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Q8N6M5

- ALLC_HUMAN

UniProt

Q8N6M5 - ALLC_HUMAN

Protein

Probable allantoicase

Gene

ALLC

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 3 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals.

    Catalytic activityi

    Allantoate + H2O = (S)-ureidoglycolate + urea.

    GO - Molecular functioni

    1. allantoicase activity Source: UniProtKB-EC

    GO - Biological processi

    1. allantoin catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable allantoicase (EC:3.5.3.4)
    Alternative name(s):
    Allantoate amidinohydrolase
    Gene namesi
    Name:ALLC
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:17377. ALLC.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24720.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 410410Probable allantoicasePRO_0000205905Add
    BLAST

    Proteomic databases

    PaxDbiQ8N6M5.
    PRIDEiQ8N6M5.

    PTM databases

    PhosphoSiteiQ8N6M5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8N6M5.
    BgeeiQ8N6M5.
    CleanExiHS_ALLC.
    GenevestigatoriQ8N6M5.

    Organism-specific databases

    HPAiHPA037742.
    HPA037743.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000252505.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N6M5.
    SMRiQ8N6M5. Positions 20-385.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the allantoicase family.Curated

    Phylogenomic databases

    eggNOGiCOG4266.
    HOGENOMiHOG000256158.
    HOVERGENiHBG004209.
    InParanoidiQ8N6M5.
    KOiK01477.
    PhylomeDBiQ8N6M5.

    Family and domain databases

    Gene3Di2.60.120.260. 2 hits.
    InterProiIPR005164. Allantoicase.
    IPR015908. Allantoicase_dom.
    IPR008979. Galactose-bd-like.
    [Graphical view]
    PANTHERiPTHR12045. PTHR12045. 1 hit.
    PfamiPF03561. Allantoicase. 2 hits.
    [Graphical view]
    SUPFAMiSSF49785. SSF49785. 2 hits.
    TIGRFAMsiTIGR02961. allantoicase. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N6M5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MADAPKEGRL TRFLDFTQLM DMASESVGGK ILFATDDFFA PAENLIKSDS    50
    PCFKEHEYTE FGKWMDGWET RRKRIPGHDW CVLRLGIQGV IRGFDVDVSY 100
    FTGDYAPRVS IQAANLEEDK LPEIPERGTR TGAAATPEEF EAIAELKSDD 150
    WSYLVPMTEL KPGNPASGHN YFLVNSQQRW THIRLNIFPD GGIARLRVFG 200
    TGQKDWTATD PKEPADLVAI AFGGVCVGFS NAKFGHPNNI IGVGGAKSMA 250
    DGWETARRLD RPPILENDEN GILLVPGCEW AVFRLAHPGV ITRIEIDTKY 300
    FEGNAPDSCK VDGCILTTQE EEAVIRQKWI LPAHKWKPLL PVTKLSPNQS 350
    HLFDSLTLEL QDVITHARLT IVPDGGVSRL RLRGFPSSIC LLRPREKPML 400
    KFSVSFKANP 410
    Length:410
    Mass (Da):45,750
    Last modified:April 5, 2011 - v3
    Checksum:i431E5D1A6D0BC159
    GO
    Isoform 2 (identifier: Q8N6M5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-248: Missing.

    Show »
    Length:162
    Mass (Da):18,305
    Checksum:iCB2BB26A1772563A
    GO

    Sequence cautioni

    The sequence AAY24236.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1 – 11M → T in AAY24236. (PubMed:15815621)Curated
    Sequence conflicti129 – 1291T → I in AAH29652. (PubMed:15489334)Curated
    Sequence conflicti129 – 1291T → I in AAK72970. (PubMed:12036579)Curated
    Sequence conflicti146 – 1461L → P in AAK72970. (PubMed:12036579)Curated
    Sequence conflicti320 – 3201Missing in AAF67097. (PubMed:11054555)Curated
    Sequence conflicti320 – 3201Missing in AAH29652. (PubMed:15489334)Curated
    Sequence conflicti320 – 3201Missing in AAK72970. (PubMed:12036579)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 248248Missing in isoform 2. 2 PublicationsVSP_015618Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF215924 mRNA. Translation: AAF67097.1.
    AC010907 Genomic DNA. Translation: AAY24236.1. Sequence problems.
    BC029652 mRNA. Translation: AAH29652.1.
    BC035356 mRNA. Translation: AAH35356.1.
    AF395820 mRNA. Translation: AAK72970.1.
    RefSeqiNP_060906.3. NM_018436.3.
    XP_005263908.1. XM_005263851.1. [Q8N6M5-2]
    UniGeneiHs.97899.

    Genome annotation databases

    GeneIDi55821.
    KEGGihsa:55821.
    UCSCiuc002qyf.3. human. [Q8N6M5-2]
    uc010ewt.3. human. [Q8N6M5-1]

    Polymorphism databases

    DMDMi327478594.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF215924 mRNA. Translation: AAF67097.1 .
    AC010907 Genomic DNA. Translation: AAY24236.1 . Sequence problems.
    BC029652 mRNA. Translation: AAH29652.1 .
    BC035356 mRNA. Translation: AAH35356.1 .
    AF395820 mRNA. Translation: AAK72970.1 .
    RefSeqi NP_060906.3. NM_018436.3.
    XP_005263908.1. XM_005263851.1. [Q8N6M5-2 ]
    UniGenei Hs.97899.

    3D structure databases

    ProteinModelPortali Q8N6M5.
    SMRi Q8N6M5. Positions 20-385.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000252505.

    PTM databases

    PhosphoSitei Q8N6M5.

    Polymorphism databases

    DMDMi 327478594.

    Proteomic databases

    PaxDbi Q8N6M5.
    PRIDEi Q8N6M5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 55821.
    KEGGi hsa:55821.
    UCSCi uc002qyf.3. human. [Q8N6M5-2 ]
    uc010ewt.3. human. [Q8N6M5-1 ]

    Organism-specific databases

    CTDi 55821.
    GeneCardsi GC02P003705.
    HGNCi HGNC:17377. ALLC.
    HPAi HPA037742.
    HPA037743.
    MIMi 612396. gene.
    neXtProti NX_Q8N6M5.
    PharmGKBi PA24720.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4266.
    HOGENOMi HOG000256158.
    HOVERGENi HBG004209.
    InParanoidi Q8N6M5.
    KOi K01477.
    PhylomeDBi Q8N6M5.

    Miscellaneous databases

    GenomeRNAii 55821.
    NextBioi 61010.
    PROi Q8N6M5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8N6M5.
    Bgeei Q8N6M5.
    CleanExi HS_ALLC.
    Genevestigatori Q8N6M5.

    Family and domain databases

    Gene3Di 2.60.120.260. 2 hits.
    InterProi IPR005164. Allantoicase.
    IPR015908. Allantoicase_dom.
    IPR008979. Galactose-bd-like.
    [Graphical view ]
    PANTHERi PTHR12045. PTHR12045. 1 hit.
    Pfami PF03561. Allantoicase. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49785. SSF49785. 2 hits.
    TIGRFAMsi TIGR02961. allantoicase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Human allantoicase gene: cDNA cloning, genomic organization and chromosome localization."
      Vigetti D., Monetti C., Acquati F., Taramelli R., Bernardini G.
      Gene 256:253-260(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Fetal spleen.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain.
    4. "Genomic organization and chromosome localization of the murine and human allantoicase gene."
      Vigetti D., Monetti C., Prati M., Gornati R., Bernardini G.
      Gene 289:13-17(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 35-372 (ISOFORM 1), GENE STRUCTURE.

    Entry informationi

    Entry nameiALLC_HUMAN
    AccessioniPrimary (citable) accession number: Q8N6M5
    Secondary accession number(s): Q53T95
    , Q5RL81, Q96RE6, Q9NZA7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2005
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 91 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3