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Protein

AN1-type zinc finger protein 2A

Gene

ZFAND2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri7 – 52AN1-type 1PROSITE-ProRule annotationAdd BLAST46
Zinc fingeri97 – 145AN1-type 2PROSITE-ProRule annotationAdd BLAST49

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
AN1-type zinc finger protein 2A
Gene namesi
Name:ZFAND2A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000178381.11
HGNCiHGNC:28073 ZFAND2A
MIMi610699 gene
neXtProtiNX_Q8N6M9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000178381
PharmGKBiPA142670526

Polymorphism and mutation databases

BioMutaiZFAND2A
DMDMi229462785

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002698881 – 145AN1-type zinc finger protein 2AAdd BLAST145

Proteomic databases

MaxQBiQ8N6M9
PaxDbiQ8N6M9
PeptideAtlasiQ8N6M9
PRIDEiQ8N6M9
ProteomicsDBi72201

PTM databases

iPTMnetiQ8N6M9
PhosphoSitePlusiQ8N6M9

Expressioni

Gene expression databases

BgeeiENSG00000178381
CleanExiHS_ZFAND2A
ExpressionAtlasiQ8N6M9 baseline and differential
GenevisibleiQ8N6M9 HS

Organism-specific databases

HPAiHPA019469

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RNF216Q9NWF94EBI-3921109,EBI-723313

Protein-protein interaction databases

BioGridi124747, 2 interactors
IntActiQ8N6M9, 6 interactors
STRINGi9606.ENSP00000314619

Structurei

3D structure databases

ProteinModelPortaliQ8N6M9
SMRiQ8N6M9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri7 – 52AN1-type 1PROSITE-ProRule annotationAdd BLAST46
Zinc fingeri97 – 145AN1-type 2PROSITE-ProRule annotationAdd BLAST49

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG3183 Eukaryota
ENOG4111JCH LUCA
GeneTreeiENSGT00730000110968
HOGENOMiHOG000243115
HOVERGENiHBG061194
InParanoidiQ8N6M9
PhylomeDBiQ8N6M9
TreeFamiTF314219

Family and domain databases

Gene3Di4.10.1110.10, 2 hits
InterProiView protein in InterPro
IPR035896 AN1-like_Znf
IPR000058 Znf_AN1
PfamiView protein in Pfam
PF01428 zf-AN1, 2 hits
SMARTiView protein in SMART
SM00154 ZnF_AN1, 2 hits
SUPFAMiSSF118310 SSF118310, 2 hits
PROSITEiView protein in PROSITE
PS51039 ZF_AN1, 2 hits

Sequencei

Sequence statusi: Complete.

Q8N6M9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFPDLGKHC SEKTCKQLDF LPVKCDACKQ DFCKDHFPYA AHKCPFAFQK
60 70 80 90 100
DVHVPVCPLC NTPIPVKKGQ IPDVVVGDHI DRDCDSHPGK KKEKIFTYRC
110 120 130 140
SKEGCKKKEM LQMVCAQCHG NFCIQHRHPL DHSCRHGSRP TIKAG
Length:145
Mass (Da):16,477
Last modified:May 5, 2009 - v2
Checksum:i7726D71465B4D44C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05529553H → L1 PublicationCorresponds to variant dbSNP:rs17855544Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH236953 Genomic DNA Translation: EAL23939.1
CH471144 Genomic DNA Translation: EAW87196.1
BC029558 mRNA Translation: AAH29558.1
CCDSiCCDS5323.1
RefSeqiNP_872297.2, NM_182491.2
UniGeneiHs.648111

Genome annotation databases

EnsembliENST00000316495; ENSP00000314619; ENSG00000178381
GeneIDi90637
KEGGihsa:90637
UCSCiuc003skc.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZFN2A_HUMAN
AccessioniPrimary (citable) accession number: Q8N6M9
Secondary accession number(s): A4D220
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: May 5, 2009
Last modified: June 20, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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