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Q8N6M6

- AMPO_HUMAN

UniProt

Q8N6M6 - AMPO_HUMAN

Protein

Aminopeptidase O

Gene

AOPEP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    Aminopeptidases catalyze the hydrolysis of amino acid residues from the N-terminus of peptide or protein substrates. Able to cleave angiotensin III to generate angiotensin IV, a bioactive peptide of the renin-angiotensin pathway. Not able to cleave angiotensin I and angiotensin II. May play a role in the proteolytic processing of bioactive peptides in tissues such as testis and heart.1 Publication

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Enzyme regulationi

    Strongly inhibited by ophenanthroline, a metalloprotease inhibitor. Inhibited by arphamenine A, a potent inhibitor of aminopeptidases. Not affected by AEBSF and E-64, which are common inhibitors of serine- and cysteine-proteases, respectively.1 Publication

    Kineticsi

    1. KM=6 µM for Arg-AMC1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi479 – 4791Zinc; catalyticBy similarity
    Active sitei480 – 4801Proton acceptorBy similarity
    Metal bindingi483 – 4831Zinc; catalyticBy similarity
    Metal bindingi502 – 5021Zinc; catalyticBy similarity
    Sitei586 – 5861Transition state stabilizerBy similarity

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB
    2. metallopeptidase activity Source: UniProtKB
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. leukotriene biosynthetic process Source: InterPro
    2. proteolysis Source: UniProtKB

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    SABIO-RKQ8N6M6.

    Protein family/group databases

    MEROPSiM01.028.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aminopeptidase O (EC:3.4.11.-)
    Short name:
    AP-O
    Gene namesi
    Name:AOPEP
    Synonyms:C9orf3, ONPEP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:1361. C9orf3.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleolus Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25978.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 819819Aminopeptidase OPRO_0000095091Add
    BLAST

    Proteomic databases

    PaxDbiQ8N6M6.
    PRIDEiQ8N6M6.

    PTM databases

    PhosphoSiteiQ8N6M6.

    Expressioni

    Tissue specificityi

    Predominantly expressed in pancreas, placenta, liver, testis and heart. Expressed at lower level in brain, lung and kidney.1 Publication

    Gene expression databases

    ArrayExpressiQ8N6M6.
    BgeeiQ8N6M6.
    CleanExiHS_C9orf3.
    GenevestigatoriQ8N6M6.

    Organism-specific databases

    HPAiHPA004633.

    Interactioni

    Protein-protein interaction databases

    BioGridi124346. 1 interaction.
    STRINGi9606.ENSP00000297979.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N6M6.
    SMRiQ8N6M6. Positions 244-818.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M1 family.Curated

    Phylogenomic databases

    eggNOGiNOG122535.
    HOVERGENiHBG050496.
    InParanoidiQ8N6M6.
    KOiK09606.
    OMAiAIRIWYK.
    OrthoDBiEOG741Z1Q.
    PhylomeDBiQ8N6M6.
    TreeFamiTF332004.

