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Protein

Probable allantoicase

Gene

ALLC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals.

Catalytic activityi

Allantoate + H2O = (S)-ureidoglycolate + urea.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciZFISH:HS14364-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable allantoicase (EC:3.5.3.4)
Alternative name(s):
Allantoate amidinohydrolase
Gene namesi
Name:ALLC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:17377. ALLC.

Pathology & Biotechi

Organism-specific databases

DisGeNETi55821.
PharmGKBiPA24720.

Polymorphism and mutation databases

DMDMi327478594.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002059051 – 410Probable allantoicaseAdd BLAST410

Proteomic databases

PaxDbiQ8N6M5.
PeptideAtlasiQ8N6M5.
PRIDEiQ8N6M5.

PTM databases

iPTMnetiQ8N6M5.
PhosphoSitePlusiQ8N6M5.

Expressioni

Gene expression databases

BgeeiENSG00000151360.
CleanExiHS_ALLC.

Organism-specific databases

HPAiHPA037742.
HPA037743.

Interactioni

Protein-protein interaction databases

BioGridi120929. 1 interactor.
IntActiQ8N6M5. 1 interactor.
STRINGi9606.ENSP00000252505.

Structurei

3D structure databases

ProteinModelPortaliQ8N6M5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the allantoicase family.Curated

Phylogenomic databases

eggNOGiKOG4145. Eukaryota.
COG4266. LUCA.
HOGENOMiHOG000256158.
HOVERGENiHBG004209.
InParanoidiQ8N6M5.
KOiK01477.
PhylomeDBiQ8N6M5.

Family and domain databases

Gene3Di2.60.120.260. 2 hits.
HAMAPiMF_00813. Allantoicase. 1 hit.
InterProiIPR005164. Allantoicase.
IPR015908. Allantoicase_dom.
IPR008979. Galactose-bd-like.
[Graphical view]
PANTHERiPTHR12045. PTHR12045. 1 hit.
PfamiPF03561. Allantoicase. 2 hits.
[Graphical view]
PIRSFiPIRSF016516. Allantoicase. 1 hit.
SUPFAMiSSF49785. SSF49785. 2 hits.
TIGRFAMsiTIGR02961. allantoicase. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N6M5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADAPKEGRL TRFLDFTQLM DMASESVGGK ILFATDDFFA PAENLIKSDS
60 70 80 90 100
PCFKEHEYTE FGKWMDGWET RRKRIPGHDW CVLRLGIQGV IRGFDVDVSY
110 120 130 140 150
FTGDYAPRVS IQAANLEEDK LPEIPERGTR TGAAATPEEF EAIAELKSDD
160 170 180 190 200
WSYLVPMTEL KPGNPASGHN YFLVNSQQRW THIRLNIFPD GGIARLRVFG
210 220 230 240 250
TGQKDWTATD PKEPADLVAI AFGGVCVGFS NAKFGHPNNI IGVGGAKSMA
260 270 280 290 300
DGWETARRLD RPPILENDEN GILLVPGCEW AVFRLAHPGV ITRIEIDTKY
310 320 330 340 350
FEGNAPDSCK VDGCILTTQE EEAVIRQKWI LPAHKWKPLL PVTKLSPNQS
360 370 380 390 400
HLFDSLTLEL QDVITHARLT IVPDGGVSRL RLRGFPSSIC LLRPREKPML
410
KFSVSFKANP
Length:410
Mass (Da):45,750
Last modified:April 5, 2011 - v3
Checksum:i431E5D1A6D0BC159
GO
Isoform 2 (identifier: Q8N6M5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-248: Missing.

Show »
Length:162
Mass (Da):18,305
Checksum:iCB2BB26A1772563A
GO

Sequence cautioni

The sequence AAY24236 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1M → T in AAY24236 (PubMed:15815621).Curated1
Sequence conflicti129T → I in AAH29652 (PubMed:15489334).Curated1
Sequence conflicti129T → I in AAK72970 (PubMed:12036579).Curated1
Sequence conflicti146L → P in AAK72970 (PubMed:12036579).Curated1
Sequence conflicti320Missing in AAF67097 (PubMed:11054555).Curated1
Sequence conflicti320Missing in AAH29652 (PubMed:15489334).Curated1
Sequence conflicti320Missing in AAK72970 (PubMed:12036579).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0156181 – 248Missing in isoform 2. 2 PublicationsAdd BLAST248

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF215924 mRNA. Translation: AAF67097.1.
AC010907 Genomic DNA. Translation: AAY24236.1. Sequence problems.
BC029652 mRNA. Translation: AAH29652.1.
BC035356 mRNA. Translation: AAH35356.1.
AF395820 mRNA. Translation: AAK72970.1.
RefSeqiNP_060906.3. NM_018436.3.
UniGeneiHs.97899.

Genome annotation databases

GeneIDi55821.
KEGGihsa:55821.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF215924 mRNA. Translation: AAF67097.1.
AC010907 Genomic DNA. Translation: AAY24236.1. Sequence problems.
BC029652 mRNA. Translation: AAH29652.1.
BC035356 mRNA. Translation: AAH35356.1.
AF395820 mRNA. Translation: AAK72970.1.
RefSeqiNP_060906.3. NM_018436.3.
UniGeneiHs.97899.

3D structure databases

ProteinModelPortaliQ8N6M5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120929. 1 interactor.
IntActiQ8N6M5. 1 interactor.
STRINGi9606.ENSP00000252505.

PTM databases

iPTMnetiQ8N6M5.
PhosphoSitePlusiQ8N6M5.

Polymorphism and mutation databases

DMDMi327478594.

Proteomic databases

PaxDbiQ8N6M5.
PeptideAtlasiQ8N6M5.
PRIDEiQ8N6M5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi55821.
KEGGihsa:55821.

Organism-specific databases

CTDi55821.
DisGeNETi55821.
GeneCardsiALLC.
HGNCiHGNC:17377. ALLC.
HPAiHPA037742.
HPA037743.
MIMi612396. gene.
neXtProtiNX_Q8N6M5.
PharmGKBiPA24720.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4145. Eukaryota.
COG4266. LUCA.
HOGENOMiHOG000256158.
HOVERGENiHBG004209.
InParanoidiQ8N6M5.
KOiK01477.
PhylomeDBiQ8N6M5.

Enzyme and pathway databases

BioCyciZFISH:HS14364-MONOMER.

Miscellaneous databases

GenomeRNAii55821.
PROiQ8N6M5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000151360.
CleanExiHS_ALLC.

Family and domain databases

Gene3Di2.60.120.260. 2 hits.
HAMAPiMF_00813. Allantoicase. 1 hit.
InterProiIPR005164. Allantoicase.
IPR015908. Allantoicase_dom.
IPR008979. Galactose-bd-like.
[Graphical view]
PANTHERiPTHR12045. PTHR12045. 1 hit.
PfamiPF03561. Allantoicase. 2 hits.
[Graphical view]
PIRSFiPIRSF016516. Allantoicase. 1 hit.
SUPFAMiSSF49785. SSF49785. 2 hits.
TIGRFAMsiTIGR02961. allantoicase. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiALLC_HUMAN
AccessioniPrimary (citable) accession number: Q8N6M5
Secondary accession number(s): Q53T95
, Q5RL81, Q96RE6, Q9NZA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: April 5, 2011
Last modified: November 2, 2016
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.