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Protein

Methyltransferase-like protein 25

Gene

METTL25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Putative methyltransferase.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Methyltransferase-like protein 25 (EC:2.1.1.-)
Gene namesi
Name:METTL25
Synonyms:C12orf26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000127720.7
HGNCiHGNC:26228 METTL25
neXtProtiNX_Q8N6Q8

Pathology & Biotechi

Organism-specific databases

DisGeNETi84190
OpenTargetsiENSG00000127720
PharmGKBiPA142672297

Polymorphism and mutation databases

BioMutaiMETTL25
DMDMi317373346

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002521481 – 603Methyltransferase-like protein 25Add BLAST603

Proteomic databases

EPDiQ8N6Q8
MaxQBiQ8N6Q8
PaxDbiQ8N6Q8
PeptideAtlasiQ8N6Q8
PRIDEiQ8N6Q8

PTM databases

iPTMnetiQ8N6Q8
PhosphoSitePlusiQ8N6Q8

Expressioni

Gene expression databases

BgeeiENSG00000127720
CleanExiHS_C12orf26
ExpressionAtlasiQ8N6Q8 baseline and differential
GenevisibleiQ8N6Q8 HS

Organism-specific databases

HPAiHPA039534
HPA041207

Interactioni

Protein-protein interaction databases

BioGridi123938, 5 interactors
IntActiQ8N6Q8, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ8N6Q8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG2651 Eukaryota
ENOG410XPIU LUCA
GeneTreeiENSGT00530000063745
HOGENOMiHOG000054213
HOVERGENiHBG057610
InParanoidiQ8N6Q8
OMAiTARMMAC
OrthoDBiEOG091G0IIF
PhylomeDBiQ8N6Q8
TreeFamiTF312998

Family and domain databases

InterProiView protein in InterPro
IPR025714 Methyltranfer_dom
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF13679 Methyltransf_32, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit

Sequencei

Sequence statusi: Complete.

Q8N6Q8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASCPLPVT PDLPTLRAKL QGLLQFLRDA LSISNAHTVD FYTESVWEEL
60 70 80 90 100
VDLPPETVLA ALRKSASETE ALPSETRPLV EAEWEAGMTD FPKIFCETSQ
110 120 130 140 150
KLVSVEAFAL AAKYYSVQNL GICTPFEQLL VALRGNQNQR IGENQKAVEF
160 170 180 190 200
MNMKKSHEVQ AMSELISSIA DYYGIKQVID LGSGKGYLSS FLSLKYGLKV
210 220 230 240 250
YGIDSSNTNT HGAEERNRKL KKHWKLCHAQ SRLDVNGLAL KMAKERKVQN
260 270 280 290 300
KVKNKADTEE VFNNSPTNQE KMPTSAILPD FSGSVISNIR NQMETLHSQP
310 320 330 340 350
HQEENLCFEN SFSLINLLPI NAVEPTSSQQ IPNRETSEAN KERRKMTSKS
360 370 380 390 400
SESNIYSPLT SFITADSELH DIIKDLEDCL MVGLHTCGDL APNTLRIFTS
410 420 430 440 450
NSEIKGVCSV GCCYHLLSEE FENQHKERTQ EKWGFPMCHY LKEERWCCGR
460 470 480 490 500
NARMSACLAL ERVAAGQGLP TESLFYRAVL QDIIKDCYGI TKCDRHVGKI
510 520 530 540 550
YSKCSSFLDY VRRSLKKLGL DESKLPEKII MNYYEKYKPR MNELEAFNML
560 570 580 590 600
KVVLAPCIET LILLDRLCYL KEQEDIAWSA LVKLFDPVKS PRCYAVIALK

KQQ
Length:603
Mass (Da):68,213
Last modified:January 11, 2011 - v2
Checksum:iA2D2C51ABEBF8668
GO

Sequence cautioni

The sequence BAB15484 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti85E → V in BAB15484 (PubMed:14702039).Curated1
Sequence conflicti152N → S in BAB15484 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027779249Q → K1 PublicationCorresponds to variant dbSNP:rs4296098Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC083811 Genomic DNA No translation available.
AC089998 Genomic DNA No translation available.
BC029120 mRNA Translation: AAH29120.1
AK026442 mRNA Translation: BAB15484.1 Sequence problems.
CCDSiCCDS9024.1
RefSeqiNP_001306604.1, NM_001319675.1
NP_001334863.1, NM_001347934.1
NP_115606.2, NM_032230.2
UniGeneiHs.506222

Genome annotation databases

EnsembliENST00000248306; ENSP00000248306; ENSG00000127720
GeneIDi84190
KEGGihsa:84190
UCSCiuc001szq.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMET25_HUMAN
AccessioniPrimary (citable) accession number: Q8N6Q8
Secondary accession number(s): Q9H5Y3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: January 11, 2011
Last modified: March 28, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health