    Family and domain databases

    InterProiIPR016024. ARM-type_fold.
    IPR001930. Peptidase_M1.
    IPR015211. Peptidase_M1_C.
    IPR014782. Peptidase_M1_N.
    [Graphical view]
    PANTHERiPTHR11533. PTHR11533. 1 hit.
    PfamiPF09127. Leuk-A4-hydro_C. 1 hit.
    PF01433. Peptidase_M1. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N6M6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDIQLDPARD DLPLMANTSH ILVKHYVLDL DVDFESQVIE GTIVLFLEDG    50
    NRFKKQNSSI EEACQSESNK ACKFGMPEPC HIPVTNARTF SSEMEYNDFA 100
    ICSKGEKDTS DKDGNHDNQE HASGISSSKY CCDTGNHGSE DFLLVLDCCD 150
    LSVLKVEEVD VAAVPGLEKF TRSPELTVVS EEFRNQIVRE LVTLPANRWR 200
    EQLDYYARCS QAPGCGELLF DTDTWSLQIR KTGAQTATDF PHAIRIWYKT 250
    KPEGRSVTWT SDQSGRPCVY TVGSPINNRA LFPCQEPPVA MSTWQATVRA 300
    AASFVVLMSG ENSAKPTQLW EECSSWYYYV TMPMPASTFT IAVGCWTEMK 350
    METWSSNDLA TERPFSPSEA NFRHVGVCSH MEYPCRFQNA SATTQEIIPH 400
    RVFAPVCLTG ACQETLLRLI PPCLSAAHSV LGAHPFSRLD VLIVPANFPS 450
    LGMASPHIMF LSQSILTGGN HLCGTRLCHE IAHAWFGLAI GARDWTEEWL 500
    SEGFATHLED VFWATAQQLA PYEAREQQEL RACLRWRRLQ DEMQCSPEEM 550
    QVLRPSKDKT GHTSDSGASV IKHGLNPEKI FMQVHYLKGY FLLRFLAKRL 600
    GDETYFSFLR KFVHTFHGQL ILSQDFLQML LENIPEEKRL ELSVENIYQD 650
    WLESSGIPKP LQRERRAGAE CGLARQVRAE VTKWIGVNRR PRKRKRREKE 700
    EVFEKLLPDQ LVLLLEHLLE QKTLSPRTLQ SLQRTYHLQD QDAEVRHRWC 750
    ELIVKHKFTK AYKSVERFLQ EDQAMGVYLY GELMVSEDAR QQQLARRCFE 800
    RTKEQMDRSS AQVVAEMLF 819
    Length:819
    Mass (Da):93,572
    Last modified:March 15, 2005 - v2
    Checksum:i9EB4F19295B92674
    GO
    Isoform 2 (identifier: Q8N6M6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         455-553: Missing.

    Show »
    Length:720
    Mass (Da):82,105
    Checksum:i12A6A6169C56A627
    GO
    Isoform 3 (identifier: Q8N6M6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         555-565: PSKDKTGHTSD → FPHVGGCSGSFS
         566-819: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:566
    Mass (Da):63,363
    Checksum:i3E9D4D00E45C2A46
    GO
    Isoform 4 (identifier: Q8N6M6-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         455-553: Missing.
         774-784: AMGVYLYGELM → VGVIFQQMGIL
         785-819: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:685
    Mass (Da):77,937
    Checksum:i57667BB61D258FD2
    GO

    Sequence cautioni

    The sequence AAH20194.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB55210.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti179 – 1791V → A.
    Corresponds to variant rs16911679 [ dbSNP | Ensembl ].
    VAR_021511
    Natural varianti179 – 1791V → I.
    Corresponds to variant rs16911679 [ dbSNP | Ensembl ].
    VAR_057053
    Natural varianti255 – 2551R → Q.
    Corresponds to variant rs16911681 [ dbSNP | Ensembl ].
    VAR_057054
    Natural varianti386 – 3861R → C.
    Corresponds to variant rs34557833 [ dbSNP | Ensembl ].
    VAR_057055

