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Protein

IQ domain-containing protein F1

Gene

IQCF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in sperm capacitation and acrosome reaction.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

SignaLinkiQ8N6M8.

Names & Taxonomyi

Protein namesi
Recommended name:
IQ domain-containing protein F1Curated
Gene namesi
Name:IQCF1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000173389.15.
HGNCiHGNC:28607. IQCF1.

Subcellular locationi

Keywords - Cellular componenti

Cytoplasmic vesicle

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000173389.
PharmGKBiPA134895829.

Polymorphism and mutation databases

BioMutaiIQCF1.
DMDMi229462886.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002825561 – 205IQ domain-containing protein F1Add BLAST205

Proteomic databases

PaxDbiQ8N6M8.
PeptideAtlasiQ8N6M8.
PRIDEiQ8N6M8.

PTM databases

iPTMnetiQ8N6M8.
PhosphoSitePlusiQ8N6M8.

Expressioni

Gene expression databases

BgeeiENSG00000173389.
CleanExiHS_IQCF1.
ExpressionAtlasiQ8N6M8. baseline and differential.
GenevisibleiQ8N6M8. HS.

Interactioni

Subunit structurei

Interacts with calmodulin.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi126306. 55 interactors.
STRINGi9606.ENSP00000307958.

Structurei

3D structure databases

ProteinModelPortaliQ8N6M8.
SMRiQ8N6M8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 97IQ 1PROSITE-ProRule annotationAdd BLAST30
Domaini124 – 153IQ 2PROSITE-ProRule annotationAdd BLAST30

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410JAMG. Eukaryota.
ENOG41118H0. LUCA.
GeneTreeiENSGT00390000004641.
HOGENOMiHOG000060238.
HOVERGENiHBG071368.
InParanoidiQ8N6M8.
OMAiHSCASRG.
OrthoDBiEOG091G0SPR.
PhylomeDBiQ8N6M8.
TreeFamiTF337908.

Family and domain databases

InterProiView protein in InterPro
IPR000048. IQ_motif_EF-hand-BS.
PfamiView protein in Pfam
PF00612. IQ. 2 hits.
SMARTiView protein in SMART
SM00015. IQ. 2 hits.
PROSITEiView protein in PROSITE
PS50096. IQ. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N6M8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEKQPQKTK EPSKEDEPQQ KEMPTHLSLG AESKAEAKTP VLVETQTVDN
60 70 80 90 100
ANEKSEKPPE NQKKLSDKDT VATKIQAWWR GTLVRRALLH AALSACIIQC
110 120 130 140 150
WWRLILSKIL KKRRQAALEA FSRKEWAAVT LQSQARMWRI RRRYCQVLNA
160 170 180 190 200
VRIIQAYWRC RSCASRGFIK GQYRVTANQL HLQLEILLDS GPCIVTECIP

FSIKE
Length:205
Mass (Da):23,699
Last modified:May 5, 2009 - v2
Checksum:iB13B0E3573927D19
GO
Isoform 2 (identifier: Q8N6M8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     58-81: PPENQKKLSDKDTVATKIQAWWRG → VCQWNMVIVSMDWKSLESEDLRNL
     82-205: Missing.

Note: No experimental confirmation available.
Show »
Length:81
Mass (Da):9,286
Checksum:i5A92D5A17335585D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05509676Q → K1 PublicationCorresponds to variant dbSNP:rs17852683Ensembl.1
Natural variantiVAR_031414114R → Q. Corresponds to variant dbSNP:rs11927897Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02418458 – 81PPENQ…AWWRG → VCQWNMVIVSMDWKSLESED LRNL in isoform 2. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_02418582 – 205Missing in isoform 2. 1 PublicationAdd BLAST124

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC097636 Genomic DNA. No translation available.
BC029595 mRNA. Translation: AAH29595.1.
BC034228 mRNA. Translation: AAH34228.1.
CCDSiCCDS2836.1. [Q8N6M8-1]
RefSeqiNP_689610.2. NM_152397.2. [Q8N6M8-1]
UniGeneiHs.671210.

Genome annotation databases

EnsembliENST00000310914; ENSP00000307958; ENSG00000173389. [Q8N6M8-1]
GeneIDi132141.
KEGGihsa:132141.
UCSCiuc003dbv.4. human. [Q8N6M8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIQCF1_HUMAN
AccessioniPrimary (citable) accession number: Q8N6M8
Secondary accession number(s): Q8N711
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: May 5, 2009
Last modified: September 27, 2017
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations