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Protein

Protocadherin-20

Gene

PCDH20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein.

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciZFISH:G66-33909-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin-20
Alternative name(s):
Protocadherin-13
Gene namesi
Name:PCDH20
Synonyms:PCDH13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:14257. PCDH20.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini61 – 890ExtracellularSequence analysisAdd BLAST830
Transmembranei891 – 911HelicalSequence analysisAdd BLAST21
Topological domaini912 – 951CytoplasmicSequence analysisAdd BLAST40

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi64881.
OpenTargetsiENSG00000197991.
ENSG00000280165.
PharmGKBiPA33004.

Polymorphism and mutation databases

BioMutaiPCDH20.
DMDMi544584765.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 60Sequence analysisAdd BLAST60
ChainiPRO_000000400561 – 951Protocadherin-20Add BLAST891

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi135N-linked (GlcNAc...)Sequence analysis1
Glycosylationi326N-linked (GlcNAc...)Sequence analysis1
Glycosylationi332N-linked (GlcNAc...)Sequence analysis1
Glycosylationi680N-linked (GlcNAc...)Sequence analysis1
Glycosylationi748N-linked (GlcNAc...)Sequence analysis1
Glycosylationi803N-linked (GlcNAc...)Sequence analysis1
Glycosylationi844N-linked (GlcNAc...)Sequence analysis1
Glycosylationi849N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8N6Y1.
PRIDEiQ8N6Y1.

PTM databases

iPTMnetiQ8N6Y1.
PhosphoSitePlusiQ8N6Y1.

Expressioni

Gene expression databases

BgeeiENSG00000197991.
CleanExiHS_PCDH20.
GenevisibleiQ8N6Y1. HS.

Interactioni

Protein-protein interaction databases

BioGridi122337. 51 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ8N6Y1.
SMRiQ8N6Y1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 209Cadherin 1PROSITE-ProRule annotationAdd BLAST146
Domaini210 – 320Cadherin 2PROSITE-ProRule annotationAdd BLAST111
Domaini321 – 535Cadherin 3PROSITE-ProRule annotationAdd BLAST215
Domaini536 – 639Cadherin 4PROSITE-ProRule annotationAdd BLAST104
Domaini640 – 742Cadherin 5PROSITE-ProRule annotationAdd BLAST103
Domaini746 – 863Cadherin 6PROSITE-ProRule annotationAdd BLAST118

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFFV. Eukaryota.
ENOG4110RHM. LUCA.
GeneTreeiENSGT00850000132246.
HOGENOMiHOG000234535.
HOVERGENiHBG053523.
InParanoidiQ8N6Y1.
KOiK16498.
OMAiVPRYIAN.
OrthoDBiEOG091G011P.
PhylomeDBiQ8N6Y1.
TreeFamiTF320624.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N6Y1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGRGNARSS QALGVSWCPA TWHPRLDMGR LHRPRSSTSY RNLPHLFLFF
60 70 80 90 100
LFVGPFSCLG SYSRATELLY SLNEGLPAGV LIGSLAEDLR LLPRSAGRPD
110 120 130 140 150
PQSQLPERTG AEWNPPLSFS LASRGLSGQY VTLDNRSGEL HTSAQEIDRE
160 170 180 190 200
ALCVEGGGGT AWSGSVSISS SPSDSCLLLL DVLVLPQEYF RFVKVKIAIR
210 220 230 240 250
DINDNAPQFP VSQISVWVPE NAPVNTRLAI EHPAVDPDVG INGVQTYRLL
260 270 280 290 300
DYHGMFTLDV EENENGERTP YLIVMGALDR ETQDQYVSII IAEDGGSPPL
310 320 330 340 350
LGSATLTIGI SDINDNCPLF TDSQINVTVY GNATVGTPIA AVQAVDKDLG
360 370 380 390 400
TNAQITYSYS QKVPQASKDL FHLDENTGVI KLFSKIGGSV LESHKLTILA
410 420 430 440 450
NGPGCIPAVI TALVSIIKVI FRPPEIVPRY IANEIDGVVY LKELEPVNTP
460 470 480 490 500
IAFFTIRDPE GKYKVNCYLD GEGPFRLSPY KPYNNEYLLE TTKPMDYELQ
510 520 530 540 550
QFYEVAVVAW NSEGFHVKRV IKVQLLDDND NAPIFLQPLI ELTIEENNSP
560 570 580 590 600
NAFLTKLYAT DADSEERGQV SYFLGPDAPS YFSLDSVTGI LTVSTQLDRE
610 620 630 640 650
EKEKYRYTVR AVDCGKPPRE SVATVALTVL DKNDNSPRFI NKDFSFFVPE
660 670 680 690 700
NFPGYGEIGV ISVTDADAGR NGWVALSVVN QSDIFVIDTG KGMLRAKVSL
710 720 730 740 750
DREQQSSYTL WVEAVDGGEP ALSSTAKITI LLLDINDNPP LVLFPQSNMS
760 770 780 790 800
YLLVLPSTLP GSPVTEVYAV DKDTGMNAVI AYSIIGRRGP RPESFRIDPK
810 820 830 840 850
TGNITLEEAL LQTDYGLHRL LVKVSDHGYP EPLHSTVMVN LFVNDTVSNE
860 870 880 890 900
SYIESLLRKE PEINIEEKEP QISIEPTHRK VESVSCMPTL VALSVISLGS
910 920 930 940 950
ITLVTGMGIY ICLRKGEKHP REDENLEVQI PLKGKIDLHM RERKPMDISN