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei455 – 55399Missing in isoform 2 and isoform 4. 2 PublicationsVSP_013161Add
    BLAST
    Alternative sequencei555 – 56511PSKDKTGHTSD → FPHVGGCSGSFS in isoform 3. 1 PublicationVSP_013162Add
    BLAST
    Alternative sequencei566 – 819254Missing in isoform 3. 1 PublicationVSP_013163Add
    BLAST
    Alternative sequencei774 – 78411AMGVYLYGELM → VGVIFQQMGIL in isoform 4. 1 PublicationVSP_013164Add
    BLAST
    Alternative sequencei785 – 81935Missing in isoform 4. 1 PublicationVSP_013165Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ560639 mRNA. Translation: CAD90259.1.
    AK027581 mRNA. Translation: BAB55210.1. Different initiation.
    AK057450 mRNA. Translation: BAB71491.1.
    AL157936, AL353768, AL354893 Genomic DNA. Translation: CAI13040.1.
    AL353768, AL157936, AL354893 Genomic DNA. Translation: CAI41125.1.
    AL354893, AL157936, AL353768 Genomic DNA. Translation: CAI41325.1.
    AL157936, AL353768, AL354893 Genomic DNA. Translation: CAI13039.1.
    AL353768, AL157936, AL354893 Genomic DNA. Translation: CAI41126.1.
    AL354893, AL157936, AL353768 Genomic DNA. Translation: CAI41326.1.
    AL157936, AL353768 Genomic DNA. Translation: CAI13037.1.
    AL353768, AL157936 Genomic DNA. Translation: CAI41124.1.
    AL157936, AL353768, AL354893 Genomic DNA. Translation: CAI13041.1.
    AL353768, AL157936, AL354893 Genomic DNA. Translation: CAI41127.1.
    AL354893, AL157936, AL353768 Genomic DNA. Translation: CAI41327.1.
    AL157936 Genomic DNA. Translation: CAI13038.1.
    BC020194 mRNA. Translation: AAH20194.1. Different initiation.
    BC029616 mRNA. Translation: AAH29616.1.
    CCDSiCCDS55327.1. [Q8N6M6-3]
    CCDS55328.1. [Q8N6M6-1]
    CCDS6713.1. [Q8N6M6-2]
    RefSeqiNP_001180258.1. NM_001193329.1. [Q8N6M6-1]
    NP_001180260.1. NM_001193331.2. [Q8N6M6-3]
    NP_116212.3. NM_032823.5. [Q8N6M6-2]
    XP_006717369.1. XM_006717306.1. [Q8N6M6-1]
    UniGeneiHs.434253.

    Genome annotation databases

    EnsembliENST00000277198; ENSP00000277198; ENSG00000148120. [Q8N6M6-3]
    ENST00000297979; ENSP00000297979; ENSG00000148120. [Q8N6M6-2]
    ENST00000375315; ENSP00000364464; ENSG00000148120. [Q8N6M6-1]
    GeneIDi84909.
    KEGGihsa:84909.
    UCSCiuc004aux.2. human. [Q8N6M6-3]
    uc004auy.3. human. [Q8N6M6-2]
    uc004auz.1. human. [Q8N6M6-4]
    uc004ava.3. human. [Q8N6M6-1]

    Polymorphism databases

    DMDMi61211648.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ560639 mRNA. Translation: CAD90259.1 .
    AK027581 mRNA. Translation: BAB55210.1 . Different initiation.
    AK057450 mRNA. Translation: BAB71491.1 .
    AL157936 , AL353768 , AL354893 Genomic DNA. Translation: CAI13040.1 .
    AL353768 , AL157936 , AL354893 Genomic DNA. Translation: CAI41125.1 .
    AL354893 , AL157936 , AL353768 Genomic DNA. Translation: CAI41325.1 .
    AL157936 , AL353768 , AL354893 Genomic DNA. Translation: CAI13039.1 .
    AL353768 , AL157936 , AL354893 Genomic DNA. Translation: CAI41126.1 .
    AL354893 , AL157936 , AL353768 Genomic DNA. Translation: CAI41326.1 .
    AL157936 , AL353768 Genomic DNA. Translation: CAI13037.1 .
    AL353768 , AL157936 Genomic DNA. Translation: CAI41124.1 .
    AL157936 , AL353768 , AL354893 Genomic DNA. Translation: CAI13041.1 .
    AL353768 , AL157936 , AL354893 Genomic DNA. Translation: CAI41127.1 .
    AL354893 , AL157936 , AL353768 Genomic DNA. Translation: CAI41327.1 .
    AL157936 Genomic DNA. Translation: CAI13038.1 .
    BC020194 mRNA. Translation: AAH20194.1 . Different initiation.
    BC029616 mRNA. Translation: AAH29616.1 .
    CCDSi CCDS55327.1. [Q8N6M6-3 ]
    CCDS55328.1. [Q8N6M6-1 ]
    CCDS6713.1. [Q8N6M6-2 ]
    RefSeqi NP_001180258.1. NM_001193329.1. [Q8N6M6-1 ]
    NP_001180260.1. NM_001193331.2. [Q8N6M6-3 ]
    NP_116212.3. NM_032823.5. [Q8N6M6-2 ]
    XP_006717369.1. XM_006717306.1. [Q8N6M6-1 ]
    UniGenei Hs.434253.

    3D structure databases

    ProteinModelPortali Q8N6M6.
    SMRi Q8N6M6. Positions 244-818.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124346. 1 interaction.
    STRINGi 9606.ENSP00000297979.

    Protein family/group databases

    MEROPSi M01.028.

    PTM databases

    PhosphoSitei Q8N6M6.

    Polymorphism databases

    DMDMi 61211648.

    Proteomic databases

    PaxDbi Q8N6M6.
    PRIDEi Q8N6M6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000277198 ; ENSP00000277198 ; ENSG00000148120 . [Q8N6M6-3 ]
    ENST00000297979 ; ENSP00000297979 ; ENSG00000148120 . [Q8N6M6-2 ]
    ENST00000375315 ; ENSP00000364464 ; ENSG00000148120 . [Q8N6M6-1 ]
    GeneIDi 84909.
    KEGGi hsa:84909.
    UCSCi uc004aux.2. human. [Q8N6M6-3 ]
    uc004auy.3. human. [Q8N6M6-2 ]
    uc004auz.1. human. [Q8N6M6-4 ]
    uc004ava.3. human. [Q8N6M6-1 ]

    Organism-specific databases

    CTDi 84909.
    GeneCardsi GC09P097488.
    HGNCi HGNC:1361. C9orf3.
    HPAi HPA004633.
    neXtProti NX_Q8N6M6.
    PharmGKBi PA25978.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG122535.
    HOVERGENi HBG050496.
    InParanoidi Q8N6M6.
    KOi K09606.
    OMAi AIRIWYK.
    OrthoDBi EOG741Z1Q.
    PhylomeDBi Q8N6M6.
    TreeFami TF332004.

    Enzyme and pathway databases

    SABIO-RK Q8N6M6.

    Miscellaneous databases

    ChiTaRSi C9orf3. human.
    GenomeRNAii 84909.
    NextBioi 75288.
    PROi Q8N6M6.

    Gene expression databases

    ArrayExpressi Q8N6M6.
    Bgeei Q8N6M6.
    CleanExi HS_C9orf3.
    Genevestigatori Q8N6M6.

    Family and domain databases

    InterProi IPR016024. ARM-type_fold.
    IPR001930. Peptidase_M1.
    IPR015211. Peptidase_M1_C.
    IPR014782. Peptidase_M1_N.
    [Graphical view ]
    PANTHERi PTHR11533. PTHR11533. 1 hit.
    Pfami PF09127. Leuk-A4-hydro_C. 1 hit.
    PF01433. Peptidase_M1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of human aminopeptidase O, a novel metalloprotease with structural similarity to aminopeptidase B and leukotriene A4 hydrolase."
      Diaz-Perales A., Quesada V., Sanchez L.M., Ugalde A.P., Suarez M.F., Fueyo A., Lopez-Otin C.
      J. Biol. Chem. 280:14310-14317(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, ENZYME REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, ENZYME ACTIVITY, TISSUE SPECIFICITY.
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 178-819 (ISOFORM 4).
      Tissue: Teratocarcinoma and Testis.
    3. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 219-819 (ISOFORM 1).
      Tissue: Lung and Muscle.

    Entry informationi

    Entry nameiAMPO_HUMAN
    AccessioniPrimary (citable) accession number: Q8N6M6
    Secondary accession number(s): Q5T9B1
    , Q5T9B3, Q5T9B4, Q8WUL6, Q96M23, Q96SS1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. Peptidase families
      Classification of peptidase families and list of entries
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3