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Protein

Protein KASH5

Gene

CCDC155

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Required for telomere attachment to nuclear envelope in the prophase of meiosis and for rapid telomere prophase movements implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly. Required for homologue pairing during meiotic prophase in spermatocytes and probably oocytes. Essential for male and female gametogenesis. Recruits cytoplasmic dynein to telomere attachment sites at the nuclear envelope in spermatocytes. In oocytes is involved in meiotic resumption and spindle formation.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processMeiosis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein KASH5
Alternative name(s):
Coiled-coil domain-containing protein 155
KASH domain-containing protein 5
Gene namesi
Name:CCDC155
Synonyms:KASH5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000161609.9.
HGNCiHGNC:26520. CCDC155.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 521CytoplasmicSequence analysisAdd BLAST521
Transmembranei522 – 542Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini543 – 562Perinuclear spaceSequence analysisAdd BLAST20

Keywords - Cellular componenti

Chromosome, Membrane, Nucleus, Telomere

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000161609.
PharmGKBiPA162381684.

Polymorphism and mutation databases

BioMutaiCCDC155.
DMDMi187671940.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003315271 – 562Protein KASH5Add BLAST562

Proteomic databases

PaxDbiQ8N6L0.
PeptideAtlasiQ8N6L0.
PRIDEiQ8N6L0.

Expressioni

Gene expression databases

BgeeiENSG00000161609.
CleanExiHS_CCDC155.
ExpressionAtlasiQ8N6L0. baseline and differential.
GenevisibleiQ8N6L0. HS.

Organism-specific databases

HPAiHPA019937.
HPA019940.

Interactioni

Subunit structurei

Core component the LINC complex which is composed of inner nuclear membrane SUN domain-containing proteins coupled to outer nuclear membrane KASH domain-containing nesprins. SUN and KASH domain-containing proteins seem to bind each other promiscuously; however, differentially expression of LINC complex constituents is giving rise to specific assemblies. At least SUN1/2-containing core LINC complexes are proposed to be hexameric composed of three protomers of each KASH and SUN domain-containing protein. Interacts (via the last 22 AA) with SUN1; this interaction mediates its telomere localization by forming a SUN1:KASH5 LINC complex. Component of a probable SUN2:KASH5 LINC complex. Self-associates. Interacts with DYNC1H1, DCTN1, DYNC1I1/2 and PAFAH1B1; suggesting the association with the dynein-dynactin motor complex.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
B2R9H73EBI-749265,EBI-10175711
ABHD1Q96SE03EBI-749265,EBI-10293349
ADIPOQA8K6603EBI-749265,EBI-10174479
ADIPOQQ158483EBI-749265,EBI-10827839
ATF7P175443EBI-749265,EBI-765623
BAG5Q9UL155EBI-749265,EBI-356517
BCL2L2Q928437EBI-749265,EBI-707714
BET1Q53XK03EBI-749265,EBI-10242927
C10orf4D3DR403EBI-749265,EBI-10176576
C17orf62Q9BQA95EBI-749265,EBI-2680384
CDC73Q6P1J96EBI-749265,EBI-930143
CDKL3Q8IVW43EBI-749265,EBI-3919850
CIB3Q96Q773EBI-749265,EBI-10292696
CLDN8P567483EBI-749265,EBI-10215641
CRABP2P293735EBI-749265,EBI-10204806
CXCL9Q073253EBI-749265,EBI-3911467
EMDP504027EBI-749265,EBI-489887
FAM161AQ3B8203EBI-749265,EBI-719941
FAM50BQ9Y2474EBI-749265,EBI-742802
FAM90A1Q86YD73EBI-749265,EBI-6658203
FATE1Q969F05EBI-749265,EBI-743099
FIS1Q9Y3D63EBI-749265,EBI-3385283
FTCDO959543EBI-749265,EBI-10192648
GABARAPL2P605203EBI-749265,EBI-720116
GALNT2Q104715EBI-749265,EBI-10226985
GIMAP5Q96F154EBI-749265,EBI-6166686
GOSR2O146535EBI-749265,EBI-4401517
GPATCH4Q5T3I05EBI-749265,EBI-2372076
GPR25O001555EBI-749265,EBI-10178951
HMOX1Q96DI83EBI-749265,EBI-10284700
ITM2BQ9Y2873EBI-749265,EBI-2866431
JAGN1Q8N5M95EBI-749265,EBI-10266796
LARP1Q6PKG03EBI-749265,EBI-1052114
LENG1Q96BZ83EBI-749265,EBI-726510
LHFPL5Q8TAF88EBI-749265,EBI-2820517
MALLQ130213EBI-749265,EBI-750078
MARCH2Q9P0N83EBI-749265,EBI-10317612
MFSD5Q6N0753EBI-749265,EBI-3920969
MMP14P502813EBI-749265,EBI-992788
MS4A1P118363EBI-749265,EBI-2808234
MTX2O754315EBI-749265,EBI-7415268
NRIP3Q9NQ355EBI-749265,EBI-10311735
NSG1P428575EBI-749265,EBI-6380741
OLFM4Q6UX063EBI-749265,EBI-2804156
PDGFRAP162343EBI-749265,EBI-2861522
PLP2Q049413EBI-749265,EBI-608347
PPP1R18Q6NYC85EBI-749265,EBI-2557469
RIPPLY2Q5TAB79EBI-749265,EBI-10246897
RNF146Q9NTX73EBI-749265,EBI-722397
RNF146Q9NTX7-24EBI-749265,EBI-11750630
RSRC2Q7L4I2-23EBI-749265,EBI-10256202
RTP2Q5QGT73EBI-749265,EBI-10244780
SENP2Q9HC625EBI-749265,EBI-714881
SERP2Q8N6R15EBI-749265,EBI-749270
SGTAO437659EBI-749265,EBI-347996
SLC30A2Q9BRI38EBI-749265,EBI-8644112
SLC41A2Q96JW45EBI-749265,EBI-10290130
SLNO006313EBI-749265,EBI-10180786
SMCO4Q9NRQ53EBI-749265,EBI-8640191
STBD1O952103EBI-749265,EBI-2947137
STX5Q131905EBI-749265,EBI-714206
TCF25Q9BQ703EBI-749265,EBI-745182
TMEM11P171524EBI-749265,EBI-723946
TMEM14CQ9P0S93EBI-749265,EBI-2339195
TMEM199Q8N5113EBI-749265,EBI-10265825
TMEM41AQ96HV53EBI-749265,EBI-10288884
TMPRSS4Q9NRS43EBI-749265,EBI-10313040
TMPRSS4Q9NRS4-33EBI-749265,EBI-10312990
TRAF3IP3Q9Y2285EBI-749265,EBI-765817
TSHZ3Q63HK53EBI-749265,EBI-9053916
UPK2O005263EBI-749265,EBI-10179682
VAMP1P237633EBI-749265,EBI-10201335
VAMP4O753793EBI-749265,EBI-744953
VAMP4O75379-23EBI-749265,EBI-10187996
ZNF250P15622-33EBI-749265,EBI-10177272

GO - Molecular functioni

Protein-protein interaction databases

BioGridi127094. 70 interactors.
IntActiQ8N6L0. 115 interactors.
MINTiMINT-1472874.
STRINGi9606.ENSP00000404220.

Structurei

3D structure databases

ProteinModelPortaliQ8N6L0.
SMRiQ8N6L0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili164 – 349Sequence analysisAdd BLAST186

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi448 – 451Poly-Glu4
Compositional biasi528 – 536Poly-Leu9

Domaini

The C-terminal 22 AA is required and sufficient for localization to telomeres at the nuclear envelope.By similarity

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWIE. Eukaryota.
ENOG4111U72. LUCA.
GeneTreeiENSGT00420000029926.
HOVERGENiHBG064472.
InParanoidiQ8N6L0.
OMAiACDPQRT.
OrthoDBiEOG091G06B2.
PhylomeDBiQ8N6L0.
TreeFamiTF337560.

Family and domain databases

InterProiView protein in InterPro
IPR024950. DUSP.
IPR011992. EF-hand-dom_pair.
IPR028170. KASH5.
IPR028168. KASH5_coiled-coil.
PANTHERiPTHR10159. PTHR10159. 2 hits.
PTHR10159:SF376. PTHR10159:SF376. 2 hits.
PfamiView protein in Pfam
PF14662. KASH_CCD. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8N6L0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLPEGPVGG PTAEMYLRER PEEARLGMPV SLEEQILNST FEACDPQRTG
60 70 80 90 100
TVAVAQVLAY LEAVTGQGPQ DARLQTLANS LDPNGEGPKA TVDLDTFLVV
110 120 130 140 150
MRDWIAACQL HGGLELEEET AFQGALTSRQ LPSGCPEAEE PANLESFGGE
160 170 180 190 200
DPRPELQATA DLLSSLEDLE LSNRRLVGEN AKLQRSMETA EEGSARLGEE
210 220 230 240 250
ILALRKQLHS TQQALQFAKA MDEELEDLKT LARSLEEQNR SLLAQARQAE
260 270 280 290 300
KEQQHLVAEM ETLQEENGKL LAERDGVKKR SQELAMEKDT LKRQLFECEH
310 320 330 340 350
LICQRDTILS ERTRDVESLA QTLEEYRVTT QELRLEISRL EEQLSQTYEG
360 370 380 390 400
PDELPEGAQL RRVGWTELLP PSLGLEIEAI RQKQEVATAD LSNPLCGVWQ
410 420 430 440 450
WEEVIHETSE ETEFPSEAPA GGQRNFQGEP AHPEEGRKEP SMWLTRREEE
460 470 480 490 500
EDAESQVTAD LPVPLGAPRP GDIPENPPER PARRELQQAL VPVMKKLVPV
510 520 530 540 550
RRRAWGQLCL PPQRLRVTRH PLIPAPVLGL LLLLLLSVLL LGPSPPPTWP
560
HLQLCYLQPP PV
Length:562
Mass (Da):62,783
Last modified:April 29, 2008 - v2
Checksum:i39F47D3F236A9918
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059597116L → P. Corresponds to variant dbSNP:rs8102582Ensembl.1
Natural variantiVAR_059598129R → Q1 PublicationCorresponds to variant dbSNP:rs10405154Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057220 mRNA. Translation: BAB71384.1.
AC010619 Genomic DNA. No translation available.
AC010643 Genomic DNA. No translation available.
CH471177 Genomic DNA. Translation: EAW52478.1.
BC029811 mRNA. Translation: AAH29811.1.
CCDSiCCDS46140.1.
RefSeqiNP_653289.3. NM_144688.4.
UniGeneiHs.662085.
Hs.743867.

Genome annotation databases

EnsembliENST00000447857; ENSP00000404220; ENSG00000161609.
GeneIDi147872.
KEGGihsa:147872.
UCSCiuc002pnm.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKASH5_HUMAN
AccessioniPrimary (citable) accession number: Q8N6L0
Secondary accession number(s): Q96MC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: October 25, 2017
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations