ID USBP1_HUMAN Reviewed; 703 AA. AC Q8N6Y0; A8K7L6; B2RCR9; Q8NBX7; Q96KH3; Q9BYI8; DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2002, sequence version 1. DT 27-MAR-2024, entry version 151. DE RecName: Full=Harmonin-binding protein USHBP1 {ECO:0000305}; DE AltName: Full=AIE-75-binding protein; DE AltName: Full=Mutated in colon cancer protein 2; DE Short=MCC-2; DE AltName: Full=Usher syndrome type-1C protein-binding protein 1; DE Short=USH1C-binding protein 1; GN Name=USHBP1 {ECO:0000312|EMBL:AAH27910.1}; GN Synonyms=AIEBP {ECO:0000312|EMBL:BAB41203.1}, MCC2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] {ECO:0000305, ECO:0000312|EMBL:BAB41203.1} RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), INTERACTION WITH USH1C, RP TISSUE SPECIFICITY, AND VARIANT VAL-439. RC TISSUE=Kidney {ECO:0000312|EMBL:BAB43978.1}, and Placenta RC {ECO:0000312|EMBL:BAB41203.1}; RX PubMed=11311560; DOI=10.1016/s0378-1119(01)00378-x; RA Ishikawa S., Kobayashi I., Hamada J., Tada M., Hirai A., Furuuchi K., RA Takahashi Y., Ba Y., Moriuchi T.; RT "Interaction of MCC2, a novel homologue of MCC tumor suppressor, with PDZ- RT domain protein AIE-75."; RL Gene 267:101-110(2001). RN [2] {ECO:0000305, ECO:0000312|EMBL:BAC11443.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Placenta {ECO:0000312|EMBL:BAC11443.1}, and Spleen; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] {ECO:0000305, ECO:0000312|EMBL:AAH27910.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- SUBUNIT: Interacts via its C-terminus with the first PDZ domain of CC USH1C. {ECO:0000269|PubMed:11311560}. CC -!- INTERACTION: CC Q8N6Y0; Q8NFV4-4: ABHD11; NbExp=3; IntAct=EBI-739895, EBI-12318443; CC Q8N6Y0; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-739895, EBI-11096309; CC Q8N6Y0; Q8TDX5-2: ACMSD; NbExp=3; IntAct=EBI-739895, EBI-12809094; CC Q8N6Y0; Q9NX04: AIRIM; NbExp=3; IntAct=EBI-739895, EBI-8643161; CC Q8N6Y0; Q99996-2: AKAP9; NbExp=3; IntAct=EBI-739895, EBI-9641546; CC Q8N6Y0; Q7Z3H0-1: ANKRD33; NbExp=3; IntAct=EBI-739895, EBI-16746154; CC Q8N6Y0; Q96IX9: ANKRD36BP1; NbExp=3; IntAct=EBI-739895, EBI-744859; CC Q8N6Y0; P53365: ARFIP2; NbExp=3; IntAct=EBI-739895, EBI-638194; CC Q8N6Y0; Q96C12: ARMC5; NbExp=3; IntAct=EBI-739895, EBI-6425121; CC Q8N6Y0; Q8WXK1: ASB15; NbExp=3; IntAct=EBI-739895, EBI-12809012; CC Q8N6Y0; P48047: ATP5PO; NbExp=3; IntAct=EBI-739895, EBI-355815; CC Q8N6Y0; O75934: BCAS2; NbExp=3; IntAct=EBI-739895, EBI-1050106; CC Q8N6Y0; O43521: BCL2L11; NbExp=3; IntAct=EBI-739895, EBI-526406; CC Q8N6Y0; O15155: BET1; NbExp=2; IntAct=EBI-739895, EBI-749204; CC Q8N6Y0; Q9BXY8: BEX2; NbExp=3; IntAct=EBI-739895, EBI-745073; CC Q8N6Y0; Q00994: BEX3; NbExp=6; IntAct=EBI-739895, EBI-741753; CC Q8N6Y0; Q12934-2: BFSP1; NbExp=3; IntAct=EBI-739895, EBI-12123320; CC Q8N6Y0; Q13515: BFSP2; NbExp=6; IntAct=EBI-739895, EBI-10229433; CC Q8N6Y0; Q6AI39: BICRAL; NbExp=3; IntAct=EBI-739895, EBI-1012434; CC Q8N6Y0; P78537: BLOC1S1; NbExp=3; IntAct=EBI-739895, EBI-348630; CC Q8N6Y0; Q9H2G9: BLZF1; NbExp=3; IntAct=EBI-739895, EBI-2548012; CC Q8N6Y0; Q96GS4: BORCS6; NbExp=3; IntAct=EBI-739895, EBI-10193358; CC Q8N6Y0; Q6PJG6: BRAT1; NbExp=3; IntAct=EBI-739895, EBI-10826195; CC Q8N6Y0; P55201-2: BRPF1; NbExp=3; IntAct=EBI-739895, EBI-12065306; CC Q8N6Y0; Q8TAB5: C1orf216; NbExp=7; IntAct=EBI-739895, EBI-747505; CC Q8N6Y0; Q0VAL7: C21orf58; NbExp=3; IntAct=EBI-739895, EBI-10226774; CC Q8N6Y0; Q8NA61-2: CBY2; NbExp=3; IntAct=EBI-739895, EBI-11524851; CC Q8N6Y0; Q8IW40: CCDC103; NbExp=3; IntAct=EBI-739895, EBI-10261970; CC Q8N6Y0; Q8IYX3: CCDC116; NbExp=6; IntAct=EBI-739895, EBI-744311; CC Q8N6Y0; Q96HB5-4: CCDC120; NbExp=3; IntAct=EBI-739895, EBI-10185348; CC Q8N6Y0; Q6ZUS5: CCDC121; NbExp=3; IntAct=EBI-739895, EBI-2836982; CC Q8N6Y0; Q8IYE0: CCDC146; NbExp=3; IntAct=EBI-739895, EBI-10749669; CC Q8N6Y0; Q8IYE0-2: CCDC146; NbExp=3; IntAct=EBI-739895, EBI-10247802; CC Q8N6Y0; Q8NFR7: CCDC148; NbExp=3; IntAct=EBI-739895, EBI-2349862; CC Q8N6Y0; A0A1B0GWI1: CCDC196; NbExp=3; IntAct=EBI-739895, EBI-10181422; CC Q8N6Y0; Q8NCU1: CCDC197; NbExp=3; IntAct=EBI-739895, EBI-750686; CC Q8N6Y0; O60826: CCDC22; NbExp=3; IntAct=EBI-739895, EBI-3943153; CC Q8N6Y0; Q8N4L8: CCDC24; NbExp=6; IntAct=EBI-739895, EBI-1104933; CC Q8N6Y0; Q7Z6N9: CCDC28A; NbExp=3; IntAct=EBI-739895, EBI-10258115; CC Q8N6Y0; Q96M95-2: CCDC42; NbExp=3; IntAct=EBI-739895, EBI-11750401; CC Q8N6Y0; Q9NVE4: CCDC87; NbExp=3; IntAct=EBI-739895, EBI-749261; CC Q8N6Y0; Q8TD31-3: CCHCR1; NbExp=6; IntAct=EBI-739895, EBI-10175300; CC Q8N6Y0; Q16543: CDC37; NbExp=3; IntAct=EBI-739895, EBI-295634; CC Q8N6Y0; Q99459: CDC5L; NbExp=3; IntAct=EBI-739895, EBI-374880; CC Q8N6Y0; P38936: CDKN1A; NbExp=3; IntAct=EBI-739895, EBI-375077; CC Q8N6Y0; Q6IPU0: CENPP; NbExp=6; IntAct=EBI-739895, EBI-10250303; CC Q8N6Y0; Q96MT8-3: CEP63; NbExp=5; IntAct=EBI-739895, EBI-11522539; CC Q8N6Y0; Q76N32: CEP68; NbExp=3; IntAct=EBI-739895, EBI-9051024; CC Q8N6Y0; Q76N32-2: CEP68; NbExp=3; IntAct=EBI-739895, EBI-11975967; CC Q8N6Y0; Q8IYR0: CFAP206; NbExp=3; IntAct=EBI-739895, EBI-749051; CC Q8N6Y0; Q8NE01: CNNM3; NbExp=3; IntAct=EBI-739895, EBI-741032; CC Q8N6Y0; Q8NE01-3: CNNM3; NbExp=3; IntAct=EBI-739895, EBI-10269984; CC Q8N6Y0; Q9BT78: COPS4; NbExp=7; IntAct=EBI-739895, EBI-742413; CC Q8N6Y0; Q7L5N1: COPS6; NbExp=3; IntAct=EBI-739895, EBI-486838; CC Q8N6Y0; Q99627: COPS8; NbExp=3; IntAct=EBI-739895, EBI-2510102; CC Q8N6Y0; Q9UI47-2: CTNNA3; NbExp=3; IntAct=EBI-739895, EBI-11962928; CC Q8N6Y0; Q9NSA3: CTNNBIP1; NbExp=3; IntAct=EBI-739895, EBI-747082; CC Q8N6Y0; Q9P2B4: CTTNBP2NL; NbExp=3; IntAct=EBI-739895, EBI-1774273; CC