##gff-version 3 Q8N6G6 UniProtKB Signal peptide 1 28 . . . . Q8N6G6 UniProtKB Chain 29 1762 . . . ID=PRO_0000035860;Note=ADAMTS-like protein 1 Q8N6G6 UniProtKB Domain 33 82 . . . Note=TSP type-1 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210 Q8N6G6 UniProtKB Domain 376 424 . . . Note=TSP type-1 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210 Q8N6G6 UniProtKB Domain 436 493 . . . Note=TSP type-1 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210 Q8N6G6 UniProtKB Domain 522 584 . . . Note=TSP type-1 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210 Q8N6G6 UniProtKB Domain 607 665 . . . Note=TSP type-1 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210 Q8N6G6 UniProtKB Domain 666 729 . . . Note=TSP type-1 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210 Q8N6G6 UniProtKB Domain 788 850 . . . Note=TSP type-1 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210 Q8N6G6 UniProtKB Domain 861 963 . . . Note=Ig-like C2-type 1 Q8N6G6 UniProtKB Domain 1164 1266 . . . Note=Ig-like C2-type 2 Q8N6G6 UniProtKB Domain 1286 1369 . . . Note=Ig-like C2-type 3 Q8N6G6 UniProtKB Domain 1395 1485 . . . Note=Ig-like C2-type 4 Q8N6G6 UniProtKB Domain 1545 1608 . . . Note=TSP type-1 8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210 Q8N6G6 UniProtKB Domain 1666 1726 . . . Note=TSP type-1 9;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00210 Q8N6G6 UniProtKB Domain 1726 1762 . . . Note=PLAC;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00233 Q8N6G6 UniProtKB Region 1120 1164 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8N6G6 UniProtKB Compositional bias 1123 1154 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8N6G6 UniProtKB Site 36 36 . . . Note=Not glycosylated;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19671700;Dbxref=PMID:19671700 Q8N6G6 UniProtKB Glycosylation 39 39 . . . Note=C-linked (Man) tryptophan;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19671700;Dbxref=PMID:19671700 Q8N6G6 UniProtKB Glycosylation 42 42 . . . Note=C-linked (Man) tryptophan;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19671700;Dbxref=PMID:19671700 Q8N6G6 UniProtKB Glycosylation 48 48 . . . Note=O-linked (Fuc...) threonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19671700;Dbxref=PMID:19671700 Q8N6G6 UniProtKB Glycosylation 251 251 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17395588;Dbxref=PMID:17395588 Q8N6G6 UniProtKB Glycosylation 312 312 . . . Note=O-linked (Fuc...) threonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17395588;Dbxref=PMID:17395588 Q8N6G6 UniProtKB Glycosylation 391 391 . . . Note=O-linked (Fuc...) serine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17395588;Dbxref=PMID:17395588 Q8N6G6 UniProtKB Glycosylation 451 451 . . . Note=O-linked (Fuc...) threonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17395588;Dbxref=PMID:17395588 Q8N6G6 UniProtKB Disulfide bond 45 76 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q8N6G6 UniProtKB Disulfide bond 49 81 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q8N6G6 UniProtKB Disulfide bond 60 66 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q8N6G6 UniProtKB Disulfide bond 534 578 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q8N6G6 UniProtKB Disulfide bond 538 583 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q8N6G6 UniProtKB Disulfide bond 549 567 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q8N6G6 UniProtKB Disulfide bond 678 723 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q8N6G6 UniProtKB Disulfide bond 682 728 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q8N6G6 UniProtKB Disulfide bond 693 712 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q8N6G6 UniProtKB Disulfide bond 800 844 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q8N6G6 UniProtKB Disulfide bond 804 849 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q8N6G6 UniProtKB Disulfide bond 815 832 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q8N6G6 UniProtKB Disulfide bond 899 947 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q8N6G6 UniProtKB Disulfide bond 1202 1250 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q8N6G6 UniProtKB Disulfide bond 1308 1353 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q8N6G6 UniProtKB Disulfide bond 1418 1469 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q8N6G6 UniProtKB Alternative sequence 1 1299 . . . ID=VSP_039322;Note=In isoform 5 and isoform 6. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12975309,ECO:0000303|PubMed:15489334;Dbxref=PMID:12975309,PMID:15489334 Q8N6G6 UniProtKB Alternative sequence 362 378 . . . ID=VSP_039323;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q8N6G6 UniProtKB Alternative sequence 448 456 . . . ID=VSP_039324;Note=In isoform 2. CTVTCGQGL->VTVPSFFVH;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q8N6G6 UniProtKB Alternative sequence 457 1762 . . . ID=VSP_039325;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q8N6G6 UniProtKB Alternative sequence 526 1762 . . . ID=VSP_039326;Note=In isoform 1. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11805097,ECO:0000303|PubMed:12975309,ECO:0000303|PubMed:14702039;Dbxref=PMID:11805097,PMID:12975309,PMID:14702039 Q8N6G6 UniProtKB Alternative sequence 670 683 . . . ID=VSP_039327;Note=In isoform 4. WEIGKWSPCSLTCG->SSIDSAWNACNVLC;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.7 Q8N6G6 UniProtKB Alternative sequence 684 1762 . . . ID=VSP_039328;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.7 Q8N6G6 UniProtKB Alternative sequence 1300 1311 . . . ID=VSP_039329;Note=In isoform 5 and isoform 6. QGVNVTINCQVA->MSGVFCFFFFFL;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12975309,ECO:0000303|PubMed:15489334;Dbxref=PMID:12975309,PMID:15489334 Q8N6G6 UniProtKB Alternative sequence 1549 1557 . . . ID=VSP_039330;Note=In isoform 5. WMVTSWSAC->AMGLASGLT;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309 Q8N6G6 UniProtKB Alternative sequence 1558 1762 . . . ID=VSP_039331;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309 Q8N6G6 UniProtKB Natural variant 242 242 . . . ID=VAR_017174;Note=S->N;Dbxref=dbSNP:rs776755 Q8N6G6 UniProtKB Mutagenesis 36 36 . . . Note=Small reduction in secretion of ADAMTSL1. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19671700;Dbxref=PMID:19671700 Q8N6G6 UniProtKB Mutagenesis 39 39 . . . Note=Significant reduction in secretion of ADAMTSL1. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19671700;Dbxref=PMID:19671700 Q8N6G6 UniProtKB Mutagenesis 39 39 . . . Note=Abolishes secretion of ADAMTSL1. W->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19671700;Dbxref=PMID:19671700 Q8N6G6 UniProtKB Mutagenesis 42 42 . . . Note=Modest reduction in secretion of ADAMTSL1. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19671700;Dbxref=PMID:19671700 Q8N6G6 UniProtKB Mutagenesis 42 42 . . . Note=Abolishes secretion of ADAMTSL1. W->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19671700;Dbxref=PMID:19671700 Q8N6G6 UniProtKB Mutagenesis 251 251 . . . Note=Abolishes N-glycosylation. Reduces secretion of ADAMTSL1. N->Q Q8N6G6 UniProtKB Mutagenesis 312 312 . . . Note=Small increase in secretion of ADAMTSL1. About 40%25 increase in secretion of ADAMTSL1%3B when associated with A-391. Dramatic increase in secretion of ADAMTSL1%3B when associated with A-391 and A-451. T->A Q8N6G6 UniProtKB Mutagenesis 385 385 . . . Note=Significant reduction in secretion of ADAMTSL1. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19671700;Dbxref=PMID:19671700 Q8N6G6 UniProtKB Mutagenesis 385 385 . . . Note=No effect on secretion of ADAMTSL1. W->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19671700;Dbxref=PMID:19671700 Q8N6G6 UniProtKB Mutagenesis 391 391 . . . Note=Small increase in secretion of ADAMTSL1. About 40%25 increase in secretion of ADAMTSL1%3B when associated with A-312. Dramatic increase in secretion of ADAMTSL1%3B when associated with A-312 and A-451. S->A Q8N6G6 UniProtKB Mutagenesis 445 445 . . . Note=Modest reduction in secretion of ADAMTSL1. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19671700;Dbxref=PMID:19671700 Q8N6G6 UniProtKB Mutagenesis 451 451 . . . Note=Small increase in secretion of ADAMTSL1. Dramatic increase in secretion of ADAMTSL1%3B when associated with A-312 and A-391. T->A Q8N6G6 UniProtKB Sequence conflict 54 55 . . . Note=SY->AN;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8N6G6 UniProtKB Sequence conflict 208 208 . . . Note=I->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8N6G6 UniProtKB Sequence conflict 1409 1409 . . . Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305