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Protein

Stress-associated endoplasmic reticulum protein 2

Gene

SERP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation (Potential).Curated

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Stress-associated endoplasmic reticulum protein 2
Alternative name(s):
Ribosome-associated membrane protein RAMP4-2
Gene namesi
Name:SERP2
Synonyms:C13orf21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:20607. SERP2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3737CytoplasmicSequence analysisAdd
BLAST
Transmembranei38 – 5821Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST
Topological domaini59 – 657LumenalSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162402953.

Polymorphism and mutation databases

BioMutaiSERP2.
DMDMi74751068.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6565Stress-associated endoplasmic reticulum protein 2PRO_0000274799Add
BLAST

Proteomic databases

EPDiQ8N6R1.
PaxDbiQ8N6R1.
PeptideAtlasiQ8N6R1.
PRIDEiQ8N6R1.
TopDownProteomicsiQ8N6R1.

Expressioni

Gene expression databases

BgeeiQ8N6R1.
CleanExiHS_SERP2.
ExpressionAtlasiQ8N6R1. baseline and differential.
GenevisibleiQ8N6R1. HS.

Organism-specific databases

HPAiHPA038970.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC155Q8N6L03EBI-749270,EBI-749265

Protein-protein interaction databases

BioGridi132508. 3 interactions.
IntActiQ8N6R1. 3 interactions.
STRINGi9606.ENSP00000368477.

Structurei

3D structure databases

ProteinModelPortaliQ8N6R1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RAMP4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3491. Eukaryota.
ENOG411221U. LUCA.
GeneTreeiENSGT00390000012245.
HOVERGENiHBG058555.
InParanoidiQ8N6R1.
OMAiQYPVAPW.
PhylomeDBiQ8N6R1.
TreeFamiTF313229.

Family and domain databases

InterProiIPR010580. ER_stress-assoc.
[Graphical view]
PANTHERiPTHR15601. PTHR15601. 1 hit.
PfamiPF06624. RAMP4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N6R1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAKQRIRMA NEKHSKNITQ RGNVAKTLRP QEEKYPVGPW LLALFVFVVC
60
GSAIFQIIQS IRMGM
Length:65
Mass (Da):7,431
Last modified:October 1, 2002 - v1
Checksum:i4CA89CEF04336C06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC029067 mRNA. Translation: AAH29067.1.
AL138960 Genomic DNA. Translation: CAI12995.1.
CCDSiCCDS31965.1.
RefSeqiNP_001010897.1. NM_001010897.1.
UniGeneiHs.377972.

Genome annotation databases

EnsembliENST00000379179; ENSP00000368477; ENSG00000151778.
GeneIDi387923.
KEGGihsa:387923.
UCSCiuc001uzj.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC029067 mRNA. Translation: AAH29067.1.
AL138960 Genomic DNA. Translation: CAI12995.1.
CCDSiCCDS31965.1.
RefSeqiNP_001010897.1. NM_001010897.1.
UniGeneiHs.377972.

3D structure databases

ProteinModelPortaliQ8N6R1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132508. 3 interactions.
IntActiQ8N6R1. 3 interactions.
STRINGi9606.ENSP00000368477.

Polymorphism and mutation databases

BioMutaiSERP2.
DMDMi74751068.

Proteomic databases

EPDiQ8N6R1.
PaxDbiQ8N6R1.
PeptideAtlasiQ8N6R1.
PRIDEiQ8N6R1.
TopDownProteomicsiQ8N6R1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379179; ENSP00000368477; ENSG00000151778.
GeneIDi387923.
KEGGihsa:387923.
UCSCiuc001uzj.3. human.

Organism-specific databases

CTDi387923.
GeneCardsiSERP2.
HGNCiHGNC:20607. SERP2.
HPAiHPA038970.
neXtProtiNX_Q8N6R1.
PharmGKBiPA162402953.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3491. Eukaryota.
ENOG411221U. LUCA.
GeneTreeiENSGT00390000012245.
HOVERGENiHBG058555.
InParanoidiQ8N6R1.
OMAiQYPVAPW.
PhylomeDBiQ8N6R1.
TreeFamiTF313229.

Miscellaneous databases

ChiTaRSiSERP2. human.
GenomeRNAii387923.
PROiQ8N6R1.

Gene expression databases

BgeeiQ8N6R1.
CleanExiHS_SERP2.
ExpressionAtlasiQ8N6R1. baseline and differential.
GenevisibleiQ8N6R1. HS.

Family and domain databases

InterProiIPR010580. ER_stress-assoc.
[Graphical view]
PANTHERiPTHR15601. PTHR15601. 1 hit.
PfamiPF06624. RAMP4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiSERP2_HUMAN
AccessioniPrimary (citable) accession number: Q8N6R1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 1, 2002
Last modified: July 6, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.