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Q8N6M6

- AMPO_HUMAN

UniProt

Q8N6M6 - AMPO_HUMAN

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Protein
Aminopeptidase O
Gene
AOPEP, C9orf3, ONPEP
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Aminopeptidases catalyze the hydrolysis of amino acid residues from the N-terminus of peptide or protein substrates. Able to cleave angiotensin III to generate angiotensin IV, a bioactive peptide of the renin-angiotensin pathway. Not able to cleave angiotensin I and angiotensin II. May play a role in the proteolytic processing of bioactive peptides in tissues such as testis and heart.1 Publication

Cofactori

Binds 1 zinc ion per subunit By similarity.

Enzyme regulationi

Strongly inhibited by ophenanthroline, a metalloprotease inhibitor. Inhibited by arphamenine A, a potent inhibitor of aminopeptidases. Not affected by AEBSF and E-64, which are common inhibitors of serine- and cysteine-proteases, respectively.1 Publication

Kineticsi

  1. KM=6 µM for Arg-AMC1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi479 – 4791Zinc; catalytic By similarity
Active sitei480 – 4801Proton acceptor By similarity
Metal bindingi483 – 4831Zinc; catalytic By similarity
Metal bindingi502 – 5021Zinc; catalytic By similarity
Sitei586 – 5861Transition state stabilizer By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB
  2. metallopeptidase activity Source: UniProtKB
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. leukotriene biosynthetic process Source: InterPro
  2. proteolysis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

SABIO-RKQ8N6M6.

Protein family/group databases

MEROPSiM01.028.

Names & Taxonomyi

Protein namesi
Recommended name:
Aminopeptidase O (EC:3.4.11.-)
Short name:
AP-O
Gene namesi
Name:AOPEP
Synonyms:C9orf3, ONPEP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:1361. C9orf3.

Subcellular locationi

Cytoplasm Reviewed prediction

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleolus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25978.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 819819Aminopeptidase O
PRO_0000095091Add
BLAST

Proteomic databases

PaxDbiQ8N6M6.
PRIDEiQ8N6M6.

PTM databases

PhosphoSiteiQ8N6M6.

Expressioni

Tissue specificityi

Predominantly expressed in pancreas, placenta, liver, testis and heart. Expressed at lower level in brain, lung and kidney.1 Publication

Gene expression databases

ArrayExpressiQ8N6M6.
BgeeiQ8N6M6.
CleanExiHS_C9orf3.
GenevestigatoriQ8N6M6.

Organism-specific databases

HPAiHPA004633.

Interactioni

Protein-protein interaction databases

BioGridi124346. 1 interaction.
STRINGi9606.ENSP00000297979.

Structurei

3D structure databases

ProteinModelPortaliQ8N6M6.
SMRiQ8N6M6. Positions 244-818.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M1 family.

Phylogenomic databases

eggNOGiNOG122535.
HOVERGENiHBG050496.
InParanoidiQ8N6M6.
KOiK09606.
OMAiAIRIWYK.
OrthoDBiEOG741Z1Q.
PhylomeDBiQ8N6M6.
TreeFamiTF332004.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR001930. Peptidase_M1.
IPR015211. Peptidase_M1_C.
IPR014782. Peptidase_M1_N.
[Graphical view]
PANTHERiPTHR11533. PTHR11533. 1 hit.
PfamiPF09127. Leuk-A4-hydro_C. 1 hit.
PF01433. Peptidase_M1. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N6M6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDIQLDPARD DLPLMANTSH ILVKHYVLDL DVDFESQVIE GTIVLFLEDG    50
NRFKKQNSSI EEACQSESNK ACKFGMPEPC HIPVTNARTF SSEMEYNDFA 100
ICSKGEKDTS DKDGNHDNQE HASGISSSKY CCDTGNHGSE DFLLVLDCCD 150
LSVLKVEEVD VAAVPGLEKF TRSPELTVVS EEFRNQIVRE LVTLPANRWR 200
EQLDYYARCS QAPGCGELLF DTDTWSLQIR KTGAQTATDF PHAIRIWYKT 250
KPEGRSVTWT SDQSGRPCVY TVGSPINNRA LFPCQEPPVA MSTWQATVRA 300
AASFVVLMSG ENSAKPTQLW EECSSWYYYV TMPMPASTFT IAVGCWTEMK 350
METWSSNDLA TERPFSPSEA NFRHVGVCSH MEYPCRFQNA SATTQEIIPH 400
RVFAPVCLTG ACQETLLRLI PPCLSAAHSV LGAHPFSRLD VLIVPANFPS 450
LGMASPHIMF LSQSILTGGN HLCGTRLCHE IAHAWFGLAI GARDWTEEWL 500
SEGFATHLED VFWATAQQLA PYEAREQQEL RACLRWRRLQ DEMQCSPEEM 550
QVLRPSKDKT GHTSDSGASV IKHGLNPEKI FMQVHYLKGY FLLRFLAKRL 600
GDETYFSFLR KFVHTFHGQL ILSQDFLQML LENIPEEKRL ELSVENIYQD 650
WLESSGIPKP LQRERRAGAE CGLARQVRAE VTKWIGVNRR PRKRKRREKE 700
EVFEKLLPDQ LVLLLEHLLE QKTLSPRTLQ SLQRTYHLQD QDAEVRHRWC 750
ELIVKHKFTK AYKSVERFLQ EDQAMGVYLY GELMVSEDAR QQQLARRCFE 800
RTKEQMDRSS AQVVAEMLF 819
Length:819
Mass (Da):93,572
Last modified:March 15, 2005 - v2
Checksum:i9EB4F19295B92674
GO
Isoform 2 (identifier: Q8N6M6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     455-553: Missing.

Show »
Length:720
Mass (Da):82,105
Checksum:i12A6A6169C56A627
GO
Isoform 3 (identifier: Q8N6M6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     555-565: PSKDKTGHTSD → FPHVGGCSGSFS
     566-819: Missing.

Note: No experimental confirmation available.

Show »
Length:566
Mass (Da):63,363
Checksum:i3E9D4D00E45C2A46
GO
Isoform 4 (identifier: Q8N6M6-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     455-553: Missing.
     774-784: AMGVYLYGELM → VGVIFQQMGIL
     785-819: Missing.

Note: No experimental confirmation available.

Show »
Length:685
Mass (Da):77,937
Checksum:i57667BB61D258FD2
GO

Sequence cautioni

The sequence AAH20194.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAB55210.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti179 – 1791V → A.
Corresponds to variant rs16911679 [ dbSNP | Ensembl ].
VAR_021511
Natural varianti179 – 1791V → I.
Corresponds to variant rs16911679 [ dbSNP | Ensembl ].
VAR_057053
Natural varianti255 – 2551R → Q.
Corresponds to variant rs16911681 [ dbSNP | Ensembl ].
VAR_057054
Natural varianti386 – 3861R → C.
Corresponds to variant rs34557833 [ dbSNP | Ensembl ].
VAR_057055

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei455 – 55399Missing in isoform 2 and isoform 4.
VSP_013161Add
BLAST
Alternative sequencei555 – 56511PSKDKTGHTSD → FPHVGGCSGSFS in isoform 3.
VSP_013162Add
BLAST
Alternative sequencei566 – 819254Missing in isoform 3.
VSP_013163Add
BLAST
Alternative sequencei774 – 78411AMGVYLYGELM → VGVIFQQMGIL in isoform 4.
VSP_013164Add
BLAST
Alternative sequencei785 – 81935Missing in isoform 4.
VSP_013165Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ560639 mRNA. Translation: CAD90259.1.
AK027581 mRNA. Translation: BAB55210.1. Different initiation.
AK057450 mRNA. Translation: BAB71491.1.
AL157936, AL353768, AL354893 Genomic DNA. Translation: CAI13040.1.
AL353768, AL157936, AL354893 Genomic DNA. Translation: CAI41125.1.
AL354893, AL157936, AL353768 Genomic DNA. Translation: CAI41325.1.
AL157936, AL353768, AL354893 Genomic DNA. Translation: CAI13039.1.
AL353768, AL157936, AL354893 Genomic DNA. Translation: CAI41126.1.
AL354893, AL157936, AL353768 Genomic DNA. Translation: CAI41326.1.
AL157936, AL353768 Genomic DNA. Translation: CAI13037.1.
AL353768, AL157936 Genomic DNA. Translation: CAI41124.1.
AL157936, AL353768, AL354893 Genomic DNA. Translation: CAI13041.1.
AL353768, AL157936, AL354893 Genomic DNA. Translation: CAI41127.1.
AL354893, AL157936, AL353768 Genomic DNA. Translation: CAI41327.1.
AL157936 Genomic DNA. Translation: CAI13038.1.
BC020194 mRNA. Translation: AAH20194.1. Different initiation.
BC029616 mRNA. Translation: AAH29616.1.
CCDSiCCDS55327.1. [Q8N6M6-3]
CCDS55328.1. [Q8N6M6-1]
CCDS6713.1. [Q8N6M6-2]
RefSeqiNP_001180258.1. NM_001193329.1. [Q8N6M6-1]
NP_001180260.1. NM_001193331.2. [Q8N6M6-3]
NP_116212.3. NM_032823.5. [Q8N6M6-2]
XP_006717369.1. XM_006717306.1. [Q8N6M6-1]
UniGeneiHs.434253.

