ID ZN655_HUMAN Reviewed; 491 AA. AC Q8N720; A4D291; A6NGD3; B4E3M4; B7Z9Q9; D6W5T4; Q8IV00; Q8TA89; Q96EZ3; AC Q9BQ85; DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot. DT 17-OCT-2006, sequence version 3. DT 24-JAN-2024, entry version 175. DE RecName: Full=Zinc finger protein 655; DE AltName: Full=Vav-interacting Krueppel-like protein; GN Name=ZNF655; Synonyms=VIK; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND INTERACTION WITH VAV1 AND CDK4. RX PubMed=15558030; DOI=10.1038/sj.onc.1208043; RA Houlard M., Romero-Portillo F., Germani A., Depaux A., Regnier-Ricard F., RA Gisselbrecht S., Varin-Blank N.; RT "Characterization of VIK-1: a new Vav-interacting Kruppel-like protein."; RL Oncogene 24:28-38(2005). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4). RC TISSUE=Brain, Small intestine, Trachea, and Uterus; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12853948; DOI=10.1038/nature01782; RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H., RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., RA Wilson R.K.; RT "The DNA sequence of human chromosome 7."; RL Nature 424:157-164(2003). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12690205; DOI=10.1126/science.1083423; RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D., RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., RA Adams M.D., Tsui L.-C.; RT "Human chromosome 7: DNA sequence and biology."; RL Science 300:767-772(2003). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT RP ASP-52. RC TISSUE=Brain, Cervix, Pancreas, Placenta, and Skin; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [7] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60 (ISOFORM 2), AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007; RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., RA Greff Z., Keri G., Stemmann O., Mann M.; RT "Kinase-selective enrichment enables quantitative phosphoproteomics of the RT kinome across the cell cycle."; RL Mol. Cell 31:438-448(2008). RN [8] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60 (ISOFORM 2), AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=18669648; DOI=10.1073/pnas.0805139105; RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., RA Elledge S.J., Gygi S.P.; RT "A quantitative atlas of mitotic phosphorylation."; RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). RN [9] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60 (ISOFORM 2), AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=20068231; DOI=10.1126/scisignal.2000475; RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.; RT "Quantitative phosphoproteomics reveals widespread full phosphorylation RT site occupancy during mitosis."; RL Sci. Signal. 3:RA3-RA3(2010). RN [10] RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-77; LYS-190 AND LYS-201, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=28112733; DOI=10.1038/nsmb.3366; RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C., RA Nielsen M.L.; RT "Site-specific mapping of the human SUMO proteome reveals co-modification RT with phosphorylation."; RL Nat. Struct. Mol. Biol. 24:325-336(2017). CC -!- FUNCTION: May be involved in transcriptional regulation. CC -!- SUBUNIT: Interacts with VAV1 and CDK4. {ECO:0000269|PubMed:15558030}. CC -!- INTERACTION: CC Q8N720; Q9UKU0-7: ACSL6; NbExp=3; IntAct=EBI-625509, EBI-12883224; CC Q8N720; X5D778: ANKRD11; NbExp=3; IntAct=EBI-625509, EBI-17183751; CC Q8N720; Q9BXS5: AP1M1; NbExp=3; IntAct=EBI-625509, EBI-541426; CC Q8N720; Q9NWX5: ASB6; NbExp=3; IntAct=EBI-625509, EBI-6425205; CC Q8N720; O95671: ASMTL; NbExp=3; IntAct=EBI-625509, EBI-743231; CC Q8N720; Q7L5A3: ATOSB; NbExp=3; IntAct=EBI-625509, EBI-745689; CC Q8N720; Q8N5M1: ATPAF2; NbExp=3; IntAct=EBI-625509, EBI-1166928; CC Q8N720; Q99728: BARD1; NbExp=3; IntAct=EBI-625509, EBI-473181; CC Q8N720; Q96GS4: BORCS6; NbExp=3; IntAct=EBI-625509, EBI-10193358; CC Q8N720; Q13895: BYSL; NbExp=3; IntAct=EBI-625509, EBI-358049; CC Q8N720; Q6P047: C8orf74; NbExp=3; IntAct=EBI-625509, EBI-8466055; CC Q8N720; Q9Y6W3: CAPN7; NbExp=3; IntAct=EBI-625509, EBI-1765641; CC Q8N720; Q9H257: CARD9; NbExp=3; IntAct=EBI-625509, EBI-751319; CC Q8N720; Q9H257-2: CARD9; NbExp=3; IntAct=EBI-625509, EBI-11530605; CC Q8N720; Q8NA61: CBY2; NbExp=4; IntAct=EBI-625509, EBI-741724; CC Q8N720; Q8IYX3: CCDC116; NbExp=3; IntAct=EBI-625509, EBI-744311; CC Q8N720; H3BU77: CCDC179; NbExp=3; IntAct=EBI-625509, EBI-17766379; CC Q8N720; Q2TAC2-2: CCDC57; NbExp=3; IntAct=EBI-625509, EBI-10961624; CC Q8N720; Q96AQ1: CCDC74A; NbExp=3; IntAct=EBI-625509, EBI-8466689; CC Q8N720; Q8TD31-3: CCHCR1; NbExp=3; IntAct=EBI-625509, EBI-10175300; CC Q8N720; P51946: CCNH; NbExp=3; IntAct=EBI-625509, EBI-741406; CC Q8N720; Q16543: CDC37; NbExp=3; IntAct=EBI-625509, EBI-295634; CC Q8N720; P11802: CDK4; NbExp=6; IntAct=EBI-625509, EBI-295644; CC Q8N720; Q86X02: CDR2L; NbExp=3; IntAct=EBI-625509, EBI-11063830; CC Q8N720; Q8IYX8: CEP57L1; NbExp=3; IntAct=EBI-625509, EBI-1104570; CC Q8N720; Q9UBL6-2: CPNE7; NbExp=3; IntAct=EBI-625509, EBI-12012272; CC Q8N720; Q9BSW2: CRACR2A; NbExp=3; IntAct=EBI-625509, EBI-739773; CC Q8N720; Q2TBE0: CWF19L2; NbExp=3; IntAct=EBI-625509, EBI-5453285; CC Q8N720; Q8NFT6-2: DBF4B; NbExp=3; IntAct=EBI-625509, EBI-12205861; CC Q8N720; Q05D60: DEUP1; NbExp=3; IntAct=EBI-625509, EBI-748597; CC Q8N720; Q92785: DPF2; NbExp=3; IntAct=EBI-625509, EBI-359932; CC Q8N720; Q13115: DUSP4; NbExp=3; IntAct=EBI-625509, EBI-6591081; CC Q8N720; Q9H6Z9: EGLN3; NbExp=3; IntAct=EBI-625509, EBI-1175354; CC Q8N720; Q13541: EIF4EBP1; NbExp=3; IntAct=EBI-625509, EBI-74090; CC Q8N720; Q9Y6C2-2: EMILIN1; NbExp=3; IntAct=EBI-625509, EBI-11748557; CC Q8N720; Q9UI08-2: EVL; NbExp=3; IntAct=EBI-625509, EBI-6448852; CC Q8N720; Q9NQT4: EXOSC5; NbExp=5; IntAct=EBI-625509, EBI-371876; CC Q8N720; O95864-3: FADS2; NbExp=3; IntAct=EBI-625509, EBI-12057609; CC Q8N720; Q8TBF8: FAM81A; NbExp=3; IntAct=EBI-625509, EBI-11993062; CC Q8N720; Q96LP2: FAM81B; NbExp=3; IntAct=EBI-625509, EBI-10290827; CC Q8N720; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-625509, EBI-6658203; CC Q8N720; O95363: FARS2; NbExp=3; IntAct=EBI-625509, EBI-2513774; CC Q8N720; Q14192: FHL2; NbExp=3; IntAct=EBI-625509, EBI-701903; CC Q8N720; O75344: FKBP6; NbExp=3; IntAct=EBI-625509, EBI-744771; CC Q8N720; P55040: GEM; NbExp=3; IntAct=EBI-625509, EBI-744104; CC Q8N720; P14136: GFAP; NbExp=3; IntAct=EBI-625509, EBI-744302; CC Q8N720; P09211: GSTP1; NbExp=3; IntAct=EBI-625509, EBI-353467; CC Q8N720; Q96NT3-2: GUCD1; NbExp=3; IntAct=EBI-625509, EBI-11978177; CC Q8N720; Q9GZV7: HAPLN2; NbExp=3; IntAct=EBI-625509, EBI-11956675; CC Q8N720; Q96MH2: HEXIM2; NbExp=3; IntAct=EBI-625509, EBI-5460660; CC Q8N720; Q9NSC5: HOMER3; NbExp=3; IntAct=EBI-625509, EBI-748420; CC Q8N720; Q9UJC3: HOOK1; NbExp=3; IntAct=EBI-625509, EBI-746704; CC Q8N720; P09067: HOXB5; NbExp=3; IntAct=EBI-625509, EBI-3893317; CC Q8N720; P37235: HPCAL1; NbExp=3; IntAct=EBI-625509, EBI-749311; CC Q8N720; Q9H2F3: HSD3B7; NbExp=3; IntAct=EBI-625509, EBI-3918847; CC Q8N720; P42858: HTT; NbExp=14; IntAct=EBI-625509, EBI-466029; CC Q8N720; Q13907-2: IDI1; NbExp=3; IntAct=EBI-625509, EBI-13341351; CC Q8N720; Q9NV31: IMP3; NbExp=3; IntAct=EBI-625509, EBI-747481; CC Q8N720; Q9NVR2: INTS10; NbExp=3; IntAct=EBI-625509, EBI-536703; CC Q8N720; Q96PC2: IP6K3; NbExp=3; IntAct=EBI-625509, EBI-10990676; CC Q8N720; P18084: ITGB5; NbExp=3; IntAct=EBI-625509, EBI-1223434; CC Q8N720; O75564-2: JRK; NbExp=3; IntAct=EBI-625509, EBI-17181882; CC Q8N720; Q9BVG8: KIFC3; NbExp=3; IntAct=EBI-625509, EBI-2125614; CC Q8N720; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-625509, EBI-14069005; CC Q8N720; Q6A162: KRT40; NbExp=3; IntAct=EBI-625509, EBI-10171697; CC Q8N720; Q01546: KRT76; NbExp=3; IntAct=EBI-625509, EBI-2952745; CC Q8N720; P78386: KRT85; NbExp=3; IntAct=EBI-625509, EBI-1049371; CC Q8N720; O43790: KRT86; NbExp=3; IntAct=EBI-625509, EBI-9996498; CC Q8N720; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-625509, EBI-3958099; CC Q8N720; Q9BYQ0: KRTAP9-8; NbExp=3; IntAct=EBI-625509, EBI-11958364; CC Q8N720; Q5T5A8: LCE3C; NbExp=3; IntAct=EBI-625509, EBI-10245291; CC Q8N720; Q5TA78: LCE4A; NbExp=3; IntAct=EBI-625509, EBI-10246358; CC Q8N720; Q5TCM9: LCE5A; NbExp=3; IntAct=EBI-625509, EBI-11955689; CC Q8N720; Q8TCE9: LGALS14; NbExp=5; IntAct=EBI-625509, EBI-10274069; CC Q8N720; P25791-3: LMO2; NbExp=3; IntAct=EBI-625509, EBI-11959475; CC Q8N720; Q8TBB1: LNX1; NbExp=5; IntAct=EBI-625509, EBI-739832; CC Q8N720; A0A024R6W8: LRRC29; NbExp=3; IntAct=EBI-625509, EBI-10276755; CC Q8N720; Q8N5G2: MACO1; NbExp=3; IntAct=EBI-625509, EBI-2683507; CC Q8N720; Q9UI95: MAD2L2; NbExp=3; IntAct=EBI-625509, EBI-77889; CC Q8N720; Q96E03: MAGEA2B; NbExp=3; IntAct=EBI-625509, EBI-10239285; CC Q8N720; O95983-2: MBD3; NbExp=3; IntAct=EBI-625509, EBI-11978579; CC Q8N720; Q13503: MED21; NbExp=3; IntAct=EBI-625509, EBI-394678; CC Q8N720; Q9Y316: MEMO1; NbExp=3; IntAct=EBI-625509, EBI-1104564; CC Q8N720; Q8WXB1: METTL21A; NbExp=3; IntAct=EBI-625509, EBI-8652459; CC Q8N720; Q9NYP9: MIS18A; NbExp=3; IntAct=EBI-625509, EBI-1104552; CC Q8N720; Q8WV92: MITD1; NbExp=3; IntAct=EBI-625509, EBI-2691489; CC Q8N720; Q13368: MPP3; NbExp=3; IntAct=EBI-625509, EBI-716157; CC Q8N720; Q9Y605: MRFAP1; NbExp=3; IntAct=EBI-625509, EBI-995714; CC Q8N720; Q13084: MRPL28; NbExp=3; IntAct=EBI-625509, EBI-723426; CC Q8N720; Q96QG7: MTMR9; NbExp=3; IntAct=EBI-625509, EBI-744593; CC Q8N720; P50539-3: MXI1; NbExp=3; IntAct=EBI-625509, EBI-10211940; CC Q8N720; P41227: NAA10; NbExp=3; IntAct=EBI-625509, EBI-747693; CC Q8N720; O14777: NDC80; NbExp=3; IntAct=EBI-625509, EBI-715849; CC Q8N720; Q7Z6G3-2: NECAB2; NbExp=3; IntAct=EBI-625509, EBI-10172876; CC Q8N720; Q9NPG2: NGB; NbExp=3; IntAct=EBI-625509, EBI-10311409; CC Q8N720; Q6P988: NOTUM; NbExp=3; IntAct=EBI-625509, EBI-16147014; CC Q8N720; O43809: NUDT21; NbExp=3; IntAct=EBI-625509, EBI-355720; CC Q8N720; Q9BRQ3: NUDT22; NbExp=3; IntAct=EBI-625509, EBI-10297093; CC Q8N720; Q9NPJ8-3: NXT2; NbExp=3; IntAct=EBI-625509, EBI-10698339; CC Q8N720; O43482: OIP5; NbExp=3; IntAct=EBI-625509, EBI-536879; CC Q8N720; Q01804: OTUD4; NbExp=3; IntAct=EBI-625509, EBI-1054396; CC Q8N720; Q99572: P2RX7; NbExp=3; IntAct=EBI-625509, EBI-1753251; CC Q8N720; Q96AL5: PBX3; NbExp=3; IntAct=EBI-625509, EBI-741171; CC Q8N720; Q92824-2: PCSK5; NbExp=3; IntAct=EBI-625509, EBI-11956269; CC Q8N720; P16118: PFKFB1; NbExp=3; IntAct=EBI-625509, EBI-709807; CC Q8N720; O15160: POLR1C; NbExp=3; IntAct=EBI-625509, EBI-1055079; CC Q8N720; P0CG20: PRR35; NbExp=3; IntAct=EBI-625509, EBI-11986293; CC Q8N720; Q6NUQ1: RINT1; NbExp=5; IntAct=EBI-625509, EBI-726876; CC Q8N720; P23921: RRM1; NbExp=3; IntAct=EBI-625509, EBI-717006; CC Q8N720; Q06455-2: RUNX1T1; NbExp=3; IntAct=EBI-625509, EBI-11984663; CC Q8N720; Q9H788: SH2D4A; NbExp=3; IntAct=EBI-625509, EBI-747035; CC Q8N720; O43699-3: SIGLEC6; NbExp=3; IntAct=EBI-625509, EBI-12161783; CC Q8N720; Q9UP95: SLC12A4; NbExp=3; IntAct=EBI-625509, EBI-7244836; CC Q8N720; Q96GM5: SMARCD1; NbExp=3; IntAct=EBI-625509, EBI-358489; CC Q8N720; Q9H0W8: SMG9; NbExp=3; IntAct=EBI-625509, EBI-2872322; CC Q8N720; Q5MJ10: SPANXN2; NbExp=3; IntAct=EBI-625509, EBI-12023934; CC Q8N720; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-625509, EBI-5235340; CC Q8N720; O43610: SPRY3; NbExp=3; IntAct=EBI-625509, EBI-12290641; CC Q8N720; A0A286YEY3: SRGAP2B; NbExp=3; IntAct=EBI-625509, EBI-17766455; CC Q8N720; Q5T011-5: SZT2; NbExp=3; IntAct=EBI-625509, EBI-10245139; CC Q8N720; Q8N8B7-2: TCEANC; NbExp=3; IntAct=EBI-625509, EBI-11955057; CC Q8N720; Q8WW24: TEKT4; NbExp=3; IntAct=EBI-625509, EBI-750487; CC Q8N720; O15482: TEX28P2; NbExp=3; IntAct=EBI-625509, EBI-751954; CC Q8N720; Q8TBB0: THAP6; NbExp=3; IntAct=EBI-625509, EBI-3925505; CC Q8N720; P62072: TIMM10; NbExp=3; IntAct=EBI-625509, EBI-1200391; CC Q8N720; Q9UKI8: TLK1; NbExp=3; IntAct=EBI-625509, EBI-740492; CC Q8N720; Q12933: TRAF2; NbExp=3; IntAct=EBI-625509, EBI-355744; CC Q8N720; O00463: TRAF5; NbExp=3; IntAct=EBI-625509, EBI-523498; CC Q8N720; P0DI81-3: TRAPPC2; NbExp=3; IntAct=EBI-625509, EBI-11961968; CC Q8N720; Q8WV44: TRIM41; NbExp=3; IntAct=EBI-625509, EBI-725997; CC Q8N720; Q6ZMU5: TRIM72; NbExp=3; IntAct=EBI-625509, EBI-2341648; CC Q8N720; Q9UJ04: TSPYL4; NbExp=3; IntAct=EBI-625509, EBI-308511; CC Q8N720; O14530: TXNDC9; NbExp=3; IntAct=EBI-625509, EBI-707554; CC Q8N720; Q8N6Y0: USHBP1; NbExp=3; IntAct=EBI-625509, EBI-739895; CC Q8N720; P15498: VAV1; NbExp=5; IntAct=EBI-625509, EBI-625518; CC Q8N720; O14972: VPS26C; NbExp=3; IntAct=EBI-625509, EBI-7207091; CC Q8N720; Q9Y2B5: VPS9D1; NbExp=3; IntAct=EBI-625509, EBI-9031083; CC Q8N720; P23025: XPA; NbExp=3; IntAct=EBI-625509, EBI-295222; CC Q8N720; P62699: YPEL5; NbExp=3; IntAct=EBI-625509, EBI-11721624; CC Q8N720; Q05516: ZBTB16; NbExp=3; IntAct=EBI-625509, EBI-711925; CC Q8N720; Q53FD0-2: ZC2HC1C; NbExp=5; IntAct=EBI-625509, EBI-14104088; CC Q8N720; Q9Y3S2: ZNF330; NbExp=3; IntAct=EBI-625509, EBI-373456; CC Q8N720; Q9H707: ZNF552; NbExp=3; IntAct=EBI-625509, EBI-2555731; CC Q8N720; Q5T619: ZNF648; NbExp=3; IntAct=EBI-625509, EBI-11985915; CC Q8N720; Q3KQV3: ZNF792; NbExp=3; IntAct=EBI-625509, EBI-10240849; CC Q8N720; Q96EG3: ZNF837; NbExp=3; IntAct=EBI-625509, EBI-11962574; CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=4; CC Name=1; CC IsoId=Q8N720-1; Sequence=Displayed; CC Name=2; CC IsoId=Q8N720-2; Sequence=VSP_036030, VSP_036031; CC Name=3; CC IsoId=Q8N720-3; Sequence=VSP_041157; CC Name=4; CC IsoId=Q8N720-4; Sequence=VSP_044809, VSP_044810; CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein CC family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY099353; AAM33786.1; -; mRNA. DR EMBL; AK027114; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; AK304785; BAG65536.1; -; mRNA. DR EMBL; AK314593; BAG37165.1; -; mRNA. DR EMBL; AK316024; BAH14395.1; -; mRNA. DR EMBL; AC005020; AAS02017.1; -; Genomic_DNA. DR EMBL; CH236956; EAL23871.1; -; Genomic_DNA. DR EMBL; CH471091; EAW76650.1; -; Genomic_DNA. DR EMBL; CH236956; EAL23870.1; -; Genomic_DNA. DR EMBL; CH471091; EAW76651.1; -; Genomic_DNA. DR EMBL; BC000823; AAH00823.1; -; mRNA. DR EMBL; BC004288; AAH04288.1; -; mRNA. DR EMBL; BC007378; AAH07378.1; -; mRNA. DR EMBL; BC011816; AAH11816.1; -; mRNA. DR EMBL; BC024770; AAH24770.1; -; mRNA. DR EMBL; BC037407; AAH37407.1; -; mRNA. DR CCDS; CCDS34695.1; -. [Q8N720-4] DR CCDS; CCDS47655.1; -. [Q8N720-3] DR CCDS; CCDS5669.1; -. [Q8N720-1] DR CCDS; CCDS5670.1; -. [Q8N720-2] DR RefSeq; NP_001009958.1; NM_001009958.1. [Q8N720-4] DR RefSeq; NP_001009960.1; NM_001009960.1. [Q8N720-1] DR RefSeq; NP_001077425.1; NM_001083956.1. [Q8N720-3] DR RefSeq; NP_001078835.1; NM_001085366.1. [Q8N720-4] DR RefSeq; NP_001078836.1; NM_001085367.1. [Q8N720-2] DR RefSeq; NP_001078837.1; NM_001085368.1. [Q8N720-3] DR RefSeq; NP_076966.1; NM_024061.3. [Q8N720-2] DR RefSeq; NP_612503.1; NM_138494.2. [Q8N720-1] DR RefSeq; XP_016868092.1; XM_017012603.1. DR RefSeq; XP_016868093.1; XM_017012604.1. DR RefSeq; XP_016868095.1; XM_017012606.1. DR RefSeq; XP_016868096.1; XM_017012607.1. DR AlphaFoldDB; Q8N720; -. DR SMR; Q8N720; -. DR BioGRID; 122495; 179. DR DIP; DIP-34108N; -. DR IntAct; Q8N720; 160. DR MINT; Q8N720; -. DR STRING; 9606.ENSP00000393876; -. DR iPTMnet; Q8N720; -. DR PhosphoSitePlus; Q8N720; -. DR BioMuta; ZNF655; -. DR DMDM; 116242863; -. DR EPD; Q8N720; -. DR jPOST; Q8N720; -. DR MassIVE; Q8N720; -. DR MaxQB; Q8N720; -. DR PaxDb; 9606-ENSP00000393876; -. DR PeptideAtlas; Q8N720; -. DR ProteomicsDB; 1117; -. DR ProteomicsDB; 72255; -. [Q8N720-1] DR ProteomicsDB; 72256; -. [Q8N720-2] DR ProteomicsDB; 72257; -. [Q8N720-3] DR Pumba; Q8N720; -. DR Antibodypedia; 16203; 94 antibodies from 15 providers. DR DNASU; 79027; -. DR Ensembl; ENST00000252713.9; ENSP00000252713.4; ENSG00000197343.11. [Q8N720-1] DR Ensembl; ENST00000320583.9; ENSP00000322363.5; ENSG00000197343.11. [Q8N720-2] DR Ensembl; ENST00000357864.6; ENSP00000350530.2; ENSG00000197343.11. [Q8N720-4] DR Ensembl; ENST00000394163.2; ENSP00000377718.2; ENSG00000197343.11. [Q8N720-1] DR Ensembl; ENST00000424881.5; ENSP00000393876.1; ENSG00000197343.11. [Q8N720-3] DR Ensembl; ENST00000440391.5; ENSP00000396396.1; ENSG00000197343.11. [Q8N720-4] DR