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Q8N6Q8 (MET25_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Methyltransferase-like protein 25

EC=2.1.1.-
Gene names
Name:METTL25
Synonyms:C12orf26
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length603 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Putative methyltransferase By similarity.

Sequence caution

The sequence BAB15484.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionmethyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 603603Methyltransferase-like protein 25
PRO_0000252148

Natural variations

Natural variant2491Q → K. Ref.2
Corresponds to variant rs4296098 [ dbSNP | Ensembl ].
VAR_027779

Experimental info

Sequence conflict851E → V in BAB15484. Ref.3
Sequence conflict1521N → S in BAB15484. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q8N6Q8 [UniParc].

Last modified January 11, 2011. Version 2.
Checksum: A2D2C51ABEBF8668

FASTA60368,213
        10         20         30         40         50         60 
MAASCPLPVT PDLPTLRAKL QGLLQFLRDA LSISNAHTVD FYTESVWEEL VDLPPETVLA 

        70         80         90        100        110        120 
ALRKSASETE ALPSETRPLV EAEWEAGMTD FPKIFCETSQ KLVSVEAFAL AAKYYSVQNL 

       130        140        150        160        170        180 
GICTPFEQLL VALRGNQNQR IGENQKAVEF MNMKKSHEVQ AMSELISSIA DYYGIKQVID 

       190        200        210        220        230        240 
LGSGKGYLSS FLSLKYGLKV YGIDSSNTNT HGAEERNRKL KKHWKLCHAQ SRLDVNGLAL 

       250        260        270        280        290        300 
KMAKERKVQN KVKNKADTEE VFNNSPTNQE KMPTSAILPD FSGSVISNIR NQMETLHSQP 

       310        320        330        340        350        360 
HQEENLCFEN SFSLINLLPI NAVEPTSSQQ IPNRETSEAN KERRKMTSKS SESNIYSPLT 

       370        380        390        400        410        420 
SFITADSELH DIIKDLEDCL MVGLHTCGDL APNTLRIFTS NSEIKGVCSV GCCYHLLSEE 

       430        440        450        460        470        480 
FENQHKERTQ EKWGFPMCHY LKEERWCCGR NARMSACLAL ERVAAGQGLP TESLFYRAVL 

       490        500        510        520        530        540 
QDIIKDCYGI TKCDRHVGKI YSKCSSFLDY VRRSLKKLGL DESKLPEKII MNYYEKYKPR 

       550        560        570        580        590        600 
MNELEAFNML KVVLAPCIET LILLDRLCYL KEQEDIAWSA LVKLFDPVKS PRCYAVIALK 


KQQ 

« Hide

References

[1]"The finished DNA sequence of human chromosome 12."
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. expand/collapse author list , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-249.
Tissue: Colon.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-240.
Tissue: Ileal mucosa.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC083811 Genomic DNA. No translation available.
AC089998 Genomic DNA. No translation available.
BC029120 mRNA. Translation: AAH29120.1.
AK026442 mRNA. Translation: BAB15484.1. Sequence problems.
CCDSCCDS9024.1.
RefSeqNP_115606.2. NM_032230.2.
UniGeneHs.506222.

3D structure databases

ProteinModelPortalQ8N6Q8.
SMRQ8N6Q8. Positions 175-217.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123938. 1 interaction.

PTM databases

PhosphoSiteQ8N6Q8.

Polymorphism databases

DMDM317373346.

Proteomic databases

MaxQBQ8N6Q8.
PaxDbQ8N6Q8.
PRIDEQ8N6Q8.

Protocols and materials databases

DNASU84190.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000248306; ENSP00000248306; ENSG00000127720.
GeneID84190.
KEGGhsa:84190.
UCSCuc001szq.3. human.

Organism-specific databases

CTD84190.
GeneCardsGC12P082754.
HGNCHGNC:26228. METTL25.
HPAHPA039534.
HPA041207.
neXtProtNX_Q8N6Q8.
PharmGKBPA142672297.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG313369.
HOGENOMHOG000054213.
HOVERGENHBG057610.
InParanoidQ8N6Q8.
OMATNTHGAQ.
OrthoDBEOG7TBC1S.
PhylomeDBQ8N6Q8.
TreeFamTF312998.

Gene expression databases

ArrayExpressQ8N6Q8.
BgeeQ8N6Q8.
CleanExHS_C12orf26.
GenevestigatorQ8N6Q8.

Family and domain databases

Gene3D3.40.50.150. 1 hit.
InterProIPR025714. Methyltranfer_dom.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamPF13679. Methyltransf_32. 1 hit.
[Graphical view]
SUPFAMSSF53335. SSF53335. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi84190.
NextBio73582.

Entry information

Entry nameMET25_HUMAN
AccessionPrimary (citable) accession number: Q8N6Q8
Secondary accession number(s): Q9H5Y3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: January 11, 2011
Last modified: July 9, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM