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Q8N6M5 (ALLC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable allantoicase

EC=3.5.3.4
Alternative name(s):
Allantoate amidinohydrolase
Gene names
Name:ALLC
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length410 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals.

Catalytic activity

Allantoate + H2O = (S)-ureidoglycolate + urea.

Sequence similarities

Belongs to the allantoicase family.

Sequence caution

The sequence AAY24236.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processallantoin catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionallantoicase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8N6M5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8N6M5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-248: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 410410Probable allantoicase
PRO_0000205905

Natural variations

Alternative sequence1 – 248248Missing in isoform 2.
VSP_015618

Experimental info

Sequence conflict11M → T in AAY24236. Ref.2
Sequence conflict1291T → I in AAH29652. Ref.3
Sequence conflict1291T → I in AAK72970. Ref.4
Sequence conflict1461L → P in AAK72970. Ref.4
Sequence conflict3201Missing in AAF67097. Ref.1
Sequence conflict3201Missing in AAH29652. Ref.3
Sequence conflict3201Missing in AAK72970. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 5, 2011. Version 3.
Checksum: 431E5D1A6D0BC159

FASTA41045,750
        10         20         30         40         50         60 
MADAPKEGRL TRFLDFTQLM DMASESVGGK ILFATDDFFA PAENLIKSDS PCFKEHEYTE 

        70         80         90        100        110        120 
FGKWMDGWET RRKRIPGHDW CVLRLGIQGV IRGFDVDVSY FTGDYAPRVS IQAANLEEDK 

       130        140        150        160        170        180 
LPEIPERGTR TGAAATPEEF EAIAELKSDD WSYLVPMTEL KPGNPASGHN YFLVNSQQRW 

       190        200        210        220        230        240 
THIRLNIFPD GGIARLRVFG TGQKDWTATD PKEPADLVAI AFGGVCVGFS NAKFGHPNNI 

       250        260        270        280        290        300 
IGVGGAKSMA DGWETARRLD RPPILENDEN GILLVPGCEW AVFRLAHPGV ITRIEIDTKY 

       310        320        330        340        350        360 
FEGNAPDSCK VDGCILTTQE EEAVIRQKWI LPAHKWKPLL PVTKLSPNQS HLFDSLTLEL 

       370        380        390        400        410 
QDVITHARLT IVPDGGVSRL RLRGFPSSIC LLRPREKPML KFSVSFKANP 

« Hide

Isoform 2 [UniParc].

Checksum: CB2BB26A1772563A
Show »

FASTA16218,305

References

« Hide 'large scale' references
[1]"Human allantoicase gene: cDNA cloning, genomic organization and chromosome localization."
Vigetti D., Monetti C., Acquati F., Taramelli R., Bernardini G.
Gene 256:253-260(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Tissue: Fetal spleen.
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain.
[4]"Genomic organization and chromosome localization of the murine and human allantoicase gene."
Vigetti D., Monetti C., Prati M., Gornati R., Bernardini G.
Gene 289:13-17(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 35-372 (ISOFORM 1), GENE STRUCTURE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF215924 mRNA. Translation: AAF67097.1.
AC010907 Genomic DNA. Translation: AAY24236.1. Sequence problems.
BC029652 mRNA. Translation: AAH29652.1.
BC035356 mRNA. Translation: AAH35356.1.
AF395820 mRNA. Translation: AAK72970.1.
RefSeqNP_060906.3. NM_018436.3.
XP_005263908.1. XM_005263851.1.
UniGeneHs.97899.

3D structure databases

ProteinModelPortalQ8N6M5.
SMRQ8N6M5. Positions 20-385.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000252505.

PTM databases

PhosphoSiteQ8N6M5.

Polymorphism databases

DMDM327478594.

Proteomic databases

PaxDbQ8N6M5.
PRIDEQ8N6M5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID55821.
KEGGhsa:55821.
UCSCuc002qyf.3. human. [Q8N6M5-2]
uc010ewt.3. human. [Q8N6M5-1]

Organism-specific databases

CTD55821.
GeneCardsGC02P003705.
HGNCHGNC:17377. ALLC.
HPAHPA037742.
HPA037743.
MIM612396. gene.
neXtProtNX_Q8N6M5.
PharmGKBPA24720.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG4266.
HOGENOMHOG000256158.
HOVERGENHBG004209.
InParanoidQ8N6M5.
KOK01477.
PhylomeDBQ8N6M5.

Gene expression databases

ArrayExpressQ8N6M5.
BgeeQ8N6M5.
CleanExHS_ALLC.
GenevestigatorQ8N6M5.

Family and domain databases

Gene3D2.60.120.260. 2 hits.
InterProIPR005164. Allantoicase.
IPR015908. Allantoicase_dom.
IPR008979. Galactose-bd-like.
[Graphical view]
PANTHERPTHR12045. PTHR12045. 1 hit.
PfamPF03561. Allantoicase. 2 hits.
[Graphical view]
SUPFAMSSF49785. SSF49785. 2 hits.
TIGRFAMsTIGR02961. allantoicase. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi55821.
NextBio61010.
PROQ8N6M5.
SOURCESearch...

Entry information

Entry nameALLC_HUMAN
AccessionPrimary (citable) accession number: Q8N6M5
Secondary accession number(s): Q53T95 expand/collapse secondary AC list , Q5RL81, Q96RE6, Q9NZA7
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: April 5, 2011
Last modified: April 16, 2014
This is version 89 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM