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Q8N6H7

- ARFG2_HUMAN

UniProt

Q8N6H7 - ARFG2_HUMAN

Protein

ADP-ribosylation factor GTPase-activating protein 2

Gene

ARFGAP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri26 – 4924C4-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ARF GTPase activator activity Source: InterPro
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. protein transport Source: UniProtKB-KW
    2. regulation of ARF GTPase activity Source: InterPro
    3. vesicle-mediated transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    GTPase activation

    Keywords - Biological processi

    ER-Golgi transport, Protein transport, Transport

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ADP-ribosylation factor GTPase-activating protein 2
    Short name:
    ARF GAP 2
    Alternative name(s):
    GTPase-activating protein ZNF289
    Zinc finger protein 289
    Gene namesi
    Name:ARFGAP2
    Synonyms:ZNF289
    ORF Names:Nbla10535
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:13504. ARFGAP2.

    Subcellular locationi

    Cytoplasm 1 Publication. Golgi apparatus membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
    Note: Also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate compartment.

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. Golgi apparatus Source: HPA
    3. Golgi membrane Source: UniProtKB-SubCell
    4. nucleolus Source: HPA
    5. plasma membrane Source: HPA

    Keywords - Cellular componenti

    Cytoplasm, Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162376868.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 521520ADP-ribosylation factor GTPase-activating protein 2PRO_0000278468Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei146 – 1461Phosphoserine4 Publications
    Modified residuei240 – 2401PhosphoserineBy similarity
    Modified residuei368 – 3681Phosphoserine4 Publications
    Modified residuei432 – 4321Phosphoserine3 Publications
    Modified residuei433 – 4331Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ8N6H7.
    PaxDbiQ8N6H7.
    PeptideAtlasiQ8N6H7.
    PRIDEiQ8N6H7.

    PTM databases

    PhosphoSiteiQ8N6H7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8N6H7.
    BgeeiQ8N6H7.
    CleanExiHS_ARFGAP2.
    GenevestigatoriQ8N6H7.

    Organism-specific databases

    HPAiHPA016649.
    HPA018152.

    Interactioni

    Subunit structurei

    Interacts with the coatomer complex. Interacts with the C-terminal appendage domain of COPG1.2 Publications

    Protein-protein interaction databases

    BioGridi124065. 3 interactions.
    STRINGi9606.ENSP00000327309.

    Structurei

    Secondary structure

    1
    521
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi7 – 1913
    Helixi21 – 244
    Turni27 – 293
    Beta strandi36 – 383
    Turni39 – 424
    Beta strandi43 – 453
    Helixi47 – 5610
    Turni58 – 603
    Beta strandi63 – 686
    Helixi74 – 829
    Helixi85 – 9410
    Helixi102 – 1065
    Helixi109 – 12416

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2P57X-ray1.80A3-130[»]
    ProteinModelPortaliQ8N6H7.
    SMRiQ8N6H7. Positions 4-127.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8N6H7.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini11 – 127117Arf-GAPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni97 – 521425Required for interaction with coatomerAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili242 – 30867Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Arf-GAP domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri26 – 4924C4-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5347.
    HOGENOMiHOG000162970.
    HOVERGENiHBG050563.
    InParanoidiQ8N6H7.
    KOiK12493.
    OMAiDTDATWG.
    OrthoDBiEOG7B8S42.
    PhylomeDBiQ8N6H7.
    TreeFamiTF313985.