Ensembl; ENST00000493277.5; ENSP00000419135.1; ENSG00000197343.11. [Q8N720-3] DR GeneID; 79027; -. DR KEGG; hsa:79027; -. DR MANE-Select; ENST00000252713.9; ENSP00000252713.4; NM_138494.3; NP_612503.1. DR UCSC; uc003urc.4; human. [Q8N720-1] DR AGR; HGNC:30899; -. DR CTD; 79027; -. DR DisGeNET; 79027; -. DR GeneCards; ZNF655; -. DR HGNC; HGNC:30899; ZNF655. DR HPA; ENSG00000197343; Low tissue specificity. DR MIM; 617891; gene. DR neXtProt; NX_Q8N720; -. DR OpenTargets; ENSG00000197343; -. DR PharmGKB; PA134883537; -. DR VEuPathDB; HostDB:ENSG00000197343; -. DR eggNOG; KOG1721; Eukaryota. DR GeneTree; ENSGT00760000119441; -. DR HOGENOM; CLU_127743_0_0_1; -. DR InParanoid; Q8N720; -. DR OMA; HQRIHHQ; -. DR OrthoDB; 670620at2759; -. DR PhylomeDB; Q8N720; -. DR TreeFam; TF344137; -. DR PathwayCommons; Q8N720; -. DR Reactome; R-HSA-212436; Generic Transcription Pathway. DR SignaLink; Q8N720; -. DR BioGRID-ORCS; 79027; 16 hits in 1174 CRISPR screens. DR ChiTaRS; ZNF655; human. DR GeneWiki; ZNF655; -. DR GenomeRNAi; 79027; -. DR Pharos; Q8N720; Tbio. DR PRO; PR:Q8N720; -. DR Proteomes; UP000005640; Chromosome 7. DR RNAct; Q8N720; Protein. DR Bgee; ENSG00000197343; Expressed in ileal mucosa and 181 other cell types or tissues. DR ExpressionAtlas; Q8N720; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB. DR GO; GO:0005730; C:nucleolus; IDA:UniProtKB. DR GO; GO:0005634; C:nucleus; IDA:UniProtKB. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central. DR GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; IDA:UniProtKB. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central. DR Gene3D; 3.30.160.60; Classic Zinc Finger; 8. DR InterPro; IPR036236; Znf_C2H2_sf. DR InterPro; IPR013087; Znf_C2H2_type. DR PANTHER; PTHR23234:SF6; ZINC FINGER PROTEIN 655; 1. DR PANTHER; PTHR23234; ZNF44 PROTEIN; 1. DR Pfam; PF00096; zf-C2H2; 5. DR SMART; SM00355; ZnF_C2H2; 7. DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 6. DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 6. DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6. DR Genevisible; Q8N720; HS. PE 1: Evidence at protein level; KW Alternative splicing; DNA-binding; Isopeptide bond; Metal-binding; Nucleus; KW Phosphoprotein; Reference proteome; Repeat; Transcription; KW Transcription regulation; Ubl conjugation; Zinc; Zinc-finger. FT CHAIN 1..491 FT /note="Zinc finger protein 655" FT /id="PRO_0000047700" FT ZN_FING 212..234 FT /note="C2H2-type 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 240..262 FT /note="C2H2-type 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 303..325 FT /note="C2H2-type 3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 330..353 FT /note="C2H2-type 4" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 380..402 FT /note="C2H2-type 5" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 408..430 FT /note="C2H2-type 6" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT REGION 1..52 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 12..39 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT CROSSLNK 77 FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with FT G-Cter in SUMO2)" FT /evidence="ECO:0007744|PubMed:28112733" FT CROSSLNK 190 FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with FT G-Cter in SUMO2)" FT /evidence="ECO:0007744|PubMed:28112733" FT CROSSLNK 201 FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with FT G-Cter in SUMO2)" FT /evidence="ECO:0007744|PubMed:28112733" FT VAR_SEQ 45 FT /note="G -> GGFPISKPDGISQLEQDLQVFDLETKTREVLRDDCS (in FT isoform 3)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_041157" FT VAR_SEQ 46..181 FT /note="DGETREENKLLIPKQKISEEVHSYKVRVGRLKHDITQVPETREVYKSEDRLE FT RLQEILRKFLYLEREFRQITISKETFTSEKNNECHEPEKSFSLDSTIDADQRVLRIQNT FT DDNDKYDMSFNQNSASGKHEHLNLT -> APPVPQVPALPREGSPGDQAAALLTARYQE FT FVTFEDVAVHLTREEWGYLDPVQRDLYREVMLENYGNVVSLGILLRLPTTRIHSVNSCP FT ALSHTQASAFSGETLAVLTAGISKRWPKYRLPIDIARPCSETPFPRL (in isoform FT 2)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_036030" FT VAR_SEQ 46..110 FT /note="DGETREENKLLIPKQKISEEVHSYKVRVGRLKHDITQVPETREVYKSEDRLE FT RLQEILRKFLYLE -> GILLRLPTTRIHSVNSCPALSHTQASAFSGETLAVLTAGISK FT RWPKYRLPIDIARPCSETPFPRL (in isoform 4)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_044809" FT VAR_SEQ 111..491 FT /note="Missing (in isoform 4)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_044810" FT VAR_SEQ 182..491 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_036031" FT VARIANT 52 FT /note="E -> D (in dbSNP:rs17853754)" FT /evidence="ECO:0000269|PubMed:15489334" FT /id="VAR_028165" FT CONFLICT 178 FT /note="L -> S (in Ref. 2; BAH14395)" FT /evidence="ECO:0000305" FT MOD_RES Q8N720-2:60 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:18669648, FT ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231" SQ SEQUENCE 491 AA; 57407 MW; 04FD791D769C3A80 CRC64; MEEIPAQEAA GSPRVQFQSL ETQSECLSPE PQFVQDTDME QGLTGDGETR EENKLLIPKQ KISEEVHSYK VRVGRLKHDI TQVPETREVY KSEDRLERLQ EILRKFLYLE REFRQITISK ETFTSEKNNE CHEPEKSFSL DSTIDADQRV LRIQNTDDND KYDMSFNQNS ASGKHEHLNL TEDFQSSECK ESLMDLSHLN KWESIPNTEK SYKCDVCGKI FHQSSALTRH QRIHTREKPY KCKECEKSFS QSSSLSRHKR IHTREKPYKC EASDKSCEAS DKSCSPSSGI IQHKKIHTRA KSYKCSSCER VFSRSVHLTQ HQKIHKEMPC KCTVCGSDFC HTSYLLEHQR VHHEEKAYEY DEYGLAYIKQ QGIHFREKPY TCSECGKDFR LNSHLIQHQR IHTGEKAHEC NECGKAFSQT SCLIQHHKMH RKEKSYECNE YEGSFSHSSD LILQQEVLTR QKAFDCDVWE KNSSQRAHLV QHQSIHTKEN S //