Q8N6Y0; Q9UIA0: CYTH4; NbExp=3; IntAct=EBI-739895, EBI-11521003; CC Q8N6Y0; Q13561: DCTN2; NbExp=3; IntAct=EBI-739895, EBI-715074; CC Q8N6Y0; O75935-2: DCTN3; NbExp=3; IntAct=EBI-739895, EBI-12091947; CC Q8N6Y0; Q05D60: DEUP1; NbExp=3; IntAct=EBI-739895, EBI-748597; CC Q8N6Y0; O60941: DTNB; NbExp=3; IntAct=EBI-739895, EBI-740402; CC Q8N6Y0; O60941-5: DTNB; NbExp=3; IntAct=EBI-739895, EBI-11984733; CC Q8N6Y0; Q8WWB3: DYDC1; NbExp=7; IntAct=EBI-739895, EBI-740680; CC Q8N6Y0; O60573: EIF4E2; NbExp=3; IntAct=EBI-739895, EBI-398610; CC Q8N6Y0; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-739895, EBI-744099; CC Q8N6Y0; P07992: ERCC1; NbExp=3; IntAct=EBI-739895, EBI-750962; CC Q8N6Y0; Q9UPT5-1: EXOC7; NbExp=3; IntAct=EBI-739895, EBI-6251402; CC Q8N6Y0; Q8IYI6: EXOC8; NbExp=5; IntAct=EBI-739895, EBI-742102; CC Q8N6Y0; O95990-3: FAM107A; NbExp=3; IntAct=EBI-739895, EBI-10192902; CC Q8N6Y0; Q9BQ89: FAM110A; NbExp=6; IntAct=EBI-739895, EBI-1752811; CC Q8N6Y0; Q9H5Z6: FAM124B; NbExp=3; IntAct=EBI-739895, EBI-741626; CC Q8N6Y0; Q96MY7: FAM161B; NbExp=3; IntAct=EBI-739895, EBI-7225287; CC Q8N6Y0; A0A0S2Z3R2: FANCG; NbExp=3; IntAct=EBI-739895, EBI-16438045; CC Q8N6Y0; Q8TES7-6: FBF1; NbExp=3; IntAct=EBI-739895, EBI-10244131; CC Q8N6Y0; O94868-3: FCHSD2; NbExp=3; IntAct=EBI-739895, EBI-11958845; CC Q8N6Y0; Q96RD9: FCRL5; NbExp=3; IntAct=EBI-739895, EBI-12091825; CC Q8N6Y0; P02792: FTL; NbExp=3; IntAct=EBI-739895, EBI-713279; CC Q8N6Y0; O95995: GAS8; NbExp=3; IntAct=EBI-739895, EBI-1052570; CC Q8N6Y0; Q8WXI9: GATAD2B; NbExp=3; IntAct=EBI-739895, EBI-923440; CC Q8N6Y0; P55040: GEM; NbExp=3; IntAct=EBI-739895, EBI-744104; CC Q8N6Y0; Q8NEA9: GMCL2; NbExp=3; IntAct=EBI-739895, EBI-745707; CC Q8N6Y0; B1APZ0: GNG4; NbExp=3; IntAct=EBI-739895, EBI-10175453; CC Q8N6Y0; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-739895, EBI-5916454; CC Q8N6Y0; Q0D2H9: GOLGA8DP; NbExp=3; IntAct=EBI-739895, EBI-10181276; CC Q8N6Y0; Q08AF8: GOLGA8G; NbExp=3; IntAct=EBI-739895, EBI-10181260; CC Q8N6Y0; Q9Y4H4: GPSM3; NbExp=3; IntAct=EBI-739895, EBI-347538; CC Q8N6Y0; Q96CS2: HAUS1; NbExp=3; IntAct=EBI-739895, EBI-2514791; CC Q8N6Y0; Q9BT25: HAUS8; NbExp=3; IntAct=EBI-739895, EBI-2558143; CC Q8N6Y0; O14964: HGS; NbExp=4; IntAct=EBI-739895, EBI-740220; CC Q8N6Y0; Q9NP66: HMG20A; NbExp=3; IntAct=EBI-739895, EBI-740641; CC Q8N6Y0; Q9P0W2: HMG20B; NbExp=3; IntAct=EBI-739895, EBI-713401; CC Q8N6Y0; Q8IY31: IFT20; NbExp=3; IntAct=EBI-739895, EBI-744203; CC Q8N6Y0; Q14005-2: IL16; NbExp=3; IntAct=EBI-739895, EBI-17178971; CC Q8N6Y0; Q9NV31: IMP3; NbExp=6; IntAct=EBI-739895, EBI-747481; CC Q8N6Y0; A0A0C4DG38: ING3; NbExp=3; IntAct=EBI-739895, EBI-10263367; CC Q8N6Y0; Q96HW7: INTS4; NbExp=3; IntAct=EBI-739895, EBI-5663129; CC Q8N6Y0; Q13352: ITGB3BP; NbExp=3; IntAct=EBI-739895, EBI-712105; CC Q8N6Y0; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-739895, EBI-2556193; CC Q8N6Y0; Q2KHM9: KIAA0753; NbExp=3; IntAct=EBI-739895, EBI-2805604; CC Q8N6Y0; Q6P597-3: KLC3; NbExp=3; IntAct=EBI-739895, EBI-12076930; CC Q8N6Y0; Q9NSK0: KLC4; NbExp=3; IntAct=EBI-739895, EBI-949319; CC Q8N6Y0; Q2WGJ6: KLHL38; NbExp=6; IntAct=EBI-739895, EBI-6426443; CC Q8N6Y0; P52292: KPNA2; NbExp=3; IntAct=EBI-739895, EBI-349938; CC Q8N6Y0; P02533: KRT14; NbExp=3; IntAct=EBI-739895, EBI-702178; CC Q8N6Y0; P08779: KRT16; NbExp=3; IntAct=EBI-739895, EBI-356410; CC Q8N6Y0; P35900: KRT20; NbExp=3; IntAct=EBI-739895, EBI-742094; CC Q8N6Y0; Q7Z3Y9: KRT26; NbExp=3; IntAct=EBI-739895, EBI-12084444; CC Q8N6Y0; Q7Z3Y8: KRT27; NbExp=3; IntAct=EBI-739895, EBI-3044087; CC Q8N6Y0; Q7Z3Y7: KRT28; NbExp=3; IntAct=EBI-739895, EBI-11980489; CC Q8N6Y0; Q15323: KRT31; NbExp=3; IntAct=EBI-739895, EBI-948001; CC Q8N6Y0; O76014: KRT37; NbExp=3; IntAct=EBI-739895, EBI-1045716; CC Q8N6Y0; O76015: KRT38; NbExp=6; IntAct=EBI-739895, EBI-1047263; CC Q8N6Y0; Q6A162: KRT40; NbExp=3; IntAct=EBI-739895, EBI-10171697; CC Q8N6Y0; Q3SY84: KRT71; NbExp=3; IntAct=EBI-739895, EBI-2952676; CC Q8N6Y0; O95678: KRT75; NbExp=3; IntAct=EBI-739895, EBI-2949715; CC Q8N6Y0; Q5XKE5: KRT79; NbExp=3; IntAct=EBI-739895, EBI-2514135; CC Q8N6Y0; Q96BZ8: LENG1; NbExp=3; IntAct=EBI-739895, EBI-726510; CC Q8N6Y0; Q96FQ7: LINC00526; NbExp=3; IntAct=EBI-739895, EBI-10286106; CC Q8N6Y0; O15481: MAGEB4; NbExp=6; IntAct=EBI-739895, EBI-751857; CC Q8N6Y0; P59942: MCCD1; NbExp=3; IntAct=EBI-739895, EBI-11987923; CC Q8N6Y0; P33993: MCM7; NbExp=3; IntAct=EBI-739895, EBI-355924; CC Q8N6Y0; Q96EZ8: MCRS1; NbExp=6; IntAct=EBI-739895, EBI-348259; CC Q8N6Y0; Q9P086: MED11; NbExp=3; IntAct=EBI-739895, EBI-394704; CC Q8N6Y0; Q9NPJ6: MED4; NbExp=6; IntAct=EBI-739895, EBI-394607; CC Q8N6Y0; A8MW99: MEI4; NbExp=3; IntAct=EBI-739895, EBI-19944212; CC Q8N6Y0; A6NJ78-4: METTL15; NbExp=3; IntAct=EBI-739895, EBI-10174029; CC Q8N6Y0; Q8IVT4: MGC50722; NbExp=3; IntAct=EBI-739895, EBI-14086479; CC Q8N6Y0; Q5JXC2: MIIP; NbExp=5; IntAct=EBI-739895, EBI-2801965; CC Q8N6Y0; Q13064: MKRN3; NbExp=3; IntAct=EBI-739895, EBI-2340269; CC Q8N6Y0; Q8NEH6: MNS1; NbExp=3; IntAct=EBI-739895, EBI-743811; CC Q8N6Y0; P00540: MOS; NbExp=6; IntAct=EBI-739895, EBI-1757866; CC Q8N6Y0; Q9Y3D9: MRPS23; NbExp=3; IntAct=EBI-739895, EBI-1054270; CC Q8N6Y0; P50539-4: MXI1; NbExp=3; IntAct=EBI-739895, EBI-16436111; CC Q8N6Y0; P15173: MYOG; NbExp=5; IntAct=EBI-739895, EBI-3906629; CC Q8N6Y0; Q9NP98: MYOZ1; NbExp=3; IntAct=EBI-739895, EBI-744402; CC Q8N6Y0; Q6IBW4-4: NCAPH2; NbExp=3; IntAct=EBI-739895, EBI-10247000; CC Q8N6Y0; O14777: NDC80; NbExp=4; IntAct=EBI-739895, EBI-715849; CC Q8N6Y0; Q7Z6G3-2: NECAB2; NbExp=3; IntAct=EBI-739895, EBI-10172876; CC Q8N6Y0; I6L9F6: NEFL; NbExp=3; IntAct=EBI-739895, EBI-10178578; CC Q8N6Y0; Q9BVI4: NOC4L; NbExp=2; IntAct=EBI-739895, EBI-395927; CC Q8N6Y0; P37198: NUP62; NbExp=3; IntAct=EBI-739895, EBI-347978; CC Q8N6Y0; A5D8V7: ODAD3; NbExp=3; IntAct=EBI-739895, EBI-8466445; CC Q8N6Y0; O43482: OIP5; NbExp=3; IntAct=EBI-739895, EBI-536879; CC Q8N6Y0; Q9HBI0: PARVG; NbExp=6; IntAct=EBI-739895, EBI-3921217; CC Q8N6Y0; P26367: PAX6; NbExp=3; IntAct=EBI-739895, EBI-747278; CC Q8N6Y0; Q9BYU1: PBX4; NbExp=3; IntAct=EBI-739895, EBI-10302990; CC Q8N6Y0; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-739895, EBI-79165; CC Q8N6Y0; Q16512: PKN1; NbExp=3; IntAct=EBI-739895, EBI-602382; CC Q8N6Y0; Q96KN3: PKNOX2; NbExp=3; IntAct=EBI-739895, EBI-2692890; CC Q8N6Y0; Q6P1K2: PMF1; NbExp=3; IntAct=EBI-739895, EBI-713832; CC Q8N6Y0; Q6PIY2: POLM; NbExp=3; IntAct=EBI-739895, EBI-10253863; CC Q8N6Y0; Q969H6: POP5; NbExp=3; IntAct=EBI-739895, EBI-366525; CC Q8N6Y0; Q9BZL4: PPP1R12C; NbExp=3; IntAct=EBI-739895, EBI-721802; CC Q8N6Y0; Q15435: PPP1R7; NbExp=3; IntAct=EBI-739895, EBI-1024281; CC Q8N6Y0; Q15172: PPP2R5A; NbExp=3; IntAct=EBI-739895, EBI-641666; CC Q8N6Y0; Q14738: PPP2R5D; NbExp=3; IntAct=EBI-739895, EBI-396563; CC Q8N6Y0; P54646: PRKAA2; NbExp=3; IntAct=EBI-739895, EBI-1383852; CC Q8N6Y0; P85299-2: PRR5; NbExp=3; IntAct=EBI-739895, EBI-12944296; CC Q8N6Y0; P47897: QARS1; NbExp=3; IntAct=EBI-739895, EBI-347462; CC Q8N6Y0; Q9UJF2: RASAL2; NbExp=3; IntAct=EBI-739895, EBI-359444; CC Q8N6Y0; Q9P2K3-2: RCOR3; NbExp=3; IntAct=EBI-739895, EBI-1504830; CC Q8N6Y0; Q6P9E2: RECK; NbExp=3; IntAct=EBI-739895, EBI-10253121; CC Q8N6Y0; Q8N443: RIBC1; NbExp=3; IntAct=EBI-739895, EBI-10265323; CC Q8N6Y0; Q6NUQ1: RINT1; NbExp=3; IntAct=EBI-739895, EBI-726876; CC Q8N6Y0; Q5VTR2: RNF20; NbExp=3; IntAct=EBI-739895, EBI-2372238; CC Q8N6Y0; Q14D33: RTP5; NbExp=3; IntAct=EBI-739895, EBI-10217913; CC Q8N6Y0; Q86UD0: SAPCD2; NbExp=3; IntAct=EBI-739895, EBI-2561646; CC Q8N6Y0; P21673: SAT1; NbExp=3; IntAct=EBI-739895, EBI-711613; CC Q8N6Y0; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-739895, EBI-748391; CC Q8N6Y0; P09683: SCT; NbExp=3; IntAct=EBI-739895, EBI-12844598; CC Q8N6Y0; Q9UDX3: SEC14L4; NbExp=6; IntAct=EBI-739895, EBI-10320311; CC Q8N6Y0; Q9C0C4: SEMA4C; NbExp=3; IntAct=EBI-739895, EBI-10303490; CC Q8N6Y0; Q9UJW9: SERTAD3; NbExp=7; IntAct=EBI-739895, EBI-748621; CC Q8N6Y0; Q9H788-2: SH2D4A; NbExp=3; IntAct=EBI-739895, EBI-10308083; CC Q8N6Y0; Q92529: SHC3; NbExp=3; IntAct=EBI-739895, EBI-79084; CC Q8N6Y0; Q96GM5: SMARCD1; NbExp=4; IntAct=EBI-739895, EBI-358489; CC Q8N6Y0; Q969G3: SMARCE1; NbExp=3; IntAct=EBI-739895, EBI-455078; CC Q8N6Y0; Q5JUK2: SOHLH1; NbExp=3; IntAct=EBI-739895, EBI-12288855; CC Q8N6Y0; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-739895, EBI-742688; CC Q8N6Y0; Q6ZRS2-3: