phosphoprotein; Polymorphism; Repeat; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    491       Zinc finger protein 655.
FT                                /FTId=PRO_0000047700.
FT   ZN_FING     212    234       C2H2-type 1.
FT   ZN_FING     240    262       C2H2-type 2.
FT   ZN_FING     303    325       C2H2-type 3.
FT   ZN_FING     330    353       C2H2-type 4.
FT   ZN_FING     380    402       C2H2-type 5.
FT   ZN_FING     408    430       C2H2-type 6.
FT   MOD_RES      12     12       Phosphoserine.
FT   VAR_SEQ      46    181       DGETREENKLLIPKQKISEEVHSYKVRVGRLKHDITQVPET
FT                                REVYKSEDRLERLQEILRKFLYLEREFRQITISKETFTSEK
FT                                NNECHEPEKSFSLDSTIDADQRVLRIQNTDDNDKYDMSFNQ
FT                                NSASGKHEHLNLT -> APPVPQVPALPREGSPGDQAAALL
FT                                TARYQEFVTFEDVAVHLTREEWGYLDPVQRDLYREVMLENY
FT                                GNVVSLGILLRLPTTRIHSVNSCPALSHTQASAFSGETLAV
FT                                LTAGISKRWPKYRLPIDIARPCSETPFPRL (in
FT                                isoform 2).
FT                                /FTId=VSP_036030.
FT   VAR_SEQ     182    491       Missing (in isoform 2).
FT                                /FTId=VSP_036031.
FT   VARIANT      52     52       E -> D.
FT                                /FTId=VAR_028165.
SQ   SEQUENCE   491 AA;  57407 MW;  04FD791D769C3A80 CRC64;
     MEEIPAQEAA GSPRVQFQSL ETQSECLSPE PQFVQDTDME QGLTGDGETR EENKLLIPKQ
     KISEEVHSYK VRVGRLKHDI TQVPETREVY KSEDRLERLQ EILRKFLYLE REFRQITISK
     ETFTSEKNNE CHEPEKSFSL DSTIDADQRV LRIQNTDDND KYDMSFNQNS ASGKHEHLNL
     TEDFQSSECK ESLMDLSHLN KWESIPNTEK SYKCDVCGKI FHQSSALTRH QRIHTREKPY
     KCKECEKSFS QSSSLSRHKR IHTREKPYKC EASDKSCEAS DKSCSPSSGI IQHKKIHTRA
     KSYKCSSCER VFSRSVHLTQ HQKIHKEMPC KCTVCGSDFC HTSYLLEHQR VHHEEKAYEY
     DEYGLAYIKQ QGIHFREKPY TCSECGKDFR LNSHLIQHQR IHTGEKAHEC NECGKAFSQT
     SCLIQHHKMH RKEKSYECNE YEGSFSHSSD LILQQEVLTR QKAFDCDVWE KNSSQRAHLV
     QHQSIHTKEN S
//