ID   MET25_HUMAN             Reviewed;         603 AA.
AC   Q8N6Q8; Q9H5Y3;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-JAN-2011, sequence version 2.
DT   27-MAR-2024, entry version 141.
DE   RecName: Full=Probable methyltransferase-like protein 25 {ECO:0000305};
DE            EC=2.1.1.- {ECO:0000305};
GN   Name=METTL25; Synonyms=C12orf26;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16541075; DOI=10.1038/nature04569;
RA   Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA   Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA   Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA   Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA   Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA   Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA   Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA   Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA   Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA   Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA   Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA   Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA   Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA   Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA   Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA   Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA   Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA   David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA   D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA   Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA   Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA   Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA   LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA   Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA   Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA   Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA   Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA   Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA   Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA   Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA   Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA   Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA   Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA   Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA   Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA   Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA   Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA   Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA   Gibbs R.A.;
RT   "The finished DNA sequence of human chromosome 12.";
RL   Nature 440:346-351(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LYS-249.
RC   TISSUE=Colon;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-240.
RC   TISSUE=Ileal mucosa;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
CC   -!- FUNCTION: Probable methyltransferase. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB15484.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR   EMBL; AC083811; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC089998; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC029120; AAH29120.1; -; mRNA.
DR   EMBL; AK026442; BAB15484.1; ALT_SEQ; mRNA.
DR   CCDS; CCDS9024.1; -.
DR   RefSeq; NP_001306604.1; NM_001319675.1.
DR   RefSeq; NP_001334863.1; NM_001347934.1.
DR   RefSeq; NP_115606.2; NM_032230.2.
DR   AlphaFoldDB; Q8N6Q8; -.
DR   BioGRID; 123938; 9.
DR   IntAct; Q8N6Q8; 5.
DR   STRING; 9606.ENSP00000248306; -.
DR   iPTMnet; Q8N6Q8; -.
DR   PhosphoSitePlus; Q8N6Q8; -.
DR   BioMuta; METTL25; -.
DR   DMDM; 317373346; -.
DR   EPD; Q8N6Q8; -.
DR   jPOST; Q8N6Q8; -.
DR   MassIVE; Q8N6Q8; -.
DR   MaxQB; Q8N6Q8; -.
DR   PaxDb; 9606-ENSP00000248306; -.
DR   PeptideAtlas; Q8N6Q8; -.
DR   ProteomicsDB; 72215; -.
DR   Pumba; Q8N6Q8; -.
DR   Antibodypedia; 51966; 104 antibodies from 12 providers.
DR   DNASU; 84190; -.
DR   Ensembl; ENST00000248306.8; ENSP00000248306.3; ENSG00000127720.8.
DR   GeneID; 84190; -.
DR   KEGG; hsa:84190; -.
DR   MANE-Select; ENST00000248306.8; ENSP00000248306.3; NM_032230.3; NP_115606.2.
DR   UCSC; uc001szq.4; human.
DR   AGR; HGNC:26228; -.
DR   CTD; 84190; -.
DR   DisGeNET; 84190; -.
DR   GeneCards; METTL25; -.
DR   HGNC; HGNC:26228; METTL25.
DR   HPA; ENSG00000127720; Low tissue specificity.
DR   neXtProt; NX_Q8N6Q8; -.
DR   OpenTargets; ENSG00000127720; -.
DR   PharmGKB; PA142672297; -.
DR   VEuPathDB; HostDB:ENSG00000127720; -.
DR   eggNOG; KOG2651; Eukaryota.
DR   GeneTree; ENSGT00530000063745; -.
DR   HOGENOM; CLU_016581_2_0_1; -.
DR   InParanoid; Q8N6Q8; -.
DR   OMA; CCYHLLR; -.
DR   OrthoDB; 3060170at2759; -.
DR   PhylomeDB; Q8N6Q8; -.
DR   TreeFam; TF312998; -.
DR   PathwayCommons; Q8N6Q8; -.
DR   SignaLink; Q8N6Q8; -.
DR   BioGRID-ORCS; 84190; 20 hits in 1149 CRISPR screens.
DR   ChiTaRS; METTL25; human.
DR   GenomeRNAi; 84190; -.
DR   Pharos; Q8N6Q8; Tdark.
DR   PRO; PR:Q8N6Q8; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; Q8N6Q8; Protein.
DR   Bgee; ENSG00000127720; Expressed in germinal epithelium of ovary and 182 other cell types or tissues.
DR   ExpressionAtlas; Q8N6Q8; baseline and differential.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR025714; Methyltranfer_dom.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR12496; CGI-41 METHYLTRANSFERASE; 1.
DR   PANTHER; PTHR12496:SF9; METHYLTRANSFERASE-LIKE PROTEIN 25-RELATED; 1.
DR   Pfam; PF13679; Methyltransf_32; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   Genevisible; Q8N6Q8; HS.
PE   2: Evidence at transcript level;
KW   Methyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..603
FT                   /note="Probable methyltransferase-like protein 25"
FT                   /id="PRO_0000252148"
FT   REGION          326..352
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         249
FT                   /note="Q -> K (in dbSNP:rs4296098)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_027779"
FT   CONFLICT        85
FT                   /note="E -> V (in Ref. 3; BAB15484)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        152
FT                   /note="N -> S (in Ref. 3; BAB15484)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   603 AA;  68213 MW;  A2D2C51ABEBF8668 CRC64;
     MAASCPLPVT PDLPTLRAKL QGLLQFLRDA LSISNAHTVD FYTESVWEEL VDLPPETVLA
     ALRKSASETE ALPSETRPLV EAEWEAGMTD FPKIFCETSQ KLVSVEAFAL AAKYYSVQNL
     GICTPFEQLL VALRGNQNQR IGENQKAVEF MNMKKSHEVQ AMSELISSIA DYYGIKQVID
     LGSGKGYLSS FLSLKYGLKV YGIDSSNTNT HGAEERNRKL KKHWKLCHAQ SRLDVNGLAL
     KMAKERKVQN KVKNKADTEE VFNNSPTNQE KMPTSAILPD FSGSVISNIR NQMETLHSQP
     HQEENLCFEN SFSLINLLPI NAVEPTSSQQ IPNRETSEAN KERRKMTSKS SESNIYSPLT
     SFITADSELH DIIKDLEDCL MVGLHTCGDL APNTLRIFTS NSEIKGVCSV GCCYHLLSEE
     FENQHKERTQ EKWGFPMCHY LKEERWCCGR NARMSACLAL ERVAAGQGLP TESLFYRAVL
     QDIIKDCYGI TKCDRHVGKI YSKCSSFLDY VRRSLKKLGL DESKLPEKII MNYYEKYKPR
     MNELEAFNML KVVLAPCIET LILLDRLCYL KEQEDIAWSA LVKLFDPVKS PRCYAVIALK
     KQQ
//