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Protein

Probable allantoicase

Gene

ALLC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals.

Catalytic activityi

Allantoate + H2O = (S)-ureidoglycolate + urea.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable allantoicase (EC:3.5.3.4)
Alternative name(s):
Allantoate amidinohydrolase
Gene namesi
Name:ALLC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

EuPathDBiHostDB:ENSG00000151360.9
HGNCiHGNC:17377 ALLC
MIMi612396 gene
neXtProtiNX_Q8N6M5

Pathology & Biotechi

Organism-specific databases

DisGeNETi55821
MalaCardsiALLC
OpenTargetsiENSG00000151360
PharmGKBiPA24720

Polymorphism and mutation databases

DMDMi327478594

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002059051 – 391Probable allantoicaseAdd BLAST391

Proteomic databases

PaxDbiQ8N6M5
PeptideAtlasiQ8N6M5
PRIDEiQ8N6M5

PTM databases

iPTMnetiQ8N6M5
PhosphoSitePlusiQ8N6M5

Expressioni

Gene expression databases

BgeeiENSG00000151360
CleanExiHS_ALLC

Interactioni

Protein-protein interaction databases

BioGridi120929, 1 interactor
IntActiQ8N6M5, 1 interactor
MINTiQ8N6M5
STRINGi9606.ENSP00000252505

Structurei

3D structure databases

ProteinModelPortaliQ8N6M5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the allantoicase family.Curated

Phylogenomic databases

eggNOGiKOG4145 Eukaryota
COG4266 LUCA
GeneTreeiENSGT00390000001793
HOGENOMiHOG000256158
HOVERGENiHBG004209
InParanoidiQ8N6M5
KOiK01477
OMAiNHFKGNF
OrthoDBiEOG091G0BRW
PhylomeDBiQ8N6M5
TreeFamiTF324677

Family and domain databases

Gene3Di2.60.120.260, 2 hits
HAMAPiMF_00813 Allantoicase, 1 hit
InterProiView protein in InterPro
IPR005164 Allantoicase
IPR015908 Allantoicase_dom
IPR008979 Galactose-bd-like_sf
PANTHERiPTHR12045 PTHR12045, 1 hit
PfamiView protein in Pfam
PF03561 Allantoicase, 2 hits
PIRSFiPIRSF016516 Allantoicase, 1 hit
SUPFAMiSSF49785 SSF49785, 2 hits
TIGRFAMsiTIGR02961 allantoicase, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N6M5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDMASESVGG KILFATDDFF APAENLIKSD SPCFKEHEYT EFGKWMDGWE
60 70 80 90 100
TRRKRIPGHD WCVLRLGIQG VIRGFDVDVS YFTGDYAPRV SIQAANLEED
110 120 130 140 150
KLPEIPERGT RTGAAATPEE FEAIAELKSD DWSYLVPMTE LKPGNPASGH
160 170 180 190 200
NYFLVNSQQR WTHIRLNIFP DGGIARLRVF GTGQKDWTAT DPKEPADLVA
210 220 230 240 250
IAFGGVCVGF SNAKFGHPNN IIGVGGAKSM ADGWETARRL DRPPILENDE
260 270 280 290 300
NGILLVPGCE WAVFRLAHPG VITRIEIDTK YFEGNAPDSC KVDGCILTTQ
310 320 330 340 350
EEEAVIRQKW ILPAHKWKPL LPVTKLSPNQ SHLFDSLTLE LQDVITHARL
360 370 380 390
TIVPDGGVSR LRLRGFPSSI CLLRPREKPM LKFSVSFKAN P
Length:391
Mass (Da):43,559
Last modified:April 25, 2018 - v4
Checksum:iC8B5FFDD67BE0B9B
GO
Isoform 2 (identifier: Q8N6M5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-229: Missing.

Show »
Length:162
Mass (Da):18,305
Checksum:iCB2BB26A1772563A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti110T → I in AAH29652 (PubMed:15489334).Curated1
Sequence conflicti110T → I in AAK72970 (PubMed:12036579).Curated1
Sequence conflicti127L → P in AAK72970 (PubMed:12036579).Curated1
Sequence conflicti301Missing in AAF67097 (PubMed:11054555).Curated1
Sequence conflicti301Missing in AAH29652 (PubMed:15489334).Curated1
Sequence conflicti301Missing in AAK72970 (PubMed:12036579).Curated1

Polymorphismi

Product of a polymorphic gene which also produces a longer 410-residue protein due to a polymorphism which affects Met-1, resulting in a longer protein starting at an upstream Met.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0802991M → MADAPKEGRLTRFLDFTQLM. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0156181 – 229Missing in isoform 2. 2 PublicationsAdd BLAST229

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF215924 mRNA Translation: AAF67097.1
AK302299 mRNA Translation: BAG63639.1
AC010907 Genomic DNA Translation: AAY24236.1
CH471053 Genomic DNA Translation: EAX01050.1
BC029652 mRNA Translation: AAH29652.1
BC035356 mRNA Translation: AAH35356.1
AF395820 mRNA Translation: AAK72970.1
RefSeqiNP_060906.3, NM_018436.3
UniGeneiHs.97899

Genome annotation databases

EnsembliENST00000252505; ENSP00000252505; ENSG00000151360 [Q8N6M5-1]
GeneIDi55821
KEGGihsa:55821

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiALLC_HUMAN
AccessioniPrimary (citable) accession number: Q8N6M5
Secondary accession number(s): B4DY77
, Q53T95, Q5RL81, Q96RE6, Q9NZA7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: April 25, 2018
Last modified: May 23, 2018
This is version 116 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

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