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Protein

Acyl-CoA-binding domain-containing protein 7

Gene

ACBD7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds medium- and long-chain acyl-CoA esters.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei15 – 151Acyl-CoA
Binding sitei56 – 561Acyl-CoA
Binding sitei75 – 751Acyl-CoA

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA-binding domain-containing protein 7
Gene namesi
Name:ACBD7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:17715. ACBD7.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134884059.

Polymorphism and mutation databases

BioMutaiACBD7.
DMDMi74751066.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8888Acyl-CoA-binding domain-containing protein 7PRO_0000247588Add
BLAST

Proteomic databases

EPDiQ8N6N7.
MaxQBiQ8N6N7.
PaxDbiQ8N6N7.
PeptideAtlasiQ8N6N7.
PRIDEiQ8N6N7.

PTM databases

iPTMnetiQ8N6N7.

Expressioni

Gene expression databases

BgeeiQ8N6N7.
CleanExiHS_ACBD7.

Organism-specific databases

HPAiHPA043326.

Interactioni

Protein-protein interaction databases

BioGridi135940. 11 interactions.
STRINGi9606.ENSP00000367453.

Structurei

Secondary structure

1
88
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 1312Combined sources
Helixi14 – 163Combined sources
Helixi23 – 3715Combined sources
Turni46 – 494Combined sources
Helixi51 – 6111Combined sources
Turni62 – 654Combined sources
Helixi68 – 8619Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3EPYX-ray2.00A/B1-88[»]
ProteinModelPortaliQ8N6N7.
SMRiQ8N6N7. Positions 1-88.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8N6N7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 8886ACBPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni30 – 345Acyl-CoA binding

Sequence similaritiesi

Belongs to the ACBD7 family.Curated
Contains 1 ACB (acyl-CoA-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0817. Eukaryota.
COG4281. LUCA.
GeneTreeiENSGT00840000129776.
HOGENOMiHOG000261845.
HOVERGENiHBG000398.
InParanoidiQ8N6N7.
OMAiWEAWNLQ.
OrthoDBiEOG7SN8G8.
PhylomeDBiQ8N6N7.
TreeFamiTF335802.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
InterProiIPR000582. Acyl-CoA-binding_protein.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
[Graphical view]
PfamiPF00887. ACBP. 1 hit.
[Graphical view]
PRINTSiPR00689. ACOABINDINGP.
SUPFAMiSSF47027. SSF47027. 1 hit.
PROSITEiPS51228. ACB_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N6N7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALQADFDRA AEDVRKLKAR PDDGELKELY GLYKQAIVGD INIACPGMLD
60 70 80
LKGKAKWEAW NLKKGLSTED ATSAYISKAK ELIEKYGI
Length:88
Mass (Da):9,790
Last modified:October 1, 2002 - v1
Checksum:iF79EFF3BD7B2138B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095538 mRNA. Translation: BAG53080.1.
AL590365 Genomic DNA. Translation: CAH73964.1.
CH471072 Genomic DNA. Translation: EAW86243.1.
BC029526 mRNA. Translation: AAH29526.1.
CCDSiCCDS31153.1.
RefSeqiNP_001034933.1. NM_001039844.2.
UniGeneiHs.644598.
Hs.723069.

Genome annotation databases

EnsembliENST00000356189; ENSP00000367453; ENSG00000176244.
GeneIDi414149.
KEGGihsa:414149.
UCSCiuc001inv.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095538 mRNA. Translation: BAG53080.1.
AL590365 Genomic DNA. Translation: CAH73964.1.
CH471072 Genomic DNA. Translation: EAW86243.1.
BC029526 mRNA. Translation: AAH29526.1.
CCDSiCCDS31153.1.
RefSeqiNP_001034933.1. NM_001039844.2.
UniGeneiHs.644598.
Hs.723069.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3EPYX-ray2.00A/B1-88[»]
ProteinModelPortaliQ8N6N7.
SMRiQ8N6N7. Positions 1-88.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi135940. 11 interactions.
STRINGi9606.ENSP00000367453.

PTM databases

iPTMnetiQ8N6N7.

Polymorphism and mutation databases

BioMutaiACBD7.
DMDMi74751066.

Proteomic databases

EPDiQ8N6N7.
MaxQBiQ8N6N7.
PaxDbiQ8N6N7.
PeptideAtlasiQ8N6N7.
PRIDEiQ8N6N7.

Protocols and materials databases

DNASUi414149.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356189; ENSP00000367453; ENSG00000176244.
GeneIDi414149.
KEGGihsa:414149.
UCSCiuc001inv.4. human.

Organism-specific databases

CTDi414149.
GeneCardsiACBD7.
H-InvDBHIX0018171.
HGNCiHGNC:17715. ACBD7.
HPAiHPA043326.
neXtProtiNX_Q8N6N7.
PharmGKBiPA134884059.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0817. Eukaryota.
COG4281. LUCA.
GeneTreeiENSGT00840000129776.
HOGENOMiHOG000261845.
HOVERGENiHBG000398.
InParanoidiQ8N6N7.
OMAiWEAWNLQ.
OrthoDBiEOG7SN8G8.
PhylomeDBiQ8N6N7.
TreeFamiTF335802.

Miscellaneous databases

EvolutionaryTraceiQ8N6N7.
GenomeRNAii414149.
PROiQ8N6N7.

Gene expression databases

BgeeiQ8N6N7.
CleanExiHS_ACBD7.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
InterProiIPR000582. Acyl-CoA-binding_protein.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
[Graphical view]
PfamiPF00887. ACBP. 1 hit.
[Graphical view]
PRINTSiPR00689. ACOABINDINGP.
SUPFAMiSSF47027. SSF47027. 1 hit.
PROSITEiPS51228. ACB_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "Crystal structure of human acyl-COA binding domain 7 complexed with palmitoyl-COA."
    Structural genomics consortium (SGC)
    Submitted (JAN-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).

Entry informationi

Entry nameiACBD7_HUMAN
AccessioniPrimary (citable) accession number: Q8N6N7
Secondary accession number(s): A6NCI2, B3KTG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2002
Last modified: July 6, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.