Reviewed, UniProtKB/Swiss-Prot Q8N6M5 (ALLC_HUMAN)

Names and origin

Protein names

Recommended name:
    Probable allantoicase
    EC=3.5.3.4
Alternative name(s):
    Allantoate amidinohydrolase

Gene names

Name:

ALLC

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	410 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals.
Catalytic activity	Allantoate + H2O = (S)-ureidoglycolate + urea.
Sequence similarities	Belongs to the allantoicase family.
Sequence caution	The sequence AAY24236.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	allantoicase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8N6M5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8N6M5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-248: Missing.

Isoform 3 (identifier: Q8N6M5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     322-322: Missing.

Isoform 4 (identifier: Q8N6M5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-248: Missing.
     322-322: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 410	410	Probable allantoicase		PRO_0000205905
Natural variations
	Alternative sequence	1 – 248	248	Missing in isoform 2 and isoform 4.		VSP_015618
	Alternative sequence	322	1	Missing in isoform 3 and isoform 4.		VSP_015619
Experimental info
	Sequence conflict	129	1	I → T in AAY24236. Ref.2
	Sequence conflict	146	1	L → P in AAK72970. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified September 13, 2005. Version 2. Checksum: DA1906FFD407FE9A	FASTA	410	45,762
	10 20 30 40 50 60 MADAPKEGRL TRFLDFTQLM DMASESVGGK ILFATDDFFA PAENLIKSDS PCFKEHEYTE 70 80 90 100 110 120 FGKWMDGWET RRKRIPGHDW CVLRLGIQGV IRGFDVDVSY FTGDYAPRVS IQAANLEEDK 130 140 150 160 170 180 LPEIPERGIR TGAAATPEEF EAIAELKSDD WSYLVPMTEL KPGNPASGHN YFLVNSQQRW 190 200 210 220 230 240 THIRLNIFPD GGIARLRVFG TGQKDWTATD PKEPADLVAI AFGGVCVGFS NAKFGHPNNI 250 260 270 280 290 300 IGVGGAKSMA DGWETARRLD RPPILENDEN GILLVPGCEW AVFRLAHPGV ITRIEIDTKY 310 320 330 340 350 360 FEGNAPDSCK VDGCILTTQE EEAVIRQKWI LPAHKWKPLL PVTKLSPNQS HLFDSLTLEL 370 380 390 400 410 QDVITHARLT IVPDGGVSRL RLRGFPSSIC LLRPREKPML KFSVSFKANP
	Isoform 2. Checksum: CB2BB26A1772563A	FASTA	162	18,305
	10 20 30 40 50 60 MADGWETARR LDRPPILEND ENGILLVPGC EWAVFRLAHP GVITRIEIDT KYFEGNAPDS 70 80 90 100 110 120 CKVDGCILTT QEEEAVIRQK WILPAHKWKP LLPVTKLSPN QSHLFDSLTL ELQDVITHAR 130 140 150 160 LTIVPDGGVS RLRLRGFPSS ICLLRPREKP MLKFSVSFKA NP
	Isoform 3. Checksum: D2B5FF70C3574D02	FASTA	409	45,633
	10 20 30 40 50 60 MADAPKEGRL TRFLDFTQLM DMASESVGGK ILFATDDFFA PAENLIKSDS PCFKEHEYTE 70 80 90 100 110 120 FGKWMDGWET RRKRIPGHDW CVLRLGIQGV IRGFDVDVSY FTGDYAPRVS IQAANLEEDK 130 140 150 160 170 180 LPEIPERGIR TGAAATPEEF EAIAELKSDD WSYLVPMTEL KPGNPASGHN YFLVNSQQRW 190 200 210 220 230 240 THIRLNIFPD GGIARLRVFG TGQKDWTATD PKEPADLVAI AFGGVCVGFS NAKFGHPNNI 250 260 270 280 290 300 IGVGGAKSMA DGWETARRLD RPPILENDEN GILLVPGCEW AVFRLAHPGV ITRIEIDTKY 310 320 330 340 350 360 FEGNAPDSCK VDGCILTTQE EAVIRQKWIL PAHKWKPLLP VTKLSPNQSH LFDSLTLELQ 370 380 390 400 DVITHARLTI VPDGGVSRLR LRGFPSSICL LRPREKPMLK FSVSFKANP
	Isoform 4. Checksum: 10016AB3B6FFED1F	FASTA	161	18,176
	10 20 30 40 50 60 MADGWETARR LDRPPILEND ENGILLVPGC EWAVFRLAHP GVITRIEIDT KYFEGNAPDS 70 80 90 100 110 120 CKVDGCILTT QEEAVIRQKW ILPAHKWKPL LPVTKLSPNQ SHLFDSLTLE LQDVITHARL 130 140 150 160 TIVPDGGVSR LRLRGFPSSI CLLRPREKPM LKFSVSFKAN P

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human allantoicase gene: cDNA cloning, genomic organization and chromosome localization." Vigetti D., Monetti C., Acquati F., Taramelli R., Bernardini G. Gene 256:253-260(2000) [PubMed: 11054555] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4). Tissue: Fetal spleen.
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Brain.
[4]	"Genomic organization and chromosome localization of the murine and human allantoicase gene." Vigetti D., Monetti C., Prati M., Gornati R., Bernardini G. Gene 289:13-17(2002) [PubMed: 12036579] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 35-372 (ISOFORMS 3/4), GENE STRUCTURE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF215924 mRNA. Translation: AAF67097.1. AC010907 Genomic DNA. Translation: AAY24236.1. Sequence problems. BC029652 mRNA. Translation: AAH29652.1. BC035356 mRNA. Translation: AAH35356.1. AF395820 mRNA. Translation: AAK72970.1.
IPI	IPI00167035. IPI00398000. IPI00640397. IPI00644362.
RefSeq	NP_060906.3.
UniGene	Hs.97899
3D structure databases
SMR	Q8N6M5. Positions 15-385.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8N6M5.
Genome annotation databases
Ensembl	ENST00000403787; ENSP00000383965; ENSG00000151360; Homo sapiens. [Genome view]
GeneID	55821.
KEGG	hsa:55821.
UCSC	uc002qyf.1. human. uc010ewt.1. human.
Organism-specific databases
CTD	55821.
GeneCards	GC02P003683.
HGNC	HGNC:17377. ALLC.
MIM	612396. gene.
PharmGKB	PA24720.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG09633.
HOGENOM	HBG480577.
HOVERGEN	Q8N6M5.
InParanoid	Q8N6M5.
PhylomeDB	Q8N6M5.
Enzyme and pathway databases
BRENDA	3.5.3.4. 247.
Gene expression databases
ArrayExpress	Q8N6M5.
Bgee	Q8N6M5.
CleanEx	HS_ALLC.
Genevestigator	Q8N6M5.
GermOnline	ENSG00000151360. Homo sapiens.
Family and domain databases
InterPro	IPR005164. Allantoicase. IPR015908. Allantoicase_dom. IPR008979. Galactose-bd-like. [Graphical view]
PANTHER	PTHR12045. Allantoicase. 1 hit.
Pfam	PF03561. Allantoicase. 2 hits. [Graphical view]
TIGRFAMs	TIGR02961. allantoicase. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	61010.
SOURCE	Search...

Entry information

Entry name

ALLC_HUMAN

Accession

Primary (citable) accession number: Q8N6M5
Secondary accession number(s): Q53T95 , Q5RL81, Q96RE6, Q9NZA7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2005
Last sequence update:	September 13, 2005
Last modified:	February 9, 2010
This is version 59 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.