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Q8N6G6

- ATL1_HUMAN

UniProt

Q8N6G6 - ATL1_HUMAN

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Protein

ADAMTS-like protein 1

Gene
ADAMTSL1, ADAMTSR1, C9orf94, UNQ528/PRO1071
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei36 – 361Not glycosylated

GO - Molecular functioni

  1. metallopeptidase activity Source: InterPro
  2. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiREACT_200626. O-glycosylation of TSR domain-containing proteins.
SignaLinkiQ8N6G6.

Names & Taxonomyi

Protein namesi
Recommended name:
ADAMTS-like protein 1
Short name:
ADAMTSL-1
Alternative name(s):
Punctin-1
Gene namesi
Synonyms:ADAMTSR1, C9orf94
ORF Names:UNQ528/PRO1071
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:14632. ADAMTSL1.

Subcellular locationi

Secretedextracellular spaceextracellular matrix 3 Publications

GO - Cellular componenti

  1. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi36 – 361W → A: Small reduction in secretion of ADAMTSL1. 1 Publication
Mutagenesisi39 – 391W → A: Significant reduction in secretion of ADAMTSL1. 1 Publication
Mutagenesisi39 – 391W → F: Abolishes secretion of ADAMTSL1. 1 Publication
Mutagenesisi42 – 421W → A: Modest reduction in secretion of ADAMTSL1. 1 Publication
Mutagenesisi42 – 421W → F: Abolishes secretion of ADAMTSL1. 1 Publication
Mutagenesisi251 – 2511N → Q: Abolishes N-glycosylation. Reduces secretion of ADAMTSL1.
Mutagenesisi312 – 3121T → A: Small increase in secretion of ADAMTSL1. About 40% increase in secretion of ADAMTSL1; when associated with A-391. Dramatic increase in secretion of ADAMTSL1; when associated with A-391 and A-451.
Mutagenesisi385 – 3851W → A: Significant reduction in secretion of ADAMTSL1. 1 Publication
Mutagenesisi385 – 3851W → F: No effect on secretion of ADAMTSL1. 1 Publication
Mutagenesisi391 – 3911S → A: Small increase in secretion of ADAMTSL1. About 40% increase in secretion of ADAMTSL1; when associated with A-312. Dramatic increase in secretion of ADAMTSL1; when associated with A-312 and A-451.
Mutagenesisi445 – 4451W → A: Modest reduction in secretion of ADAMTSL1. 1 Publication
Mutagenesisi451 – 4511T → A: Small increase in secretion of ADAMTSL1. Dramatic increase in secretion of ADAMTSL1; when associated with A-312 and A-391.

Organism-specific databases

PharmGKBiPA24554.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Add
BLAST
Chaini29 – 17621734ADAMTS-like protein 1PRO_0000035860Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi39 – 391C-linked (Man)1 Publication
Glycosylationi42 – 421C-linked (Man)1 Publication
Disulfide bondi45 ↔ 76 By similarity
Glycosylationi48 – 481O-linked (Fuc...)1 Publication
Disulfide bondi49 ↔ 81 By similarity
Disulfide bondi60 ↔ 66 By similarity
Glycosylationi251 – 2511N-linked (GlcNAc...)1 Publication
Glycosylationi312 – 3121O-linked (Fuc...)1 Publication
Glycosylationi391 – 3911O-linked (Fuc...)1 Publication
Glycosylationi451 – 4511O-linked (Fuc...)1 Publication
Disulfide bondi534 ↔ 578 By similarity
Disulfide bondi538 ↔ 583 By similarity
Disulfide bondi549 ↔ 567 By similarity
Disulfide bondi678 ↔ 723 By similarity
Disulfide bondi682 ↔ 728 By similarity
Disulfide bondi693 ↔ 712 By similarity
Disulfide bondi800 ↔ 844 By similarity
Disulfide bondi804 ↔ 849 By similarity
Disulfide bondi815 ↔ 832 By similarity
Disulfide bondi899 ↔ 947 By similarity
Disulfide bondi1202 ↔ 1250 By similarity
Disulfide bondi1308 ↔ 1353 By similarity
Disulfide bondi1418 ↔ 1469 By similarity

Post-translational modificationi

C-, N- and O-glycosylated. O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTSL1. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion.3 Publications
Disulfide bonds are present.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8N6G6.
PRIDEiQ8N6G6.

PTM databases

PhosphoSiteiQ8N6G6.

Expressioni

Tissue specificityi

Expressed primarily in adult skeletal muscle.1 Publication

Gene expression databases

ArrayExpressiQ8N6G6.
BgeeiQ8N6G6.
CleanExiHS_ADAMTSL1.
GenevestigatoriQ8N6G6.

