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Protein

Stress-associated endoplasmic reticulum protein 2

Gene

SERP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation (Potential).Curated

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Stress-associated endoplasmic reticulum protein 2
Alternative name(s):
Ribosome-associated membrane protein RAMP4-2
Gene namesi
Name:SERP2
Synonyms:C13orf21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000151778.10
HGNCiHGNC:20607 SERP2
neXtProtiNX_Q8N6R1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37CytoplasmicSequence analysisAdd BLAST37
Transmembranei38 – 58Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini59 – 65LumenalSequence analysis7

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi387923
OpenTargetsiENSG00000151778
PharmGKBiPA162402953

Polymorphism and mutation databases

BioMutaiSERP2
DMDMi74751068

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002747991 – 65Stress-associated endoplasmic reticulum protein 2Add BLAST65

Proteomic databases

PaxDbiQ8N6R1
PeptideAtlasiQ8N6R1
PRIDEiQ8N6R1
TopDownProteomicsiQ8N6R1

PTM databases

iPTMnetiQ8N6R1
PhosphoSitePlusiQ8N6R1

Expressioni

Gene expression databases

BgeeiENSG00000151778
CleanExiHS_SERP2
ExpressionAtlasiQ8N6R1 baseline and differential
GenevisibleiQ8N6R1 HS

Organism-specific databases

HPAiHPA038970

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC155Q8N6L05EBI-749270,EBI-749265

Protein-protein interaction databases

BioGridi132508, 4 interactors
IntActiQ8N6R1, 16 interactors
STRINGi9606.ENSP00000368477

Structurei

3D structure databases

ProteinModelPortaliQ8N6R1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RAMP4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3491 Eukaryota
ENOG411221U LUCA
GeneTreeiENSGT00390000012245
HOVERGENiHBG058555
InParanoidiQ8N6R1
OMAiKNVNNRG
OrthoDBiEOG091G17CZ
PhylomeDBiQ8N6R1
TreeFamiTF313229

Family and domain databases

InterProiView protein in InterPro
IPR010580 ER_stress-assoc
PANTHERiPTHR15601 PTHR15601, 1 hit
PfamiView protein in Pfam
PF06624 RAMP4, 1 hit

Sequencei

Sequence statusi: Complete.

Q8N6R1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAKQRIRMA NEKHSKNITQ RGNVAKTLRP QEEKYPVGPW LLALFVFVVC
60
GSAIFQIIQS IRMGM
Length:65
Mass (Da):7,431
Last modified:October 1, 2002 - v1
Checksum:i4CA89CEF04336C06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC029067 mRNA Translation: AAH29067.1
AL138960 Genomic DNA No translation available.
CCDSiCCDS31965.1
RefSeqiNP_001010897.1, NM_001010897.2
NP_001333909.1, NM_001346980.1
UniGeneiHs.377972

Genome annotation databases

EnsembliENST00000379179; ENSP00000368477; ENSG00000151778
GeneIDi387923
KEGGihsa:387923
UCSCiuc001uzj.3 human

Entry informationi

Entry nameiSERP2_HUMAN
AccessioniPrimary (citable) accession number: Q8N6R1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 1, 2002
Last modified: April 25, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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