I
Length:951
Mass (Da):104,919
Last modified:September 18, 2013 - v2
Checksum:iE8506B94A686A591
GO

Sequence cautioni

The sequence AAH27907 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti291I → T in AAF89690 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036111523V → M in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169693 mRNA. Translation: AAF89690.1.
AK289924 mRNA. Translation: BAF82613.1.
AL833830 mRNA. Translation: CAD38690.1.
AL592490 Genomic DNA. Translation: CAH73802.3.
CH471124 Genomic DNA. Translation: EAW52085.1.
BC027907 mRNA. Translation: AAH27907.1. Different initiation.
CCDSiCCDS9442.2.
RefSeqiNP_073754.2. NM_022843.3.
XP_016876197.1. XM_017020708.1.
UniGeneiHs.391781.

Genome annotation databases

EnsembliENST00000409204; ENSP00000387250; ENSG00000280165.
GeneIDi64881.
KEGGihsa:64881.
UCSCiuc001vid.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169693 mRNA. Translation: AAF89690.1.
AK289924 mRNA. Translation: BAF82613.1.
AL833830 mRNA. Translation: CAD38690.1.
AL592490 Genomic DNA. Translation: CAH73802.3.
CH471124 Genomic DNA. Translation: EAW52085.1.
BC027907 mRNA. Translation: AAH27907.1. Different initiation.
CCDSiCCDS9442.2.
RefSeqiNP_073754.2. NM_022843.3.
XP_016876197.1. XM_017020708.1.
UniGeneiHs.391781.

3D structure databases

ProteinModelPortaliQ8N6Y1.
SMRiQ8N6Y1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122337. 51 interactors.

PTM databases

iPTMnetiQ8N6Y1.
PhosphoSitePlusiQ8N6Y1.

Polymorphism and mutation databases

BioMutaiPCDH20.
DMDMi544584765.

Proteomic databases

PaxDbiQ8N6Y1.
PRIDEiQ8N6Y1.

Protocols and materials databases

DNASUi64881.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409204; ENSP00000387250; ENSG00000280165.
GeneIDi64881.
KEGGihsa:64881.
UCSCiuc001vid.5. human.

Organism-specific databases

CTDi64881.
DisGeNETi64881.
GeneCardsiPCDH20.
HGNCiHGNC:14257. PCDH20.
MIMi614449. gene.
neXtProtiNX_Q8N6Y1.
OpenTargetsiENSG00000197991.
ENSG00000280165.
PharmGKBiPA33004.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFFV. Eukaryota.
ENOG4110RHM. LUCA.
GeneTreeiENSGT00850000132246.
HOGENOMiHOG000234535.
HOVERGENiHBG053523.
InParanoidiQ8N6Y1.
KOiK16498.
OMAiVPRYIAN.
OrthoDBiEOG091G011P.
PhylomeDBiQ8N6Y1.
TreeFamiTF320624.

Enzyme and pathway databases

BioCyciZFISH:G66-33909-MONOMER.

Miscellaneous databases

GeneWikiiPCDH20.
GenomeRNAii64881.
PROiQ8N6Y1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197991.
CleanExiHS_PCDH20.
GenevisibleiQ8N6Y1. HS.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCD20_HUMAN
AccessioniPrimary (citable) accession number: Q8N6Y1
Secondary accession number(s): A8K1K9
, B1AQU2, Q8NDN4, Q9NRT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: September 18, 2013
Last modified: November 2, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.