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Protein

Methyltransferase-like protein 13

Gene

METTL13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Methyltransferase-like protein 13 (EC:2.1.1.-)
Gene namesi
Name:METTL13
Synonyms:KIAA0859
ORF Names:CGI-01
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:24248. METTL13.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164722256.

Polymorphism and mutation databases

BioMutaiMETTL13.
DMDMi67461056.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 699699Methyltransferase-like protein 13PRO_0000050779Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei267 – 2671Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8N6R0.
PaxDbiQ8N6R0.
PRIDEiQ8N6R0.

PTM databases

PhosphoSiteiQ8N6R0.

Expressioni

Gene expression databases

BgeeiQ8N6R0.
CleanExiHS_KIAA0859.
ExpressionAtlasiQ8N6R0. baseline and differential.
GenevisibleiQ8N6R0. HS.

Organism-specific databases

HPAiHPA044498.
HPA053705.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SNRPAP090123EBI-1053295,EBI-607085
VPS52Q8N1B43EBI-1053295,EBI-2799833

Protein-protein interaction databases

BioGridi119632. 12 interactions.
IntActiQ8N6R0. 4 interactions.
MINTiMINT-3086086.
STRINGi9606.ENSP00000354920.

Structurei

3D structure databases

ProteinModelPortaliQ8N6R0.
SMRiQ8N6R0. Positions 11-182, 474-610.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily.Curated

Phylogenomic databases

eggNOGiNOG331905.
GeneTreeiENSGT00510000047399.
InParanoidiQ8N6R0.
OMAiGEKAFEW.
OrthoDBiEOG72C4ZT.
PhylomeDBiQ8N6R0.
TreeFamiTF105906.

Family and domain databases

Gene3Di3.40.50.150. 3 hits.
InterProiIPR013216. Methyltransf_11.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF08241. Methyltransf_11. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 3 hits.

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N6R0-5) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNLLPKSSRE FGSVDYWEKF FQQRGKKAFE WYGTYLELCG VLHKYIKPRE
60 70 80 90 100
KVLVIGCGNS ELSEQLYDVG YRDIVNIDIS EVVIKQMKEC NATRRPQMSF
110 120 130 140 150
LKMDMTQMEF PDASFQVVLD KGTLDAVLTD EEEKTLQQVD RMLAEVGRVL
160 170 180 190 200
QVGGRYLCIS LAQAHILKKA VGHFSREGWM VRVHQVANSQ DQVLEAEPQF
210 220 230 240 250
SLPVFAFIMT KFRPVPGSAL QIFELCAQEQ RKPVRLESAE RLAEAVQERQ
260 270 280 290 300
QYAWLCSQLR RKARLGSVSL DLCDGDTGEP RYTLHVVDSP TVKPSRDNHF
310 320 330 340 350
AIFIIPQGRE TEWLFGMDEG RKQLAASAGF RRLITVALHR GQQYESMDHI
360 370 380 390 400
QAELSARVME LAPAGMPTQQ QVPFLSVGGD IGVRTVQHQD CSPLSGDYVI
410 420 430 440 450
EDVQGDDKRY FRRLIFLSNR NVVQSEARLL KDVSHKAQKK RKKDRKKQRP
460 470 480 490 500
ADAEDLPAAP GQSIDKSYLC CEHHKAMIAG LALLRNPELL LEIPLALLVV
510 520 530 540 550
GLGGGSLPLF VHDHFPKSCI DAVEIDPSML EVATQWFGFS QSDRMKVHIA
560 570 580 590 600
DGLDYIASLA GGGEARPCYD VIMFDVDSKD PTLGMSCPPP AFVEQSFLQK
610 620 630 640 650
VKSILTPEGV FILNLVCRDL GLKDSVLAGL KAVFPLLYVR RIEGEVNEIL
660 670 680 690
FCQLHPEQKL ATPELLETAQ ALERTLRKPG RGWDDTYVLS DMLKTVKIV
Length:699
Mass (Da):78,768
Last modified:October 1, 2002 - v1
Checksum:i14F80A4570047DBB
GO
Isoform 2 (identifier: Q8N6R0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     643-699: Missing.

Show »
Length:642
Mass (Da):72,261
Checksum:iFBE06982F6BB67ED
GO
Isoform 3 (identifier: Q8N6R0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-86: Missing.

Show »
Length:613
Mass (Da):68,689
Checksum:iC8C2BA279A1338B9
GO
Isoform 4 (identifier: Q8N6R0-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     151-306: Missing.

Show »
Length:543
Mass (Da):61,128
Checksum:i06ECF4AFB8593785
GO
Isoform 5 (identifier: Q8N6R0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-86: Missing.
     289-505: Missing.

Show »
Length:396
Mass (Da):44,563
Checksum:iEB58F63A983893C8
GO

Sequence cautioni

The sequence BAA74882.2 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAD97213.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti115 – 1151F → L in BAD97213 (Ref. 6) Curated
Sequence conflicti498 – 4981L → S in BAD97213 (Ref. 6) Curated
Sequence conflicti514 – 5141H → Q in BAB55240 (PubMed:14702039).Curated
Sequence conflicti534 – 5341T → F in BAC11055 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti16 – 161Y → C Found in a renal cell carcinoma sample; somatic mutation. 1 Publication
VAR_064730
Natural varianti105 – 1051M → V.1 Publication
Corresponds to variant rs2232816 [ dbSNP | Ensembl ].
VAR_034040
Natural varianti359 – 3591M → I.
Corresponds to variant rs2232819 [ dbSNP | Ensembl ].
VAR_034041

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8686Missing in isoform 3 and isoform 5. 1 PublicationVSP_013919Add
BLAST
Alternative sequencei151 – 306156Missing in isoform 4. 1 PublicationVSP_013920Add
BLAST
Alternative sequencei289 – 505217Missing in isoform 5. 1 PublicationVSP_013921Add
BLAST
Alternative sequencei643 – 69957Missing in isoform 2. 1 PublicationVSP_013922Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049669 mRNA. Translation: CAB41243.1.
AB020666 mRNA. Translation: BAA74882.2. Different initiation.
AF132936 mRNA. Translation: AAD27711.1.
AK027621 mRNA. Translation: BAB55240.1.
AK074552 mRNA. Translation: BAC11055.1.
AK291740 mRNA. Translation: BAF84429.1.
AK223493 mRNA. Translation: BAD97213.1. Different initiation.
AL031864 Genomic DNA. Translation: CAI22003.1.
AL031864 Genomic DNA. Translation: CAI22000.1.
AL031864 Genomic DNA. Translation: CAI22001.1.
AL031864 Genomic DNA. Translation: CAI22002.1.
BC006814 mRNA. Translation: AAH06814.1.
BC029083 mRNA. Translation: AAH29083.1.
CCDSiCCDS1299.1. [Q8N6R0-5]
CCDS1300.1. [Q8N6R0-3]
CCDS30936.1. [Q8N6R0-1]
RefSeqiNP_001007240.1. NM_001007239.1. [Q8N6R0-1]
NP_055770.1. NM_014955.2. [Q8N6R0-3]
NP_057019.3. NM_015935.4. [Q8N6R0-5]
UniGeneiHs.494705.

Genome annotation databases

EnsembliENST00000361735; ENSP00000354920; ENSG00000010165.
ENST00000362019; ENSP00000355393; ENSG00000010165. [Q8N6R0-3]
ENST00000367737; ENSP00000356711; ENSG00000010165. [Q8N6R0-1]
GeneIDi51603.
KEGGihsa:51603.
UCSCiuc001ghz.3. human. [Q8N6R0-5]
uc001gib.3. human. [Q8N6R0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049669 mRNA. Translation: CAB41243.1.
AB020666 mRNA. Translation: BAA74882.2. Different initiation.
AF132936 mRNA. Translation: AAD27711.1.
AK027621 mRNA. Translation: BAB55240.1.
AK074552 mRNA. Translation: BAC11055.1.
AK291740 mRNA. Translation: BAF84429.1.
AK223493 mRNA. Translation: BAD97213.1. Different initiation.
AL031864 Genomic DNA. Translation: CAI22003.1.
AL031864 Genomic DNA. Translation: CAI22000.1.
AL031864 Genomic DNA. Translation: CAI22001.1.
AL031864 Genomic DNA. Translation: CAI22002.1.
BC006814 mRNA. Translation: AAH06814.1.
BC029083 mRNA. Translation: AAH29083.1.
CCDSiCCDS1299.1. [Q8N6R0-5]
CCDS1300.1. [Q8N6R0-3]
CCDS30936.1. [Q8N6R0-1]
RefSeqiNP_001007240.1. NM_001007239.1. [Q8N6R0-1]
NP_055770.1. NM_014955.2. [Q8N6R0-3]
NP_057019.3. NM_015935.4. [Q8N6R0-5]
UniGeneiHs.494705.

3D structure databases

ProteinModelPortaliQ8N6R0.
SMRiQ8N6R0. Positions 11-182, 474-610.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119632. 12 interactions.
IntActiQ8N6R0. 4 interactions.
MINTiMINT-3086086.
STRINGi9606.ENSP00000354920.

PTM databases

PhosphoSiteiQ8N6R0.

Polymorphism and mutation databases

BioMutaiMETTL13.
DMDMi67461056.

Proteomic databases

MaxQBiQ8N6R0.
PaxDbiQ8N6R0.
PRIDEiQ8N6R0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361735; ENSP00000354920; ENSG00000010165.
ENST00000362019; ENSP00000355393; ENSG00000010165. [Q8N6R0-3]
ENST00000367737; ENSP00000356711; ENSG00000010165. [Q8N6R0-1]
GeneIDi51603.
KEGGihsa:51603.
UCSCiuc001ghz.3. human. [Q8N6R0-5]
uc001gib.3. human. [Q8N6R0-1]

Organism-specific databases

CTDi51603.
GeneCardsiGC01P171750.
HGNCiHGNC:24248. METTL13.
HPAiHPA044498.
HPA053705.
neXtProtiNX_Q8N6R0.
PharmGKBiPA164722256.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG331905.
GeneTreeiENSGT00510000047399.
InParanoidiQ8N6R0.
OMAiGEKAFEW.
OrthoDBiEOG72C4ZT.
PhylomeDBiQ8N6R0.
TreeFamiTF105906.

Miscellaneous databases

GeneWikiiKIAA0859.
GenomeRNAii51603.
NextBioi55482.
PROiQ8N6R0.

Gene expression databases

BgeeiQ8N6R0.
CleanExiHS_KIAA0859.
ExpressionAtlasiQ8N6R0. baseline and differential.
GenevisibleiQ8N6R0. HS.

Family and domain databases

Gene3Di3.40.50.150. 3 hits.
InterProiIPR013216. Methyltransf_11.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF08241. Methyltransf_11. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 3 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Rhodes S.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
  2. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  4. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 5), VARIANT VAL-105.
    Tissue: Embryo, Placenta and Teratocarcinoma.
  6. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  7. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta and Testis.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-267, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  13. Cited for: VARIANT CYS-16.

Entry informationi

Entry nameiMET13_HUMAN
AccessioniPrimary (citable) accession number: Q8N6R0
Secondary accession number(s): A6NFK0
, A8K6S5, O94940, Q53EZ6, Q5TGP9, Q5TGQ0, Q8N2P8, Q96J11, Q96SQ0, Q9Y2Z1, Q9Y3M6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 1, 2002
Last modified: July 22, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.