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Protein

Keratinocyte-associated protein 2

Gene

KRTCAP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Required for efficient substrate-specific N-glycosylation probably involving the STT3A-containing OST complex. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.Curated2 Publications

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Biological processi

  • protein N-linked glycosylation via arginine Source: UniProtKB

Enzyme and pathway databases

UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratinocyte-associated protein 2
Short name:
KCP-2
Gene namesi
Name:KRTCAP2
Synonyms:KCP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000163463.11.
HGNCiHGNC:28942. KRTCAP2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 5LumenalSequence analysis5
Transmembranei6 – 23HelicalSequence analysisAdd BLAST18
Topological domaini24 – 34CytoplasmicSequence analysisAdd BLAST11
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Topological domaini56 – 75LumenalSequence analysisAdd BLAST20
Transmembranei76 – 108HelicalSequence analysisAdd BLAST33
Topological domaini109 – 136CytoplasmicSequence analysisAdd BLAST28

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000163463.
PharmGKBiPA134967679.

Polymorphism and mutation databases

DMDMi557952588.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002269921 – 136Keratinocyte-associated protein 2Add BLAST136

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei124PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N6L1.
MaxQBiQ8N6L1.
PaxDbiQ8N6L1.
PeptideAtlasiQ8N6L1.
PRIDEiQ8N6L1.
TopDownProteomicsiQ8N6L1-2. [Q8N6L1-2]

PTM databases

iPTMnetiQ8N6L1.
PhosphoSitePlusiQ8N6L1.
SwissPalmiQ8N6L1.

Expressioni

Tissue specificityi

Expressed in skin, heart, placental, liver, skeletal muscle, kidney, pancreas, keratinocytes and dermal fibroblasts.1 Publication

Gene expression databases

BgeeiENSG00000163463.
CleanExiHS_KRTCAP2.
GenevisibleiQ8N6L1. HS.

Interactioni

Subunit structurei

Accessory component of the STT3A-containing form of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits. OST can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes. Interacts with PSEN1 and NCSTN; indicative for an association with the gamma-secretase complex.By similarityCurated2 Publications

Protein-protein interaction databases

BioGridi128307. 9 interactors.
CORUMiQ8N6L1.
IntActiQ8N6L1. 8 interactors.
STRINGi9606.ENSP00000295682.

Structurei

3D structure databases

ProteinModelPortaliQ8N6L1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi133 – 136Prevents secretion from ER4

Sequence similaritiesi

Belongs to the KRTCAP2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4615. Eukaryota.
ENOG4111ZNW. LUCA.
GeneTreeiENSGT00390000003552.
HOGENOMiHOG000006286.
HOVERGENiHBG057832.
InParanoidiQ8N6L1.
OMAiLTCVSNA.
OrthoDBiEOG091G0RKT.
TreeFamiTF324347.

Family and domain databases

InterProiView protein in InterPro
IPR018614. KRTCAP2.
PANTHERiPTHR32001. PTHR32001. 1 hit.
PfamiView protein in Pfam
PF09775. Keratin_assoc. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform 1 (identifier: Q8N6L1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVVGTGTSLA LSSLLSLLLF AGMQMYSRQL ASTEWLTIQG GLLGSGLFVF
60 70 80 90 100
SLTAFNNLEN LVFGKGFQAK IFPEILLCLL LALFASGLIH RVCVTTCFIF
110 120 130
SMVGLYYINK ISSTLYQAAA PVLTPAKVTG KSKKRN
Length:136
Mass (Da):14,679
Last modified:November 13, 2013 - v2
Checksum:i090926F115D7532B
GO
Isoform 2 (identifier: Q8N6L1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRIANRTRFSSPFLARGAGWTHGRGMM

Note: Produced at low levels due to suboptimal Kozak context.
Show »
Length:162
Mass (Da):17,595
Checksum:i4351A6485FA2CC75
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti87G → S in AAO13161 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0255314G → V1 PublicationCorresponds to variant dbSNP:rs17854920Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0534391M → MRIANRTRFSSPFLARGAGW THGRGMM in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY157577 mRNA. Translation: AAO13161.2.
AK311907 mRNA. Translation: BAG34848.1.
AL607067 Genomic DNA. No translation available.
BC029806 mRNA. Translation: AAH29806.1.
BC048205 mRNA. Translation: AAH48205.1.
BC057233 mRNA. Translation: AAH57233.1.
CCDSiCCDS1096.1. [Q8N6L1-2]
RefSeqiNP_776251.1. NM_173852.3. [Q8N6L1-2]
UniGeneiHs.516671.
Hs.704676.

Genome annotation databases

EnsembliENST00000295682; ENSP00000295682; ENSG00000163463. [Q8N6L1-2]
GeneIDi200185.
KEGGihsa:200185.
UCSCiuc001fho.4. human. [Q8N6L1-1]

Keywords - Coding sequence diversityi

Alternative initiation, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKTAP2_HUMAN
AccessioniPrimary (citable) accession number: Q8N6L1
Secondary accession number(s): B2R4Q1
, Q6PG45, Q86XW2, Q8IWS4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: November 13, 2013
Last modified: October 25, 2017
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. SIMILARITY comments
    Index of protein domains and families