Q8N6N7 (ACBD7_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 76.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Acyl-CoA-binding domain-containing protein 7 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Reference proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo![]() |
Protein attributes
| Sequence length | 88 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Binds medium- and long-chain acyl-CoA esters. |
| Sequence similarities | Belongs to the ACBD7 family. Contains 1 ACB (acyl-CoA-binding) domain. |
Ontologies
| Keywords | |
|---|---|
| Ligand | Lipid-binding |
| Technical term | 3D-structure Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Molecular_function | fatty-acyl-CoA binding Inferred from electronic annotation. Source: InterPro lipid bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||
Molecule processing | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 88 | 88 | Acyl-CoA-binding domain-containing protein 7 | PRO_0000247588 | |||||||||||||||||
Regions | |||||||||||||||||||||
| Domain | 3 – 88 | 86 | ACB | ||||||||||||||||||
| Region | 30 – 34 | 5 | Acyl-CoA binding | ||||||||||||||||||
Sites | |||||||||||||||||||||
| Binding site | 15 | 1 | Acyl-CoA | ||||||||||||||||||
| Binding site | 56 | 1 | Acyl-CoA | ||||||||||||||||||
| Binding site | 75 | 1 | Acyl-CoA | ||||||||||||||||||
Secondary structure | |||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||
| Helix | 2 – 13 | 12 | |||||||||||||||||||
| Helix | 14 – 16 | 3 | |||||||||||||||||||
| Helix | 23 – 37 | 15 | |||||||||||||||||||
| Turn | 46 – 49 | 4 | |||||||||||||||||||
| Helix | 51 – 61 | 11 | |||||||||||||||||||
| Turn | 62 – 65 | 4 | |||||||||||||||||||
| Helix | 68 – 86 | 19 | |||||||||||||||||||
Sequences
References
| « Hide 'large scale' references | |
| [1] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [2] | "The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. Rogers J.Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [5] | "Crystal structure of human acyl-COA binding domain 7 complexed with palmitoyl-COA." Structural genomics consortium (SGC) Submitted (JAN-2009) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS). |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | AK095538 mRNA. Translation: BAG53080.1. AL590365 Genomic DNA. Translation: CAH73964.1. CH471072 Genomic DNA. Translation: EAW86243.1. BC029526 mRNA. Translation: AAH29526.1. | ||||||||||||
| IPI | IPI00398874. | ||||||||||||
| RefSeq | NP_001034933.1. NM_001039844.2. | ||||||||||||
| UniGene | Hs.644598. Hs.723069. | ||||||||||||
3D structure databases | |||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||
| ProteinModelPortal | Q8N6N7. | ||||||||||||
| ModBase | Search... | ||||||||||||
Polymorphism databases | |||||||||||||
| DMDM | 74751066. | ||||||||||||
Proteomic databases | |||||||||||||
| PaxDb | Q8N6N7. | ||||||||||||
| PRIDE | Q8N6N7. | ||||||||||||
Protocols and materials databases | |||||||||||||
| DNASU | 414149. | ||||||||||||
| StructuralBiologyKnowledgebase | Search... | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENST00000356189; ENSP00000367453; ENSG00000176244. | ||||||||||||
| GeneID | 414149. | ||||||||||||
| KEGG | hsa:414149. | ||||||||||||
| UCSC | uc001inv.3. human. | ||||||||||||
Organism-specific databases | |||||||||||||
| CTD | 414149. | ||||||||||||
| GeneCards | GC10M015117. | ||||||||||||
| H-InvDB | HIX0018171. | ||||||||||||
| HGNC | HGNC:17715. ACBD7. | ||||||||||||
| neXtProt | NX_Q8N6N7. | ||||||||||||
| PharmGKB | PA134884059. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| eggNOG | COG4281. | ||||||||||||
| HOGENOM | HOG000261845. | ||||||||||||
| HOVERGEN | HBG000398. | ||||||||||||
| OMA | INIACPG. | ||||||||||||
| OrthoDB | EOG4GF3GS. | ||||||||||||
| PhylomeDB | Q8N6N7. | ||||||||||||
Gene expression databases | |||||||||||||
| Bgee | Q8N6N7. | ||||||||||||
| CleanEx | HS_ACBD7. | ||||||||||||
| Genevestigator | Q8N6N7. | ||||||||||||
Family and domain databases | |||||||||||||
| Gene3D | 1.20.80.10. 1 hit. | ||||||||||||
| InterPro | IPR000582. Acyl-CoA-binding_protein. IPR014352. FERM/acyl-CoA-bd_prot_3-hlx. [Graphical view] | ||||||||||||
| Pfam | PF00887. ACBP. 1 hit. [Graphical view] | ||||||||||||
| PRINTS | PR00689. ACOABINDINGP. | ||||||||||||
| SUPFAM | SSF47027. ACBP. 1 hit. | ||||||||||||
| PROSITE | PS00880. ACB_1. False negative. PS51228. ACB_2. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other | |||||||||||||
| EvolutionaryTrace | Q8N6N7. | ||||||||||||
| GenomeRNAi | 414149. | ||||||||||||
| NextBio | 108406. | ||||||||||||
Entry information
| Entry name | ACBD7_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q8N6N7 Secondary accession number(s): A6NCI2, B3KTG8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 10 Human chromosome 10: entries, gene names and cross-references to MIM |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with
