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Protein

Coiled-coil domain-containing protein 185

Gene

CCDC185

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 185
Gene namesi
Name:CCDC185
Synonyms:C1orf65
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:26654. CCDC185.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672515.

Polymorphism and mutation databases

BioMutaiC1orf65.
DMDMi296434417.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 623623Coiled-coil domain-containing protein 185PRO_0000247114Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki528 – 528Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ8N715.
PaxDbiQ8N715.
PRIDEiQ8N715.

PTM databases

iPTMnetiQ8N715.
PhosphoSiteiQ8N715.

Expressioni

Gene expression databases

BgeeiQ8N715.
CleanExiHS_C1orf65.
GenevisibleiQ8N715. HS.

Organism-specific databases

HPAiHPA027518.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRT40Q6A1623EBI-740814,EBI-10171697
KRTAP10-7P604093EBI-740814,EBI-10172290

Protein-protein interaction databases

BioGridi127889. 12 interactions.
IntActiQ8N715. 11 interactions.
MINTiMINT-1449303.
STRINGi9606.ENSP00000355840.

Structurei

3D structure databases

ProteinModelPortaliQ8N715.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili266 – 29530Sequence analysisAdd
BLAST
Coiled coili359 – 39234Sequence analysisAdd
BLAST
Coiled coili431 – 50171Sequence analysisAdd
BLAST
Coiled coili534 – 57340Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi69 – 10537Arg-richAdd
BLAST
Compositional biasi117 – 15034Pro-richAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGGR. Eukaryota.
ENOG410XUIU. LUCA.
GeneTreeiENSGT00740000115684.
HOGENOMiHOG000133091.
HOVERGENiHBG080950.
InParanoidiQ8N715.
OMAiQSQEQWQ.
OrthoDBiEOG7P2XSJ.
PhylomeDBiQ8N715.
TreeFamiTF337827.

Family and domain databases

InterProiIPR029090. DUF4659.
[Graphical view]
PfamiPF15558. DUF4659. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N715-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGFSHFSQP PYRDLWEPPR PGGERESTQR LGGQRSGADS TACSRAGTPG
60 70 80 90 100
AESEAGACWL HPHCSFTPRP RRRGCSDSLR GSRSLSDVAR RPLERSRKHR
110 120 130 140 150
PRSRRLEDAW GETGTKPRPA WQPQTQLPPQ RPQPCPHYPL AQGDSPPPCP
160 170 180 190 200
GGAGTPLSGT FRVEKAQGGD QWAVPLGRHL GRWSPSSVPS ERSSVPSQKF
210 220 230 240 250
KRHSACVCAQ KRDSSDQVES LASRDSQPLA SSKEMRSPHT QVLKSKLEEV
260 270 280 290 300
VVSSQDQQIV ALVLTRLKKA QRIRELQQQA AKAWEELKRS DQKVQMTLER
310 320 330 340 350
ERRLLLRQSQ EQWQEKEQRK TLQSPEQRGL RRDSQRKNVP PGESRWKEQP
360 370 380 390 400
EDQESPRQEK LEKARAQAEH RKQCQVRRLR EQEKMLRNLR EQHSLQLQRR
410 420 430 440 450
LVEACRKRHL HAVEGQKKVQ DTNLSSLINY QARKVLMDCQ AKAEELLRQL
460 470 480 490 500
SLEQSFQRSQ EIHQGLRKER QRELREKAQK EEEQLQQARW RAGESEEQRK
510 520 530 540 550
MRKRILVELA DEKIRQARSH VHKTTRDKVQ HLRELNHLRE KNHHILKLKA
560 570 580 590 600
EKEEKCHIEG IKEAIKKKEQ RVQHISQGKD PNFQEFQKLP QASRREERAP
610 620
PNSSLDQMVL EAQLRACQQN RGY
Length:623
Mass (Da):72,349
Last modified:May 18, 2010 - v2
Checksum:i19103B45552CE57C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti195 – 1951V → A.
Corresponds to variant rs6689850 [ dbSNP | Ensembl ].
VAR_027066
Natural varianti329 – 3291G → D.1 Publication
Corresponds to variant rs10907376 [ dbSNP | Ensembl ].
VAR_027067
Natural varianti331 – 3311R → W.
Corresponds to variant rs6682552 [ dbSNP | Ensembl ].
VAR_027068
Natural varianti380 – 3801R → L.1 Publication
Corresponds to variant rs17852896 [ dbSNP | Ensembl ].
VAR_027069

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093047 mRNA. Translation: BAC04033.1.
AL590669 Genomic DNA. Translation: CAI16672.1.
BC030026 mRNA. Translation: AAH30026.1.
BC031066 mRNA. Translation: AAH31066.1.
CCDSiCCDS1537.1.
RefSeqiNP_689823.2. NM_152610.2.
UniGeneiHs.192090.

Genome annotation databases

EnsembliENST00000366875; ENSP00000355840; ENSG00000178395.
GeneIDi164127.
KEGGihsa:164127.
UCSCiuc001hoa.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093047 mRNA. Translation: BAC04033.1.
AL590669 Genomic DNA. Translation: CAI16672.1.
BC030026 mRNA. Translation: AAH30026.1.
BC031066 mRNA. Translation: AAH31066.1.
CCDSiCCDS1537.1.
RefSeqiNP_689823.2. NM_152610.2.
UniGeneiHs.192090.

3D structure databases

ProteinModelPortaliQ8N715.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127889. 12 interactions.
IntActiQ8N715. 11 interactions.
MINTiMINT-1449303.
STRINGi9606.ENSP00000355840.

PTM databases

iPTMnetiQ8N715.
PhosphoSiteiQ8N715.

Polymorphism and mutation databases

BioMutaiC1orf65.
DMDMi296434417.

Proteomic databases

EPDiQ8N715.
PaxDbiQ8N715.
PRIDEiQ8N715.

Protocols and materials databases

DNASUi164127.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366875; ENSP00000355840; ENSG00000178395.
GeneIDi164127.
KEGGihsa:164127.
UCSCiuc001hoa.3. human.

Organism-specific databases

CTDi164127.
GeneCardsiCCDC185.
HGNCiHGNC:26654. CCDC185.
HPAiHPA027518.
neXtProtiNX_Q8N715.
PharmGKBiPA142672515.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGGR. Eukaryota.
ENOG410XUIU. LUCA.
GeneTreeiENSGT00740000115684.
HOGENOMiHOG000133091.
HOVERGENiHBG080950.
InParanoidiQ8N715.
OMAiQSQEQWQ.
OrthoDBiEOG7P2XSJ.
PhylomeDBiQ8N715.
TreeFamiTF337827.

Miscellaneous databases

GenomeRNAii164127.
PROiQ8N715.

Gene expression databases

BgeeiQ8N715.
CleanExiHS_C1orf65.
GenevisibleiQ8N715. HS.

Family and domain databases

InterProiIPR029090. DUF4659.
[Graphical view]
PfamiPF15558. DUF4659. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ASP-329 AND LEU-380.
    Tissue: Testis.
  4. "Uncovering global SUMOylation signaling networks in a site-specific manner."
    Hendriks I.A., D'Souza R.C., Yang B., Verlaan-de Vries M., Mann M., Vertegaal A.C.
    Nat. Struct. Mol. Biol. 21:927-936(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-528, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCC185_HUMAN
AccessioniPrimary (citable) accession number: Q8N715
Secondary accession number(s): Q8N746, Q8NA93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: May 18, 2010
Last modified: June 8, 2016
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.