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Protein

Methyltransferase-like protein 25

Gene

METTL25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Putative methyltransferase.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Methyltransferase-like protein 25 (EC:2.1.1.-)
Gene namesi
Name:METTL25
Synonyms:C12orf26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:26228. METTL25.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672297.

Polymorphism and mutation databases

BioMutaiMETTL25.
DMDMi317373346.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 603603Methyltransferase-like protein 25PRO_0000252148Add
BLAST

Proteomic databases

MaxQBiQ8N6Q8.
PaxDbiQ8N6Q8.
PRIDEiQ8N6Q8.

PTM databases

PhosphoSiteiQ8N6Q8.

Expressioni

Gene expression databases

BgeeiQ8N6Q8.
CleanExiHS_C12orf26.
ExpressionAtlasiQ8N6Q8. baseline and differential.
GenevisibleiQ8N6Q8. HS.

Organism-specific databases

HPAiHPA039534.
HPA041207.

Interactioni

Protein-protein interaction databases

BioGridi123938. 6 interactions.
STRINGi9606.ENSP00000248306.

Structurei

3D structure databases

ProteinModelPortaliQ8N6Q8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG313369.
GeneTreeiENSGT00530000063745.
HOGENOMiHOG000054213.
HOVERGENiHBG057610.
InParanoidiQ8N6Q8.
OMAiTNTHGAQ.
OrthoDBiEOG7TBC1S.
PhylomeDBiQ8N6Q8.
TreeFamiTF312998.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR025714. Methyltranfer_dom.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF13679. Methyltransf_32. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8N6Q8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASCPLPVT PDLPTLRAKL QGLLQFLRDA LSISNAHTVD FYTESVWEEL
60 70 80 90 100
VDLPPETVLA ALRKSASETE ALPSETRPLV EAEWEAGMTD FPKIFCETSQ
110 120 130 140 150
KLVSVEAFAL AAKYYSVQNL GICTPFEQLL VALRGNQNQR IGENQKAVEF
160 170 180 190 200
MNMKKSHEVQ AMSELISSIA DYYGIKQVID LGSGKGYLSS FLSLKYGLKV
210 220 230 240 250
YGIDSSNTNT HGAEERNRKL KKHWKLCHAQ SRLDVNGLAL KMAKERKVQN
260 270 280 290 300
KVKNKADTEE VFNNSPTNQE KMPTSAILPD FSGSVISNIR NQMETLHSQP
310 320 330 340 350
HQEENLCFEN SFSLINLLPI NAVEPTSSQQ IPNRETSEAN KERRKMTSKS
360 370 380 390 400
SESNIYSPLT SFITADSELH DIIKDLEDCL MVGLHTCGDL APNTLRIFTS
410 420 430 440 450
NSEIKGVCSV GCCYHLLSEE FENQHKERTQ EKWGFPMCHY LKEERWCCGR
460 470 480 490 500
NARMSACLAL ERVAAGQGLP TESLFYRAVL QDIIKDCYGI TKCDRHVGKI
510 520 530 540 550
YSKCSSFLDY VRRSLKKLGL DESKLPEKII MNYYEKYKPR MNELEAFNML
560 570 580 590 600
KVVLAPCIET LILLDRLCYL KEQEDIAWSA LVKLFDPVKS PRCYAVIALK

KQQ
Length:603
Mass (Da):68,213
Last modified:January 11, 2011 - v2
Checksum:iA2D2C51ABEBF8668
GO

Sequence cautioni

The sequence BAB15484.1 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti85 – 851E → V in BAB15484 (PubMed:14702039).Curated
Sequence conflicti152 – 1521N → S in BAB15484 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti249 – 2491Q → K.1 Publication
Corresponds to variant rs4296098 [ dbSNP | Ensembl ].
VAR_027779

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC083811 Genomic DNA. No translation available.
AC089998 Genomic DNA. No translation available.
BC029120 mRNA. Translation: AAH29120.1.
AK026442 mRNA. Translation: BAB15484.1. Sequence problems.
CCDSiCCDS9024.1.
RefSeqiNP_115606.2. NM_032230.2.
UniGeneiHs.506222.

Genome annotation databases

EnsembliENST00000248306; ENSP00000248306; ENSG00000127720.
GeneIDi84190.
KEGGihsa:84190.
UCSCiuc001szq.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC083811 Genomic DNA. No translation available.
AC089998 Genomic DNA. No translation available.
BC029120 mRNA. Translation: AAH29120.1.
AK026442 mRNA. Translation: BAB15484.1. Sequence problems.
CCDSiCCDS9024.1.
RefSeqiNP_115606.2. NM_032230.2.
UniGeneiHs.506222.

3D structure databases

ProteinModelPortaliQ8N6Q8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123938. 6 interactions.
STRINGi9606.ENSP00000248306.

PTM databases

PhosphoSiteiQ8N6Q8.

Polymorphism and mutation databases

BioMutaiMETTL25.
DMDMi317373346.

Proteomic databases

MaxQBiQ8N6Q8.
PaxDbiQ8N6Q8.
PRIDEiQ8N6Q8.

Protocols and materials databases

DNASUi84190.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000248306; ENSP00000248306; ENSG00000127720.
GeneIDi84190.
KEGGihsa:84190.
UCSCiuc001szq.3. human.

Organism-specific databases

CTDi84190.
GeneCardsiGC12P082754.
HGNCiHGNC:26228. METTL25.
HPAiHPA039534.
HPA041207.
neXtProtiNX_Q8N6Q8.
PharmGKBiPA142672297.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG313369.
GeneTreeiENSGT00530000063745.
HOGENOMiHOG000054213.
HOVERGENiHBG057610.
InParanoidiQ8N6Q8.
OMAiTNTHGAQ.
OrthoDBiEOG7TBC1S.
PhylomeDBiQ8N6Q8.
TreeFamiTF312998.

Miscellaneous databases

GenomeRNAii84190.
NextBioi73582.
PROiQ8N6Q8.

Gene expression databases

BgeeiQ8N6Q8.
CleanExiHS_C12orf26.
ExpressionAtlasiQ8N6Q8. baseline and differential.
GenevisibleiQ8N6Q8. HS.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR025714. Methyltranfer_dom.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF13679. Methyltransf_32. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-249.
    Tissue: Colon.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-240.
    Tissue: Ileal mucosa.

Entry informationi

Entry nameiMET25_HUMAN
AccessioniPrimary (citable) accession number: Q8N6Q8
Secondary accession number(s): Q9H5Y3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: January 11, 2011
Last modified: June 24, 2015
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.