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Q8N6P7

- I22R1_HUMAN

UniProt

Q8N6P7 - I22R1_HUMAN

Protein

Interleukin-22 receptor subunit alpha-1

Gene

IL22RA1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.6 Publications

    GO - Molecular functioni

    1. interferon receptor activity Source: UniProtKB

    GO - Biological processi

    1. cytokine-mediated signaling pathway Source: GOC
    2. defense response to Gram-negative bacterium Source: Ensembl

    Keywords - Molecular functioni

    Receptor

    Enzyme and pathway databases

    SignaLinkiQ8N6P7.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-22 receptor subunit alpha-1
    Short name:
    IL-22 receptor subunit alpha-1
    Short name:
    IL-22R-alpha-1
    Short name:
    IL-22RA1
    Alternative name(s):
    Cytokine receptor class-II member 9
    Cytokine receptor family 2 member 9
    Short name:
    CRF2-9
    ZcytoR11
    Gene namesi
    Name:IL22RA1
    Synonyms:IL22R
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:13700. IL22RA1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi58 – 581K → A: Strongly reduced response to IL22. 1 Publication
    Mutagenesisi60 – 601Y → A or R: Loss of response to IL22. 1 Publication

    Organism-specific databases

    PharmGKBiPA29823.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1515Sequence AnalysisAdd
    BLAST
    Chaini16 – 574559Interleukin-22 receptor subunit alpha-1PRO_0000324320Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi71 ↔ 791 Publication
    Glycosylationi80 – 801N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi128 ↔ 2171 Publication
    Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8N6P7.
    PRIDEiQ8N6P7.

    PTM databases

    PhosphoSiteiQ8N6P7.

    Expressioni

    Tissue specificityi

    Expressed in colon, liver, lung, pancreas and kidney. No expression in immune cells such as monocytes, T-cells, and NK-cells. Expressed in keratinocytes of normal skin as well as in psoriatic skin lesion. Detected in normal blood brain barrier endothelial cells as well as in multiple sclerosis lesions; Strongly expressed on central nervous system vessels within infiltrated multiple sclerosis lesions. Overexpressed in synovial fluid cells from rheumatoid arthritis and spondyloarthropathy patients.5 Publications

    Inductioni

    By IFNG/IFN-gamma in keratinocytes.1 Publication

    Gene expression databases

    BgeeiQ8N6P7.
    CleanExiHS_IL22RA1.
    GenevestigatoriQ8N6P7.

    Organism-specific databases

    HPAiCAB025781.

    Interactioni

    Subunit structurei

    Heterodimer with IL10RB and with IL20RB. IL22 binding to heterodimer is greater than binding to IL22RA1 alone.3 Publications

    Protein-protein interaction databases

    BioGridi121855. 2 interactions.
    DIPiDIP-42031N.
    IntActiQ8N6P7. 2 interactions.
    MINTiMINT-147649.
    STRINGi9606.ENSP00000270800.

    Structurei

    Secondary structure

    1
    574
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi21 – 233
    Beta strandi25 – 339
    Beta strandi36 – 438
    Beta strandi49 – 5911
    Beta strandi72 – 809
    Helixi83 – 853
    Beta strandi92 – 1009
    Beta strandi105 – 1095
    Helixi115 – 1184
    Beta strandi126 – 1305
    Beta strandi132 – 1398
    Beta strandi143 – 1475
    Beta strandi153 – 1553
    Helixi156 – 1594
    Beta strandi164 – 1707
    Beta strandi177 – 19014
    Beta strandi196 – 20510
    Helixi206 – 2083
    Beta strandi215 – 2206

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3DGCX-ray2.50R/S17-226[»]
    3DLQX-ray1.90R18-228[»]
    ProteinModelPortaliQ8N6P7.
    SMRiQ8N6P7. Positions 19-225.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8N6P7.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini16 – 228213ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini250 – 574325CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei229 – 24921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini17 – 124108Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini141 – 22181Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the type II cytokine receptor family.Curated
    Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG26150.
    HOGENOMiHOG000060223.
    HOVERGENiHBG104189.
    InParanoidiQ8N6P7.
    KOiK05138.
    OMAiLTVQWES.
    OrthoDBiEOG7NPFVK.
    PhylomeDBiQ8N6P7.
    TreeFamiTF334107.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    [Graphical view]
    PfamiPF01108. Tissue_fac. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 1 hit.
    PROSITEiPS50853. FN3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8N6P7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRTLLTILTV GSLAAHAPED PSDLLQHVKF QSSNFENILT WDSGPEGTPD    50
    TVYSIEYKTY GERDWVAKKG CQRITRKSCN LTVETGNLTE LYYARVTAVS 100
    AGGRSATKMT DRFSSLQHTT LKPPDVTCIS KVRSIQMIVH PTPTPIRAGD 150
    GHRLTLEDIF HDLFYHLELQ VNRTYQMHLG GKQREYEFFG LTPDTEFLGT 200
    IMICVPTWAK ESAPYMCRVK TLPDRTWTYS FSGAFLFSMG FLVAVLCYLS 250
    YRYVTKPPAP PNSLNVQRVL TFQPLRFIQE HVLIPVFDLS GPSSLAQPVQ 300
    YSQIRVSGPR EPAGAPQRHS LSEITYLGQP DISILQPSNV PPPQILSPLS 350
    YAPNAAPEVG PPSYAPQVTP EAQFPFYAPQ AISKVQPSSY APQATPDSWP 400
    PSYGVCMEGS GKDSPTGTLS SPKHLRPKGQ LQKEPPAGSC MLGGLSLQEV 450
    TSLAMEESQE AKSLHQPLGI CTDRTSDPNV LHSGEEGTPQ YLKGQLPLLS 500
    SVQIEGHPMS LPLQPPSRPC SPSDQGPSPW GLLESLVCPK DEAKSPAPET 550
    SDLEQPTELD SLFRGLALTV QWES 574
    Length:574
    Mass (Da):63,077
    Last modified:October 1, 2002 - v1
    Checksum:iD46CC71D496F3420
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti117 – 1171Q → R in BAF84893. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti130 – 1301S → P.
    Corresponds to variant rs34900099 [ dbSNP | Ensembl ].
    VAR_039699
    Natural varianti205 – 2051V → I.
    Corresponds to variant rs16829204 [ dbSNP | Ensembl ].
    VAR_039700
    Natural varianti209 – 2091A → S.
    Corresponds to variant rs34379702 [ dbSNP | Ensembl ].
    VAR_039701
    Natural varianti222 – 2221L → P.
    Corresponds to variant rs34782294 [ dbSNP | Ensembl ].
    VAR_039702
    Natural varianti407 – 4071M → V.
    Corresponds to variant rs35401673 [ dbSNP | Ensembl ].
    VAR_039703
    Natural varianti518 – 5181R → G.2 Publications
    Corresponds to variant rs3795299 [ dbSNP | Ensembl ].
    VAR_039704

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF286095 mRNA. Translation: AAG22073.1.
    AK292204 mRNA. Translation: BAF84893.1.
    AK313971 mRNA. Translation: BAG36686.1.
    AL590683, AL591178 Genomic DNA. Translation: CAH70116.1.
    AL591178, AL590683 Genomic DNA. Translation: CAH72088.1.
    CH471134 Genomic DNA. Translation: EAW95111.1.
    BC029273 mRNA. Translation: AAH29273.1.
    CCDSiCCDS247.1.
    RefSeqiNP_067081.2. NM_021258.3.
    UniGeneiHs.110915.

    Genome annotation databases

    EnsembliENST00000270800; ENSP00000270800; ENSG00000142677.
    GeneIDi58985.
    KEGGihsa:58985.
    UCSCiuc001biq.2. human.

    Polymorphism databases

    DMDMi74751067.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF286095 mRNA. Translation: AAG22073.1 .
    AK292204 mRNA. Translation: BAF84893.1 .
    AK313971 mRNA. Translation: BAG36686.1 .
    AL590683 , AL591178 Genomic DNA. Translation: CAH70116.1 .
    AL591178 , AL590683 Genomic DNA. Translation: CAH72088.1 .
    CH471134 Genomic DNA. Translation: EAW95111.1 .
    BC029273 mRNA. Translation: AAH29273.1 .
    CCDSi CCDS247.1.
    RefSeqi NP_067081.2. NM_021258.3.
    UniGenei Hs.110915.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3DGC X-ray 2.50 R/S 17-226 [» ]
    3DLQ X-ray 1.90 R 18-228 [» ]
    ProteinModelPortali Q8N6P7.
    SMRi Q8N6P7. Positions 19-225.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121855. 2 interactions.
    DIPi DIP-42031N.
    IntActi Q8N6P7. 2 interactions.
    MINTi MINT-147649.
    STRINGi 9606.ENSP00000270800.

    PTM databases

    PhosphoSitei Q8N6P7.

    Polymorphism databases

    DMDMi 74751067.

    Proteomic databases

    PaxDbi Q8N6P7.
    PRIDEi Q8N6P7.

    Protocols and materials databases

    DNASUi 58985.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000270800 ; ENSP00000270800 ; ENSG00000142677 .
    GeneIDi 58985.
    KEGGi hsa:58985.
    UCSCi uc001biq.2. human.

    Organism-specific databases

    CTDi 58985.
    GeneCardsi GC01M024446.
    HGNCi HGNC:13700. IL22RA1.
    HPAi CAB025781.
    MIMi 605457. gene.
    neXtProti NX_Q8N6P7.
    PharmGKBi PA29823.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG26150.
    HOGENOMi HOG000060223.
    HOVERGENi HBG104189.
    InParanoidi Q8N6P7.
    KOi K05138.
    OMAi LTVQWES.
    OrthoDBi EOG7NPFVK.
    PhylomeDBi Q8N6P7.
    TreeFami TF334107.

    Enzyme and pathway databases

    SignaLinki Q8N6P7.

    Miscellaneous databases

    EvolutionaryTracei Q8N6P7.
    GenomeRNAii 58985.
    NextBioi 65126.
    PROi Q8N6P7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8N6P7.
    CleanExi HS_IL22RA1.
    Genevestigatori Q8N6P7.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    [Graphical view ]
    Pfami PF01108. Tissue_fac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 1 hit.
    PROSITEi PS50853. FN3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R."
      Xie M.-H., Aggarwal S., Ho W.-H., Foster J., Zhang Z., Stinson J., Wood W.I., Goddard A.D., Gurney A.L.
      J. Biol. Chem. 275:31335-31339(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-518.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-518.
      Tissue: Esophagus and Liver.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Adrenal cortex.
    6. "Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes."
      Kotenko S.V., Izotova L.S., Mirochnitchenko O.V., Esterova E., Dickensheets H., Donnelly R.P., Pestka S.
      J. Biol. Chem. 276:2725-2732(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBUNIT.
    7. "STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types."
      Dumoutier L., Leemans C., Lejeune D., Kotenko S.V., Renauld J.-C.
      J. Immunol. 167:3545-3549(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "IL-22, in contrast to IL-10, does not induce Ig production, due to absence of a functional IL-22 receptor on activated human B cells."
      Lecart S., Morel F., Noraz N., Pene J., Garcia M., Boniface K., Lecron J.-C., Yssel H.
      Int. Immunol. 14:1351-1356(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    9. "Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2."
      Wang M., Tan Z., Zhang R., Kotenko S.V., Liang P.
      J. Biol. Chem. 277:7341-7347(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    10. "Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions."
      Parrish-Novak J., Xu W., Brender T., Yao L., Jones C., West J., Brandt C., Jelinek L., Madden K., McKernan P.A., Foster D.C., Jaspers S., Chandrasekher Y.A.
      J. Biol. Chem. 277:47517-47523(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    11. "Melanoma differentiation-associated gene 7/interleukin (IL)-24 is a novel ligand that regulates angiogenesis via the IL-22 receptor."
      Ramesh R., Mhashilkar A.M., Tanaka F., Saito Y., Branch C.D., Sieger K., Mumm J.B., Stewart A.L., Boquoi A., Dumoutier L., Grimm E.A., Renauld J.-C., Kotenko S., Chada S.
      Cancer Res. 63:5105-5113(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    12. Cited for: TISSUE SPECIFICITY, INDUCTION.
    13. Cited for: SUBUNIT.
    14. Cited for: FUNCTION.
    15. Cited for: TISSUE SPECIFICITY.
    16. "Chronic rhinosinusitis with nasal polyps is associated with decreased expression of mucosal interleukin 22 receptor."
      Ramanathan M. Jr., Spannhake E.W., Lane A.P.
      Laryngoscope 117:1839-1843(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: ASSOCIATION WITH CHRONIC RHINOSINUSITIS.
    17. "Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation."
      Kebir H., Kreymborg K., Ifergan I., Dodelet-Devillers A., Cayrol R., Bernard M., Giuliani F., Arbour N., Becher B., Prat A.
      Nat. Med. 13:1173-1175(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    18. "The expression of IL-20 and IL-24 and their shared receptors are increased in rheumatoid arthritis and spondyloarthropathy."
      Kragstrup T.W., Otkjaer K., Holm C., Jorgensen A., Hokland M., Iversen L., Deleuran B.
      Cytokine 41:16-23(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    19. "Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism."
      Bleicher L., de Moura P.R., Watanabe L., Colau D., Dumoutier L., Renauld J.-C., Polikarpov I.
      FEBS Lett. 582:2985-2992(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 18-228 IN COMPLEX WITH IL22, MUTAGENESIS OF LYS-58 AND TYR-60, DISULFIDE BONDS.

    Entry informationi

    Entry nameiI22R1_HUMAN
    AccessioniPrimary (citable) accession number: Q8N6P7
    Secondary accession number(s): A8K839, B2R9Y9, Q9HB22
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Failure of medical and surgical therapy in Chronic rhinosinusitis with nasal polyps is associated with decreased expression of IL22RA1.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3