Organism-specific databases

HPAiHPA048566.
HPA057437.

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000369921.

Structurei

3D structure databases

ProteinModelPortaliQ8N6G6.
SMRiQ8N6G6. Positions 34-296, 888-959, 1191-1532.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 8250TSP type-1 1Add
BLAST
Domaini376 – 42449TSP type-1 2Add
BLAST
Domaini436 – 49358TSP type-1 3Add
BLAST
Domaini522 – 58463TSP type-1 4Add
BLAST
Domaini607 – 66559TSP type-1 5Add
BLAST
Domaini666 – 72964TSP type-1 6Add
BLAST
Domaini788 – 85063TSP type-1 7Add
BLAST
Domaini861 – 963103Ig-like C2-type 1Add
BLAST
Domaini1164 – 1266103Ig-like C2-type 2Add
BLAST
Domaini1286 – 136984Ig-like C2-type 3Add
BLAST
Domaini1395 – 148591Ig-like C2-type 4Add
BLAST
Domaini1545 – 160864TSP type-1 8Add
BLAST
Domaini1666 – 172661TSP type-1 9Add
BLAST
Domaini1726 – 176237PLACAdd
BLAST

Sequence similaritiesi

Contains 1 PLAC domain.
Contains 9 TSP type-1 domains.

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG272362.
HOVERGENiHBG068818.
InParanoidiQ8N6G6.
OMAiRWEIGKW.
OrthoDBiEOG7TXKFQ.
PhylomeDBiQ8N6G6.
TreeFamiTF351125.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR010909. PLAC.
IPR000884. Thrombospondin_1_rpt.
[Graphical view]
PfamiPF07679. I-set. 3 hits.
PF08686. PLAC. 1 hit.
PF00090. TSP_1. 8 hits.
[Graphical view]
PRINTSiPR01857. ADAMTSFAMILY.
SMARTiSM00408. IGc2. 4 hits.
SM00209. TSP1. 13 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 11 hits.
PROSITEiPS50835. IG_LIKE. 4 hits.
PS50900. PLAC. 1 hit.
PS50092. TSP1. 9 hits.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 3 (identifier: Q8N6G6-3) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MECCRRATPG TLLLFLAFLL LSSRTARSEE DRDGLWDAWG PWSECSRTCG     50
GGASYSLRRC LSSKSCEGRN IRYRTCSNVD CPPEAGDFRA QQCSAHNDVK 100
HHGQFYEWLP VSNDPDNPCS LKCQAKGTTL VVELAPKVLD GTRCYTESLD 150
MCISGLCQIV GCDHQLGSTV KEDNCGVCNG DGSTCRLVRG QYKSQLSATK 200
SDDTVVAIPY GSRHIRLVLK GPDHLYLETK TLQGTKGENS LSSTGTFLVD 250
NSSVDFQKFP DKEILRMAGP LTADFIVKIR NSGSADSTVQ FIFYQPIIHR 300
WRETDFFPCS ATCGGGYQLT SAECYDLRSN RVVADQYCHY YPENIKPKPK 350
LQECNLDPCP ASDGYKQIMP YDLYHPLPRW EATPWTACSS SCGGGIQSRA 400
VSCVEEDIQG HVTSVEEWKC MYTPKMPIAQ PCNIFDCPKW LAQEWSPCTV 450
TCGQGLRYRV VLCIDHRGMH TGGCSPKTKP HIKEECIVPT PCYKPKEKLP 500
VEAKLPWFKQ AQELEEGAAV SEEPSFIPEA WSACTVTCGV GTQVRIVRCQ 550
VLLSFSQSVA DLPIDECEGP KPASQRACYA GPCSGEIPEF NPDETDGLFG 600
GLQDFDELYD WEYEGFTKCS ESCGGGVQEA VVSCLNKQTR EPAEENLCVT 650
SRRPPQLLKS CNLDPCPARW EIGKWSPCSL TCGVGLQTRD VFCSHLLSRE 700
MNETVILADE LCRQPKPSTV QACNRFNCPP AWYPAQWQPC SRTCGGGVQK 750
REVLCKQRMA DGSFLELPET FCSASKPACQ QACKKDDCPS EWLLSDWTEC 800
STSCGEGTQT RSAICRKMLK TGLSTVVNST LCPPLPFSSS IRPCMLATCA 850
RPGRPSTKHS PHIAAARKVY IQTRRQRKLH FVVGGFAYLL PKTAVVLRCP 900
ARRVRKPLIT WEKDGQHLIS STHVTVAPFG YLKIHRLKPS DAGVYTCSAG 950
PAREHFVIKL IGGNRKLVAR PLSPRSEEEV LAGRKGGPKE ALQTHKHQNG 1000
IFSNGSKAEK RGLAANPGSR YDDLVSRLLE QGGWPGELLA SWEAQDSAER 1050
NTTSEEDPGA EQVLLHLPFT MVTEQRRLDD ILGNLSQQPE ELRDLYSKHL 1100
VAQLAQEIFR SHLEHQDTLL KPSERRTSPV TLSPHKHVSG FSSSLRTSST 1150
GDAGGGSRRP HRKPTILRKI SAAQQLSASE VVTHLGQTVA LASGTLSVLL 1200
HCEAIGHPRP TISWARNGEE VQFSDRILLQ PDDSLQILAP VEADVGFYTC 1250
NATNALGYDS VSIAVTLAGK PLVKTSRMTV INTEKPAVTV DIGSTIKTVQ 1300
GVNVTINCQV AGVPEAEVTW FRNKSKLGSP HHLHEGSLLL TNVSSSDQGL 1350
YSCRAANLHG ELTESTQLLI LDPPQVPTQL EDIRALLAAT GPNLPSVLTS 1400
PLGTQLVLDP GNSALLGCPI KGHPVPNITW FHGGQPIVTA TGLTHHILAA 1450
GQILQVANLS GGSQGEFSCL AQNEAGVLMQ KASLVIQDYW WSVDRLATCS 1500
ASCGNRGVQQ PRLRCLLNST EVNPAHCAGK VRPAVQPIAC NRRDCPSRWM 1550
VTSWSACTRS CGGGVQTRRV TCQKLKASGI STPVSNDMCT QVAKRPVDTQ 1600
ACNQQLCVEW AFSSWGQCNG PCIGPHLAVQ HRQVFCQTRD GITLPSEQCS 1650
ALPRPVSTQN CWSEACSVHW RVSLWTLCTA TCGNYGFQSR RVECVHARTN 1700
KAVPEHLCSW GPRPANWQRC NITPCENMEC RDTTRYCEKV KQLKLCQLSQ 1750
FKSRCCGTCG KA 1762
Length:1,762
Mass (Da):193,409
Last modified:June 15, 2010 - v4
Checksum:i2822C0A367C2EF4E
GO
Isoform 1 (identifier: Q8N6G6-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     526-1762: Missing.

Show »
Length:525
Mass (Da):58,416
Checksum:i4D797F7ECBD4FC51
GO
Isoform 2 (identifier: Q8N6G6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     362-378: Missing.
     448-456: CTVTCGQGL → VTVPSFFVH
     457-1762: Missing.

Note: No experimental confirmation available.

Show »
Length:439
Mass (Da):48,764
Checksum:iB7155590915B3F3D
GO
Isoform 4 (identifier: Q8N6G6-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     670-683: WEIGKWSPCSLTCG → SSIDSAWNACNVLC
     684-1762: Missing.

Note: No experimental confirmation available.

Show »
Length:683
Mass (Da):75,523
Checksum:i49BFADA25E9EEBB5
GO
Isoform 5 (identifier: Q8N6G6-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1299: Missing.
     1300-1311: QGVNVTINCQVA → MSGVFCFFFFFL
     1549-1557: WMVTSWSAC → AMGLASGLT
     1558-1762: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:258
Mass (Da):27,468
Checksum:iD105728584BE2DE1
GO
Isoform 6 (identifier: Q8N6G6-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1299: Missing.
     1300-1311: QGVNVTINCQVA → MSGVFCFFFFFL

Show »
Length:463
Mass (Da):50,568
Checksum:i044EA30A0BD28A00
GO

Sequence cautioni

The sequence AAI00789.1 differs from that shown. Reason: Frameshift at position 1312.
The sequence AAI00791.1 differs from that shown. Reason: Frameshift at position 1312.
The sequence AAK34948.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Mass spectrometryi

Isoform 1 : Molecular mass is 61935±595 Da from positions 28 - 525. Determined by MALDI. 1 Publication

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti242 – 2421S → N.
Corresponds to variant rs776755 [ dbSNP | Ensembl ].
VAR_017174

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 12991299Missing in isoform 5 and isoform 6. VSP_039322Add
BLAST
Alternative sequencei362 – 37817Missing in isoform 2. VSP_039323Add
BLAST
Alternative sequencei448 – 4569CTVTCGQGL → VTVPSFFVH in isoform 2. VSP_039324
Alternative sequencei457 – 17621306Missing in isoform 2. VSP_039325Add
BLAST
Alternative sequencei526 – 17621237Missing in isoform 1. VSP_039326Add
BLAST
Alternative sequencei670 – 68314WEIGK…SLTCG → SSIDSAWNACNVLC in isoform 4. VSP_039327Add
BLAST
Alternative sequencei684 – 17621079Missing in isoform 4. VSP_039328Add
BLAST
Alternative sequencei1300 – 131112QGVNV…NCQVA → MSGVFCFFFFFL in isoform 5 and isoform 6. VSP_039329Add
BLAST
Alternative sequencei1549 – 15579WMVTSWSAC → AMGLASGLT in isoform 5. VSP_039330
Alternative sequencei1558 – 1762205Missing in isoform 5. VSP_039331Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti54 – 552SY → AN in AAK84170. 1 Publication
Sequence conflicti208 – 2081I → L in AAQ88693. 1 Publication
Sequence conflicti1409 – 14091D → G in BAC03925. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF176313 mRNA. Translation: AAK84170.1.
AY358327 mRNA. Translation: AAQ88693.1.
AK092602 mRNA. Translation: BAC03925.1.
AK291956 mRNA. Translation: BAF84645.1.
AL158150 Genomic DNA. Translation: CAO03592.1.
AL353895, AL442638, AL449963 Genomic DNA. Translation: CAI14851.1.
AL591423 Genomic DNA. No translation available.
CH471071 Genomic DNA. Translation: EAW58656.1.
BC030262 mRNA. Translation: AAH30262.1.
BC100788 mRNA. Translation: AAI00789.1. Frameshift.
BC100790 mRNA. Translation: AAI00791.1. Frameshift.
AF251058 mRNA. Translation: AAK34948.1. Different initiation.
CCDSiCCDS47954.1. [Q8N6G6-3]
CCDS6485.1. [Q8N6G6-1]
RefSeqiNP_001035362.3. NM_001040272.5. [Q8N6G6-3]
NP_443098.3. NM_052866.4. [Q8N6G6-1]
UniGeneiHs.741483.

Genome annotation databases

EnsembliENST00000276935; ENSP00000276935; ENSG00000178031. [Q8N6G6-4]
ENST00000327883; ENSP00000327887; ENSG00000178031. [Q8N6G6-1]
ENST00000380545; ENSP00000369918; ENSG00000178031. [Q8N6G6-6]
ENST00000380548; ENSP00000369921; ENSG00000178031. [Q8N6G6-3]
ENST00000380566; ENSP00000369940; ENSG00000178031. [Q8N6G6-2]
ENST00000542621; ENSP00000440472; ENSG00000178031. [Q8N6G6-5]
GeneIDi92949.
KEGGihsa:92949.
UCSCiuc003znb.3. human. [Q8N6G6-2]
uc003znc.4. human. [Q8N6G6-1]
uc003zne.4. human. [Q8N6G6-3]
uc003znf.4. human. [Q8N6G6-6]

Polymorphism databases

DMDMi298286924.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF176313 mRNA. Translation: AAK84170.1 .
AY358327 mRNA. Translation: AAQ88693.1 .
AK092602 mRNA. Translation: BAC03925.1 .
AK291956 mRNA. Translation: BAF84645.1 .
AL158150 Genomic DNA. Translation: CAO03592.1 .
AL353895 , AL442638 , AL449963 Genomic DNA. Translation: CAI14851.1 .
AL591423 Genomic DNA. No translation available.
CH471071 Genomic DNA. Translation: EAW58656.1 .
BC030262 mRNA. Translation: AAH30262.1 .
BC100788 mRNA. Translation: AAI00789.1 . Frameshift.
BC100790 mRNA. Translation: AAI00791.1 . Frameshift.
AF251058 mRNA. Translation: AAK34948.1 . Different initiation.
CCDSi CCDS47954.1. [Q8N6G6-3 ]
CCDS6485.1. [Q8N6G6-1 ]
RefSeqi NP_001035362.3. NM_001040272.5. [Q8N6G6-3 ]
NP_443098.3. NM_052866.4. [Q8N6G6-1 ]
UniGenei Hs.741483.

3D structure databases

ProteinModelPortali Q8N6G6.
SMRi Q8N6G6. Positions 34-296, 888-959, 1191-1532.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000369921.

PTM databases

PhosphoSitei Q8N6G6.

Polymorphism databases

DMDMi 298286924.

Proteomic databases

PaxDbi Q8N6G6.
PRIDEi Q8N6G6.

Protocols and materials databases

DNASUi 92949.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000276935 ; ENSP00000276935 ; ENSG00000178031 . [Q8N6G6-4 ]
ENST00000327883 ; ENSP00000327887 ; ENSG00000178031 . [Q8N6G6-1 ]
ENST00000380545 ; ENSP00000369918 ; ENSG00000178031 . [Q8N6G6-6 ]
ENST00000380548 ; ENSP00000369921 ; ENSG00000178031 . [Q8N6G6-3 ]
ENST00000380566 ; ENSP00000369940 ; ENSG00000178031 . [Q8N6G6-2 ]
ENST00000542621 ; ENSP00000440472 ; ENSG00000178031 . [Q8N6G6-5 ]
GeneIDi 92949.
KEGGi hsa:92949.
UCSCi uc003znb.3. human. [Q8N6G6-2 ]
uc003znc.4. human. [Q8N6G6-1 ]
uc003zne.4. human. [Q8N6G6-3 ]
uc003znf.4. human. [Q8N6G6-6 ]

Organism-specific databases

CTDi 92949.
GeneCardsi GC09P018464.
H-InvDB HIX0007941.
HGNCi HGNC:14632. ADAMTSL1.
HPAi HPA048566.
HPA057437.
MIMi 609198. gene.
neXtProti NX_Q8N6G6.
PharmGKBi PA24554.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG272362.
HOVERGENi HBG068818.
InParanoidi Q8N6G6.
OMAi RWEIGKW.
OrthoDBi EOG7TXKFQ.
PhylomeDBi Q8N6G6.
TreeFami TF351125.

Enzyme and pathway databases

Reactomei REACT_200626. O-glycosylation of TSR domain-containing proteins.
SignaLinki Q8N6G6.

Miscellaneous databases

GeneWikii ADAMTSL1.
GenomeRNAii 92949.
NextBioi 77924.
PROi Q8N6G6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8N6G6.
Bgeei Q8N6G6.
CleanExi HS_ADAMTSL1.
Genevestigatori Q8N6G6.

Family and domain databases

Gene3Di 2.60.40.10. 4 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR010909. PLAC.
IPR000884. Thrombospondin_1_rpt.
[Graphical view ]
Pfami PF07679. I-set. 3 hits.
PF08686. PLAC. 1 hit.
PF00090. TSP_1. 8 hits.
[Graphical view ]
PRINTSi PR01857. ADAMTSFAMILY.
SMARTi SM00408. IGc2. 4 hits.
SM00209. TSP1. 13 hits.
[Graphical view ]
SUPFAMi SSF82895. SSF82895. 11 hits.
PROSITEi PS50835. IG_LIKE. 4 hits.
PS50900. PLAC. 1 hit.
PS50092. TSP1. 9 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Punctin, a novel ADAMTS-like molecule, ADAMTSL-1, in extracellular matrix."
    Hirohata S., Wang L.W., Miyagi M., Yan L., Seldin M.F., Keene D.R., Crabb J.W., Apte S.S.
    J. Biol. Chem. 277:12182-12189(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, GLYCOSYLATION, MASS SPECTROMETRY, DISULFIDE BONDS.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5).
    Tissue: Prostate.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 6).
    Tissue: Lung.
  7. Mao Y., Xie Y., Zhou Z., Zhao W., Zhao S., Wang W., Huang Y., Wang S., Tang R., Chen X., Wu C.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 214-1762 (ISOFORM 4).
  8. "O-fucosylation of thrombospondin type 1 repeats in ADAMTS-like-1/punctin-1 regulates secretion: implications for the ADAMTS superfamily."
    Wang L.W., Dlugosz M., Somerville R.P., Raed M., Haltiwanger R.S., Apte S.S.
    J. Biol. Chem. 282:17024-17031(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-251; THR-312; SER-391 AND THR-451, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
  9. "Post-translational modification of thrombospondin type-1 repeats in ADAMTS-like 1/punctin-1 by C-mannosylation of tryptophan."
    Wang L.W., Leonhard-Melief C., Haltiwanger R.S., Apte S.S.
    J. Biol. Chem. 284:30004-30015(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT TRP-39; TRP-42 AND THR-48, LACK OF GLYCOSYLATION AT TRP-36, SUBCELLULAR LOCATION, MUTAGENESIS OF TRP-36; TRP-39; TRP-42; TRP-385 AND TRP-445, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiATL1_HUMAN
AccessioniPrimary (citable) accession number: Q8N6G6
Secondary accession number(s): A6PVN1
, A8K7E1, Q496M6, Q496M8, Q5T708, Q5VZT8, Q8NAI9, Q96RW4, Q9BXY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: June 15, 2010
Last modified: September 3, 2014
This is version 112 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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