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Protein

G-protein coupled receptor 161

Gene

GPR161

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000143147-MONOMER.
ReactomeiR-HSA-5610787. Hedgehog 'off' state.
R-HSA-5632684. Hedgehog 'on' state.

Protein family/group databases

TCDBi9.A.14.1.11. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 161
Alternative name(s):
G-protein coupled receptor RE2
Gene namesi
Name:GPR161
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:23694. GPR161.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 30ExtracellularSequence analysisAdd BLAST30
Transmembranei31 – 51Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini52 – 64CytoplasmicSequence analysisAdd BLAST13
Transmembranei65 – 85Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini86 – 101ExtracellularSequence analysisAdd BLAST16
Transmembranei102 – 123Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini124 – 143CytoplasmicSequence analysisAdd BLAST20
Transmembranei144 – 164Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini165 – 190ExtracellularSequence analysisAdd BLAST26
Transmembranei191 – 211Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini212 – 269CytoplasmicSequence analysisAdd BLAST58
Transmembranei270 – 290Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini291 – 306ExtracellularSequence analysisAdd BLAST16
Transmembranei307 – 327Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini328 – 529CytoplasmicSequence analysisAdd BLAST202

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23432.
OpenTargetsiENSG00000143147.
PharmGKBiPA134931474.

Polymorphism and mutation databases

BioMutaiGPR161.
DMDMi48428085.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696461 – 529G-protein coupled receptor 161Add BLAST529

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Glycosylationi15N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi100 ↔ 178PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8N6U8.
PeptideAtlasiQ8N6U8.
PRIDEiQ8N6U8.
TopDownProteomicsiQ8N6U8-1. [Q8N6U8-1]

PTM databases

iPTMnetiQ8N6U8.
PhosphoSitePlusiQ8N6U8.

Expressioni

Gene expression databases

BgeeiENSG00000143147.
CleanExiHS_GPR161.
ExpressionAtlasiQ8N6U8. baseline and differential.
GenevisibleiQ8N6U8. HS.

Organism-specific databases

HPAiHPA015576.

Interactioni

Protein-protein interaction databases

BioGridi117000. 16 interactors.
IntActiQ8N6U8. 1 interactor.
STRINGi9606.ENSP00000271357.

Structurei

3D structure databases

ProteinModelPortaliQ8N6U8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00790000123027.
HOGENOMiHOG000112777.
HOVERGENiHBG051789.
InParanoidiQ8N6U8.
KOiK08439.
OMAiIWCALLP.
OrthoDBiEOG091G0G56.
PhylomeDBiQ8N6U8.
TreeFamiTF331895.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N6U8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLNSSLSCR KELSNLTEEE GGEGGVIITQ FIAIIVITIF VCLGNLVIVV
60 70 80 90 100
TLYKKSYLLT LSNKFVFSLT LSNFLLSVLV LPFVVTSSIR REWIFGVVWC
110 120 130 140 150
NFSALLYLLI SSASMLTLGV IAIDRYYAVL YPMVYPMKIT GNRAVMALVY
160 170 180 190 200
IWLHSLIGCL PPLFGWSSVE FDEFKWMCVA AWHREPGYTA FWQIWCALFP
210 220 230 240 250
FLVMLVCYGF IFRVARVKAR KVHCGTVVIV EEDAQRTGRK NSSTSTSSSG
260 270 280 290 300
SRRNAFQGVV YSANQCKALI TILVVLGAFM VTWGPYMVVI ASEALWGKSS
310 320 330 340 350
VSPSLETWAT WLSFASAVCH PLIYGLWNKT VRKELLGMCF GDRYYREPFV
360 370 380 390 400
QRQRTSRLFS ISNRITDLGL SPHLTALMAG GQPLGHSSST GDTGFSCSQD
410 420 430 440 450
SGTDMMLLED YTSDDNPPSH CTCPPKRRSS VTFEDEVEQI KEAAKNSILH
460 470 480 490 500
VKAEVHKSLD SYAASLAKAI EAEAKINLFG EEALPGVLVT ARTVPGGGFG
510 520
GRRGSRTLVS QRLQLQSIEE GDVLAAEQR
Length:529
Mass (Da):58,559
Last modified:October 1, 2002 - v1
Checksum:iFC7D1AC0894DC3F3
GO
Isoform 2 (identifier: Q8N6U8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     403-407: TDMML → NLRAL
     408-529: Missing.

Note: No experimental confirmation available.
Show »
Length:407
Mass (Da):45,363
Checksum:i00078B8EB5BC1F21
GO
Isoform 3 (identifier: Q8N6U8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-132: Missing.

Note: No experimental confirmation available.
Show »
Length:397
Mass (Da):43,906
Checksum:i426288987F5CF53F
GO
Isoform 4 (identifier: Q8N6U8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: MSLNSSLSCR...TIFVCLGNLV → MGGRRCVPGT...APRLESVRTS
     48-125: Missing.

Note: No experimental confirmation available.
Show »
Length:451
Mass (Da):49,701
Checksum:i0FAEB6C663961C79
GO
Isoform 5 (identifier: Q8N6U8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-125: MSLNSSLSCR...LTLGVIAIDR → MLVPVGWMNES

Show »
Length:415
Mass (Da):46,021
Checksum:iDCC21C091A3A3B4B
GO
Isoform 6 (identifier: Q8N6U8-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSARGVVQHALPTPRRGALTM

Show »
Length:549
Mass (Da):60,659
Checksum:i6FDA02198DEB9F8F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti193Q → R in BAH12873 (PubMed:14702039).Curated1
Sequence conflicti195W → R in BAH13082 (PubMed:14702039).Curated1
Sequence conflicti324Y → N in BAH12873 (PubMed:14702039).Curated1
Sequence conflicti421C → S in BAH13082 (PubMed:14702039).Curated1
Sequence conflicti500G → V in BAH12873 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0355611 – 132Missing in isoform 3. 1 PublicationAdd BLAST132
Alternative sequenceiVSP_0453291 – 125MSLNS…IAIDR → MLVPVGWMNES in isoform 5. 1 PublicationAdd BLAST125
Alternative sequenceiVSP_0447781 – 47MSLNS…LGNLV → MGGRRCVPGTLPMRAAPPGA KRLHVPLRAKGVGRSGHAPR LESVRTS in isoform 4. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_0462991M → MSARGVVQHALPTPRRGALT M in isoform 6. 1 Publication1
Alternative sequenceiVSP_04477948 – 125Missing in isoform 4. 1 PublicationAdd BLAST78
Alternative sequenceiVSP_010560403 – 407TDMML → NLRAL in isoform 2. 1 Publication5
Alternative sequenceiVSP_010561408 – 529Missing in isoform 2. 1 PublicationAdd BLAST122

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY275468 mRNA. Translation: AAP32300.1.
AF091890 mRNA. Translation: AAC61598.1.
AK056040 mRNA. Translation: BAG51611.1.
AK122656 mRNA. Translation: BAG53646.1.
AK298797 mRNA. Translation: BAH12873.1.
AK298850 mRNA. Translation: BAH12884.1.
AK299634 mRNA. Translation: BAH13082.1.
AL033532 Genomic DNA. Translation: CAI22622.1.
AL033532 Genomic DNA. Translation: CAI22623.1.
BC028163 mRNA. Translation: AAH28163.1.
CCDSiCCDS1268.1. [Q8N6U8-1]
CCDS58042.1. [Q8N6U8-3]
CCDS58043.1. [Q8N6U8-6]
CCDS58044.1. [Q8N6U8-4]
CCDS58045.1. [Q8N6U8-5]
RefSeqiNP_001254538.1. NM_001267609.1. [Q8N6U8-6]
NP_001254539.1. NM_001267610.1. [Q8N6U8-1]
NP_001254541.1. NM_001267612.1. [Q8N6U8-3]
NP_001254542.1. NM_001267613.1. [Q8N6U8-4]
NP_001254543.1. NM_001267614.1. [Q8N6U8-5]
NP_722561.1. NM_153832.2. [Q8N6U8-1]
XP_005245112.1. XM_005245055.2. [Q8N6U8-6]
XP_005245113.1. XM_005245056.2. [Q8N6U8-1]
XP_005245114.1. XM_005245057.4. [Q8N6U8-1]
XP_011507677.1. XM_011509375.2. [Q8N6U8-1]
XP_011507678.1. XM_011509376.2. [Q8N6U8-1]
XP_011507679.1. XM_011509377.1. [Q8N6U8-1]
XP_011507680.1. XM_011509378.1. [Q8N6U8-1]
XP_016856348.1. XM_017000859.1. [Q8N6U8-6]
XP_016856349.1. XM_017000860.1. [Q8N6U8-1]
XP_016856350.1. XM_017000861.1. [Q8N6U8-1]
XP_016856351.1. XM_017000862.1. [Q8N6U8-1]
UniGeneiHs.271809.

Genome annotation databases

EnsembliENST00000367835; ENSP00000356809; ENSG00000143147. [Q8N6U8-1]
ENST00000367836; ENSP00000356810; ENSG00000143147. [Q8N6U8-3]
ENST00000367838; ENSP00000356812; ENSG00000143147. [Q8N6U8-1]
ENST00000537209; ENSP00000441039; ENSG00000143147. [Q8N6U8-6]
ENST00000539777; ENSP00000437576; ENSG00000143147. [Q8N6U8-4]
ENST00000546300; ENSP00000444348; ENSG00000143147. [Q8N6U8-5]
GeneIDi23432.
KEGGihsa:23432.
UCSCiuc001gfb.5. human. [Q8N6U8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY275468 mRNA. Translation: AAP32300.1.
AF091890 mRNA. Translation: AAC61598.1.
AK056040 mRNA. Translation: BAG51611.1.
AK122656 mRNA. Translation: BAG53646.1.
AK298797 mRNA. Translation: BAH12873.1.
AK298850 mRNA. Translation: BAH12884.1.
AK299634 mRNA. Translation: BAH13082.1.
AL033532 Genomic DNA. Translation: CAI22622.1.
AL033532 Genomic DNA. Translation: CAI22623.1.
BC028163 mRNA. Translation: AAH28163.1.
CCDSiCCDS1268.1. [Q8N6U8-1]
CCDS58042.1. [Q8N6U8-3]
CCDS58043.1. [Q8N6U8-6]
CCDS58044.1. [Q8N6U8-4]
CCDS58045.1. [Q8N6U8-5]
RefSeqiNP_001254538.1. NM_001267609.1. [Q8N6U8-6]
NP_001254539.1. NM_001267610.1. [Q8N6U8-1]
NP_001254541.1. NM_001267612.1. [Q8N6U8-3]
NP_001254542.1. NM_001267613.1. [Q8N6U8-4]
NP_001254543.1. NM_001267614.1. [Q8N6U8-5]
NP_722561.1. NM_153832.2. [Q8N6U8-1]
XP_005245112.1. XM_005245055.2. [Q8N6U8-6]
XP_005245113.1. XM_005245056.2. [Q8N6U8-1]
XP_005245114.1. XM_005245057.4. [Q8N6U8-1]
XP_011507677.1. XM_011509375.2. [Q8N6U8-1]
XP_011507678.1. XM_011509376.2. [Q8N6U8-1]
XP_011507679.1. XM_011509377.1. [Q8N6U8-1]
XP_011507680.1. XM_011509378.1. [Q8N6U8-1]
XP_016856348.1. XM_017000859.1. [Q8N6U8-6]
XP_016856349.1. XM_017000860.1. [Q8N6U8-1]
XP_016856350.1. XM_017000861.1. [Q8N6U8-1]
XP_016856351.1. XM_017000862.1. [Q8N6U8-1]
UniGeneiHs.271809.

3D structure databases

ProteinModelPortaliQ8N6U8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117000. 16 interactors.
IntActiQ8N6U8. 1 interactor.
STRINGi9606.ENSP00000271357.

Protein family/group databases

TCDBi9.A.14.1.11. the g-protein-coupled receptor (gpcr) family.
GPCRDBiSearch...

PTM databases

iPTMnetiQ8N6U8.
PhosphoSitePlusiQ8N6U8.

Polymorphism and mutation databases

BioMutaiGPR161.
DMDMi48428085.

Proteomic databases

PaxDbiQ8N6U8.
PeptideAtlasiQ8N6U8.
PRIDEiQ8N6U8.
TopDownProteomicsiQ8N6U8-1. [Q8N6U8-1]

Protocols and materials databases

DNASUi23432.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367835; ENSP00000356809; ENSG00000143147. [Q8N6U8-1]
ENST00000367836; ENSP00000356810; ENSG00000143147. [Q8N6U8-3]
ENST00000367838; ENSP00000356812; ENSG00000143147. [Q8N6U8-1]
ENST00000537209; ENSP00000441039; ENSG00000143147. [Q8N6U8-6]
ENST00000539777; ENSP00000437576; ENSG00000143147. [Q8N6U8-4]
ENST00000546300; ENSP00000444348; ENSG00000143147. [Q8N6U8-5]
GeneIDi23432.
KEGGihsa:23432.
UCSCiuc001gfb.5. human. [Q8N6U8-1]

Organism-specific databases

CTDi23432.
DisGeNETi23432.
GeneCardsiGPR161.
HGNCiHGNC:23694. GPR161.
HPAiHPA015576.
MIMi612250. gene.
neXtProtiNX_Q8N6U8.
OpenTargetsiENSG00000143147.
PharmGKBiPA134931474.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00790000123027.
HOGENOMiHOG000112777.
HOVERGENiHBG051789.
InParanoidiQ8N6U8.
KOiK08439.
OMAiIWCALLP.
OrthoDBiEOG091G0G56.
PhylomeDBiQ8N6U8.
TreeFamiTF331895.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000143147-MONOMER.
ReactomeiR-HSA-5610787. Hedgehog 'off' state.
R-HSA-5632684. Hedgehog 'on' state.

Miscellaneous databases

ChiTaRSiGPR161. human.
GeneWikiiGPR161.
GenomeRNAii23432.
PROiQ8N6U8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143147.
CleanExiHS_GPR161.
ExpressionAtlasiQ8N6U8. baseline and differential.
GenevisibleiQ8N6U8. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGP161_HUMAN
AccessioniPrimary (citable) accession number: Q8N6U8
Secondary accession number(s): B3KV34
, B7Z5D7, B7Z5E8, B7Z5Z6, F5GXD6, F5H6J7, O75963, Q5TGK0, Q5TGK1, Q5TGK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.