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Q8N6S5

- AR6P6_HUMAN

UniProt

Q8N6S5 - AR6P6_HUMAN

Protein

ADP-ribosylation factor-like protein 6-interacting protein 6

Gene

ARL6IP6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ADP-ribosylation factor-like protein 6-interacting protein 6
    Short name:
    ARL-6-interacting protein 6
    Short name:
    Aip-6
    Alternative name(s):
    Phosphonoformate immuno-associated protein 1
    Gene namesi
    Name:ARL6IP6
    Synonyms:PFAAP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:24048. ARL6IP6.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134866669.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 226226ADP-ribosylation factor-like protein 6-interacting protein 6PRO_0000307324Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21Phosphoserine1 Publication
    Modified residuei36 – 361Phosphoserine1 Publication
    Modified residuei60 – 601Phosphoserine1 Publication
    Modified residuei65 – 651Phosphoserine2 Publications
    Modified residuei80 – 801PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8N6S5.
    PaxDbiQ8N6S5.
    PRIDEiQ8N6S5.

    PTM databases

    PhosphoSiteiQ8N6S5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8N6S5.
    BgeeiQ8N6S5.
    CleanExiHS_ARL6IP6.
    GenevestigatoriQ8N6S5.

    Organism-specific databases

    HPAiHPA014743.

    Interactioni

    Protein-protein interaction databases

    BioGridi127351. 2 interactions.
    IntActiQ8N6S5. 1 interaction.
    STRINGi9606.ENSP00000315357.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N6S5.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei111 – 13121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei150 – 17021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei205 – 22521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ARL6IP6 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46865.
    HOGENOMiHOG000034034.
    HOVERGENiHBG060892.
    InParanoidiQ8N6S5.
    OMAiDKRNGIF.
    OrthoDBiEOG7J9VQS.
    PhylomeDBiQ8N6S5.
    TreeFamiTF324669.

    Family and domain databases

    InterProiIPR029383. ARL6IP6.
    [Graphical view]
    PfamiPF15062. ARL6IP6. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8N6S5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSFAESGWRS ALRRRGPGTP GPVARPSYSS FTQGDSWGEG EVDEEEGCDQ    50
    VARDLRAEFS AGAWSEPRKR SVLPPDGNGS PVLPDKRNGI FPAAAGSRAQ 100
    PRRWPVQVLS ILCSLLFAIL LAFLLAIAYL IVKELHAENL KNEDDVDTGL 150
    LGFWTLLIIS LTAGFSCCSF SWTVTYFDSF EPGMFPPTPL SPARFKKLTG 200
    HSFHMGYSMA ILNGIVAALT VAWCLM 226
    Length:226
    Mass (Da):24,676
    Last modified:October 1, 2002 - v1
    Checksum:iEB236F4490BE1FFF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti21 – 211G → A in AAQ09943. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF530059 mRNA. Translation: AAQ09943.1.
    AK315657 mRNA. Translation: BAG38023.1.
    AC079344 Genomic DNA. Translation: AAX93217.1.
    CH471058 Genomic DNA. Translation: EAX11477.1.
    BC028741 mRNA. Translation: AAH28741.1.
    BC070140 mRNA. Translation: AAH70140.1.
    CCDSiCCDS2197.1.
    RefSeqiNP_689735.1. NM_152522.5.
    UniGeneiHs.643580.
    Hs.744874.

    Genome annotation databases

    EnsembliENST00000326446; ENSP00000315357; ENSG00000177917.
    GeneIDi151188.
    KEGGihsa:151188.
    UCSCiuc002tyn.3. human.

    Polymorphism databases

    DMDMi74729171.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF530059 mRNA. Translation: AAQ09943.1 .
    AK315657 mRNA. Translation: BAG38023.1 .
    AC079344 Genomic DNA. Translation: AAX93217.1 .
    CH471058 Genomic DNA. Translation: EAX11477.1 .
    BC028741 mRNA. Translation: AAH28741.1 .
    BC070140 mRNA. Translation: AAH70140.1 .
    CCDSi CCDS2197.1.
    RefSeqi NP_689735.1. NM_152522.5.
    UniGenei Hs.643580.
    Hs.744874.

    3D structure databases

    ProteinModelPortali Q8N6S5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127351. 2 interactions.
    IntActi Q8N6S5. 1 interaction.
    STRINGi 9606.ENSP00000315357.

    PTM databases

    PhosphoSitei Q8N6S5.

    Polymorphism databases

    DMDMi 74729171.

    Proteomic databases

    MaxQBi Q8N6S5.
    PaxDbi Q8N6S5.
    PRIDEi Q8N6S5.

    Protocols and materials databases

    DNASUi 151188.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000326446 ; ENSP00000315357 ; ENSG00000177917 .
    GeneIDi 151188.
    KEGGi hsa:151188.
    UCSCi uc002tyn.3. human.

    Organism-specific databases

    CTDi 151188.
    GeneCardsi GC02P153574.
    H-InvDB HIX0002514.
    HGNCi HGNC:24048. ARL6IP6.
    HPAi HPA014743.
    neXtProti NX_Q8N6S5.
    PharmGKBi PA134866669.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46865.
    HOGENOMi HOG000034034.
    HOVERGENi HBG060892.
    InParanoidi Q8N6S5.
    OMAi DKRNGIF.
    OrthoDBi EOG7J9VQS.
    PhylomeDBi Q8N6S5.
    TreeFami TF324669.

    Miscellaneous databases

    ChiTaRSi ARL6IP6. human.
    GenomeRNAii 151188.
    NextBioi 86612.
    PROi Q8N6S5.

    Gene expression databases

    ArrayExpressi Q8N6S5.
    Bgeei Q8N6S5.
    CleanExi HS_ARL6IP6.
    Genevestigatori Q8N6S5.

    Family and domain databases

    InterProi IPR029383. ARL6IP6.
    [Graphical view ]
    Pfami PF15062. ARL6IP6. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Screening and cloning of a new immuno-associated gene regulated by phosphonoformate."
      Liu Y., Cheng J., Lu Y.
      Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Esophagus.
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Lung.
    6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2; SER-36 AND SER-65, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60 AND SER-65, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiAR6P6_HUMAN
    AccessioniPrimary (citable) accession number: Q8N6S5
    Secondary accession number(s): B2RDS6, Q7Z4G7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3