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Protein

Interleukin-22 receptor subunit alpha-1

Gene

IL22RA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.6 Publications

GO - Molecular functioni

  • interferon receptor activity Source: UniProtKB
  • interleukin-20 binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000142677-MONOMER.
ReactomeiR-HSA-8854691. Interleukin-19, 20, 22, 24.
SignaLinkiQ8N6P7.
SIGNORiQ8N6P7.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-22 receptor subunit alpha-1
Short name:
IL-22 receptor subunit alpha-1
Short name:
IL-22R-alpha-1
Short name:
IL-22RA1
Alternative name(s):
Cytokine receptor class-II member 9
Cytokine receptor family 2 member 9
Short name:
CRF2-9
ZcytoR11
Gene namesi
Name:IL22RA1
Synonyms:IL22R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:13700. IL22RA1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini16 – 228ExtracellularSequence analysisAdd BLAST213
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Topological domaini250 – 574CytoplasmicSequence analysisAdd BLAST325

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi58K → A: Strongly reduced response to IL22. 1 Publication1
Mutagenesisi60Y → A or R: Loss of response to IL22. 1 Publication1

Organism-specific databases

DisGeNETi58985.
OpenTargetsiENSG00000142677.
PharmGKBiPA29823.

Polymorphism and mutation databases

BioMutaiIL22RA1.
DMDMi74751067.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_000032432016 – 574Interleukin-22 receptor subunit alpha-1Add BLAST559

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi71 ↔ 791 Publication
Glycosylationi80N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi128 ↔ 2171 Publication
Glycosylationi172N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8N6P7.
PeptideAtlasiQ8N6P7.
PRIDEiQ8N6P7.

PTM databases

iPTMnetiQ8N6P7.
PhosphoSitePlusiQ8N6P7.

Expressioni

Tissue specificityi

Expressed in colon, liver, lung, pancreas and kidney. No expression in immune cells such as monocytes, T-cells, and NK-cells. Expressed in keratinocytes of normal skin as well as in psoriatic skin lesion. Detected in normal blood brain barrier endothelial cells as well as in multiple sclerosis lesions; Strongly expressed on central nervous system vessels within infiltrated multiple sclerosis lesions. Overexpressed in synovial fluid cells from rheumatoid arthritis and spondyloarthropathy patients.5 Publications

Inductioni

By IFNG/IFN-gamma in keratinocytes.1 Publication

Gene expression databases

BgeeiENSG00000142677.
CleanExiHS_IL22RA1.
GenevisibleiQ8N6P7. HS.

Organism-specific databases

HPAiHPA042399.

Interactioni

Subunit structurei

Heterodimer with IL10RB and with IL20RB. IL22 binding to heterodimer is greater than binding to IL22RA1 alone.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
IL10RBQ083345EBI-3940749,EBI-11175900
IL22Q9GZX66EBI-3940749,EBI-8040250

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121855. 3 interactors.
DIPiDIP-42031N.
IntActiQ8N6P7. 4 interactors.
MINTiMINT-147649.
STRINGi9606.ENSP00000270800.

Structurei

Secondary structure

1574
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi21 – 23Combined sources3
Beta strandi25 – 33Combined sources9
Beta strandi36 – 43Combined sources8
Beta strandi49 – 59Combined sources11
Beta strandi72 – 80Combined sources9
Helixi83 – 85Combined sources3
Beta strandi92 – 100Combined sources9
Beta strandi105 – 109Combined sources5
Helixi115 – 118Combined sources4
Beta strandi126 – 130Combined sources5
Beta strandi132 – 139Combined sources8
Beta strandi143 – 147Combined sources5
Beta strandi153 – 155Combined sources3
Helixi156 – 159Combined sources4
Beta strandi164 – 170Combined sources7
Beta strandi177 – 190Combined sources14
Beta strandi196 – 205Combined sources10
Helixi206 – 208Combined sources3
Beta strandi215 – 220Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DGCX-ray2.50R/S17-226[»]
3DLQX-ray1.90R18-228[»]
ProteinModelPortaliQ8N6P7.
SMRiQ8N6P7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8N6P7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 124Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST108
Domaini141 – 221Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST81

Sequence similaritiesi

Belongs to the type II cytokine receptor family.Curated
Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF2U. Eukaryota.
ENOG4111CQU. LUCA.
GeneTreeiENSGT00530000063352.
HOGENOMiHOG000060223.
HOVERGENiHBG104189.
InParanoidiQ8N6P7.
KOiK05138.
OMAiSVQIEGH.
OrthoDBiEOG091G068P.
PhylomeDBiQ8N6P7.
TreeFamiTF334107.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR015373. Interferon/interleukin_rcp_dom.
[Graphical view]
PfamiPF09294. Interfer-bind. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N6P7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTLLTILTV GSLAAHAPED PSDLLQHVKF QSSNFENILT WDSGPEGTPD
60 70 80 90 100
TVYSIEYKTY GERDWVAKKG CQRITRKSCN LTVETGNLTE LYYARVTAVS
110 120 130 140 150
AGGRSATKMT DRFSSLQHTT LKPPDVTCIS KVRSIQMIVH PTPTPIRAGD
160 170 180 190 200
GHRLTLEDIF HDLFYHLELQ VNRTYQMHLG GKQREYEFFG LTPDTEFLGT
210 220 230 240 250
IMICVPTWAK ESAPYMCRVK TLPDRTWTYS FSGAFLFSMG FLVAVLCYLS
260 270 280 290 300
YRYVTKPPAP PNSLNVQRVL TFQPLRFIQE HVLIPVFDLS GPSSLAQPVQ
310 320 330 340 350
YSQIRVSGPR EPAGAPQRHS LSEITYLGQP DISILQPSNV PPPQILSPLS
360 370 380 390 400
YAPNAAPEVG PPSYAPQVTP EAQFPFYAPQ AISKVQPSSY APQATPDSWP
410 420 430 440 450
PSYGVCMEGS GKDSPTGTLS SPKHLRPKGQ LQKEPPAGSC MLGGLSLQEV
460 470 480 490 500
TSLAMEESQE AKSLHQPLGI CTDRTSDPNV LHSGEEGTPQ YLKGQLPLLS
510 520 530 540 550
SVQIEGHPMS LPLQPPSRPC SPSDQGPSPW GLLESLVCPK DEAKSPAPET
560 570
SDLEQPTELD SLFRGLALTV QWES
Length:574
Mass (Da):63,077
Last modified:October 1, 2002 - v1
Checksum:iD46CC71D496F3420
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti117Q → R in BAF84893 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039699130S → P.Corresponds to variant rs34900099dbSNPEnsembl.1
Natural variantiVAR_039700205V → I.Corresponds to variant rs16829204dbSNPEnsembl.1
Natural variantiVAR_039701209A → S.Corresponds to variant rs34379702dbSNPEnsembl.1
Natural variantiVAR_039702222L → P.Corresponds to variant rs34782294dbSNPEnsembl.1
Natural variantiVAR_039703407M → V.Corresponds to variant rs35401673dbSNPEnsembl.1
Natural variantiVAR_039704518R → G.2 PublicationsCorresponds to variant rs3795299dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF286095 mRNA. Translation: AAG22073.1.
AK292204 mRNA. Translation: BAF84893.1.
AK313971 mRNA. Translation: BAG36686.1.
AL590683, AL591178 Genomic DNA. Translation: CAH70116.1.
AL591178, AL590683 Genomic DNA. Translation: CAH72088.1.
CH471134 Genomic DNA. Translation: EAW95111.1.
BC029273 mRNA. Translation: AAH29273.1.
CCDSiCCDS247.1.
RefSeqiNP_067081.2. NM_021258.3.
UniGeneiHs.110915.

Genome annotation databases

EnsembliENST00000270800; ENSP00000270800; ENSG00000142677.
GeneIDi58985.
KEGGihsa:58985.
UCSCiuc001biq.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF286095 mRNA. Translation: AAG22073.1.
AK292204 mRNA. Translation: BAF84893.1.
AK313971 mRNA. Translation: BAG36686.1.
AL590683, AL591178 Genomic DNA. Translation: CAH70116.1.
AL591178, AL590683 Genomic DNA. Translation: CAH72088.1.
CH471134 Genomic DNA. Translation: EAW95111.1.
BC029273 mRNA. Translation: AAH29273.1.
CCDSiCCDS247.1.
RefSeqiNP_067081.2. NM_021258.3.
UniGeneiHs.110915.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DGCX-ray2.50R/S17-226[»]
3DLQX-ray1.90R18-228[»]
ProteinModelPortaliQ8N6P7.
SMRiQ8N6P7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121855. 3 interactors.
DIPiDIP-42031N.
IntActiQ8N6P7. 4 interactors.
MINTiMINT-147649.
STRINGi9606.ENSP00000270800.

PTM databases

iPTMnetiQ8N6P7.
PhosphoSitePlusiQ8N6P7.

Polymorphism and mutation databases

BioMutaiIL22RA1.
DMDMi74751067.

Proteomic databases

PaxDbiQ8N6P7.
PeptideAtlasiQ8N6P7.
PRIDEiQ8N6P7.

Protocols and materials databases

DNASUi58985.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000270800; ENSP00000270800; ENSG00000142677.
GeneIDi58985.
KEGGihsa:58985.
UCSCiuc001biq.3. human.

Organism-specific databases

CTDi58985.
DisGeNETi58985.
GeneCardsiIL22RA1.
HGNCiHGNC:13700. IL22RA1.
HPAiHPA042399.
MIMi605457. gene.
neXtProtiNX_Q8N6P7.
OpenTargetsiENSG00000142677.
PharmGKBiPA29823.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF2U. Eukaryota.
ENOG4111CQU. LUCA.
GeneTreeiENSGT00530000063352.
HOGENOMiHOG000060223.
HOVERGENiHBG104189.
InParanoidiQ8N6P7.
KOiK05138.
OMAiSVQIEGH.
OrthoDBiEOG091G068P.
PhylomeDBiQ8N6P7.
TreeFamiTF334107.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000142677-MONOMER.
ReactomeiR-HSA-8854691. Interleukin-19, 20, 22, 24.
SignaLinkiQ8N6P7.
SIGNORiQ8N6P7.

Miscellaneous databases

ChiTaRSiIL22RA1. human.
EvolutionaryTraceiQ8N6P7.
GenomeRNAii58985.
PROiQ8N6P7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000142677.
CleanExiHS_IL22RA1.
GenevisibleiQ8N6P7. HS.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR015373. Interferon/interleukin_rcp_dom.
[Graphical view]
PfamiPF09294. Interfer-bind. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiI22R1_HUMAN
AccessioniPrimary (citable) accession number: Q8N6P7
Secondary accession number(s): A8K839, B2R9Y9, Q9HB22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Failure of medical and surgical therapy in Chronic rhinosinusitis with nasal polyps is associated with decreased expression of IL22RA1.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.