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Protein

Methyltransferase-like protein 13

Gene

METTL13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Methyltransferase-like protein 13 (EC:2.1.1.-)
Gene namesi
Name:METTL13
Synonyms:KIAA0859
ORF Names:CGI-01
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000010165.19.
HGNCiHGNC:24248. METTL13.

Pathology & Biotechi

Organism-specific databases

DisGeNETi51603.
OpenTargetsiENSG00000010165.
PharmGKBiPA164722256.

Polymorphism and mutation databases

BioMutaiMETTL13.
DMDMi67461056.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000507791 – 699Methyltransferase-like protein 13Add BLAST699

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei267PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8N6R0.
PaxDbiQ8N6R0.
PeptideAtlasiQ8N6R0.
PRIDEiQ8N6R0.

PTM databases

iPTMnetiQ8N6R0.
PhosphoSitePlusiQ8N6R0.

Expressioni

Gene expression databases

BgeeiENSG00000010165.
CleanExiHS_KIAA0859.
ExpressionAtlasiQ8N6R0. baseline and differential.
GenevisibleiQ8N6R0. HS.

Organism-specific databases

HPAiHPA044498.
HPA053705.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi119632. 30 interactors.
IntActiQ8N6R0. 8 interactors.
MINTiMINT-3086086.
STRINGi9606.ENSP00000354920.

Structurei

3D structure databases

ProteinModelPortaliQ8N6R0.
SMRiQ8N6R0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily.Curated

Phylogenomic databases

eggNOGiKOG2352. Eukaryota.
ENOG410XNZZ. LUCA.
GeneTreeiENSGT00510000047399.
InParanoidiQ8N6R0.
OMAiYLACQHH.
OrthoDBiEOG091G040D.
PhylomeDBiQ8N6R0.
TreeFamiTF105906.

Family and domain databases

InterProiView protein in InterPro
IPR013216. Methyltransf_11.
IPR029063. SAM-dependent_MTases.
PfamiView protein in Pfam
PF08241. Methyltransf_11. 1 hit.
SUPFAMiSSF53335. SSF53335. 3 hits.

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N6R0-5) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNLLPKSSRE FGSVDYWEKF FQQRGKKAFE WYGTYLELCG VLHKYIKPRE
60 70 80 90 100
KVLVIGCGNS ELSEQLYDVG YRDIVNIDIS EVVIKQMKEC NATRRPQMSF
110 120 130 140 150
LKMDMTQMEF PDASFQVVLD KGTLDAVLTD EEEKTLQQVD RMLAEVGRVL
160 170 180 190 200
QVGGRYLCIS LAQAHILKKA VGHFSREGWM VRVHQVANSQ DQVLEAEPQF
210 220 230 240 250
SLPVFAFIMT KFRPVPGSAL QIFELCAQEQ RKPVRLESAE RLAEAVQERQ
260 270 280 290 300
QYAWLCSQLR RKARLGSVSL DLCDGDTGEP RYTLHVVDSP TVKPSRDNHF
310 320 330 340 350
AIFIIPQGRE TEWLFGMDEG RKQLAASAGF RRLITVALHR GQQYESMDHI
360 370 380 390 400
QAELSARVME LAPAGMPTQQ QVPFLSVGGD IGVRTVQHQD CSPLSGDYVI
410 420 430 440 450
EDVQGDDKRY FRRLIFLSNR NVVQSEARLL KDVSHKAQKK RKKDRKKQRP
460 470 480 490 500
ADAEDLPAAP GQSIDKSYLC CEHHKAMIAG LALLRNPELL LEIPLALLVV
510 520 530 540 550
GLGGGSLPLF VHDHFPKSCI DAVEIDPSML EVATQWFGFS QSDRMKVHIA
560 570 580 590 600
DGLDYIASLA GGGEARPCYD VIMFDVDSKD PTLGMSCPPP AFVEQSFLQK
610 620 630 640 650
VKSILTPEGV FILNLVCRDL GLKDSVLAGL KAVFPLLYVR RIEGEVNEIL
660 670 680 690
FCQLHPEQKL ATPELLETAQ ALERTLRKPG RGWDDTYVLS DMLKTVKIV
Length:699
Mass (Da):78,768
Last modified:October 1, 2002 - v1
Checksum:i14F80A4570047DBB
GO
Isoform 2 (identifier: Q8N6R0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     643-699: Missing.

Show »
Length:642
Mass (Da):72,261
Checksum:iFBE06982F6BB67ED
GO
Isoform 3 (identifier: Q8N6R0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-86: Missing.

Show »
Length:613
Mass (Da):68,689
Checksum:iC8C2BA279A1338B9
GO
Isoform 4 (identifier: Q8N6R0-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     151-306: Missing.

Show »
Length:543
Mass (Da):61,128
Checksum:i06ECF4AFB8593785
GO
Isoform 5 (identifier: Q8N6R0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-86: Missing.
     289-505: Missing.

Show »
Length:396
Mass (Da):44,563
Checksum:iEB58F63A983893C8
GO

Sequence cautioni

The sequence BAA74882 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD97213 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti115F → L in BAD97213 (Ref. 6) Curated1
Sequence conflicti498L → S in BAD97213 (Ref. 6) Curated1
Sequence conflicti514H → Q in BAB55240 (PubMed:14702039).Curated1
Sequence conflicti534T → F in BAC11055 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06473016Y → C Found in a renal cell carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs774565178Ensembl.1
Natural variantiVAR_034040105M → V1 PublicationCorresponds to variant dbSNP:rs2232816Ensembl.1
Natural variantiVAR_034041359M → I. Corresponds to variant dbSNP:rs2232819Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0139191 – 86Missing in isoform 3 and isoform 5. 1 PublicationAdd BLAST86
Alternative sequenceiVSP_013920151 – 306Missing in isoform 4. 1 PublicationAdd BLAST156
Alternative sequenceiVSP_013921289 – 505Missing in isoform 5. 1 PublicationAdd BLAST217
Alternative sequenceiVSP_013922643 – 699Missing in isoform 2. 1 PublicationAdd BLAST57

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049669 mRNA. Translation: CAB41243.1.
AB020666 mRNA. Translation: BAA74882.2. Different initiation.
AF132936 mRNA. Translation: AAD27711.1.
AK027621 mRNA. Translation: BAB55240.1.
AK074552 mRNA. Translation: BAC11055.1.
AK291740 mRNA. Translation: BAF84429.1.
AK223493 mRNA. Translation: BAD97213.1. Different initiation.
AL031864 Genomic DNA. Translation: CAI22003.1.
AL031864 Genomic DNA. Translation: CAI22000.1.
AL031864 Genomic DNA. Translation: CAI22001.1.
AL031864 Genomic DNA. Translation: CAI22002.1.
BC006814 mRNA. Translation: AAH06814.1.
BC029083 mRNA. Translation: AAH29083.1.
CCDSiCCDS1299.1. [Q8N6R0-5]
CCDS1300.1. [Q8N6R0-3]
CCDS30936.1. [Q8N6R0-1]
RefSeqiNP_001007240.1. NM_001007239.1. [Q8N6R0-1]
NP_055770.1. NM_014955.2. [Q8N6R0-3]
NP_057019.3. NM_015935.4. [Q8N6R0-5]
UniGeneiHs.494705.

Genome annotation databases

EnsembliENST00000361735; ENSP00000354920; ENSG00000010165. [Q8N6R0-5]
ENST00000362019; ENSP00000355393; ENSG00000010165. [Q8N6R0-3]
ENST00000367737; ENSP00000356711; ENSG00000010165. [Q8N6R0-1]
GeneIDi51603.
KEGGihsa:51603.
UCSCiuc001ghz.4. human. [Q8N6R0-5]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMET13_HUMAN
AccessioniPrimary (citable) accession number: Q8N6R0
Secondary accession number(s): A6NFK0
, A8K6S5, O94940, Q53EZ6, Q5TGP9, Q5TGQ0, Q8N2P8, Q96J11, Q96SQ0, Q9Y2Z1, Q9Y3M6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 1, 2002
Last modified: September 27, 2017
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families