Q8N6Q8 (MET25_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Methyltransferase-like protein 25
EC=2.1.1.-

Gene names

Name:	METTL25
Synonyms:	C12orf26

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	603 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Putative methyltransferase By similarity.
Sequence caution	The sequence BAB15484.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	methyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 603	603	Methyltransferase-like protein 25		PRO_0000252148
Natural variations
	Natural variant	249	1	Q → K. Ref.2 Corresponds to variant rs4296098 [ dbSNP | Ensembl ].		VAR_027779
Experimental info
	Sequence conflict	85	1	E → V in BAB15484. Ref.3
	Sequence conflict	152	1	N → S in BAB15484. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q8N6Q8 [UniParc]. Last modified January 11, 2011. Version 2. Checksum: A2D2C51ABEBF8668	FASTA	603	68,213
	10 20 30 40 50 60 MAASCPLPVT PDLPTLRAKL QGLLQFLRDA LSISNAHTVD FYTESVWEEL VDLPPETVLA 70 80 90 100 110 120 ALRKSASETE ALPSETRPLV EAEWEAGMTD FPKIFCETSQ KLVSVEAFAL AAKYYSVQNL 130 140 150 160 170 180 GICTPFEQLL VALRGNQNQR IGENQKAVEF MNMKKSHEVQ AMSELISSIA DYYGIKQVID 190 200 210 220 230 240 LGSGKGYLSS FLSLKYGLKV YGIDSSNTNT HGAEERNRKL KKHWKLCHAQ SRLDVNGLAL 250 260 270 280 290 300 KMAKERKVQN KVKNKADTEE VFNNSPTNQE KMPTSAILPD FSGSVISNIR NQMETLHSQP 310 320 330 340 350 360 HQEENLCFEN SFSLINLLPI NAVEPTSSQQ IPNRETSEAN KERRKMTSKS SESNIYSPLT 370 380 390 400 410 420 SFITADSELH DIIKDLEDCL MVGLHTCGDL APNTLRIFTS NSEIKGVCSV GCCYHLLSEE 430 440 450 460 470 480 FENQHKERTQ EKWGFPMCHY LKEERWCCGR NARMSACLAL ERVAAGQGLP TESLFYRAVL 490 500 510 520 530 540 QDIIKDCYGI TKCDRHVGKI YSKCSSFLDY VRRSLKKLGL DESKLPEKII MNYYEKYKPR 550 560 570 580 590 600 MNELEAFNML KVVLAPCIET LILLDRLCYL KEQEDIAWSA LVKLFDPVKS PRCYAVIALK KQQ

References

[1]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-249. Tissue: Colon.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-240. Tissue: Ileal mucosa.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC083811 Genomic DNA. No translation available. AC089998 Genomic DNA. No translation available. BC029120 mRNA. Translation: AAH29120.1. AK026442 mRNA. Translation: BAB15484.1. Sequence problems.
IPI	IPI00297450.
RefSeq	NP_115606.2. NM_032230.2.
UniGene	Hs.506222.
3D structure databases
ProteinModelPortal	Q8N6Q8.
SMR	Q8N6Q8. Positions 175-217.
ModBase	Search...
PTM databases
PhosphoSite	Q8N6Q8.
Polymorphism databases
DMDM	74729167.
Proteomic databases
PaxDb	Q8N6Q8.
PRIDE	Q8N6Q8.
Protocols and materials databases
DNASU	84190.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000248306; ENSP00000248306; ENSG00000127720.
GeneID	84190.
KEGG	hsa:84190.
UCSC	uc001szq.3. human.
Organism-specific databases
CTD	84190.
GeneCards	GC12P082754.
HGNC	HGNC:26228. METTL25.
HPA	HPA039534. HPA041207.
neXtProt	NX_Q8N6Q8.
PharmGKB	PA142672297.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG313369.
HOGENOM	HOG000054213.
HOVERGEN	HBG057610.
InParanoid	Q8N6Q8.
OMA	HVGKIYS.
OrthoDB	EOG4BZN2J.
PhylomeDB	Q8N6Q8.
Gene expression databases
ArrayExpress	Q8N6Q8.
Bgee	Q8N6Q8.
CleanEx	HS_C12orf26.
Genevestigator	Q8N6Q8.
GermOnline	ENSG00000127720. Homo sapiens.
Family and domain databases
InterPro	IPR025714. Methyltranfer_dom. [Graphical view]
Pfam	PF13679. Methyltransf_32. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	84190.
NextBio	73582.

Entry information

Entry name

MET25_HUMAN

Accession

Primary (citable) accession number: Q8N6Q8
Secondary accession number(s): Q9H5Y3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
Last sequence update:	January 11, 2011
Last modified:	February 6, 2013
This is version 70 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.