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Protein

Sterile alpha motif domain-containing protein 3

Gene

SAMD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Sterile alpha motif domain-containing protein 3
Short name:
SAM domain-containing protein 3
Gene namesi
Name:SAMD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000164483.16
HGNCiHGNC:21574 SAMD3
neXtProtiNX_Q8N6K7

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000164483
PharmGKBiPA134880481

Polymorphism and mutation databases

BioMutaiSAMD3
DMDMi147668009

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002794961 – 520Sterile alpha motif domain-containing protein 3Add BLAST520

Proteomic databases

EPDiQ8N6K7
PaxDbiQ8N6K7
PeptideAtlasiQ8N6K7
PRIDEiQ8N6K7

PTM databases

iPTMnetiQ8N6K7
PhosphoSitePlusiQ8N6K7

Expressioni

Gene expression databases

BgeeiENSG00000164483
CleanExiHS_SAMD3
ExpressionAtlasiQ8N6K7 baseline and differential
GenevisibleiQ8N6K7 HS

Organism-specific databases

HPAiHPA028992
HPA028993

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi127533, 7 interactors
IntActiQ8N6K7, 9 interactors
MINTiQ8N6K7

Structurei

3D structure databases

ProteinModelPortaliQ8N6K7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 71SAMPROSITE-ProRule annotationAdd BLAST68

Phylogenomic databases

eggNOGiENOG410KDKV Eukaryota
ENOG410Y0ZA LUCA
GeneTreeiENSGT00390000012396
HOGENOMiHOG000154251
HOVERGENiHBG083919
InParanoidiQ8N6K7
OMAiTDIYKKT
OrthoDBiEOG091G0D70
PhylomeDBiQ8N6K7
TreeFamiTF336040

Family and domain databases

InterProiView protein in InterPro
IPR001660 SAM
IPR013761 SAM/pointed_sf
PfamiView protein in Pfam
PF00536 SAM_1, 1 hit
SMARTiView protein in SMART
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS50105 SAM_DOMAIN, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N6K7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METWSVEQVC SWLVEKNLGE LVHRFQEEEV SGAALLALND RMVQQLVKKI
60 70 80 90 100
GHQAVLMDLI KKYKQNTQGL KSPENPKKAA LVMQTEAARD YRDEESSSPA
110 120 130 140 150
RHGEQMPSFY PAENLDNGLI DQRVLKQRRN VKQILARSKA LQWTKSYVLP
160 170 180 190 200
EFPYDVKCML AEQKCPDHSM RIRIIEFLQA DMTKYLEGSL YPSTQQYNDV
210 220 230 240 250
VNALLQAHPF LDEDGCGFFL WKRALKDRFK YVRRPIEDDE QVIRNKCKFG
260 270 280 290 300
HRRGQTRKSL ADIRFDEIKL VQIKEEAVCF DSELDEHIKW FQQEYVKTEK
310 320 330 340 350
DWREIDKRMS QTLEIRRKMI GSRTPLKDIL KLFPFLKCPY QMFREFQLLT
360 370 380 390 400
RTDIYKKTRH ILESYSENIL TSFSVVDNPI NIVLQEKMKH YTDEDMLKYM
410 420 430 440 450
KMTATCLLLP DVFGDDPSLF VIMNEQVQVS TPVLEVKNPF NMEVCEFSLY
460 470 480 490 500
LERERLTKVD DCVTALAALV AAFHVFRIEC PRRLSQTFNF LETLIFDMHS
510 520
PYFPSLKEKE NEVGFQHPLT
Length:520
Mass (Da):61,237
Last modified:March 6, 2007 - v2
Checksum:i660A7C0CF9CC6261
GO
Isoform 2 (identifier: Q8N6K7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     219-221: FLW → AGV
     222-520: Missing.

Note: No experimental confirmation available.
Show »
Length:221
Mass (Da):25,303
Checksum:i8410F79CB4485F26
GO
Isoform 3 (identifier: Q8N6K7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRSSKLQSPSPSQEKQGVYLQETAM

Show »
Length:544
Mass (Da):63,899
Checksum:i5BB1EBB0E561D42A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti276E → V in BAG63582 (PubMed:14702039).Curated1
Sequence conflicti472A → G in BAC03765 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03091094E → K1 PublicationCorresponds to variant dbSNP:rs17852709Ensembl.1
Natural variantiVAR_069418181D → N1 PublicationCorresponds to variant dbSNP:rs150968705Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0557381M → MRSSKLQSPSPSQEKQGVYL QETAM in isoform 3. 1 Publication1
Alternative sequenceiVSP_023459219 – 221FLW → AGV in isoform 2. 1 Publication3
Alternative sequenceiVSP_023460222 – 520Missing in isoform 2. 1 PublicationAdd BLAST299

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091351 mRNA Translation: BAC03644.1
AK091882 mRNA Translation: BAC03765.1
AK302228 mRNA Translation: BAG63582.1
AL355581 Genomic DNA No translation available.
AL121947 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48069.1
CH471051 Genomic DNA Translation: EAW48070.1
BC029851 mRNA Translation: AAH29851.1
BC119757 mRNA Translation: AAI19758.1
BC119758 mRNA Translation: AAI19759.1
CCDSiCCDS34539.1 [Q8N6K7-1]
CCDS64525.1 [Q8N6K7-3]
RefSeqiNP_001017373.2, NM_001017373.3 [Q8N6K7-1]
NP_001245204.1, NM_001258275.2 [Q8N6K7-1]
NP_001264114.1, NM_001277185.1 [Q8N6K7-3]
XP_016865795.1, XM_017010306.1 [Q8N6K7-1]
UniGeneiHs.440508

Genome annotation databases

EnsembliENST00000324172; ENSP00000324874; ENSG00000164483 [Q8N6K7-2]
ENST00000368134; ENSP00000357116; ENSG00000164483 [Q8N6K7-1]
ENST00000437477; ENSP00000391163; ENSG00000164483 [Q8N6K7-1]
ENST00000439090; ENSP00000403565; ENSG00000164483 [Q8N6K7-1]
ENST00000457563; ENSP00000402092; ENSG00000164483 [Q8N6K7-3]
GeneIDi154075
KEGGihsa:154075
UCSCiuc003qbw.5 human [Q8N6K7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSAMD3_HUMAN
AccessioniPrimary (citable) accession number: Q8N6K7
Secondary accession number(s): B4DY20
, E1P576, J3KQK4, Q4VXD8, Q8NAY1, Q8NB96
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 6, 2007
Last modified: March 28, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health