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Q8N6R0

- MET13_HUMAN

UniProt

Q8N6R0 - MET13_HUMAN

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Protein
Methyltransferase-like protein 13
Gene
METTL13, KIAA0859, CGI-01
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. methyltransferase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Methyltransferase-like protein 13 (EC:2.1.1.-)
Gene namesi
Name:METTL13
Synonyms:KIAA0859
ORF Names:CGI-01
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:24248. METTL13.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164722256.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 699699Methyltransferase-like protein 13
PRO_0000050779Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei267 – 2671Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8N6R0.
PaxDbiQ8N6R0.
PRIDEiQ8N6R0.

PTM databases

PhosphoSiteiQ8N6R0.

Expressioni

Gene expression databases

ArrayExpressiQ8N6R0.
BgeeiQ8N6R0.
CleanExiHS_KIAA0859.
GenevestigatoriQ8N6R0.

Organism-specific databases

HPAiHPA044498.

Interactioni

Protein-protein interaction databases

BioGridi119632. 4 interactions.
IntActiQ8N6R0. 2 interactions.
MINTiMINT-3086086.

Structurei

3D structure databases

ProteinModelPortaliQ8N6R0.
SMRiQ8N6R0. Positions 11-182, 474-610.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG331905.
InParanoidiQ8N6R0.
OMAiHPEQKLA.
OrthoDBiEOG72C4ZT.
PhylomeDBiQ8N6R0.
TreeFamiTF105906.

Family and domain databases

Gene3Di3.40.50.150. 3 hits.
InterProiIPR013216. Methyltransf_11.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF08241. Methyltransf_11. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 3 hits.

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N6R0-5) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MNLLPKSSRE FGSVDYWEKF FQQRGKKAFE WYGTYLELCG VLHKYIKPRE    50
KVLVIGCGNS ELSEQLYDVG YRDIVNIDIS EVVIKQMKEC NATRRPQMSF 100
LKMDMTQMEF PDASFQVVLD KGTLDAVLTD EEEKTLQQVD RMLAEVGRVL 150
QVGGRYLCIS LAQAHILKKA VGHFSREGWM VRVHQVANSQ DQVLEAEPQF 200
SLPVFAFIMT KFRPVPGSAL QIFELCAQEQ RKPVRLESAE RLAEAVQERQ 250
QYAWLCSQLR RKARLGSVSL DLCDGDTGEP RYTLHVVDSP TVKPSRDNHF 300
AIFIIPQGRE TEWLFGMDEG RKQLAASAGF RRLITVALHR GQQYESMDHI 350
QAELSARVME LAPAGMPTQQ QVPFLSVGGD IGVRTVQHQD CSPLSGDYVI 400
EDVQGDDKRY FRRLIFLSNR NVVQSEARLL KDVSHKAQKK RKKDRKKQRP 450
ADAEDLPAAP GQSIDKSYLC CEHHKAMIAG LALLRNPELL LEIPLALLVV 500
GLGGGSLPLF VHDHFPKSCI DAVEIDPSML EVATQWFGFS QSDRMKVHIA 550
DGLDYIASLA GGGEARPCYD VIMFDVDSKD PTLGMSCPPP AFVEQSFLQK 600
VKSILTPEGV FILNLVCRDL GLKDSVLAGL KAVFPLLYVR RIEGEVNEIL 650
FCQLHPEQKL ATPELLETAQ ALERTLRKPG RGWDDTYVLS DMLKTVKIV 699
Length:699
Mass (Da):78,768
Last modified:October 1, 2002 - v1
Checksum:i14F80A4570047DBB
GO
Isoform 2 (identifier: Q8N6R0-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     643-699: Missing.

Show »
Length:642
Mass (Da):72,261
Checksum:iFBE06982F6BB67ED
GO
Isoform 3 (identifier: Q8N6R0-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-86: Missing.

Show »
Length:613
Mass (Da):68,689
Checksum:iC8C2BA279A1338B9
GO
Isoform 4 (identifier: Q8N6R0-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     151-306: Missing.

Show »
Length:543
Mass (Da):61,128
Checksum:i06ECF4AFB8593785
GO
Isoform 5 (identifier: Q8N6R0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-86: Missing.
     289-505: Missing.

Show »
Length:396
Mass (Da):44,563
Checksum:iEB58F63A983893C8
GO

Sequence cautioni

The sequence BAA74882.2 differs from that shown. Reason: Erroneous initiation.
The sequence BAD97213.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti16 – 161Y → C Found in a renal cell carcinoma sample; somatic mutation. 1 Publication
VAR_064730
Natural varianti105 – 1051M → V.1 Publication
Corresponds to variant rs2232816 [ dbSNP | Ensembl ].
VAR_034040
Natural varianti359 – 3591M → I.
Corresponds to variant rs2232819 [ dbSNP | Ensembl ].
VAR_034041

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8686Missing in isoform 3 and isoform 5.
VSP_013919Add
BLAST
Alternative sequencei151 – 306156Missing in isoform 4.
VSP_013920Add
BLAST
Alternative sequencei289 – 505217Missing in isoform 5.
VSP_013921Add
BLAST
Alternative sequencei643 – 69957Missing in isoform 2.
VSP_013922Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti115 – 1151F → L in BAD97213. 1 Publication
Sequence conflicti498 – 4981L → S in BAD97213. 1 Publication
Sequence conflicti514 – 5141H → Q in BAB55240. 1 Publication
Sequence conflicti534 – 5341T → F in BAC11055. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL049669 mRNA. Translation: CAB41243.1.
AB020666 mRNA. Translation: BAA74882.2. Different initiation.
AF132936 mRNA. Translation: AAD27711.1.
AK027621 mRNA. Translation: BAB55240.1.
AK074552 mRNA. Translation: BAC11055.1.
AK291740 mRNA. Translation: BAF84429.1.
AK223493 mRNA. Translation: BAD97213.1. Different initiation.
AL031864 Genomic DNA. Translation: CAI22003.1.
AL031864 Genomic DNA. Translation: CAI22000.1.
AL031864 Genomic DNA. Translation: CAI22001.1.
AL031864 Genomic DNA. Translation: CAI22002.1.
BC006814 mRNA. Translation: AAH06814.1.
BC029083 mRNA. Translation: AAH29083.1.
CCDSiCCDS1299.1. [Q8N6R0-5]
CCDS1300.1. [Q8N6R0-3]
CCDS30936.1. [Q8N6R0-1]
RefSeqiNP_001007240.1. NM_001007239.1. [Q8N6R0-1]
NP_055770.1. NM_014955.2. [Q8N6R0-3]
NP_057019.3. NM_015935.4. [Q8N6R0-5]
UniGeneiHs.494705.

Genome annotation databases

EnsembliENST00000361735; ENSP00000354920; ENSG00000010165. [Q8N6R0-5]
ENST00000362019; ENSP00000355393; ENSG00000010165. [Q8N6R0-3]
ENST00000367737; ENSP00000356711; ENSG00000010165. [Q8N6R0-1]
GeneIDi51603.
KEGGihsa:51603.
UCSCiuc001ghz.3. human. [Q8N6R0-5]
uc001gib.3. human. [Q8N6R0-1]

Polymorphism databases

DMDMi67461056.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL049669 mRNA. Translation: CAB41243.1 .
AB020666 mRNA. Translation: BAA74882.2 . Different initiation.
AF132936 mRNA. Translation: AAD27711.1 .
AK027621 mRNA. Translation: BAB55240.1 .
AK074552 mRNA. Translation: BAC11055.1 .
AK291740 mRNA. Translation: BAF84429.1 .
AK223493 mRNA. Translation: BAD97213.1 . Different initiation.
AL031864 Genomic DNA. Translation: CAI22003.1 .
AL031864 Genomic DNA. Translation: CAI22000.1 .
AL031864 Genomic DNA. Translation: CAI22001.1 .
AL031864 Genomic DNA. Translation: CAI22002.1 .
BC006814 mRNA. Translation: AAH06814.1 .
BC029083 mRNA. Translation: AAH29083.1 .
CCDSi CCDS1299.1. [Q8N6R0-5 ]
CCDS1300.1. [Q8N6R0-3 ]
CCDS30936.1. [Q8N6R0-1 ]
RefSeqi NP_001007240.1. NM_001007239.1. [Q8N6R0-1 ]
NP_055770.1. NM_014955.2. [Q8N6R0-3 ]
NP_057019.3. NM_015935.4. [Q8N6R0-5 ]
UniGenei Hs.494705.

3D structure databases

ProteinModelPortali Q8N6R0.
SMRi Q8N6R0. Positions 11-182, 474-610.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119632. 4 interactions.
IntActi Q8N6R0. 2 interactions.
MINTi MINT-3086086.

PTM databases

PhosphoSitei Q8N6R0.

Polymorphism databases

DMDMi 67461056.

Proteomic databases

MaxQBi Q8N6R0.
PaxDbi Q8N6R0.
PRIDEi Q8N6R0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000361735 ; ENSP00000354920 ; ENSG00000010165 . [Q8N6R0-5 ]
ENST00000362019 ; ENSP00000355393 ; ENSG00000010165 . [Q8N6R0-3 ]
ENST00000367737 ; ENSP00000356711 ; ENSG00000010165 . [Q8N6R0-1 ]
GeneIDi 51603.
KEGGi hsa:51603.
UCSCi uc001ghz.3. human. [Q8N6R0-5 ]
uc001gib.3. human. [Q8N6R0-1 ]

Organism-specific databases

CTDi 51603.
GeneCardsi GC01P171750.
HGNCi HGNC:24248. METTL13.
HPAi HPA044498.
neXtProti NX_Q8N6R0.
PharmGKBi PA164722256.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG331905.
InParanoidi Q8N6R0.
OMAi HPEQKLA.
OrthoDBi EOG72C4ZT.
PhylomeDBi Q8N6R0.
TreeFami TF105906.

Miscellaneous databases

GeneWikii KIAA0859.
GenomeRNAii 51603.
NextBioi 55482.
PROi Q8N6R0.

Gene expression databases

ArrayExpressi Q8N6R0.
Bgeei Q8N6R0.
CleanExi HS_KIAA0859.
Genevestigatori Q8N6R0.

Family and domain databases

Gene3Di 3.40.50.150. 3 hits.
InterProi IPR013216. Methyltransf_11.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF08241. Methyltransf_11. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 3 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Rhodes S.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
  2. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  4. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 5), VARIANT VAL-105.
    Tissue: Embryo, Placenta and Teratocarcinoma.
  6. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  7. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta and Testis.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-267, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: VARIANT CYS-16.

Entry informationi

Entry nameiMET13_HUMAN
AccessioniPrimary (citable) accession number: Q8N6R0
Secondary accession number(s): A6NFK0
, A8K6S5, O94940, Q53EZ6, Q5TGP9, Q5TGQ0, Q8N2P8, Q96J11, Q96SQ0, Q9Y2Z1, Q9Y3M6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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