Genome annotation databases

EnsembliENST00000277198; ENSP00000277198; ENSG00000148120. [Q8N6M6-3]
ENST00000297979; ENSP00000297979; ENSG00000148120. [Q8N6M6-2]
ENST00000375315; ENSP00000364464; ENSG00000148120. [Q8N6M6-1]
GeneIDi84909.
KEGGihsa:84909.
UCSCiuc004aux.2. human. [Q8N6M6-3]
uc004auy.3. human. [Q8N6M6-2]
uc004auz.1. human. [Q8N6M6-4]
uc004ava.3. human. [Q8N6M6-1]

Polymorphism databases

DMDMi61211648.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ560639 mRNA. Translation: CAD90259.1 .
AK027581 mRNA. Translation: BAB55210.1 . Different initiation.
AK057450 mRNA. Translation: BAB71491.1 .
AL157936 , AL353768 , AL354893 Genomic DNA. Translation: CAI13040.1 .
AL353768 , AL157936 , AL354893 Genomic DNA. Translation: CAI41125.1 .
AL354893 , AL157936 , AL353768 Genomic DNA. Translation: CAI41325.1 .
AL157936 , AL353768 , AL354893 Genomic DNA. Translation: CAI13039.1 .
AL353768 , AL157936 , AL354893 Genomic DNA. Translation: CAI41126.1 .
AL354893 , AL157936 , AL353768 Genomic DNA. Translation: CAI41326.1 .
AL157936 , AL353768 Genomic DNA. Translation: CAI13037.1 .
AL353768 , AL157936 Genomic DNA. Translation: CAI41124.1 .
AL157936 , AL353768 , AL354893 Genomic DNA. Translation: CAI13041.1 .
AL353768 , AL157936 , AL354893 Genomic DNA. Translation: CAI41127.1 .
AL354893 , AL157936 , AL353768 Genomic DNA. Translation: CAI41327.1 .
AL157936 Genomic DNA. Translation: CAI13038.1 .
BC020194 mRNA. Translation: AAH20194.1 . Different initiation.
BC029616 mRNA. Translation: AAH29616.1 .
CCDSi CCDS55327.1. [Q8N6M6-3 ]
CCDS55328.1. [Q8N6M6-1 ]
CCDS6713.1. [Q8N6M6-2 ]
RefSeqi NP_001180258.1. NM_001193329.1. [Q8N6M6-1 ]
NP_001180260.1. NM_001193331.2. [Q8N6M6-3 ]
NP_116212.3. NM_032823.5. [Q8N6M6-2 ]
XP_006717369.1. XM_006717306.1. [Q8N6M6-1 ]
UniGenei Hs.434253.

3D structure databases

ProteinModelPortali Q8N6M6.
SMRi Q8N6M6. Positions 244-818.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124346. 1 interaction.
STRINGi 9606.ENSP00000297979.

Protein family/group databases

MEROPSi M01.028.

PTM databases

PhosphoSitei Q8N6M6.

Polymorphism databases

DMDMi 61211648.

Proteomic databases

PaxDbi Q8N6M6.
PRIDEi Q8N6M6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000277198 ; ENSP00000277198 ; ENSG00000148120 . [Q8N6M6-3 ]
ENST00000297979 ; ENSP00000297979 ; ENSG00000148120 . [Q8N6M6-2 ]
ENST00000375315 ; ENSP00000364464 ; ENSG00000148120 . [Q8N6M6-1 ]
GeneIDi 84909.
KEGGi hsa:84909.
UCSCi uc004aux.2. human. [Q8N6M6-3 ]
uc004auy.3. human. [Q8N6M6-2 ]
uc004auz.1. human. [Q8N6M6-4 ]
uc004ava.3. human. [Q8N6M6-1 ]

Organism-specific databases

CTDi 84909.
GeneCardsi GC09P097488.
HGNCi HGNC:1361. C9orf3.
HPAi HPA004633.
neXtProti NX_Q8N6M6.
PharmGKBi PA25978.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG122535.
HOVERGENi HBG050496.
InParanoidi Q8N6M6.
KOi K09606.
OMAi AIRIWYK.
OrthoDBi EOG741Z1Q.
PhylomeDBi Q8N6M6.
TreeFami TF332004.

Enzyme and pathway databases

SABIO-RK Q8N6M6.

Miscellaneous databases

ChiTaRSi C9orf3. human.
GenomeRNAii 84909.
NextBioi 75288.
PROi Q8N6M6.

Gene expression databases

ArrayExpressi Q8N6M6.
Bgeei Q8N6M6.
CleanExi HS_C9orf3.
Genevestigatori Q8N6M6.

Family and domain databases

InterProi IPR016024. ARM-type_fold.
IPR001930. Peptidase_M1.
IPR015211. Peptidase_M1_C.
IPR014782. Peptidase_M1_N.
[Graphical view ]
PANTHERi PTHR11533. PTHR11533. 1 hit.
Pfami PF09127. Leuk-A4-hydro_C. 1 hit.
PF01433. Peptidase_M1. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of human aminopeptidase O, a novel metalloprotease with structural similarity to aminopeptidase B and leukotriene A4 hydrolase."
    Diaz-Perales A., Quesada V., Sanchez L.M., Ugalde A.P., Suarez M.F., Fueyo A., Lopez-Otin C.
    J. Biol. Chem. 280:14310-14317(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, ENZYME REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, ENZYME ACTIVITY, TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 178-819 (ISOFORM 4).
    Tissue: Teratocarcinoma and Testis.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 219-819 (ISOFORM 1).
    Tissue: Lung and Muscle.

Entry informationi

Entry nameiAMPO_HUMAN
AccessioniPrimary (citable) accession number: Q8N6M6
Secondary accession number(s): Q5T9B1
, Q5T9B3, Q5T9B4, Q8WUL6, Q96M23, Q96SS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: July 9, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi