Q8N6I9 (Q8N6I9_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
GNAO1 protein EMBL AAH30027.2

Gene names

Name:

GNAO1 EMBL AAH30027.2

Organism

Homo sapiens (Human) EMBL AAH30027.2

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	302 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Ligand	GTP-binding SAAS SAAS001408 Nucleotide-binding
Molecular function	Transducer SAAS SAAS001408
Gene Ontology (GO)
Biological_process	adenylate cyclase-modulating G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: InterPro
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from electronic annotation. Source: InterPro signal transducer activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8N6I9 [UniParc]. Last modified March 1, 2004. Version 2. Checksum: B6902F0B0AA8DE09	FASTA	302	34,609
	10 20 30 40 50 60 MKIIHEDGFS GEDVKQYKPV VYSNTIQSLA AIVRAMDTLG IEYGDKERKA DAKMVCDVVS 70 80 90 100 110 120 RMEDTEPFSA ELLSAMMRLW GDSGIQECFN RSREYQLNDS AKYYLDSLDR IGAADYQPTE 130 140 150 160 170 180 QDILRTRVKT TGIVETHFTF KNLHFRLFDV GGQRSERKKW IHCFEDVTAI IFCVALSGYD 190 200 210 220 230 240 QVLHEDETTN RMHESLMLFD SICNNKFFID TSIILFLNKK DLFGEKIKKS PLTICFPEYT 250 260 270 280 290 300 GPNTYEDAAA YIQAQFESKN RSPNKEIYCH MTCATDTNNI QVVFDAVTDI IIANNLRGCG LY

References

[1]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J. Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain EMBL AAH30027.2.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC030027 mRNA. Translation: AAH30027.2.
IPI	IPI00220281.
RefSeq	NP_066268.1. NM_020988.2. NP_620073.2. NM_138736.2.
UniGene	Hs.644524.
3D structure databases
HSSP	HSSP built from PDB template 1BOF based on UniProtKB P10824.
ProteinModelPortal	Q8N6I9.
SMR	Q8N6I9. Positions 1-293.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8N6I9.
Proteomic databases
PRIDE	Q8N6I9.
Protocols and materials databases
DNASU	2775.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2775.
KEGG	hsa:2775.
Organism-specific databases
CTD	2775.
PharmGKB	PA28771.
Phylogenomic databases
HOVERGEN	HBG063184.
KO	K04534.
Gene expression databases
ArrayExpress	Q8N6I9.
Bgee	Q8N6I9.
Family and domain databases
Gene3D	1.10.400.10. 1 hit.
InterPro	IPR001408. Gprotein_alpha_I. IPR001019. Gprotein_alpha_su. IPR011025. GproteinA_insert. [Graphical view]
PANTHER	PTHR10218. PTHR10218. 1 hit.
Pfam	PF00503. G-alpha. 1 hit. [Graphical view]
PRINTS	PR00318. GPROTEINA. PR00441. GPROTEINAI.
SMART	SM00275. G_alpha. 1 hit. [Graphical view]
SUPFAM	SSF47895. Transducn_insert. 1 hit.
ProtoNet	Search...
Other
BindingDB	Q8N6I9.
ChiTaRS	GNAO1. human.
GenomeRNAi	2775.
NextBio	10916.

Entry information

Entry name

Q8N6I9_HUMAN

Accession

Primary (citable) accession number: Q8N6I9

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2002
Last sequence update:	March 1, 2004
Last modified:	May 1, 2013
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.