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Protein

Protein NATD1

Gene

NATD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NATD1
Alternative name(s):
N-acetyltransferase domain-containing protein 1
Gene namesi
Name:NATD1
Synonyms:C17orf103, GTLF3B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:30770. NATD1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164716941.

Polymorphism and mutation databases

BioMutaiGTLF3B.
DMDMi206729869.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 113113Protein NATD1PRO_0000320656Add
BLAST

Proteomic databases

MaxQBiQ8N6N6.
PaxDbiQ8N6N6.
PRIDEiQ8N6N6.

PTM databases

PhosphoSiteiQ8N6N6.

Expressioni

Gene expression databases

BgeeiQ8N6N6.
GenevisibleiQ8N6N6. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ADAMTSL4Q6UY14-33EBI-8656665,EBI-10173507
IKZF3Q9UKT93EBI-8656665,EBI-747204
NIF3L1Q9GZT83EBI-8656665,EBI-740897
TRAF2Q129333EBI-8656665,EBI-355744

Protein-protein interaction databases

BioGridi129155. 4 interactions.
IntActiQ8N6N6. 4 interactions.
STRINGi9606.ENSP00000454565.

Structurei

3D structure databases

ProteinModelPortaliQ8N6N6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 11291N-acetyltransferasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the NATD1 family.Curated
Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IZHM. Eukaryota.
ENOG41127NZ. LUCA.
GeneTreeiENSGT00390000014840.
HOVERGENiHBG055172.
InParanoidiQ8N6N6.
KOiK06975.
OMAiYFEHIYQ.
PhylomeDBiQ8N6N6.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR031165. GNAT_YJDJ.
[Graphical view]
PfamiPF14542. Acetyltransf_CG. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51729. GNAT_YJDJ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N6N6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHSAAAVPL GALEQGCPIR VEHDRRRRQF TVRLNGCHDR AVLLYEYVGK
60 70 80 90 100
RIVDLQHTEV PDAYRGRGIA KHLAKAALDF VVEEDLKAHL TCWYIQKYVK
110
ENPLPQYLER LQP
Length:113
Mass (Da):13,032
Last modified:September 23, 2008 - v2
Checksum:i0FCD9E0D48885379
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti65 – 651R → S in AAH29527 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti42 – 421V → I.
Corresponds to variant rs12449311 [ dbSNP | Ensembl ].
VAR_062227

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126856 mRNA. Translation: BAG54382.1.
AC087294 Genomic DNA. No translation available.
BC029527 mRNA. Translation: AAH29527.1.
RefSeqiNP_690878.2. NM_152914.2.
UniGeneiHs.654713.

Genome annotation databases

EnsembliENST00000611551; ENSP00000478388; ENSG00000274180.
GeneIDi256302.
KEGGihsa:256302.
UCSCiuc032exx.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126856 mRNA. Translation: BAG54382.1.
AC087294 Genomic DNA. No translation available.
BC029527 mRNA. Translation: AAH29527.1.
RefSeqiNP_690878.2. NM_152914.2.
UniGeneiHs.654713.

3D structure databases

ProteinModelPortaliQ8N6N6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129155. 4 interactions.
IntActiQ8N6N6. 4 interactions.
STRINGi9606.ENSP00000454565.

PTM databases

PhosphoSiteiQ8N6N6.

Polymorphism and mutation databases

BioMutaiGTLF3B.
DMDMi206729869.

Proteomic databases

MaxQBiQ8N6N6.
PaxDbiQ8N6N6.
PRIDEiQ8N6N6.

Protocols and materials databases

DNASUi256302.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000611551; ENSP00000478388; ENSG00000274180.
GeneIDi256302.
KEGGihsa:256302.
UCSCiuc032exx.2. human.

Organism-specific databases

CTDi256302.
GeneCardsiNATD1.
HGNCiHGNC:30770. NATD1.
neXtProtiNX_Q8N6N6.
PharmGKBiPA164716941.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZHM. Eukaryota.
ENOG41127NZ. LUCA.
GeneTreeiENSGT00390000014840.
HOVERGENiHBG055172.
InParanoidiQ8N6N6.
KOiK06975.
OMAiYFEHIYQ.
PhylomeDBiQ8N6N6.

Miscellaneous databases

ChiTaRSiC17orf103. human.
GenomeRNAii256302.
NextBioi92772.
PROiQ8N6N6.

Gene expression databases

BgeeiQ8N6N6.
GenevisibleiQ8N6N6. HS.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR031165. GNAT_YJDJ.
[Graphical view]
PfamiPF14542. Acetyltransf_CG. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51729. GNAT_YJDJ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiNATD1_HUMAN
AccessioniPrimary (citable) accession number: Q8N6N6
Secondary accession number(s): A8MWQ7, B3KX70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: September 23, 2008
Last modified: March 16, 2016
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.