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Q8N6M5

- ALLC_HUMAN

UniProt

Q8N6M5 - ALLC_HUMAN

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Protein

Probable allantoicase

Gene
ALLC
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals.

Catalytic activityi

Allantoate + H2O = (S)-ureidoglycolate + urea.

GO - Molecular functioni

  1. allantoicase activity Source: UniProtKB-EC

GO - Biological processi

  1. allantoin catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable allantoicase (EC:3.5.3.4)
Alternative name(s):
Allantoate amidinohydrolase
Gene namesi
Name:ALLC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:17377. ALLC.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24720.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 410410Probable allantoicasePRO_0000205905Add
BLAST

Proteomic databases

PaxDbiQ8N6M5.
PRIDEiQ8N6M5.

PTM databases

PhosphoSiteiQ8N6M5.

Expressioni

Gene expression databases

ArrayExpressiQ8N6M5.
BgeeiQ8N6M5.
CleanExiHS_ALLC.
GenevestigatoriQ8N6M5.

Organism-specific databases

HPAiHPA037742.
HPA037743.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000252505.

Structurei

3D structure databases

ProteinModelPortaliQ8N6M5.
SMRiQ8N6M5. Positions 20-385.

Family & Domainsi

Sequence similaritiesi

Belongs to the allantoicase family.

Phylogenomic databases

eggNOGiCOG4266.
HOGENOMiHOG000256158.
HOVERGENiHBG004209.
InParanoidiQ8N6M5.
KOiK01477.
PhylomeDBiQ8N6M5.

Family and domain databases

Gene3Di2.60.120.260. 2 hits.
InterProiIPR005164. Allantoicase.
IPR015908. Allantoicase_dom.
IPR008979. Galactose-bd-like.
[Graphical view]
PANTHERiPTHR12045. PTHR12045. 1 hit.
PfamiPF03561. Allantoicase. 2 hits.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 2 hits.
TIGRFAMsiTIGR02961. allantoicase. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N6M5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MADAPKEGRL TRFLDFTQLM DMASESVGGK ILFATDDFFA PAENLIKSDS    50
PCFKEHEYTE FGKWMDGWET RRKRIPGHDW CVLRLGIQGV IRGFDVDVSY 100
FTGDYAPRVS IQAANLEEDK LPEIPERGTR TGAAATPEEF EAIAELKSDD 150
WSYLVPMTEL KPGNPASGHN YFLVNSQQRW THIRLNIFPD GGIARLRVFG 200
TGQKDWTATD PKEPADLVAI AFGGVCVGFS NAKFGHPNNI IGVGGAKSMA 250
DGWETARRLD RPPILENDEN GILLVPGCEW AVFRLAHPGV ITRIEIDTKY 300
FEGNAPDSCK VDGCILTTQE EEAVIRQKWI LPAHKWKPLL PVTKLSPNQS 350
HLFDSLTLEL QDVITHARLT IVPDGGVSRL RLRGFPSSIC LLRPREKPML 400
KFSVSFKANP 410
Length:410
Mass (Da):45,750
Last modified:April 5, 2011 - v3
Checksum:i431E5D1A6D0BC159
GO
Isoform 2 (identifier: Q8N6M5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-248: Missing.

Show »
Length:162
Mass (Da):18,305
Checksum:iCB2BB26A1772563A
GO

Sequence cautioni

The sequence AAY24236.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 248248Missing in isoform 2. VSP_015618Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 11M → T in AAY24236. 1 Publication
Sequence conflicti129 – 1291T → I in AAH29652. 1 Publication
Sequence conflicti129 – 1291T → I in AAK72970. 1 Publication
Sequence conflicti146 – 1461L → P in AAK72970. 1 Publication
Sequence conflicti320 – 3201Missing in AAF67097. 1 Publication
Sequence conflicti320 – 3201Missing in AAH29652. 1 Publication
Sequence conflicti320 – 3201Missing in AAK72970. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF215924 mRNA. Translation: AAF67097.1.
AC010907 Genomic DNA. Translation: AAY24236.1. Sequence problems.
BC029652 mRNA. Translation: AAH29652.1.
BC035356 mRNA. Translation: AAH35356.1.
AF395820 mRNA. Translation: AAK72970.1.
RefSeqiNP_060906.3. NM_018436.3.
XP_005263908.1. XM_005263851.1. [Q8N6M5-2]
UniGeneiHs.97899.

Genome annotation databases

GeneIDi55821.
KEGGihsa:55821.
UCSCiuc002qyf.3. human. [Q8N6M5-2]
uc010ewt.3. human. [Q8N6M5-1]

Polymorphism databases

DMDMi327478594.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF215924 mRNA. Translation: AAF67097.1 .
AC010907 Genomic DNA. Translation: AAY24236.1 . Sequence problems.
BC029652 mRNA. Translation: AAH29652.1 .
BC035356 mRNA. Translation: AAH35356.1 .
AF395820 mRNA. Translation: AAK72970.1 .
RefSeqi NP_060906.3. NM_018436.3.
XP_005263908.1. XM_005263851.1. [Q8N6M5-2 ]
UniGenei Hs.97899.

3D structure databases

ProteinModelPortali Q8N6M5.
SMRi Q8N6M5. Positions 20-385.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000252505.

PTM databases

PhosphoSitei Q8N6M5.

Polymorphism databases

DMDMi 327478594.

Proteomic databases

PaxDbi Q8N6M5.
PRIDEi Q8N6M5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 55821.
KEGGi hsa:55821.
UCSCi uc002qyf.3. human. [Q8N6M5-2 ]
uc010ewt.3. human. [Q8N6M5-1 ]

Organism-specific databases

CTDi 55821.
GeneCardsi GC02P003705.
HGNCi HGNC:17377. ALLC.
HPAi HPA037742.
HPA037743.
MIMi 612396. gene.
neXtProti NX_Q8N6M5.
PharmGKBi PA24720.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4266.
HOGENOMi HOG000256158.
HOVERGENi HBG004209.
InParanoidi Q8N6M5.
KOi K01477.
PhylomeDBi Q8N6M5.

Miscellaneous databases

GenomeRNAii 55821.
NextBioi 61010.
PROi Q8N6M5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8N6M5.
Bgeei Q8N6M5.
CleanExi HS_ALLC.
Genevestigatori Q8N6M5.

Family and domain databases

Gene3Di 2.60.120.260. 2 hits.
InterProi IPR005164. Allantoicase.
IPR015908. Allantoicase_dom.
IPR008979. Galactose-bd-like.
[Graphical view ]
PANTHERi PTHR12045. PTHR12045. 1 hit.
Pfami PF03561. Allantoicase. 2 hits.
[Graphical view ]
SUPFAMi SSF49785. SSF49785. 2 hits.
TIGRFAMsi TIGR02961. allantoicase. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human allantoicase gene: cDNA cloning, genomic organization and chromosome localization."
    Vigetti D., Monetti C., Acquati F., Taramelli R., Bernardini G.
    Gene 256:253-260(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Fetal spleen.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  4. "Genomic organization and chromosome localization of the murine and human allantoicase gene."
    Vigetti D., Monetti C., Prati M., Gornati R., Bernardini G.
    Gene 289:13-17(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 35-372 (ISOFORM 1), GENE STRUCTURE.

Entry informationi

Entry nameiALLC_HUMAN
AccessioniPrimary (citable) accession number: Q8N6M5
Secondary accession number(s): Q53T95
, Q5RL81, Q96RE6, Q9NZA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: April 5, 2011
Last modified: May 14, 2014
This is version 90 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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