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Protein

UPF0728 protein C10orf53

Gene

C10orf53

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0728 protein C10orf53
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000178645.12.
HGNCiHGNC:27421. C10orf53.

Pathology & Biotechi

Organism-specific databases

DisGeNETi282966.
OpenTargetsiENSG00000178645.
PharmGKBiPA134895627.

Polymorphism and mutation databases

BioMutaiC10orf53.
DMDMi224471890.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000897941 – 93UPF0728 protein C10orf53Add BLAST93

Proteomic databases

PeptideAtlasiQ8N6V4.
PRIDEiQ8N6V4.

PTM databases

iPTMnetiQ8N6V4.

Expressioni

Gene expression databases

BgeeiENSG00000178645.
CleanExiHS_C10orf53.
GenevisibleiQ8N6V4. HS.

Organism-specific databases

HPAiHPA037951.

Interactioni

Protein-protein interaction databases

BioGridi129425. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ8N6V4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0728 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000002871.
HOGENOMiHOG000095160.
HOVERGENiHBG107691.
InParanoidiQ8N6V4.
OMAiVEHRTYR.
OrthoDBiEOG091G10RN.
PhylomeDBiQ8N6V4.
TreeFamiTF329673.

Family and domain databases

InterProiView protein in InterPro
IPR027885. UPF0728.
PfamiView protein in Pfam
PF15092. UPF0728. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N6V4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPKNAVVILR YGPYSAAGLP VEHHTFRLQG LQAVLAIDGH EVILEKIEDW
60 70 80 90
NVVELMVNEE VIFHCNIKDL EFGGDGKLDP LCEKARIAVL NAY
Note: No experimental confirmation available.
Length:93
Mass (Da):10,399
Last modified:March 3, 2009 - v3
Checksum:i0C706BDA1A4E238E
GO
Isoform 2 (identifier: Q8N6V4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-93: GDGKLDPLCEKARIAVLNAY → KPFGDASSQQFASSEESLNF

Note: No experimental confirmation available.
Show »
Length:93
Mass (Da):10,429
Checksum:iD9D0115927783D34
GO
Isoform 3 (identifier: Q8N6V4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-93: GDGKLDPLCEKARIAVLNAY → KLTPSSDKRT...GLEKRGTQPY

Note: No experimental confirmation available.
Show »
Length:157
Mass (Da):17,557
Checksum:iCA5498B0D5DC2172
GO
Isoform 4 (identifier: Q8N6V4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-93: GDGKLDPLCEKARIAVLNAY → KLTPSSDKRT...GLEKRGTQPY

Note: No experimental confirmation available.Curated
Show »
Length:157
Mass (Da):17,644
Checksum:i407C34A5D5C93462
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 4 (identifier: Q8N6V4-4)
Sequence conflicti99R → G in BI825648 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03650974 – 93GDGKL…VLNAY → KPFGDASSQQFASSEESLNF in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_03686774 – 93GDGKL…VLNAY → KLTPSSDKRTTSSSRLTFHQ LSSPCGMKVSPLQQFPQKTQ DLTCIVLAQIGSCIHFQTNL CDLGWPGLDHMLISGLEKRG TQPY in isoform 3. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_04639674 – 93GDGKL…VLNAY → KLTPSSDKRTTSSSRLTFHQ LSSPCRMKVSPLQQFPQKTQ DLTCTVLAQIGSCIHFQTNL CDLGWPGLDHMLISGLEKRG TQPY in isoform 4. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091773 mRNA. No translation available.
AC069546 Genomic DNA. No translation available.
AC073366 Genomic DNA. No translation available.
CH471187 Genomic DNA. Translation: EAW93083.1.
CH471187 Genomic DNA. Translation: EAW93085.1.
BC028127 mRNA. No translation available.
BI825648 mRNA. No translation available.
CCDSiCCDS31202.1. [Q8N6V4-4]
CCDS41521.1. [Q8N6V4-1]
RefSeqiNP_001035892.1. NM_001042427.1. [Q8N6V4-1]
NP_872360.2. NM_182554.2. [Q8N6V4-4]
UniGeneiHs.131287.

Genome annotation databases

EnsembliENST00000374111; ENSP00000363225; ENSG00000178645. [Q8N6V4-1]
ENST00000374112; ENSP00000363226; ENSG00000178645. [Q8N6V4-4]
ENST00000374113; ENSP00000363227; ENSG00000178645. [Q8N6V4-2]
ENST00000535836; ENSP00000437726; ENSG00000178645. [Q8N6V4-4]
GeneIDi282966.
KEGGihsa:282966.
UCSCiuc001jib.4. human. [Q8N6V4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCJ053_HUMAN
AccessioniPrimary (citable) accession number: Q8N6V4
Secondary accession number(s): A6NI81, A6NLE0, B9ZVK6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: March 3, 2009
Last modified: October 25, 2017
This is version 100 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries