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Protein

G-protein coupled receptor 161

Gene

GPR161

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-5610787. Hedgehog 'off' state.
R-HSA-5632684. Hedgehog 'on' state.

Protein family/group databases

TCDBi9.A.14.1.11. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 161
Alternative name(s):
G-protein coupled receptor RE2
Gene namesi
Name:GPR161
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:23694. GPR161.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030ExtracellularSequence analysisAdd
BLAST
Transmembranei31 – 5121Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini52 – 6413CytoplasmicSequence analysisAdd
BLAST
Transmembranei65 – 8521Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini86 – 10116ExtracellularSequence analysisAdd
BLAST
Transmembranei102 – 12322Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini124 – 14320CytoplasmicSequence analysisAdd
BLAST
Transmembranei144 – 16421Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini165 – 19026ExtracellularSequence analysisAdd
BLAST
Transmembranei191 – 21121Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini212 – 26958CytoplasmicSequence analysisAdd
BLAST
Transmembranei270 – 29021Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini291 – 30616ExtracellularSequence analysisAdd
BLAST
Transmembranei307 – 32721Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini328 – 529202CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134931474.

Polymorphism and mutation databases

BioMutaiGPR161.
DMDMi48428085.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 529529G-protein coupled receptor 161PRO_0000069646Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence analysis
Glycosylationi15 – 151N-linked (GlcNAc...)Sequence analysis
Disulfide bondi100 ↔ 178PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ8N6U8.
PaxDbiQ8N6U8.
PeptideAtlasiQ8N6U8.
PRIDEiQ8N6U8.
TopDownProteomicsiQ8N6U8-1. [Q8N6U8-1]

PTM databases

iPTMnetiQ8N6U8.
PhosphoSiteiQ8N6U8.

Expressioni

Gene expression databases

BgeeiQ8N6U8.
CleanExiHS_GPR161.
ExpressionAtlasiQ8N6U8. baseline and differential.
GenevisibleiQ8N6U8. HS.

Organism-specific databases

HPAiHPA015576.

Interactioni

Protein-protein interaction databases

BioGridi117000. 16 interactions.
IntActiQ8N6U8. 1 interaction.
STRINGi9606.ENSP00000271357.

Structurei

3D structure databases

ProteinModelPortaliQ8N6U8.
SMRiQ8N6U8. Positions 26-336.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00790000123027.
HOGENOMiHOG000112777.
HOVERGENiHBG051789.
InParanoidiQ8N6U8.
KOiK08439.
OMAiIWCALLP.
OrthoDBiEOG73Z2T2.
PhylomeDBiQ8N6U8.
TreeFamiTF331895.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N6U8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLNSSLSCR KELSNLTEEE GGEGGVIITQ FIAIIVITIF VCLGNLVIVV
60 70 80 90 100
TLYKKSYLLT LSNKFVFSLT LSNFLLSVLV LPFVVTSSIR REWIFGVVWC
110 120 130 140 150
NFSALLYLLI SSASMLTLGV IAIDRYYAVL YPMVYPMKIT GNRAVMALVY
160 170 180 190 200
IWLHSLIGCL PPLFGWSSVE FDEFKWMCVA AWHREPGYTA FWQIWCALFP
210 220 230 240 250
FLVMLVCYGF IFRVARVKAR KVHCGTVVIV EEDAQRTGRK NSSTSTSSSG
260 270 280 290 300
SRRNAFQGVV YSANQCKALI TILVVLGAFM VTWGPYMVVI ASEALWGKSS
310 320 330 340 350
VSPSLETWAT WLSFASAVCH PLIYGLWNKT VRKELLGMCF GDRYYREPFV
360 370 380 390 400
QRQRTSRLFS ISNRITDLGL SPHLTALMAG GQPLGHSSST GDTGFSCSQD
410 420 430 440 450
SGTDMMLLED YTSDDNPPSH CTCPPKRRSS VTFEDEVEQI KEAAKNSILH
460 470 480 490 500
VKAEVHKSLD SYAASLAKAI EAEAKINLFG EEALPGVLVT ARTVPGGGFG
510 520
GRRGSRTLVS QRLQLQSIEE GDVLAAEQR
Length:529
Mass (Da):58,559
Last modified:October 1, 2002 - v1
Checksum:iFC7D1AC0894DC3F3
GO
Isoform 2 (identifier: Q8N6U8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     403-407: TDMML → NLRAL
     408-529: Missing.

Note: No experimental confirmation available.
Show »
Length:407
Mass (Da):45,363
Checksum:i00078B8EB5BC1F21
GO
Isoform 3 (identifier: Q8N6U8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-132: Missing.

Note: No experimental confirmation available.
Show »
Length:397
Mass (Da):43,906
Checksum:i426288987F5CF53F
GO
Isoform 4 (identifier: Q8N6U8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: MSLNSSLSCR...TIFVCLGNLV → MGGRRCVPGT...APRLESVRTS
     48-125: Missing.

Note: No experimental confirmation available.
Show »
Length:451
Mass (Da):49,701
Checksum:i0FAEB6C663961C79
GO
Isoform 5 (identifier: Q8N6U8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-125: MSLNSSLSCR...LTLGVIAIDR → MLVPVGWMNES

Show »
Length:415
Mass (Da):46,021
Checksum:iDCC21C091A3A3B4B
GO
Isoform 6 (identifier: Q8N6U8-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSARGVVQHALPTPRRGALTM

Show »
Length:549
Mass (Da):60,659
Checksum:i6FDA02198DEB9F8F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti193 – 1931Q → R in BAH12873 (PubMed:14702039).Curated
Sequence conflicti195 – 1951W → R in BAH13082 (PubMed:14702039).Curated
Sequence conflicti324 – 3241Y → N in BAH12873 (PubMed:14702039).Curated
Sequence conflicti421 – 4211C → S in BAH13082 (PubMed:14702039).Curated
Sequence conflicti500 – 5001G → V in BAH12873 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 132132Missing in isoform 3. 1 PublicationVSP_035561Add
BLAST
Alternative sequencei1 – 125125MSLNS…IAIDR → MLVPVGWMNES in isoform 5. 1 PublicationVSP_045329Add
BLAST
Alternative sequencei1 – 4747MSLNS…LGNLV → MGGRRCVPGTLPMRAAPPGA KRLHVPLRAKGVGRSGHAPR LESVRTS in isoform 4. 1 PublicationVSP_044778Add
BLAST
Alternative sequencei1 – 11M → MSARGVVQHALPTPRRGALT M in isoform 6. 1 PublicationVSP_046299
Alternative sequencei48 – 12578Missing in isoform 4. 1 PublicationVSP_044779Add
BLAST
Alternative sequencei403 – 4075TDMML → NLRAL in isoform 2. 1 PublicationVSP_010560
Alternative sequencei408 – 529122Missing in isoform 2. 1 PublicationVSP_010561Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY275468 mRNA. Translation: AAP32300.1.
AF091890 mRNA. Translation: AAC61598.1.
AK056040 mRNA. Translation: BAG51611.1.
AK122656 mRNA. Translation: BAG53646.1.
AK298797 mRNA. Translation: BAH12873.1.
AK298850 mRNA. Translation: BAH12884.1.
AK299634 mRNA. Translation: BAH13082.1.
AL033532 Genomic DNA. Translation: CAI22622.1.
AL033532 Genomic DNA. Translation: CAI22623.1.
BC028163 mRNA. Translation: AAH28163.1.
CCDSiCCDS1268.1. [Q8N6U8-1]
CCDS58042.1. [Q8N6U8-3]
CCDS58043.1. [Q8N6U8-6]
CCDS58044.1. [Q8N6U8-4]
CCDS58045.1. [Q8N6U8-5]
RefSeqiNP_001254538.1. NM_001267609.1. [Q8N6U8-6]
NP_001254539.1. NM_001267610.1. [Q8N6U8-1]
NP_001254541.1. NM_001267612.1. [Q8N6U8-3]
NP_001254542.1. NM_001267613.1. [Q8N6U8-4]
NP_001254543.1. NM_001267614.1. [Q8N6U8-5]
NP_722561.1. NM_153832.2. [Q8N6U8-1]
XP_005245112.1. XM_005245055.2. [Q8N6U8-6]
XP_005245113.1. XM_005245056.2. [Q8N6U8-1]
XP_005245114.1. XM_005245057.3. [Q8N6U8-1]
XP_006711315.1. XM_006711252.1. [Q8N6U8-1]
XP_006711316.1. XM_006711253.1. [Q8N6U8-1]
XP_011507677.1. XM_011509375.1. [Q8N6U8-1]
XP_011507678.1. XM_011509376.1. [Q8N6U8-1]
XP_011507679.1. XM_011509377.1. [Q8N6U8-1]
XP_011507680.1. XM_011509378.1. [Q8N6U8-1]
UniGeneiHs.271809.

Genome annotation databases

EnsembliENST00000367835; ENSP00000356809; ENSG00000143147. [Q8N6U8-1]
ENST00000367836; ENSP00000356810; ENSG00000143147. [Q8N6U8-3]
ENST00000367838; ENSP00000356812; ENSG00000143147. [Q8N6U8-1]
ENST00000537209; ENSP00000441039; ENSG00000143147. [Q8N6U8-6]
ENST00000539777; ENSP00000437576; ENSG00000143147. [Q8N6U8-4]
ENST00000546300; ENSP00000444348; ENSG00000143147. [Q8N6U8-5]
GeneIDi23432.
KEGGihsa:23432.
UCSCiuc001gfb.5. human. [Q8N6U8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY275468 mRNA. Translation: AAP32300.1.
AF091890 mRNA. Translation: AAC61598.1.
AK056040 mRNA. Translation: BAG51611.1.
AK122656 mRNA. Translation: BAG53646.1.
AK298797 mRNA. Translation: BAH12873.1.
AK298850 mRNA. Translation: BAH12884.1.
AK299634 mRNA. Translation: BAH13082.1.
AL033532 Genomic DNA. Translation: CAI22622.1.
AL033532 Genomic DNA. Translation: CAI22623.1.
BC028163 mRNA. Translation: AAH28163.1.
CCDSiCCDS1268.1. [Q8N6U8-1]
CCDS58042.1. [Q8N6U8-3]
CCDS58043.1. [Q8N6U8-6]
CCDS58044.1. [Q8N6U8-4]
CCDS58045.1. [Q8N6U8-5]
RefSeqiNP_001254538.1. NM_001267609.1. [Q8N6U8-6]
NP_001254539.1. NM_001267610.1. [Q8N6U8-1]
NP_001254541.1. NM_001267612.1. [Q8N6U8-3]
NP_001254542.1. NM_001267613.1. [Q8N6U8-4]
NP_001254543.1. NM_001267614.1. [Q8N6U8-5]
NP_722561.1. NM_153832.2. [Q8N6U8-1]
XP_005245112.1. XM_005245055.2. [Q8N6U8-6]
XP_005245113.1. XM_005245056.2. [Q8N6U8-1]
XP_005245114.1. XM_005245057.3. [Q8N6U8-1]
XP_006711315.1. XM_006711252.1. [Q8N6U8-1]
XP_006711316.1. XM_006711253.1. [Q8N6U8-1]
XP_011507677.1. XM_011509375.1. [Q8N6U8-1]
XP_011507678.1. XM_011509376.1. [Q8N6U8-1]
XP_011507679.1. XM_011509377.1. [Q8N6U8-1]
XP_011507680.1. XM_011509378.1. [Q8N6U8-1]
UniGeneiHs.271809.

3D structure databases

ProteinModelPortaliQ8N6U8.
SMRiQ8N6U8. Positions 26-336.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117000. 16 interactions.
IntActiQ8N6U8. 1 interaction.
STRINGi9606.ENSP00000271357.

Protein family/group databases

TCDBi9.A.14.1.11. the g-protein-coupled receptor (gpcr) family.
GPCRDBiSearch...

PTM databases

iPTMnetiQ8N6U8.
PhosphoSiteiQ8N6U8.

Polymorphism and mutation databases

BioMutaiGPR161.
DMDMi48428085.

Proteomic databases

EPDiQ8N6U8.
PaxDbiQ8N6U8.
PeptideAtlasiQ8N6U8.
PRIDEiQ8N6U8.
TopDownProteomicsiQ8N6U8-1. [Q8N6U8-1]

Protocols and materials databases

DNASUi23432.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367835; ENSP00000356809; ENSG00000143147. [Q8N6U8-1]
ENST00000367836; ENSP00000356810; ENSG00000143147. [Q8N6U8-3]
ENST00000367838; ENSP00000356812; ENSG00000143147. [Q8N6U8-1]
ENST00000537209; ENSP00000441039; ENSG00000143147. [Q8N6U8-6]
ENST00000539777; ENSP00000437576; ENSG00000143147. [Q8N6U8-4]
ENST00000546300; ENSP00000444348; ENSG00000143147. [Q8N6U8-5]
GeneIDi23432.
KEGGihsa:23432.
UCSCiuc001gfb.5. human. [Q8N6U8-1]

Organism-specific databases

CTDi23432.
GeneCardsiGPR161.
HGNCiHGNC:23694. GPR161.
HPAiHPA015576.
MIMi612250. gene.
neXtProtiNX_Q8N6U8.
PharmGKBiPA134931474.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00790000123027.
HOGENOMiHOG000112777.
HOVERGENiHBG051789.
InParanoidiQ8N6U8.
KOiK08439.
OMAiIWCALLP.
OrthoDBiEOG73Z2T2.
PhylomeDBiQ8N6U8.
TreeFamiTF331895.

Enzyme and pathway databases

ReactomeiR-HSA-5610787. Hedgehog 'off' state.
R-HSA-5632684. Hedgehog 'on' state.

Miscellaneous databases

ChiTaRSiGPR161. human.
GeneWikiiGPR161.
GenomeRNAii23432.
PROiQ8N6U8.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N6U8.
CleanExiHS_GPR161.
ExpressionAtlasiQ8N6U8. baseline and differential.
GenevisibleiQ8N6U8. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of cDNA coding for G-protein coupled receptor RE2."
    Warren C.N., Aronstam R.S., Sharma S.V.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Identification of a novel G-protein coupled receptor expressed in distinct brain regions and a defined olfactory zone."
    Raming K., Konzelmann S., Breer H.
    Recept. Channels 6:141-151(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Fetal brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3; 4; 5 AND 6).
    Tissue: Brain and Teratocarcinoma.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Fetal brain.

Entry informationi

Entry nameiGP161_HUMAN
AccessioniPrimary (citable) accession number: Q8N6U8
Secondary accession number(s): B3KV34
, B7Z5D7, B7Z5E8, B7Z5Z6, F5GXD6, F5H6J7, O75963, Q5TGK0, Q5TGK1, Q5TGK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2002
Last modified: July 6, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.