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Q8N6S5

- AR6P6_HUMAN

UniProt

Q8N6S5 - AR6P6_HUMAN

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Protein

ADP-ribosylation factor-like protein 6-interacting protein 6

Gene
ARL6IP6, PFAAP1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 6-interacting protein 6
Short name:
ARL-6-interacting protein 6
Short name:
Aip-6
Alternative name(s):
Phosphonoformate immuno-associated protein 1
Gene namesi
Name:ARL6IP6
Synonyms:PFAAP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:24048. ARL6IP6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei111 – 13121Helical; Reviewed predictionAdd
BLAST
Transmembranei150 – 17021Helical; Reviewed predictionAdd
BLAST
Transmembranei205 – 22521Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134866669.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 226226ADP-ribosylation factor-like protein 6-interacting protein 6PRO_0000307324Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21Phosphoserine1 Publication
Modified residuei36 – 361Phosphoserine1 Publication
Modified residuei60 – 601Phosphoserine1 Publication
Modified residuei65 – 651Phosphoserine2 Publications
Modified residuei80 – 801Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8N6S5.
PaxDbiQ8N6S5.
PRIDEiQ8N6S5.

PTM databases

PhosphoSiteiQ8N6S5.

Expressioni

Gene expression databases

ArrayExpressiQ8N6S5.
BgeeiQ8N6S5.
CleanExiHS_ARL6IP6.
GenevestigatoriQ8N6S5.

Organism-specific databases

HPAiHPA014743.

Interactioni

Protein-protein interaction databases

BioGridi127351. 2 interactions.
IntActiQ8N6S5. 1 interaction.
STRINGi9606.ENSP00000315357.

Structurei

3D structure databases

ProteinModelPortaliQ8N6S5.

Family & Domainsi

Sequence similaritiesi

Belongs to the ARL6IP6 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46865.
HOGENOMiHOG000034034.
HOVERGENiHBG060892.
InParanoidiQ8N6S5.
OMAiDKRNGIF.
OrthoDBiEOG7J9VQS.
PhylomeDBiQ8N6S5.
TreeFamiTF324669.

Family and domain databases

InterProiIPR029383. ARL6IP6.
[Graphical view]
PfamiPF15062. ARL6IP6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N6S5-1 [UniParc]FASTAAdd to Basket

« Hide

MSFAESGWRS ALRRRGPGTP GPVARPSYSS FTQGDSWGEG EVDEEEGCDQ    50
VARDLRAEFS AGAWSEPRKR SVLPPDGNGS PVLPDKRNGI FPAAAGSRAQ 100
PRRWPVQVLS ILCSLLFAIL LAFLLAIAYL IVKELHAENL KNEDDVDTGL 150
LGFWTLLIIS LTAGFSCCSF SWTVTYFDSF EPGMFPPTPL SPARFKKLTG 200
HSFHMGYSMA ILNGIVAALT VAWCLM 226
Length:226
Mass (Da):24,676
Last modified:October 1, 2002 - v1
Checksum:iEB236F4490BE1FFF
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti21 – 211G → A in AAQ09943. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF530059 mRNA. Translation: AAQ09943.1.
AK315657 mRNA. Translation: BAG38023.1.
AC079344 Genomic DNA. Translation: AAX93217.1.
CH471058 Genomic DNA. Translation: EAX11477.1.
BC028741 mRNA. Translation: AAH28741.1.
BC070140 mRNA. Translation: AAH70140.1.
CCDSiCCDS2197.1.
RefSeqiNP_689735.1. NM_152522.5.
UniGeneiHs.643580.
Hs.744874.

Genome annotation databases

EnsembliENST00000326446; ENSP00000315357; ENSG00000177917.
GeneIDi151188.
KEGGihsa:151188.
UCSCiuc002tyn.3. human.

Polymorphism databases

DMDMi74729171.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF530059 mRNA. Translation: AAQ09943.1 .
AK315657 mRNA. Translation: BAG38023.1 .
AC079344 Genomic DNA. Translation: AAX93217.1 .
CH471058 Genomic DNA. Translation: EAX11477.1 .
BC028741 mRNA. Translation: AAH28741.1 .
BC070140 mRNA. Translation: AAH70140.1 .
CCDSi CCDS2197.1.
RefSeqi NP_689735.1. NM_152522.5.
UniGenei Hs.643580.
Hs.744874.

3D structure databases

ProteinModelPortali Q8N6S5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127351. 2 interactions.
IntActi Q8N6S5. 1 interaction.
STRINGi 9606.ENSP00000315357.

PTM databases

PhosphoSitei Q8N6S5.

Polymorphism databases

DMDMi 74729171.

Proteomic databases

MaxQBi Q8N6S5.
PaxDbi Q8N6S5.
PRIDEi Q8N6S5.

Protocols and materials databases

DNASUi 151188.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000326446 ; ENSP00000315357 ; ENSG00000177917 .
GeneIDi 151188.
KEGGi hsa:151188.
UCSCi uc002tyn.3. human.

Organism-specific databases

CTDi 151188.
GeneCardsi GC02P153574.
H-InvDB HIX0002514.
HGNCi HGNC:24048. ARL6IP6.
HPAi HPA014743.
neXtProti NX_Q8N6S5.
PharmGKBi PA134866669.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46865.
HOGENOMi HOG000034034.
HOVERGENi HBG060892.
InParanoidi Q8N6S5.
OMAi DKRNGIF.
OrthoDBi EOG7J9VQS.
PhylomeDBi Q8N6S5.
TreeFami TF324669.

Miscellaneous databases

ChiTaRSi ARL6IP6. human.
GenomeRNAii 151188.
NextBioi 86612.
PROi Q8N6S5.

Gene expression databases

ArrayExpressi Q8N6S5.
Bgeei Q8N6S5.
CleanExi HS_ARL6IP6.
Genevestigatori Q8N6S5.

Family and domain databases

InterProi IPR029383. ARL6IP6.
[Graphical view ]
Pfami PF15062. ARL6IP6. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Screening and cloning of a new immuno-associated gene regulated by phosphonoformate."
    Liu Y., Cheng J., Lu Y.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Esophagus.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Lung.
  6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2; SER-36 AND SER-65, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60 AND SER-65, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiAR6P6_HUMAN
AccessioniPrimary (citable) accession number: Q8N6S5
Secondary accession number(s): B2RDS6, Q7Z4G7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi