Q8N6R0 (MET13_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 91.
History...
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Methyltransferase-like protein 13 EC=2.1.1.- | ||||||
| Gene names |
| ||||||
| Organism | Homo sapiens (Human) [Reference proteome] | ||||||
| Taxonomic identifier | 9606 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo![]() |
Protein attributes
| Sequence length | 699 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Sequence similarities | Belongs to the methyltransferase superfamily. |
| Sequence caution | The sequence BAA74882.2 differs from that shown. Reason: Erroneous initiation. The sequence BAD97213.1 differs from that shown. Reason: Erroneous initiation. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Alternative splicing Polymorphism |
| Molecular function | Methyltransferase Transferase |
| PTM | Phosphoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Molecular_function | methyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Alternative products
| This entry describes 5 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q8N6R0-5) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q8N6R0-4) The sequence of this isoform differs from the canonical sequence as follows: 643-699: Missing. | ||||||
| Isoform 3 (identifier: Q8N6R0-3) The sequence of this isoform differs from the canonical sequence as follows: 1-86: Missing. | ||||||
| Isoform 4 (identifier: Q8N6R0-1) The sequence of this isoform differs from the canonical sequence as follows: 151-306: Missing. | ||||||
| Isoform 5 (identifier: Q8N6R0-2) The sequence of this isoform differs from the canonical sequence as follows: 1-86: Missing. 289-505: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 699 | 699 | Methyltransferase-like protein 13 | PRO_0000050779 | |||||
Amino acid modifications | |||||||||
| Modified residue | 267 | 1 | Phosphoserine Ref.9 | ||||||
Natural variations | |||||||||
| Alternative sequence | 1 – 86 | 86 | Missing in isoform 3 and isoform 5. | VSP_013919 | |||||
| Alternative sequence | 151 – 306 | 156 | Missing in isoform 4. | VSP_013920 | |||||
| Alternative sequence | 289 – 505 | 217 | Missing in isoform 5. | VSP_013921 | |||||
| Alternative sequence | 643 – 699 | 57 | Missing in isoform 2. | VSP_013922 | |||||
| Natural variant | 16 | 1 | Y → C Found in a renal cell carcinoma sample; somatic mutation. Ref.11 | VAR_064730 | |||||
| Natural variant | 105 | 1 | M → V. Ref.5 Corresponds to variant rs2232816 [ dbSNP | Ensembl ]. | VAR_034040 | |||||
| Natural variant | 359 | 1 | M → I. Corresponds to variant rs2232819 [ dbSNP | Ensembl ]. | VAR_034041 | |||||
Experimental info | |||||||||
| Sequence conflict | 115 | 1 | F → L in BAD97213. Ref.6 | ||||||
| Sequence conflict | 498 | 1 | L → S in BAD97213. Ref.6 | ||||||
| Sequence conflict | 514 | 1 | H → Q in BAB55240. Ref.5 | ||||||
| Sequence conflict | 534 | 1 | T → F in BAC11055. Ref.5 | ||||||
Sequences
| ||||||||||||||||||||||||||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | Rhodes S. Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). |
| [2] | "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain. |
| [3] | "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION. |
| [4] | "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics." Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C. Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). |
| [5] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 5), VARIANT VAL-105. Tissue: Embryo, Placenta and Teratocarcinoma. |
| [6] | Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). |
| [7] | "The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. Bentley D.R.Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [8] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Placenta and Testis. |
| [9] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-267, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [10] | "Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. |
| [11] | "Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma." Varela I., Tarpey P., Raine K., Huang D., Ong C.K., Stephens P., Davies H., Jones D., Lin M.L., Teague J., Bignell G., Butler A., Cho J., Dalgliesh G.L., Galappaththige D., Greenman C., Hardy C., Jia M. Futreal P.A.Nature 469:539-542(2011) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT CYS-16. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AL049669 mRNA. Translation: CAB41243.1. AB020666 mRNA. Translation: BAA74882.2. Different initiation. AF132936 mRNA. Translation: AAD27711.1. AK027621 mRNA. Translation: BAB55240.1. AK074552 mRNA. Translation: BAC11055.1. AK291740 mRNA. Translation: BAF84429.1. AK223493 mRNA. Translation: BAD97213.1. Different initiation. AL031864 Genomic DNA. Translation: CAI22003.1. AL031864 Genomic DNA. Translation: CAI22000.1. AL031864 Genomic DNA. Translation: CAI22001.1. AL031864 Genomic DNA. Translation: CAI22002.1. BC006814 mRNA. Translation: AAH06814.1. BC029083 mRNA. Translation: AAH29083.1. |
| IPI | IPI00384061. IPI00409639. IPI00479432. IPI00514340. IPI00604631. |
| RefSeq | NP_001007240.1. NM_001007239.1. NP_055770.1. NM_014955.2. NP_057019.3. NM_015935.4. |
| UniGene | Hs.494705. |
3D structure databases | |
| ProteinModelPortal | Q8N6R0. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q8N6R0. |
Polymorphism databases | |
| DMDM | 67461056. |
Proteomic databases | |
| PaxDb | Q8N6R0. |
| PRIDE | Q8N6R0. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000361735; ENSP00000354920; ENSG00000010165. ENST00000362019; ENSP00000355393; ENSG00000010165. ENST00000367737; ENSP00000356711; ENSG00000010165. |
| GeneID | 51603. |
| KEGG | hsa:51603. |
| UCSC | uc001ghz.3. human. uc001gib.3. human. |
Organism-specific databases | |
| CTD | 51603. |
| GeneCards | GC01P171750. |
| HGNC | HGNC:24248. METTL13. |
| HPA | HPA044498. |
| neXtProt | NX_Q8N6R0. |
| PharmGKB | PA164722256. |
| HUGE | Search... |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | NOG331905. |
| InParanoid | Q8N6R0. |
| OMA | HPEQKLA. |
Gene expression databases | |
| ArrayExpress | Q8N6R0. |
| Bgee | Q8N6R0. |
| CleanEx | HS_KIAA0859. |
| Genevestigator | Q8N6R0. |
| GermOnline | ENSG00000010165. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR013216. Methyltransf_11. [Graphical view] |
| Pfam | PF08241. Methyltransf_11. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| GenomeRNAi | 51603. |
| NextBio | 55482. |
Entry information
| Entry name | MET13_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q8N6R0 Secondary accession number(s): A6NFK0 Q9Y3M6 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 1 Human chromosome 1: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| SIMILARITY comments Index of protein domains and families |

Clusters with
