Q8N6M5 (ALLC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable allantoicase
EC=3.5.3.4

Alternative name(s):
Allantoate amidinohydrolase

Gene names

Name:

ALLC

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	410 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals.
Catalytic activity	Allantoate + H2O = (S)-ureidoglycolate + urea.
Sequence similarities	Belongs to the allantoicase family.
Sequence caution	The sequence AAY24236.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	allantoin catabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	allantoicase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8N6M5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8N6M5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-248: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 410	410	Probable allantoicase		PRO_0000205905
Natural variations
	Alternative sequence	1 – 248	248	Missing in isoform 2.		VSP_015618
Experimental info
	Sequence conflict	1	1	M → T in AAY24236. Ref.2
	Sequence conflict	129	1	T → I in AAH29652. Ref.3
	Sequence conflict	129	1	T → I in AAK72970. Ref.4
	Sequence conflict	146	1	L → P in AAK72970. Ref.4
	Sequence conflict	320	1	Missing in AAF67097. Ref.1
	Sequence conflict	320	1	Missing in AAH29652. Ref.3
	Sequence conflict	320	1	Missing in AAK72970. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 5, 2011. Version 3. Checksum: 431E5D1A6D0BC159	FASTA	410	45,750
	10 20 30 40 50 60 MADAPKEGRL TRFLDFTQLM DMASESVGGK ILFATDDFFA PAENLIKSDS PCFKEHEYTE 70 80 90 100 110 120 FGKWMDGWET RRKRIPGHDW CVLRLGIQGV IRGFDVDVSY FTGDYAPRVS IQAANLEEDK 130 140 150 160 170 180 LPEIPERGTR TGAAATPEEF EAIAELKSDD WSYLVPMTEL KPGNPASGHN YFLVNSQQRW 190 200 210 220 230 240 THIRLNIFPD GGIARLRVFG TGQKDWTATD PKEPADLVAI AFGGVCVGFS NAKFGHPNNI 250 260 270 280 290 300 IGVGGAKSMA DGWETARRLD RPPILENDEN GILLVPGCEW AVFRLAHPGV ITRIEIDTKY 310 320 330 340 350 360 FEGNAPDSCK VDGCILTTQE EEAVIRQKWI LPAHKWKPLL PVTKLSPNQS HLFDSLTLEL 370 380 390 400 410 QDVITHARLT IVPDGGVSRL RLRGFPSSIC LLRPREKPML KFSVSFKANP
	Isoform 2 [UniParc]. Checksum: CB2BB26A1772563A	FASTA	162	18,305
	10 20 30 40 50 60 MADGWETARR LDRPPILEND ENGILLVPGC EWAVFRLAHP GVITRIEIDT KYFEGNAPDS 70 80 90 100 110 120 CKVDGCILTT QEEEAVIRQK WILPAHKWKP LLPVTKLSPN QSHLFDSLTL ELQDVITHAR 130 140 150 160 LTIVPDGGVS RLRLRGFPSS ICLLRPREKP MLKFSVSFKA NP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human allantoicase gene: cDNA cloning, genomic organization and chromosome localization." Vigetti D., Monetti C., Acquati F., Taramelli R., Bernardini G. Gene 256:253-260(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Fetal spleen.
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Brain.
[4]	"Genomic organization and chromosome localization of the murine and human allantoicase gene." Vigetti D., Monetti C., Prati M., Gornati R., Bernardini G. Gene 289:13-17(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 35-372 (ISOFORM 1), GENE STRUCTURE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF215924 mRNA. Translation: AAF67097.1. AC010907 Genomic DNA. Translation: AAY24236.1. Sequence problems. BC029652 mRNA. Translation: AAH29652.1. BC035356 mRNA. Translation: AAH35356.1. AF395820 mRNA. Translation: AAK72970.1.
IPI	IPI00167035. IPI00644362.
RefSeq	NP_060906.3. NM_018436.3.
UniGene	Hs.97899.
3D structure databases
ProteinModelPortal	Q8N6M5.
SMR	Q8N6M5. Positions 20-385.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000252505.
PTM databases
PhosphoSite	Q8N6M5.
Polymorphism databases
DMDM	82583672.
Proteomic databases
PaxDb	Q8N6M5.
PRIDE	Q8N6M5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	55821.
KEGG	hsa:55821.
UCSC	uc002qyf.3. human. uc010ewt.3. human.
Organism-specific databases
CTD	55821.
GeneCards	GC02P003705.
HGNC	HGNC:17377. ALLC.
HPA	HPA037743.
MIM	612396. gene.
neXtProt	NX_Q8N6M5.
PharmGKB	PA24720.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG4266.
HOGENOM	HOG000256158.
HOVERGEN	HBG004209.
InParanoid	Q8N6M5.
KO	K01477.
Gene expression databases
ArrayExpress	Q8N6M5.
Bgee	Q8N6M5.
CleanEx	HS_ALLC.
Genevestigator	Q8N6M5.
GermOnline	ENSG00000151360. Homo sapiens.
Family and domain databases
InterPro	IPR005164. Allantoicase. IPR015908. Allantoicase_dom. IPR008979. Galactose-bd-like. [Graphical view]
PANTHER	PTHR12045. PTHR12045. 1 hit.
Pfam	PF03561. Allantoicase. 2 hits. [Graphical view]
SUPFAM	SSF49785. Gal_bind_like. 2 hits.
TIGRFAMs	TIGR02961. allantoicase. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	55821.
NextBio	61010.
SOURCE	Search...

Entry information

Entry name

ALLC_HUMAN

Accession

Primary (citable) accession number: Q8N6M5
Secondary accession number(s): Q53T95 , Q5RL81, Q96RE6, Q9NZA7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2005
Last sequence update:	April 5, 2011
Last modified:	May 1, 2013
This is version 81 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.