SRCAP; NbExp=3; IntAct=EBI-739895, EBI-12029182; CC Q8N6Y0; P30626: SRI; NbExp=3; IntAct=EBI-739895, EBI-750459; CC Q8N6Y0; O75558: STX11; NbExp=3; IntAct=EBI-739895, EBI-714135; CC Q8N6Y0; P57105: SYNJ2BP; NbExp=6; IntAct=EBI-739895, EBI-1049004; CC Q8N6Y0; Q5VWN6: TASOR2; NbExp=3; IntAct=EBI-739895, EBI-745958; CC Q8N6Y0; Q8N8B7-2: TCEANC; NbExp=3; IntAct=EBI-739895, EBI-11955057; CC Q8N6Y0; Q9BT92: TCHP; NbExp=3; IntAct=EBI-739895, EBI-740781; CC Q8N6Y0; Q969V4: TEKT1; NbExp=3; IntAct=EBI-739895, EBI-10180409; CC Q8N6Y0; Q6YHU6: THADA; NbExp=3; IntAct=EBI-739895, EBI-2824523; CC Q8N6Y0; Q96FV9: THOC1; NbExp=3; IntAct=EBI-739895, EBI-1765605; CC Q8N6Y0; Q9Y5L4: TIMM13; NbExp=3; IntAct=EBI-739895, EBI-1057344; CC Q8N6Y0; Q8N7U7-2: TPRX1; NbExp=3; IntAct=EBI-739895, EBI-14115717; CC Q8N6Y0; Q9BYV2: TRIM54; NbExp=6; IntAct=EBI-739895, EBI-2130429; CC Q8N6Y0; Q8N7C3: TRIML2; NbExp=3; IntAct=EBI-739895, EBI-11059915; CC Q8N6Y0; Q99816: TSG101; NbExp=3; IntAct=EBI-739895, EBI-346882; CC Q8N6Y0; Q5W5X9-3: TTC23; NbExp=3; IntAct=EBI-739895, EBI-9090990; CC Q8N6Y0; Q8N5M4: TTC9C; NbExp=3; IntAct=EBI-739895, EBI-2851213; CC Q8N6Y0; Q6ZVT0-3: TTLL10; NbExp=3; IntAct=EBI-739895, EBI-11979997; CC Q8N6Y0; P40222: TXLNA; NbExp=6; IntAct=EBI-739895, EBI-359793; CC Q8N6Y0; Q8N3L3: TXLNB; NbExp=6; IntAct=EBI-739895, EBI-6116822; CC Q8N6Y0; Q96B02: UBE2W; NbExp=3; IntAct=EBI-739895, EBI-716589; CC Q8N6Y0; Q96FI0: UBE2W; NbExp=3; IntAct=EBI-739895, EBI-10285774; CC Q8N6Y0; Q5T124: UBXN11; NbExp=3; IntAct=EBI-739895, EBI-746004; CC Q8N6Y0; Q5T124-6: UBXN11; NbExp=3; IntAct=EBI-739895, EBI-11524408; CC Q8N6Y0; O75604: USP2; NbExp=3; IntAct=EBI-739895, EBI-743272; CC Q8N6Y0; Q548N1: VPS28; NbExp=3; IntAct=EBI-739895, EBI-10243107; CC Q8N6Y0; Q9UK41: VPS28; NbExp=6; IntAct=EBI-739895, EBI-727424; CC Q8N6Y0; B2RXF5: ZBTB42; NbExp=3; IntAct=EBI-739895, EBI-12287587; CC Q8N6Y0; Q15911-2: ZFHX3; NbExp=3; IntAct=EBI-739895, EBI-10237226; CC Q8N6Y0; Q68DK2-5: ZFYVE26; NbExp=6; IntAct=EBI-739895, EBI-8656416; CC Q8N6Y0; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-739895, EBI-740727; CC Q8N6Y0; Q6P088: ZNF483; NbExp=3; IntAct=EBI-739895, EBI-10196963; CC Q8N6Y0; Q8N720: ZNF655; NbExp=3; IntAct=EBI-739895, EBI-625509; CC Q8N6Y0; A0A0S2Z5X4: ZNF688; NbExp=3; IntAct=EBI-739895, EBI-16429014; CC Q8N6Y0; A0A0S2Z6P0: ZNF688; NbExp=3; IntAct=EBI-739895, EBI-16429989; CC Q8N6Y0; Q7L2R6: ZNF765; NbExp=3; IntAct=EBI-739895, EBI-9676069; CC Q8N6Y0; G4XUV3; NbExp=3; IntAct=EBI-739895, EBI-10177989; CC Q8N6Y0; Q8N9J2; NbExp=3; IntAct=EBI-739895, EBI-10268244; CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1 {ECO:0000269|PubMed:11311560, ECO:0000269|PubMed:14702039, CC ECO:0000269|PubMed:15489334}; CC IsoId=Q8N6Y0-1; Sequence=Displayed; CC Name=2 {ECO:0000269|PubMed:11311560}; CC IsoId=Q8N6Y0-2; Sequence=VSP_052080; CC -!- TISSUE SPECIFICITY: Highest level of expression in heart, and moderate CC to low expression in skeletal muscle, kidney, liver, small intestine, CC placenta and lung. {ECO:0000269|PubMed:11311560}. CC -!- MISCELLANEOUS: [Isoform 2]: Due to the retention of an intron in the CC cDNA leading to a prematurate stop codon. CC {ECO:0000269|PubMed:11311560}. CC -!- SIMILARITY: Belongs to the MCC family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=BAC11443.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB026290; BAB41203.1; -; mRNA. DR EMBL; AB040046; BAB43978.1; -; mRNA. DR EMBL; AK075162; BAC11443.1; ALT_INIT; mRNA. DR EMBL; AK292031; BAF84720.1; -; mRNA. DR EMBL; AK315239; BAG37666.1; -; mRNA. DR EMBL; BC027910; AAH27910.1; -; mRNA. DR CCDS; CCDS12353.1; -. [Q8N6Y0-1] DR RefSeq; NP_001284632.1; NM_001297703.1. DR RefSeq; NP_001308346.1; NM_001321417.1. [Q8N6Y0-1] DR RefSeq; NP_114147.2; NM_031941.3. [Q8N6Y0-1] DR AlphaFoldDB; Q8N6Y0; -. DR SMR; Q8N6Y0; -. DR BioGRID; 123791; 252. DR IntAct; Q8N6Y0; 252. DR MINT; Q8N6Y0; -. DR STRING; 9606.ENSP00000252597; -. DR iPTMnet; Q8N6Y0; -. DR PhosphoSitePlus; Q8N6Y0; -. DR BioMuta; USHBP1; -. DR DMDM; 74729194; -. DR EPD; Q8N6Y0; -. DR MassIVE; Q8N6Y0; -. DR PaxDb; 9606-ENSP00000252597; -. DR PeptideAtlas; Q8N6Y0; -. DR ProteomicsDB; 72246; -. [Q8N6Y0-1] DR Pumba; Q8N6Y0; -. DR Antibodypedia; 65308; 43 antibodies from 15 providers. DR DNASU; 83878; -. DR Ensembl; ENST00000252597.8; ENSP00000252597.2; ENSG00000130307.12. [Q8N6Y0-1] DR Ensembl; ENST00000597928.5; ENSP00000469562.1; ENSG00000130307.12. [Q8N6Y0-2] DR GeneID; 83878; -. DR KEGG; hsa:83878; -. DR MANE-Select; ENST00000252597.8; ENSP00000252597.2; NM_031941.4; NP_114147.2. DR UCSC; uc002nfs.2; human. [Q8N6Y0-1] DR AGR; HGNC:24058; -. DR CTD; 83878; -. DR DisGeNET; 83878; -. DR GeneCards; USHBP1; -. DR HGNC; HGNC:24058; USHBP1. DR HPA; ENSG00000130307; Low tissue specificity. DR MIM; 611810; gene. DR neXtProt; NX_Q8N6Y0; -. DR OpenTargets; ENSG00000130307; -. DR PharmGKB; PA134909077; -. DR VEuPathDB; HostDB:ENSG00000130307; -. DR eggNOG; KOG3512; Eukaryota. DR GeneTree; ENSGT00530000063974; -. DR HOGENOM; CLU_024579_0_0_1; -. DR InParanoid; Q8N6Y0; -. DR OMA; PLIGHEP; -. DR OrthoDB; 5319610at2759; -. DR PhylomeDB; Q8N6Y0; -. DR TreeFam; TF105384; -. DR PathwayCommons; Q8N6Y0; -. DR SignaLink; Q8N6Y0; -. DR BioGRID-ORCS; 83878; 21 hits in 1145 CRISPR screens. DR ChiTaRS; USHBP1; human. DR GenomeRNAi; 83878; -. DR Pharos; Q8N6Y0; Tbio. DR PRO; PR:Q8N6Y0; -. DR Proteomes; UP000005640; Chromosome 19. DR RNAct; Q8N6Y0; Protein. DR Bgee; ENSG00000130307; Expressed in apex of heart and 104 other cell types or tissues. DR ExpressionAtlas; Q8N6Y0; baseline and differential. DR GO; GO:0030165; F:PDZ domain binding; IPI:HGNC-UCL. DR InterPro; IPR040171; USBP1-like. DR InterPro; IPR019536; USHBP1_PDZ-bd. DR PANTHER; PTHR23347; COLORECTAL MUTANT CANCER PROTEIN MCC PROTEIN -RELATED; 1. DR PANTHER; PTHR23347:SF5; USHER SYNDROME TYPE-1C PROTEIN-BINDING PROTEIN 1; 1. DR Pfam; PF10506; USHBP1_PDZ-bd; 1. DR Genevisible; Q8N6Y0; HS. PE 1: Evidence at protein level; KW Alternative splicing; Coiled coil; Reference proteome. FT CHAIN 1..703 FT /note="Harmonin-binding protein USHBP1" FT /id="PRO_0000252109" FT REGION 1..113 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 138..172 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 228..256 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 396..416 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 540..583 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 189..227 FT /evidence="ECO:0000255" FT COILED 289..309 FT /evidence="ECO:0000255" FT COILED 476..513 FT /evidence="ECO:0000255" FT COILED 596..681 FT /evidence="ECO:0000255" FT COMPBIAS 234..249 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 398..416 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT VAR_SEQ 69..703 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:11311560" FT /id="VSP_052080" FT VARIANT 439 FT /note="M -> V (in dbSNP:rs9676419)" FT /evidence="ECO:0000269|PubMed:11311560" FT /id="VAR_027753" FT VARIANT 525 FT /note="V -> M (in dbSNP:rs12459398)" FT /id="VAR_027754" FT VARIANT 677 FT /note="A -> V (in dbSNP:rs1043963)" FT /id="VAR_051481" FT CONFLICT 233 FT /note="H -> R (in Ref. 2; BAF84720)" FT /evidence="ECO:0000305" FT CONFLICT 400 FT /note="A -> T (in Ref. 1; BAB41203)" FT /evidence="ECO:0000305" FT CONFLICT 454 FT /note="T -> I (in Ref. 1; BAB41203)" FT /evidence="ECO:0000305" FT CONFLICT 572 FT /note="G -> D (in Ref. 2; BAG37666)" FT /evidence="ECO:0000305" FT CONFLICT 586 FT /note="D -> G (in Ref. 3; BAC11443)" FT /evidence="ECO:0000305" FT CONFLICT 633 FT /note="N -> S (in Ref. 3; BAC11443)" FT /evidence="ECO:0000305" SQ SEQUENCE 703 AA; 76068 MW; 75BD22E490DC1467 CRC64; MSARATRPRS RRGRHAPPGE LDPVAESSEE VEAASGSSKP SFAPPPVSSG LEQLGPMEEV SGQGLGSRTD KKMDGGSGRE LASAPEVPHK PAVEAHQAPE AALQYKETVP PGNGAPDVFQ TLQHTLSSLE AAAAAWRHQP PSHSGPMEFE GTSEGGAGSL GKQEGAGSCQ REAARLAERN AWLRLALSSR EDELVRTQAS LEAIRAEKET LQKEVQELQD SLLRLEPCPH LSHNQAGGSG SGSSSSEADR EPWETQDSFS LAHPLLRRLR SHSSTQILGS LPNQPLSPEM HIMEAQMEQL RGSIEKLKCF NRLLSAVLQG YKGRCEGLSM QLGQREAEAT ALHLALQYSE HCEEAYRVLL ALREADSGAG DEAPMSDLQA AEKEAWRLLA QEEAAMDAGA QQNPQPSPEG SSVDKPTPQE VAFQLRSYVQ RLQERRSLMK ILSEPGPTLA PMPTVPRAEA MVQAILGTQA GPALPRLEKT QIQQDLVAAR EALADLMLRL QLVRREKRGL ELREAALRAL GPAHVLLLEQ LRWERAELQA GGANSSGGHS SGGGSSGDEE EWYQGLPAVP GGTSGIDGGQ VGRAWDPEKL AQELAASLTR TLDLQEQLQS LRRELEQVAQ KGRARRSQSA ELNRDLCKAH SALVLAFRGA HRKQEEQRRK LEQQMALMEA QQAEEVAVLE ATARALGKPR PPLPPPQLGD TFL //