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Protein

Protein KASH5

Gene

CCDC155

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in meiotic chromosome dynamics and homolog pairing.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein KASH5
Alternative name(s):
Coiled-coil domain-containing protein 155
KASH domain-containing protein 5
Gene namesi
Name:CCDC155
Synonyms:KASH5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:26520. CCDC155.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 521521CytoplasmicSequence analysisAdd
BLAST
Transmembranei522 – 54221Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST
Topological domaini543 – 56220Perinuclear spaceSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Membrane, Nucleus, Telomere

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162381684.

Polymorphism and mutation databases

BioMutaiCCDC155.
DMDMi187671940.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 562562Protein KASH5PRO_0000331527Add
BLAST

Proteomic databases

EPDiQ8N6L0.
PaxDbiQ8N6L0.
PeptideAtlasiQ8N6L0.
PRIDEiQ8N6L0.

Expressioni

Gene expression databases

BgeeiQ8N6L0.
CleanExiHS_CCDC155.
ExpressionAtlasiQ8N6L0. baseline and differential.
GenevisibleiQ8N6L0. HS.

Organism-specific databases

HPAiHPA019937.
HPA019940.

Interactioni

Subunit structurei

Interacts (via the last 22 AA) with SUN1; this interaction mediates telomere localization. Interacts with dynein-dynactin motor complex.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
B2R9H73EBI-749265,EBI-10175711
ABHD1Q96SE03EBI-749265,EBI-10293349
ADIPOQA8K6603EBI-749265,EBI-10174479
ATF7P175443EBI-749265,EBI-765623
BAG5Q9UL153EBI-749265,EBI-356517
BCL2L2Q928433EBI-749265,EBI-707714
BET1Q53XK03EBI-749265,EBI-10242927
C10orf4D3DR403EBI-749265,EBI-10176576
C17orf62Q9BQA93EBI-749265,EBI-2680384
CDC73Q6P1J93EBI-749265,EBI-930143
CDKL3Q8IVW43EBI-749265,EBI-3919850
CIB3Q96Q773EBI-749265,EBI-10292696
CLDN8P567483EBI-749265,EBI-10215641
CRABP2P293733EBI-749265,EBI-10204806
CXCL9Q073253EBI-749265,EBI-3911467
FAM161AQ3B8203EBI-749265,EBI-719941
FAM90A1Q86YD73EBI-749265,EBI-6658203
FATE1Q969F03EBI-749265,EBI-743099
FIS1Q9Y3D63EBI-749265,EBI-3385283
FTCDO959543EBI-749265,EBI-10192648
GABARAPL2P605203EBI-749265,EBI-720116
GALNT2Q104713EBI-749265,EBI-10226985
GOSR2O146533EBI-749265,EBI-4401517
GPATCH4Q5T3I03EBI-749265,EBI-2372076
GPR25O001553EBI-749265,EBI-10178951
HMOX1Q96DI83EBI-749265,EBI-10284700
ITM2BQ9Y2873EBI-749265,EBI-2866431
JAGN1Q8N5M93EBI-749265,EBI-10266796
LARP1Q6PKG03EBI-749265,EBI-1052114
LENG1Q96BZ83EBI-749265,EBI-726510
LHFPL5Q8TAF83EBI-749265,EBI-2820517
MALLQ130213EBI-749265,EBI-750078
MARCH2Q9P0N83EBI-749265,EBI-10317612
MFSD5Q6N0753EBI-749265,EBI-3920969
MMP14P502813EBI-749265,EBI-992788
MS4A1P118363EBI-749265,EBI-2808234
MTX2O754313EBI-749265,EBI-7415268
NRIP3Q9NQ353EBI-749265,EBI-10311735
NSG1P428573EBI-749265,EBI-6380741
OLFM4Q6UX063EBI-749265,EBI-2804156
PDGFRAP162343EBI-749265,EBI-2861522
PLP2Q049413EBI-749265,EBI-608347
PPP1R18Q6NYC83EBI-749265,EBI-2557469
RIPPLY2Q5TAB73EBI-749265,EBI-10246897
RNF146Q9NTX73EBI-749265,EBI-722397
RSRC2Q7L4I2-23EBI-749265,EBI-10256202
RTP2Q5QGT73EBI-749265,EBI-10244780
SENP2Q9HC623EBI-749265,EBI-714881
SERP2Q8N6R13EBI-749265,EBI-749270
SGTAO437653EBI-749265,EBI-347996
SLC30A2Q9BRI33EBI-749265,EBI-8644112
SLC41A2Q96JW43EBI-749265,EBI-10290130
SLNO006313EBI-749265,EBI-10180786
SMCO4Q9NRQ53EBI-749265,EBI-8640191
STBD1O952103EBI-749265,EBI-2947137
STX5Q131903EBI-749265,EBI-714206
TCF25Q9BQ703EBI-749265,EBI-745182
TMEM14CQ9P0S93EBI-749265,EBI-2339195
TMEM199Q8N5113EBI-749265,EBI-10265825
TMEM41AQ96HV53EBI-749265,EBI-10288884
TMPRSS4Q9NRS43EBI-749265,EBI-10313040
TMPRSS4Q9NRS4-33EBI-749265,EBI-10312990
TRAF3IP3Q9Y2283EBI-749265,EBI-765817
TSHZ3A1L0U73EBI-749265,EBI-10171826
UPK2O005263EBI-749265,EBI-10179682
VAMP1P237633EBI-749265,EBI-10201335
VAMP4O753793EBI-749265,EBI-744953
VAMP4O75379-23EBI-749265,EBI-10187996
ZNF250P15622-33EBI-749265,EBI-10177272

Protein-protein interaction databases

BioGridi127094. 70 interactions.
IntActiQ8N6L0. 70 interactions.
MINTiMINT-1472874.
STRINGi9606.ENSP00000404220.

Structurei

3D structure databases

ProteinModelPortaliQ8N6L0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili164 – 349186Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi448 – 4514Poly-Glu
Compositional biasi528 – 5369Poly-Leu

Domaini

The C-terminal 22 AA is required and sufficient for localization to telomeres at the nuclear envelope.By similarity

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWIE. Eukaryota.
ENOG4111U72. LUCA.
GeneTreeiENSGT00420000029926.
HOVERGENiHBG064472.
InParanoidiQ8N6L0.
OMAiACDPQRT.
OrthoDBiEOG7PGDS7.
PhylomeDBiQ8N6L0.
TreeFamiTF337560.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR024950. DUSP.
IPR011992. EF-hand-dom_pair.
IPR028170. KASH5.
IPR028168. KASH5_coiled-coil.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 2 hits.
PTHR10159:SF341. PTHR10159:SF341. 2 hits.
PfamiPF14662. KASH_CCD. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8N6L0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLPEGPVGG PTAEMYLRER PEEARLGMPV SLEEQILNST FEACDPQRTG
60 70 80 90 100
TVAVAQVLAY LEAVTGQGPQ DARLQTLANS LDPNGEGPKA TVDLDTFLVV
110 120 130 140 150
MRDWIAACQL HGGLELEEET AFQGALTSRQ LPSGCPEAEE PANLESFGGE
160 170 180 190 200
DPRPELQATA DLLSSLEDLE LSNRRLVGEN AKLQRSMETA EEGSARLGEE
210 220 230 240 250
ILALRKQLHS TQQALQFAKA MDEELEDLKT LARSLEEQNR SLLAQARQAE
260 270 280 290 300
KEQQHLVAEM ETLQEENGKL LAERDGVKKR SQELAMEKDT LKRQLFECEH
310 320 330 340 350
LICQRDTILS ERTRDVESLA QTLEEYRVTT QELRLEISRL EEQLSQTYEG
360 370 380 390 400
PDELPEGAQL RRVGWTELLP PSLGLEIEAI RQKQEVATAD LSNPLCGVWQ
410 420 430 440 450
WEEVIHETSE ETEFPSEAPA GGQRNFQGEP AHPEEGRKEP SMWLTRREEE
460 470 480 490 500
EDAESQVTAD LPVPLGAPRP GDIPENPPER PARRELQQAL VPVMKKLVPV
510 520 530 540 550
RRRAWGQLCL PPQRLRVTRH PLIPAPVLGL LLLLLLSVLL LGPSPPPTWP
560
HLQLCYLQPP PV
Length:562
Mass (Da):62,783
Last modified:April 29, 2008 - v2
Checksum:i39F47D3F236A9918
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti116 – 1161L → P.
Corresponds to variant rs8102582 [ dbSNP | Ensembl ].
VAR_059597
Natural varianti129 – 1291R → Q.1 Publication
Corresponds to variant rs10405154 [ dbSNP | Ensembl ].
VAR_059598

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057220 mRNA. Translation: BAB71384.1.
AC010619 Genomic DNA. No translation available.
AC010643 Genomic DNA. No translation available.
CH471177 Genomic DNA. Translation: EAW52478.1.
BC029811 mRNA. Translation: AAH29811.1.
CCDSiCCDS46140.1.
RefSeqiNP_653289.3. NM_144688.4.
UniGeneiHs.662085.
Hs.743867.

Genome annotation databases

EnsembliENST00000447857; ENSP00000404220; ENSG00000161609.
GeneIDi147872.
KEGGihsa:147872.
UCSCiuc002pnm.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057220 mRNA. Translation: BAB71384.1.
AC010619 Genomic DNA. No translation available.
AC010643 Genomic DNA. No translation available.
CH471177 Genomic DNA. Translation: EAW52478.1.
BC029811 mRNA. Translation: AAH29811.1.
CCDSiCCDS46140.1.
RefSeqiNP_653289.3. NM_144688.4.
UniGeneiHs.662085.
Hs.743867.

3D structure databases

ProteinModelPortaliQ8N6L0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127094. 70 interactions.
IntActiQ8N6L0. 70 interactions.
MINTiMINT-1472874.
STRINGi9606.ENSP00000404220.

Polymorphism and mutation databases

BioMutaiCCDC155.
DMDMi187671940.

Proteomic databases

EPDiQ8N6L0.
PaxDbiQ8N6L0.
PeptideAtlasiQ8N6L0.
PRIDEiQ8N6L0.

Protocols and materials databases

DNASUi147872.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000447857; ENSP00000404220; ENSG00000161609.
GeneIDi147872.
KEGGihsa:147872.
UCSCiuc002pnm.3. human.

Organism-specific databases

CTDi147872.
GeneCardsiCCDC155.
HGNCiHGNC:26520. CCDC155.
HPAiHPA019937.
HPA019940.
neXtProtiNX_Q8N6L0.
PharmGKBiPA162381684.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWIE. Eukaryota.
ENOG4111U72. LUCA.
GeneTreeiENSGT00420000029926.
HOVERGENiHBG064472.
InParanoidiQ8N6L0.
OMAiACDPQRT.
OrthoDBiEOG7PGDS7.
PhylomeDBiQ8N6L0.
TreeFamiTF337560.

Miscellaneous databases

ChiTaRSiCCDC155. human.
GenomeRNAii147872.
PROiQ8N6L0.

Gene expression databases

BgeeiQ8N6L0.
CleanExiHS_CCDC155.
ExpressionAtlasiQ8N6L0. baseline and differential.
GenevisibleiQ8N6L0. HS.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR024950. DUSP.
IPR011992. EF-hand-dom_pair.
IPR028170. KASH5.
IPR028168. KASH5_coiled-coil.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 2 hits.
PTHR10159:SF341. PTHR10159:SF341. 2 hits.
PfamiPF14662. KASH_CCD. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-129.
    Tissue: Brain.

Entry informationi

Entry nameiKASH5_HUMAN
AccessioniPrimary (citable) accession number: Q8N6L0
Secondary accession number(s): Q96MC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: July 6, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.