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Protein

OTU domain-containing protein 6B

Gene

OTUD6B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Miscellaneous

No deubiquitinase activity has been detected when tested (PubMed:23827681). May require some post-translational modification to be active.1 Publication

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei155By similarity1
Active sitei158NucleophileBy similarity1
Active sitei277By similarity1

GO - Molecular functioni

GO - Biological processi

  • protein deubiquitination Source: UniProtKB

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
OTU domain-containing protein 6B (EC:3.4.19.12)
Alternative name(s):
DUBA-5
Gene namesi
Name:OTUD6B
Synonyms:DUBA5
ORF Names:CGI-77
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000155100.10.
HGNCiHGNC:24281. OTUD6B.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000155100.
PharmGKBiPA142671219.

Polymorphism and mutation databases

BioMutaiOTUD6B.
DMDMi74729149.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000762791 – 293OTU domain-containing protein 6BAdd BLAST293

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8N6M0.
MaxQBiQ8N6M0.
PaxDbiQ8N6M0.
PeptideAtlasiQ8N6M0.
PRIDEiQ8N6M0.

PTM databases

iPTMnetiQ8N6M0.
PhosphoSitePlusiQ8N6M0.

Expressioni

Gene expression databases

BgeeiENSG00000155100.
CleanExiHS_OTUD6B.
ExpressionAtlasiQ8N6M0. baseline and differential.
GenevisibleiQ8N6M0. HS.

Organism-specific databases

HPAiHPA024046.
HPA024503.
HPA024772.

Interactioni

Protein-protein interaction databases

BioGridi119647. 32 interactors.
IntActiQ8N6M0. 13 interactors.
STRINGi9606.ENSP00000285420.

Structurei

3D structure databases

ProteinModelPortaliQ8N6M0.
SMRiQ8N6M0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini147 – 284OTUPROSITE-ProRule annotationAdd BLAST138

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni152 – 158Cys-loopBy similarity7
Regioni219 – 229Variable-loopBy similarityAdd BLAST11
Regioni267 – 277His-loopBy similarityAdd BLAST11

Phylogenomic databases

eggNOGiKOG2606. Eukaryota.
COG5539. LUCA.
GeneTreeiENSGT00390000012840.
HOGENOMiHOG000192906.
HOVERGENiHBG080227.
InParanoidiQ8N6M0.
KOiK18342.
PhylomeDBiQ8N6M0.
TreeFamiTF315010.

Family and domain databases

InterProiView protein in InterPro
IPR003323. OTU_dom.
PfamiView protein in Pfam
PF02338. OTU. 1 hit.
PROSITEiView protein in PROSITE
PS50802. OTU. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N6M0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAVLTEELD EEEQLLRRHR KEKKELQAKI QGMKNAVPKN DKKRRKQLTE
60 70 80 90 100
DVAKLEKEME QKHREELEQL KLTTKENKID SVAVNISNLV LENQPPRISK
110 120 130 140 150
AQKRREKKAA LEKEREERIA EAEIENLTGA RHMESEKLAQ ILAARQLEIK
160 170 180 190 200
QIPSDGHCMY KAIEDQLKEK DCALTVVALR SQTAEYMQSH VEDFLPFLTN
210 220 230 240 250
PNTGDMYTPE EFQKYCEDIV NTAAWGGQLE LRALSHILQT PIEIIQADSP
260 270 280 290
PIIVGEEYSK KPLILVYMRH AYGLGEHYNS VTRLVNIVTE NCS
Length:293
Mass (Da):33,813
Last modified:October 1, 2002 - v1
Checksum:i468DB88E2637D869
GO
Isoform 2 (identifier: Q8N6M0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-105: MEAVLTEELD...PRISKAQKRR → MISK

Note: No experimental confirmation available.
Show »
Length:192
Mass (Da):21,809
Checksum:iDB3F389CEE3BEB3E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti285 – 293VNIVTENCS → GKHSY in AAD34073 (PubMed:10810093).Curated9

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034144283R → Q1 PublicationCorresponds to variant dbSNP:rs3210518Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0553781 – 105MEAVL…AQKRR → MISK in isoform 2. 1 PublicationAdd BLAST105

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151836 mRNA. Translation: AAD34073.1.
AK291646 mRNA. Translation: BAF84335.1.
AK293843 mRNA. Translation: BAG57241.1.
AC087439 Genomic DNA. No translation available.
BC029760 mRNA. Translation: AAH29760.1.
AL137441 mRNA. Translation: CAB70738.1.
CCDSiCCDS69513.1. [Q8N6M0-2]
PIRiT46264.
RefSeqiNP_001273674.1. NM_001286745.1. [Q8N6M0-2]
NP_057107.3. NM_016023.3.
XP_011515431.2. XM_011517129.2. [Q8N6M0-2]
UniGeneiHs.30532.

Genome annotation databases

EnsembliENST00000404789; ENSP00000384190; ENSG00000155100. [Q8N6M0-1]
ENST00000615618; ENSP00000481196; ENSG00000155100. [Q8N6M0-2]
GeneIDi51633.
KEGGihsa:51633.
UCSCiuc011lgh.3. human. [Q8N6M0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOTU6B_HUMAN
AccessioniPrimary (citable) accession number: Q8N6M0
Secondary accession number(s): A8K6I1
, B4DEY0, Q9NTA4, Q9Y387
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: October 1, 2002
Last modified: November 22, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot