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Q8N6P7

- I22R1_HUMAN

UniProt

Q8N6P7 - I22R1_HUMAN

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Protein
Interleukin-22 receptor subunit alpha-1
Gene
IL22RA1, IL22R
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.6 Publications

GO - Molecular functioni

  1. interferon receptor activity Source: UniProtKB

GO - Biological processi

  1. cytokine-mediated signaling pathway Source: GOC
  2. defense response to Gram-negative bacterium Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

SignaLinkiQ8N6P7.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-22 receptor subunit alpha-1
Short name:
IL-22 receptor subunit alpha-1
Short name:
IL-22R-alpha-1
Short name:
IL-22RA1
Alternative name(s):
Cytokine receptor class-II member 9
Cytokine receptor family 2 member 9
Short name:
CRF2-9
ZcytoR11
Gene namesi
Name:IL22RA1
Synonyms:IL22R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:13700. IL22RA1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini16 – 228213Extracellular Reviewed prediction
Add
BLAST
Transmembranei229 – 24921Helical; Reviewed prediction
Add
BLAST
Topological domaini250 – 574325Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi58 – 581K → A: Strongly reduced response to IL22. 1 Publication
Mutagenesisi60 – 601Y → A or R: Loss of response to IL22. 1 Publication

Organism-specific databases

PharmGKBiPA29823.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515 Reviewed prediction
Add
BLAST
Chaini16 – 574559Interleukin-22 receptor subunit alpha-1
PRO_0000324320Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi71 ↔ 791 Publication
Glycosylationi80 – 801N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi128 ↔ 2171 Publication
Glycosylationi172 – 1721N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8N6P7.
PRIDEiQ8N6P7.

PTM databases

PhosphoSiteiQ8N6P7.

Expressioni

Tissue specificityi

Expressed in colon, liver, lung, pancreas and kidney. No expression in immune cells such as monocytes, T-cells, and NK-cells. Expressed in keratinocytes of normal skin as well as in psoriatic skin lesion. Detected in normal blood brain barrier endothelial cells as well as in multiple sclerosis lesions; Strongly expressed on central nervous system vessels within infiltrated multiple sclerosis lesions. Overexpressed in synovial fluid cells from rheumatoid arthritis and spondyloarthropathy patients.5 Publications

Inductioni

By IFNG/IFN-gamma in keratinocytes.1 Publication

Gene expression databases

BgeeiQ8N6P7.
CleanExiHS_IL22RA1.
GenevestigatoriQ8N6P7.

Organism-specific databases

HPAiCAB025781.

Interactioni

Subunit structurei

Heterodimer with IL10RB and with IL20RB. IL22 binding to heterodimer is greater than binding to IL22RA1 alone.2 Publications

Protein-protein interaction databases

BioGridi121855. 2 interactions.
DIPiDIP-42031N.
IntActiQ8N6P7. 2 interactions.
MINTiMINT-147649.
STRINGi9606.ENSP00000270800.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi21 – 233
Beta strandi25 – 339
Beta strandi36 – 438
Beta strandi49 – 5911
Beta strandi72 – 809
Helixi83 – 853
Beta strandi92 – 1009
Beta strandi105 – 1095
Helixi115 – 1184
Beta strandi126 – 1305
Beta strandi132 – 1398
Beta strandi143 – 1475
Beta strandi153 – 1553
Helixi156 – 1594
Beta strandi164 – 1707
Beta strandi177 – 19014
Beta strandi196 – 20510
Helixi206 – 2083
Beta strandi215 – 2206

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3DGCX-ray2.50R/S17-226[»]
3DLQX-ray1.90R18-228[»]
ProteinModelPortaliQ8N6P7.
SMRiQ8N6P7. Positions 19-225.

Miscellaneous databases

EvolutionaryTraceiQ8N6P7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 124108Fibronectin type-III 1
Add
BLAST
Domaini141 – 22181Fibronectin type-III 2
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG26150.
HOGENOMiHOG000060223.
HOVERGENiHBG104189.
InParanoidiQ8N6P7.
KOiK05138.
OMAiLTVQWES.
OrthoDBiEOG7NPFVK.
PhylomeDBiQ8N6P7.
TreeFamiTF334107.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF01108. Tissue_fac. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N6P7-1 [UniParc]FASTAAdd to Basket

« Hide

MRTLLTILTV GSLAAHAPED PSDLLQHVKF QSSNFENILT WDSGPEGTPD    50
TVYSIEYKTY GERDWVAKKG CQRITRKSCN LTVETGNLTE LYYARVTAVS 100
AGGRSATKMT DRFSSLQHTT LKPPDVTCIS KVRSIQMIVH PTPTPIRAGD 150
GHRLTLEDIF HDLFYHLELQ VNRTYQMHLG GKQREYEFFG LTPDTEFLGT 200
IMICVPTWAK ESAPYMCRVK TLPDRTWTYS FSGAFLFSMG FLVAVLCYLS 250
YRYVTKPPAP PNSLNVQRVL TFQPLRFIQE HVLIPVFDLS GPSSLAQPVQ 300
YSQIRVSGPR EPAGAPQRHS LSEITYLGQP DISILQPSNV PPPQILSPLS 350
YAPNAAPEVG PPSYAPQVTP EAQFPFYAPQ AISKVQPSSY APQATPDSWP 400
PSYGVCMEGS GKDSPTGTLS SPKHLRPKGQ LQKEPPAGSC MLGGLSLQEV 450
TSLAMEESQE AKSLHQPLGI CTDRTSDPNV LHSGEEGTPQ YLKGQLPLLS 500
SVQIEGHPMS LPLQPPSRPC SPSDQGPSPW GLLESLVCPK DEAKSPAPET 550
SDLEQPTELD SLFRGLALTV QWES 574
Length:574
Mass (Da):63,077
Last modified:October 1, 2002 - v1
Checksum:iD46CC71D496F3420
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti130 – 1301S → P.
Corresponds to variant rs34900099 [ dbSNP | Ensembl ].
VAR_039699
Natural varianti205 – 2051V → I.
Corresponds to variant rs16829204 [ dbSNP | Ensembl ].
VAR_039700
Natural varianti209 – 2091A → S.
Corresponds to variant rs34379702 [ dbSNP | Ensembl ].
VAR_039701
Natural varianti222 – 2221L → P.
Corresponds to variant rs34782294 [ dbSNP | Ensembl ].
VAR_039702
Natural varianti407 – 4071M → V.
Corresponds to variant rs35401673 [ dbSNP | Ensembl ].
VAR_039703
Natural varianti518 – 5181R → G.2 Publications
Corresponds to variant rs3795299 [ dbSNP | Ensembl ].
VAR_039704

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti117 – 1171Q → R in BAF84893. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF286095 mRNA. Translation: AAG22073.1.
AK292204 mRNA. Translation: BAF84893.1.
AK313971 mRNA. Translation: BAG36686.1.
AL590683, AL591178 Genomic DNA. Translation: CAH70116.1.
AL591178, AL590683 Genomic DNA. Translation: CAH72088.1.
CH471134 Genomic DNA. Translation: EAW95111.1.
BC029273 mRNA. Translation: AAH29273.1.
CCDSiCCDS247.1.
RefSeqiNP_067081.2. NM_021258.3.
UniGeneiHs.110915.

Genome annotation databases

EnsembliENST00000270800; ENSP00000270800; ENSG00000142677.
GeneIDi58985.
KEGGihsa:58985.
UCSCiuc001biq.2. human.

Polymorphism databases

DMDMi74751067.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF286095 mRNA. Translation: AAG22073.1 .
AK292204 mRNA. Translation: BAF84893.1 .
AK313971 mRNA. Translation: BAG36686.1 .
AL590683 , AL591178 Genomic DNA. Translation: CAH70116.1 .
AL591178 , AL590683 Genomic DNA. Translation: CAH72088.1 .
CH471134 Genomic DNA. Translation: EAW95111.1 .
BC029273 mRNA. Translation: AAH29273.1 .
CCDSi CCDS247.1.
RefSeqi NP_067081.2. NM_021258.3.
UniGenei Hs.110915.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3DGC X-ray 2.50 R/S 17-226 [» ]
3DLQ X-ray 1.90 R 18-228 [» ]
ProteinModelPortali Q8N6P7.
SMRi Q8N6P7. Positions 19-225.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121855. 2 interactions.
DIPi DIP-42031N.
IntActi Q8N6P7. 2 interactions.
MINTi MINT-147649.
STRINGi 9606.ENSP00000270800.

PTM databases

PhosphoSitei Q8N6P7.

Polymorphism databases

DMDMi 74751067.

Proteomic databases

PaxDbi Q8N6P7.
PRIDEi Q8N6P7.

Protocols and materials databases

DNASUi 58985.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000270800 ; ENSP00000270800 ; ENSG00000142677 .
GeneIDi 58985.
KEGGi hsa:58985.
UCSCi uc001biq.2. human.

Organism-specific databases

CTDi 58985.
GeneCardsi GC01M024446.
HGNCi HGNC:13700. IL22RA1.
HPAi CAB025781.
MIMi 605457. gene.
neXtProti NX_Q8N6P7.
PharmGKBi PA29823.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG26150.
HOGENOMi HOG000060223.
HOVERGENi HBG104189.
InParanoidi Q8N6P7.
KOi K05138.
OMAi LTVQWES.
OrthoDBi EOG7NPFVK.
PhylomeDBi Q8N6P7.
TreeFami TF334107.

Enzyme and pathway databases

SignaLinki Q8N6P7.

Miscellaneous databases

EvolutionaryTracei Q8N6P7.
GenomeRNAii 58985.
NextBioi 65126.
PROi Q8N6P7.
SOURCEi Search...

Gene expression databases

Bgeei Q8N6P7.
CleanExi HS_IL22RA1.
Genevestigatori Q8N6P7.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
[Graphical view ]
Pfami PF01108. Tissue_fac. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 1 hit.
PROSITEi PS50853. FN3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R."
    Xie M.-H., Aggarwal S., Ho W.-H., Foster J., Zhang Z., Stinson J., Wood W.I., Goddard A.D., Gurney A.L.
    J. Biol. Chem. 275:31335-31339(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-518.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-518.
    Tissue: Esophagus and Liver.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Adrenal cortex.
  6. "Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes."
    Kotenko S.V., Izotova L.S., Mirochnitchenko O.V., Esterova E., Dickensheets H., Donnelly R.P., Pestka S.
    J. Biol. Chem. 276:2725-2732(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT.
  7. "STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types."
    Dumoutier L., Leemans C., Lejeune D., Kotenko S.V., Renauld J.-C.
    J. Immunol. 167:3545-3549(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "IL-22, in contrast to IL-10, does not induce Ig production, due to absence of a functional IL-22 receptor on activated human B cells."
    Lecart S., Morel F., Noraz N., Pene J., Garcia M., Boniface K., Lecron J.-C., Yssel H.
    Int. Immunol. 14:1351-1356(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  9. "Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2."
    Wang M., Tan Z., Zhang R., Kotenko S.V., Liang P.
    J. Biol. Chem. 277:7341-7347(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions."
    Parrish-Novak J., Xu W., Brender T., Yao L., Jones C., West J., Brandt C., Jelinek L., Madden K., McKernan P.A., Foster D.C., Jaspers S., Chandrasekher Y.A.
    J. Biol. Chem. 277:47517-47523(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "Melanoma differentiation-associated gene 7/interleukin (IL)-24 is a novel ligand that regulates angiogenesis via the IL-22 receptor."
    Ramesh R., Mhashilkar A.M., Tanaka F., Saito Y., Branch C.D., Sieger K., Mumm J.B., Stewart A.L., Boquoi A., Dumoutier L., Grimm E.A., Renauld J.-C., Kotenko S., Chada S.
    Cancer Res. 63:5105-5113(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  12. Cited for: TISSUE SPECIFICITY, INDUCTION.
  13. Cited for: SUBUNIT.
  14. Cited for: FUNCTION.
  15. Cited for: TISSUE SPECIFICITY.
  16. "Chronic rhinosinusitis with nasal polyps is associated with decreased expression of mucosal interleukin 22 receptor."
    Ramanathan M. Jr., Spannhake E.W., Lane A.P.
    Laryngoscope 117:1839-1843(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: ASSOCIATION WITH CHRONIC RHINOSINUSITIS.
  17. "Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation."
    Kebir H., Kreymborg K., Ifergan I., Dodelet-Devillers A., Cayrol R., Bernard M., Giuliani F., Arbour N., Becher B., Prat A.
    Nat. Med. 13:1173-1175(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  18. "The expression of IL-20 and IL-24 and their shared receptors are increased in rheumatoid arthritis and spondyloarthropathy."
    Kragstrup T.W., Otkjaer K., Holm C., Jorgensen A., Hokland M., Iversen L., Deleuran B.
    Cytokine 41:16-23(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  19. "Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism."
    Bleicher L., de Moura P.R., Watanabe L., Colau D., Dumoutier L., Renauld J.-C., Polikarpov I.
    FEBS Lett. 582:2985-2992(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 18-228 IN COMPLEX WITH IL22, MUTAGENESIS OF LYS-58 AND TYR-60, DISULFIDE BONDS.

Entry informationi

Entry nameiI22R1_HUMAN
AccessioniPrimary (citable) accession number: Q8N6P7
Secondary accession number(s): A8K839, B2R9Y9, Q9HB22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Failure of medical and surgical therapy in Chronic rhinosinusitis with nasal polyps is associated with decreased expression of IL22RA1.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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