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Q8N6Q8

- MET25_HUMAN

UniProt

Q8N6Q8 - MET25_HUMAN

Protein

Methyltransferase-like protein 25

Gene

METTL25

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 2 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Putative methyltransferase.By similarity

    GO - Molecular functioni

    1. methyltransferase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methyltransferase-like protein 25 (EC:2.1.1.-)
    Gene namesi
    Name:METTL25
    Synonyms:C12orf26
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:26228. METTL25.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672297.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 603603Methyltransferase-like protein 25PRO_0000252148Add
    BLAST

    Proteomic databases

    MaxQBiQ8N6Q8.
    PaxDbiQ8N6Q8.
    PRIDEiQ8N6Q8.

    PTM databases

    PhosphoSiteiQ8N6Q8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8N6Q8.
    BgeeiQ8N6Q8.
    CleanExiHS_C12orf26.
    GenevestigatoriQ8N6Q8.

    Organism-specific databases

    HPAiHPA039534.
    HPA041207.

    Interactioni

    Protein-protein interaction databases

    BioGridi123938. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N6Q8.
    SMRiQ8N6Q8. Positions 175-217.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG313369.
    HOGENOMiHOG000054213.
    HOVERGENiHBG057610.
    InParanoidiQ8N6Q8.
    OMAiTNTHGAQ.
    OrthoDBiEOG7TBC1S.
    PhylomeDBiQ8N6Q8.
    TreeFamiTF312998.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR025714. Methyltranfer_dom.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF13679. Methyltransf_32. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8N6Q8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAASCPLPVT PDLPTLRAKL QGLLQFLRDA LSISNAHTVD FYTESVWEEL    50
    VDLPPETVLA ALRKSASETE ALPSETRPLV EAEWEAGMTD FPKIFCETSQ 100
    KLVSVEAFAL AAKYYSVQNL GICTPFEQLL VALRGNQNQR IGENQKAVEF 150
    MNMKKSHEVQ AMSELISSIA DYYGIKQVID LGSGKGYLSS FLSLKYGLKV 200
    YGIDSSNTNT HGAEERNRKL KKHWKLCHAQ SRLDVNGLAL KMAKERKVQN 250
    KVKNKADTEE VFNNSPTNQE KMPTSAILPD FSGSVISNIR NQMETLHSQP 300
    HQEENLCFEN SFSLINLLPI NAVEPTSSQQ IPNRETSEAN KERRKMTSKS 350
    SESNIYSPLT SFITADSELH DIIKDLEDCL MVGLHTCGDL APNTLRIFTS 400
    NSEIKGVCSV GCCYHLLSEE FENQHKERTQ EKWGFPMCHY LKEERWCCGR 450
    NARMSACLAL ERVAAGQGLP TESLFYRAVL QDIIKDCYGI TKCDRHVGKI 500
    YSKCSSFLDY VRRSLKKLGL DESKLPEKII MNYYEKYKPR MNELEAFNML 550
    KVVLAPCIET LILLDRLCYL KEQEDIAWSA LVKLFDPVKS PRCYAVIALK 600
    KQQ 603
    Length:603
    Mass (Da):68,213
    Last modified:January 11, 2011 - v2
    Checksum:iA2D2C51ABEBF8668
    GO

    Sequence cautioni

    The sequence BAB15484.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti85 – 851E → V in BAB15484. (PubMed:14702039)Curated
    Sequence conflicti152 – 1521N → S in BAB15484. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti249 – 2491Q → K.1 Publication
    Corresponds to variant rs4296098 [ dbSNP | Ensembl ].
    VAR_027779

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC083811 Genomic DNA. No translation available.
    AC089998 Genomic DNA. No translation available.
    BC029120 mRNA. Translation: AAH29120.1.
    AK026442 mRNA. Translation: BAB15484.1. Sequence problems.
    CCDSiCCDS9024.1.
    RefSeqiNP_115606.2. NM_032230.2.
    UniGeneiHs.506222.

    Genome annotation databases

    EnsembliENST00000248306; ENSP00000248306; ENSG00000127720.
    GeneIDi84190.
    KEGGihsa:84190.
    UCSCiuc001szq.3. human.

    Polymorphism databases

    DMDMi317373346.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC083811 Genomic DNA. No translation available.
    AC089998 Genomic DNA. No translation available.
    BC029120 mRNA. Translation: AAH29120.1 .
    AK026442 mRNA. Translation: BAB15484.1 . Sequence problems.
    CCDSi CCDS9024.1.
    RefSeqi NP_115606.2. NM_032230.2.
    UniGenei Hs.506222.

    3D structure databases

    ProteinModelPortali Q8N6Q8.
    SMRi Q8N6Q8. Positions 175-217.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123938. 1 interaction.

    PTM databases

    PhosphoSitei Q8N6Q8.

    Polymorphism databases

    DMDMi 317373346.

    Proteomic databases

    MaxQBi Q8N6Q8.
    PaxDbi Q8N6Q8.
    PRIDEi Q8N6Q8.

    Protocols and materials databases

    DNASUi 84190.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000248306 ; ENSP00000248306 ; ENSG00000127720 .
    GeneIDi 84190.
    KEGGi hsa:84190.
    UCSCi uc001szq.3. human.

    Organism-specific databases

    CTDi 84190.
    GeneCardsi GC12P082754.
    HGNCi HGNC:26228. METTL25.
    HPAi HPA039534.
    HPA041207.
    neXtProti NX_Q8N6Q8.
    PharmGKBi PA142672297.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG313369.
    HOGENOMi HOG000054213.
    HOVERGENi HBG057610.
    InParanoidi Q8N6Q8.
    OMAi TNTHGAQ.
    OrthoDBi EOG7TBC1S.
    PhylomeDBi Q8N6Q8.
    TreeFami TF312998.

    Miscellaneous databases

    GenomeRNAii 84190.
    NextBioi 73582.

    Gene expression databases

    ArrayExpressi Q8N6Q8.
    Bgeei Q8N6Q8.
    CleanExi HS_C12orf26.
    Genevestigatori Q8N6Q8.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR025714. Methyltranfer_dom.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF13679. Methyltransf_32. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-249.
      Tissue: Colon.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-240.
      Tissue: Ileal mucosa.

    Entry informationi

    Entry nameiMET25_HUMAN
    AccessioniPrimary (citable) accession number: Q8N6Q8
    Secondary accession number(s): Q9H5Y3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 81 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations

    External Data

    Dasty 3