    Family and domain databases

    InterProiIPR001164. ArfGAP.
    [Graphical view]
    PfamiPF01412. ArfGap. 1 hit.
    [Graphical view]
    PRINTSiPR00405. REVINTRACTNG.
    SMARTiSM00105. ArfGap. 1 hit.
    [Graphical view]
    PROSITEiPS50115. ARFGAP. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N6H7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAEPNKTEI QTLFKRLRAV PTNKACFDCG AKNPSWASIT YGVFLCIDCS    50
    GVHRSLGVHL SFIRSTELDS NWNWFQLRCM QVGGNANATA FFRQHGCTAN 100
    DANTKYNSRA AQMYREKIRQ LGSAALARHG TDLWIDNMSS AVPNHSPEKK 150
    DSDFFTEHTQ PPAWDAPATE PSGTQQPAPS TESSGLAQPE HGPNTDLLGT 200
    SPKASLELKS SIIGKKKPAA AKKGLGAKKG LGAQKVSSQS FSEIERQAQV 250
    AEKLREQQAA DAKKQAEESM VASMRLAYQE LQIDRKKEEK KLQNLEGKKR 300
    EQAERLGMGL VSRSSVSHSV LSEMQVIEQE TPVSAKSSRS QLDLFDDVGT 350
    FASGPPKYKD NPFSLGESFG SRWDTDAAWG MDRVEEKEPE VTISSIRPIS 400
    ERATNRREVE SRSSGLESSE ARQKFAGAKA ISSDMFFGRE VDAEYEARSR 450
    LQQLSGSSAI SSSDLFGDMD GAHGAGSVSL GNVLPTADIA QFKQGVKSVA 500
    GKMAVLANGV MNSLQDRYGS Y 521
    Length:521
    Mass (Da):56,720
    Last modified:October 1, 2002 - v1
    Checksum:i16655EBA94D29E81
    GO
    Isoform 2 (identifier: Q8N6H7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-79: Missing.
         133-160: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:414
    Mass (Da):44,543
    Checksum:iCB86DEEF636E8D91
    GO
    Isoform 3 (identifier: Q8N6H7-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-269: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:252
    Mass (Da):27,535
    Checksum:i8DFD0EE52D062600
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti40 – 401T → M in BAB55144. (PubMed:14702039)Curated
    Sequence conflicti107 – 1071N → S in BAB55144. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti143 – 1431P → R.
    Corresponds to variant rs11542793 [ dbSNP | Ensembl ].
    VAR_048321
    Natural varianti339 – 3391R → H.
    Corresponds to variant rs34662994 [ dbSNP | Ensembl ].
    VAR_048322
    Natural varianti406 – 4061R → W.
    Corresponds to variant rs35950498 [ dbSNP | Ensembl ].
    VAR_048323
    Natural varianti411 – 4111S → N.1 Publication
    Corresponds to variant rs3740691 [ dbSNP | Ensembl ].
    VAR_030780

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 269269Missing in isoform 3. 1 PublicationVSP_056054Add
    BLAST
    Alternative sequencei1 – 7979Missing in isoform 2. 1 PublicationVSP_056055Add
    BLAST
    Alternative sequencei133 – 16028Missing in isoform 2. 1 PublicationVSP_056056Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK027482 mRNA. Translation: BAB55144.1.
    AK301785 mRNA. Translation: BAG63241.1.
    AK315992 mRNA. Translation: BAH14363.1.
    AC090589 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW67963.1.
    CH471064 Genomic DNA. Translation: EAW67968.1.
    BC030148 mRNA. Translation: AAH30148.1.
    AL834337 mRNA. Translation: CAD39004.1.
    AB073358 mRNA. Translation: BAE45716.1.
    CCDSiCCDS7926.1.
    RefSeqiNP_001229761.1. NM_001242832.1.
    NP_115765.2. NM_032389.4.
    UniGeneiHs.436204.

    Genome annotation databases

    EnsembliENST00000319543; ENSP00000327309; ENSG00000149182.
    ENST00000419701; ENSP00000389264; ENSG00000149182.
    ENST00000524782; ENSP00000434442; ENSG00000149182.
    GeneIDi84364.
    KEGGihsa:84364.
    UCSCiuc001ndt.3. human.

    Polymorphism databases

    DMDMi74729129.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK027482 mRNA. Translation: BAB55144.1 .
    AK301785 mRNA. Translation: BAG63241.1 .
    AK315992 mRNA. Translation: BAH14363.1 .
    AC090589 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW67963.1 .
    CH471064 Genomic DNA. Translation: EAW67968.1 .
    BC030148 mRNA. Translation: AAH30148.1 .
    AL834337 mRNA. Translation: CAD39004.1 .
    AB073358 mRNA. Translation: BAE45716.1 .
    CCDSi CCDS7926.1.
    RefSeqi NP_001229761.1. NM_001242832.1.
    NP_115765.2. NM_032389.4.
    UniGenei Hs.436204.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2P57 X-ray 1.80 A 3-130 [» ]
    ProteinModelPortali Q8N6H7.
    SMRi Q8N6H7. Positions 4-127.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124065. 3 interactions.
    STRINGi 9606.ENSP00000327309.

    PTM databases

    PhosphoSitei Q8N6H7.

    Polymorphism databases

    DMDMi 74729129.

    Proteomic databases

    MaxQBi Q8N6H7.
    PaxDbi Q8N6H7.
    PeptideAtlasi Q8N6H7.
    PRIDEi Q8N6H7.

    Protocols and materials databases

    DNASUi 84364.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000319543 ; ENSP00000327309 ; ENSG00000149182 .
    ENST00000419701 ; ENSP00000389264 ; ENSG00000149182 .
    ENST00000524782 ; ENSP00000434442 ; ENSG00000149182 .
    GeneIDi 84364.
    KEGGi hsa:84364.
    UCSCi uc001ndt.3. human.

    Organism-specific databases

    CTDi 84364.
    GeneCardsi GC11M047185.
    HGNCi HGNC:13504. ARFGAP2.
    HPAi HPA016649.
    HPA018152.
    MIMi 606908. gene.
    neXtProti NX_Q8N6H7.
    PharmGKBi PA162376868.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5347.
    HOGENOMi HOG000162970.
    HOVERGENi HBG050563.
    InParanoidi Q8N6H7.
    KOi K12493.
    OMAi DTDATWG.
    OrthoDBi EOG7B8S42.
    PhylomeDBi Q8N6H7.
    TreeFami TF313985.

    Miscellaneous databases

    EvolutionaryTracei Q8N6H7.
    GenomeRNAii 84364.
    NextBioi 74137.
    PROi Q8N6H7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8N6H7.
    Bgeei Q8N6H7.
    CleanExi HS_ARFGAP2.
    Genevestigatori Q8N6H7.

    Family and domain databases

    InterProi IPR001164. ArfGAP.
    [Graphical view ]
    Pfami PF01412. ArfGap. 1 hit.
    [Graphical view ]
    PRINTSi PR00405. REVINTRACTNG.
    SMARTi SM00105. ArfGap. 1 hit.
    [Graphical view ]
    PROSITEi PS50115. ARFGAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
      Tissue: Brain, Teratocarcinoma and Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Eye.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-521 (ISOFORM 1).
      Tissue: Amygdala.
    6. "Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma."
      Ohira M., Morohashi A., Nakamura Y., Isogai E., Furuya K., Hamano S., Machida T., Aoyama M., Fukumura M., Miyazaki K., Suzuki Y., Sugano S., Hirato J., Nakagawara A.
      Cancer Lett. 197:63-68(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 41-521 (ISOFORM 1), VARIANT ASN-411.
      Tissue: Neuroblastoma.
    7. "Gamma-COP appendage domain -- structure and function."
      Watson P.J., Frigerio G., Collins B.M., Duden R., Owen D.J.
      Traffic 5:79-88(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH COPG1.
    8. "Two human ARFGAPs associated with COP-I-coated vesicles."
      Frigerio G., Grimsey N., Dale M., Majoul I., Duden R.
      Traffic 8:1644-1655(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH COATOMER.
    9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-368, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-146; SER-368 AND SER-432, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-146 AND SER-368, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-146; SER-368 AND SER-432, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-146; SER-432 AND SER-433, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    16. "Gap domain of ZNF289, an ID1-regulated zinc finger protein."
      Structural genomics consortium (SGC)
      Submitted (MAR-2007) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 2-130.

    Entry informationi

    Entry nameiARFG2_HUMAN
    AccessioniPrimary (citable) accession number: Q8N6H7
    Secondary accession number(s): B4DX29
    , B7Z9M7, D3DQQ9, Q3LIF2, Q8N3I1, Q96SX7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 20, 2007
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Vero cells overexpressing truncated ARFGAP2 show accumulation of cholera toxin A subunit in the Golgi complex rather than the endoplasmic reticulum.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3