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Protein

IQ domain-containing protein F1

Gene

IQCF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in sperm capacitation and acrosome reaction.By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ8N6M8.

Names & Taxonomyi

Protein namesi
Recommended name:
IQ domain-containing protein F1Curated
Gene namesi
Name:IQCF1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:28607. IQCF1.

Subcellular locationi

GO - Cellular componenti

  • acrosomal vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134895829.

Polymorphism and mutation databases

BioMutaiIQCF1.
DMDMi229462886.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 205205IQ domain-containing protein F1PRO_0000282556Add
BLAST

Proteomic databases

PaxDbiQ8N6M8.
PRIDEiQ8N6M8.

PTM databases

iPTMnetiQ8N6M8.
PhosphoSiteiQ8N6M8.

Expressioni

Gene expression databases

BgeeiQ8N6M8.
CleanExiHS_IQCF1.
ExpressionAtlasiQ8N6M8. baseline and differential.
GenevisibleiQ8N6M8. HS.

Interactioni

Subunit structurei

Interacts with calmodulin.By similarity

Protein-protein interaction databases

BioGridi126306. 46 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ8N6M8.
SMRiQ8N6M8. Positions 64-114.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 9730IQ 1PROSITE-ProRule annotationAdd
BLAST
Domaini124 – 15330IQ 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 IQ domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410JAMG. Eukaryota.
ENOG41118H0. LUCA.
GeneTreeiENSGT00390000004641.
HOGENOMiHOG000060238.
HOVERGENiHBG071368.
InParanoidiQ8N6M8.
OMAiHSCASRG.
OrthoDBiEOG7PCJJ9.
PhylomeDBiQ8N6M8.
TreeFamiTF337908.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
[Graphical view]
PfamiPF00612. IQ. 2 hits.
[Graphical view]
SMARTiSM00015. IQ. 2 hits.
[Graphical view]
PROSITEiPS50096. IQ. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N6M8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEKQPQKTK EPSKEDEPQQ KEMPTHLSLG AESKAEAKTP VLVETQTVDN
60 70 80 90 100
ANEKSEKPPE NQKKLSDKDT VATKIQAWWR GTLVRRALLH AALSACIIQC
110 120 130 140 150
WWRLILSKIL KKRRQAALEA FSRKEWAAVT LQSQARMWRI RRRYCQVLNA
160 170 180 190 200
VRIIQAYWRC RSCASRGFIK GQYRVTANQL HLQLEILLDS GPCIVTECIP

FSIKE
Length:205
Mass (Da):23,699
Last modified:May 5, 2009 - v2
Checksum:iB13B0E3573927D19
GO
Isoform 2 (identifier: Q8N6M8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     58-81: PPENQKKLSDKDTVATKIQAWWRG → VCQWNMVIVSMDWKSLESEDLRNL
     82-205: Missing.

Note: No experimental confirmation available.
Show »
Length:81
Mass (Da):9,286
Checksum:i5A92D5A17335585D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti76 – 761Q → K.1 Publication
Corresponds to variant rs17852683 [ dbSNP | Ensembl ].
VAR_055096
Natural varianti114 – 1141R → Q.
Corresponds to variant rs11927897 [ dbSNP | Ensembl ].
VAR_031414

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei58 – 8124PPENQ…AWWRG → VCQWNMVIVSMDWKSLESED LRNL in isoform 2. 1 PublicationVSP_024184Add
BLAST
Alternative sequencei82 – 205124Missing in isoform 2. 1 PublicationVSP_024185Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC097636 Genomic DNA. No translation available.
BC029595 mRNA. Translation: AAH29595.1.
BC034228 mRNA. Translation: AAH34228.1.
CCDSiCCDS2836.1. [Q8N6M8-1]
RefSeqiNP_689610.2. NM_152397.2. [Q8N6M8-1]
UniGeneiHs.671210.

Genome annotation databases

EnsembliENST00000310914; ENSP00000307958; ENSG00000173389. [Q8N6M8-1]
GeneIDi132141.
KEGGihsa:132141.
UCSCiuc003dbv.4. human. [Q8N6M8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC097636 Genomic DNA. No translation available.
BC029595 mRNA. Translation: AAH29595.1.
BC034228 mRNA. Translation: AAH34228.1.
CCDSiCCDS2836.1. [Q8N6M8-1]
RefSeqiNP_689610.2. NM_152397.2. [Q8N6M8-1]
UniGeneiHs.671210.

3D structure databases

ProteinModelPortaliQ8N6M8.
SMRiQ8N6M8. Positions 64-114.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126306. 46 interactions.

PTM databases

iPTMnetiQ8N6M8.
PhosphoSiteiQ8N6M8.

Polymorphism and mutation databases

BioMutaiIQCF1.
DMDMi229462886.

Proteomic databases

PaxDbiQ8N6M8.
PRIDEiQ8N6M8.

Protocols and materials databases

DNASUi132141.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310914; ENSP00000307958; ENSG00000173389. [Q8N6M8-1]
GeneIDi132141.
KEGGihsa:132141.
UCSCiuc003dbv.4. human. [Q8N6M8-1]

Organism-specific databases

CTDi132141.
GeneCardsiIQCF1.
HGNCiHGNC:28607. IQCF1.
neXtProtiNX_Q8N6M8.
PharmGKBiPA134895829.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JAMG. Eukaryota.
ENOG41118H0. LUCA.
GeneTreeiENSGT00390000004641.
HOGENOMiHOG000060238.
HOVERGENiHBG071368.
InParanoidiQ8N6M8.
OMAiHSCASRG.
OrthoDBiEOG7PCJJ9.
PhylomeDBiQ8N6M8.
TreeFamiTF337908.

Enzyme and pathway databases

SignaLinkiQ8N6M8.

Miscellaneous databases

GenomeRNAii132141.
PROiQ8N6M8.

Gene expression databases

BgeeiQ8N6M8.
CleanExiHS_IQCF1.
ExpressionAtlasiQ8N6M8. baseline and differential.
GenevisibleiQ8N6M8. HS.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
[Graphical view]
PfamiPF00612. IQ. 2 hits.
[Graphical view]
SMARTiSM00015. IQ. 2 hits.
[Graphical view]
PROSITEiPS50096. IQ. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT LYS-76.
    Tissue: Brain and Testis.
  3. "A novel acrosomal protein, IQCF1, involved in sperm capacitation and the acrosome reaction."
    Fang P., Xu W., Li D., Zhao X., Dai J., Wang Z., Yan X., Qin M., Zhang Y., Xu C., Wang L., Qiao Z.
    Andrology 3:332-344(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiIQCF1_HUMAN
AccessioniPrimary (citable) accession number: Q8N6M8
Secondary accession number(s): Q8N711
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: May 5, 2009
Last modified: June 8, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.