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Q8N6I4 (TM251_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane protein 251
Gene names
Name:TMEM251
Synonyms:C14orf109
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length163 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the TMEM251 family.

Sequence caution

The sequence AAH30119.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8N6I4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8N6I4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.
Isoform 3 (identifier: Q8N6I4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLAFSEM
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 163163Transmembrane protein 251
PRO_0000089916

Regions

Transmembrane40 – 6021Helical; Potential
Transmembrane98 – 11821Helical; Potential

Natural variations

Alternative sequence1 – 3232Missing in isoform 2.
VSP_036175
Alternative sequence11M → MLAFSEM in isoform 3.
VSP_045689

Experimental info

Sequence conflict152 – 1532SN → FY in BM554490. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 20, 2009. Version 4.
Checksum: 805D11CD73B20650

FASTA16318,747
        10         20         30         40         50         60 
MPKPPDYSEL SDSLTLAVGT GRFSGPLHRA WRMMNFRQRM GWIGVGLYLL ASAAAFYYVF 

        70         80         90        100        110        120 
EISETYNRLA LEHIQQHPEE PLEGTTWTHS LKAQLLSLPF WVWTVIFLVP YLQMFLFLYS 

       130        140        150        160 
CTRADPKTVG YCIIPICLAV ICNRHQAFVK ASNQISRLQL IDT 

« Hide

Isoform 2 [UniParc].

Checksum: AB25FB43AAFD72CC
Show »

FASTA13115,222
Isoform 3 [UniParc].

Checksum: ACC354A94E11790A
Show »

FASTA16919,426

References

[1]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Embryonic brain.
[2]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-149 (ISOFORM 1).
Tissue: Brain and Melanoma.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL080118 mRNA. Translation: CAB45717.2.
AL110118 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81518.1.
BC030119 mRNA. Translation: AAH30119.2. Different initiation.
BM554490 mRNA. No translation available.
CX785861 mRNA. No translation available.
CCDSCCDS41980.1. [Q8N6I4-2]
CCDS45158.1. [Q8N6I4-3]
PIRT12454.
RefSeqNP_001092091.1. NM_001098621.1. [Q8N6I4-3]
NP_056491.1. NM_015676.1. [Q8N6I4-2]
UniGeneHs.275352.
Hs.648806.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000388431.

Polymorphism databases

DMDM221222535.

Proteomic databases

MaxQBQ8N6I4.
PaxDbQ8N6I4.
PRIDEQ8N6I4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000283534; ENSP00000283534; ENSG00000153485. [Q8N6I4-2]
ENST00000415050; ENSP00000388431; ENSG00000153485. [Q8N6I4-3]
GeneID26175.
KEGGhsa:26175.
UCSCuc001ybk.4. human. [Q8N6I4-1]

Organism-specific databases

CTD26175.
GeneCardsGC14P093653.
H-InvDBHIX0011913.
HGNCHGNC:20218. TMEM251.
HPAHPA048559.
neXtProtNX_Q8N6I4.
PharmGKBPA134977710.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG47941.
HOGENOMHOG000111822.
HOVERGENHBG058826.
InParanoidQ8N6I4.
OMARAWRMMN.
OrthoDBEOG75MVZ2.
PhylomeDBQ8N6I4.
TreeFamTF332722.

Gene expression databases

BgeeQ8N6I4.
CleanExHS_C14orf109.
GenevestigatorQ8N6I4.

Family and domain databases

InterProIPR028024. TMEM251.
[Graphical view]
PfamPF15190. DUF4583. 1 hit.
[Graphical view]
ProDomPD641273. PD641273. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Other

GenomeRNAi26175.
NextBio35535280.
PROQ8N6I4.

Entry information

Entry nameTM251_HUMAN
AccessionPrimary (citable) accession number: Q8N6I4
Secondary accession number(s): J3KQ65, Q9Y4S5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: January 20, 2009
Last modified: July 9, 2014
This is version 87 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Uncharacterized protein families (UPF)

List of uncharacterized protein family (UPF) entries

SIMILARITY comments

Index of protein domains and families

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM