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Q8N6G6

- ATL1_HUMAN

UniProt

Q8N6G6 - ATL1_HUMAN

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Protein

ADAMTS-like protein 1

Gene

ADAMTSL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei36 – 361Not glycosylated

GO - Molecular functioni

  1. metallopeptidase activity Source: InterPro
  2. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiREACT_200626. O-glycosylation of TSR domain-containing proteins.
SignaLinkiQ8N6G6.

Names & Taxonomyi

Protein namesi
Recommended name:
ADAMTS-like protein 1
Short name:
ADAMTSL-1
Alternative name(s):
Punctin-1
Gene namesi
Name:ADAMTSL1
Synonyms:ADAMTSR1, C9orf94
ORF Names:UNQ528/PRO1071
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:14632. ADAMTSL1.

Subcellular locationi

Secretedextracellular spaceextracellular matrix 3 Publications

GO - Cellular componenti

  1. proteinaceous extracellular matrix Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi36 – 361W → A: Small reduction in secretion of ADAMTSL1. 1 Publication
Mutagenesisi39 – 391W → A: Significant reduction in secretion of ADAMTSL1. 1 Publication
Mutagenesisi39 – 391W → F: Abolishes secretion of ADAMTSL1. 1 Publication
Mutagenesisi42 – 421W → A: Modest reduction in secretion of ADAMTSL1. 1 Publication
Mutagenesisi42 – 421W → F: Abolishes secretion of ADAMTSL1. 1 Publication
Mutagenesisi251 – 2511N → Q: Abolishes N-glycosylation. Reduces secretion of ADAMTSL1.
Mutagenesisi312 – 3121T → A: Small increase in secretion of ADAMTSL1. About 40% increase in secretion of ADAMTSL1; when associated with A-391. Dramatic increase in secretion of ADAMTSL1; when associated with A-391 and A-451.
Mutagenesisi385 – 3851W → A: Significant reduction in secretion of ADAMTSL1. 1 Publication
Mutagenesisi385 – 3851W → F: No effect on secretion of ADAMTSL1. 1 Publication
Mutagenesisi391 – 3911S → A: Small increase in secretion of ADAMTSL1. About 40% increase in secretion of ADAMTSL1; when associated with A-312. Dramatic increase in secretion of ADAMTSL1; when associated with A-312 and A-451.
Mutagenesisi445 – 4451W → A: Modest reduction in secretion of ADAMTSL1. 1 Publication
Mutagenesisi451 – 4511T → A: Small increase in secretion of ADAMTSL1. Dramatic increase in secretion of ADAMTSL1; when associated with A-312 and A-391.

Organism-specific databases

PharmGKBiPA24554.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Add
BLAST
Chaini29 – 17621734ADAMTS-like protein 1PRO_0000035860Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi39 – 391C-linked (Man)
Glycosylationi42 – 421C-linked (Man)
Disulfide bondi45 ↔ 76By similarity
Glycosylationi48 – 481O-linked (Fuc...)1 Publication
Disulfide bondi49 ↔ 81By similarity
Disulfide bondi60 ↔ 66By similarity
Glycosylationi251 – 2511N-linked (GlcNAc...)1 Publication
Glycosylationi312 – 3121O-linked (Fuc...)1 Publication
Glycosylationi391 – 3911O-linked (Fuc...)1 Publication
Glycosylationi451 – 4511O-linked (Fuc...)1 Publication
Disulfide bondi534 ↔ 578By similarity
Disulfide bondi538 ↔ 583By similarity
Disulfide bondi549 ↔ 567By similarity
Disulfide bondi678 ↔ 723By similarity
Disulfide bondi682 ↔ 728By similarity
Disulfide bondi693 ↔ 712By similarity
Disulfide bondi800 ↔ 844By similarity
Disulfide bondi804 ↔ 849By similarity
Disulfide bondi815 ↔ 832By similarity
Disulfide bondi899 ↔ 947By similarity
Disulfide bondi1202 ↔ 1250By similarity
Disulfide bondi1308 ↔ 1353By similarity
Disulfide bondi1418 ↔ 1469By similarity

Post-translational modificationi

C-, N- and O-glycosylated. O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTSL1. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion.3 Publications
Disulfide bonds are present.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8N6G6.
PRIDEiQ8N6G6.

PTM databases

PhosphoSiteiQ8N6G6.

Expressioni

Tissue specificityi

Expressed primarily in adult skeletal muscle.1 Publication

Gene expression databases

BgeeiQ8N6G6.
CleanExiHS_ADAMTSL1.
ExpressionAtlasiQ8N6G6. baseline and differential.
GenevestigatoriQ8N6G6.

Organism-specific databases

HPAiHPA048566.
HPA057437.

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000369921.

Structurei

3D structure databases

ProteinModelPortaliQ8N6G6.
SMRiQ8N6G6. Positions 34-296, 888-956, 1164-1532.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 8250TSP type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini376 – 42449TSP type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini436 – 49358TSP type-1 3PROSITE-ProRule annotationAdd
BLAST
Domaini522 – 58463TSP type-1 4PROSITE-ProRule annotationAdd
BLAST
Domaini607 – 66559TSP type-1 5PROSITE-ProRule annotationAdd
BLAST
Domaini666 – 72964TSP type-1 6PROSITE-ProRule annotationAdd
BLAST
Domaini788 – 85063TSP type-1 7PROSITE-ProRule annotationAdd
BLAST
Domaini861 – 963103Ig-like C2-type 1Add
BLAST
Domaini1164 – 1266103Ig-like C2-type 2Add
BLAST
Domaini1286 – 136984Ig-like C2-type 3Add
BLAST
Domaini1395 – 148591Ig-like C2-type 4Add
BLAST
Domaini1545 – 160864TSP type-1 8PROSITE-ProRule annotationAdd
BLAST
Domaini1666 – 172661TSP type-1 9PROSITE-ProRule annotationAdd
BLAST
Domaini1726 – 176237PLACPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PLAC domain.PROSITE-ProRule annotation
Contains 9 TSP type-1 domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG272362.
GeneTreeiENSGT00760000118885.
HOVERGENiHBG068818.
InParanoidiQ8N6G6.
OMAiRWEIGKW.
OrthoDBiEOG7TXKFQ.
PhylomeDBiQ8N6G6.
TreeFamiTF351125.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR010909. PLAC.
IPR000884. Thrombospondin_1_rpt.
[Graphical view]
PfamiPF07679. I-set. 3 hits.
PF08686. PLAC. 1 hit.
PF00090. TSP_1. 8 hits.
[Graphical view]
PRINTSiPR01857. ADAMTSFAMILY.
SMARTiSM00408. IGc2. 4 hits.
SM00209. TSP1. 13 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 11 hits.
PROSITEiPS50835. IG_LIKE. 4 hits.
PS50900. PLAC. 1 hit.
PS50092. TSP1. 9 hits.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 3 (identifier: Q8N6G6-3) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MECCRRATPG TLLLFLAFLL LSSRTARSEE DRDGLWDAWG PWSECSRTCG
60 70 80 90 100
GGASYSLRRC LSSKSCEGRN IRYRTCSNVD CPPEAGDFRA QQCSAHNDVK
110 120 130 140 150
HHGQFYEWLP VSNDPDNPCS LKCQAKGTTL VVELAPKVLD GTRCYTESLD
160 170 180 190 200
MCISGLCQIV GCDHQLGSTV KEDNCGVCNG DGSTCRLVRG QYKSQLSATK
210 220 230 240 250
SDDTVVAIPY GSRHIRLVLK GPDHLYLETK TLQGTKGENS LSSTGTFLVD
260 270 280 290 300
NSSVDFQKFP DKEILRMAGP LTADFIVKIR NSGSADSTVQ FIFYQPIIHR
310 320 330 340 350
WRETDFFPCS ATCGGGYQLT SAECYDLRSN RVVADQYCHY YPENIKPKPK
360 370 380 390 400
LQECNLDPCP ASDGYKQIMP YDLYHPLPRW EATPWTACSS SCGGGIQSRA
410 420 430 440 450
VSCVEEDIQG HVTSVEEWKC MYTPKMPIAQ PCNIFDCPKW LAQEWSPCTV
460 470 480 490 500
TCGQGLRYRV VLCIDHRGMH TGGCSPKTKP HIKEECIVPT PCYKPKEKLP
510 520 530 540 550
VEAKLPWFKQ AQELEEGAAV SEEPSFIPEA WSACTVTCGV GTQVRIVRCQ
560 570 580 590 600
VLLSFSQSVA DLPIDECEGP KPASQRACYA GPCSGEIPEF NPDETDGLFG
610 620 630 640 650
GLQDFDELYD WEYEGFTKCS ESCGGGVQEA VVSCLNKQTR EPAEENLCVT
660 670 680 690 700
SRRPPQLLKS CNLDPCPARW EIGKWSPCSL TCGVGLQTRD VFCSHLLSRE
710 720 730 740 750
MNETVILADE LCRQPKPSTV QACNRFNCPP AWYPAQWQPC SRTCGGGVQK
760 770 780 790 800
REVLCKQRMA DGSFLELPET FCSASKPACQ QACKKDDCPS EWLLSDWTEC
810 820 830 840 850
STSCGEGTQT RSAICRKMLK TGLSTVVNST LCPPLPFSSS IRPCMLATCA
860 870 880 890 900
RPGRPSTKHS PHIAAARKVY IQTRRQRKLH FVVGGFAYLL PKTAVVLRCP
910 920 930 940 950
ARRVRKPLIT WEKDGQHLIS STHVTVAPFG YLKIHRLKPS DAGVYTCSAG
960 970 980 990 1000
PAREHFVIKL IGGNRKLVAR PLSPRSEEEV LAGRKGGPKE ALQTHKHQNG
1010 1020 1030 1040 1050
IFSNGSKAEK RGLAANPGSR YDDLVSRLLE QGGWPGELLA SWEAQDSAER
1060 1070 1080 1090 1100
NTTSEEDPGA EQVLLHLPFT MVTEQRRLDD ILGNLSQQPE ELRDLYSKHL
1110 1120 1130 1140 1150
VAQLAQEIFR SHLEHQDTLL KPSERRTSPV TLSPHKHVSG FSSSLRTSST
1160 1170 1180 1190 1200
GDAGGGSRRP HRKPTILRKI SAAQQLSASE VVTHLGQTVA LASGTLSVLL
1210 1220 1230 1240 1250
HCEAIGHPRP TISWARNGEE VQFSDRILLQ PDDSLQILAP VEADVGFYTC
1260 1270 1280 1290 1300
NATNALGYDS VSIAVTLAGK PLVKTSRMTV INTEKPAVTV DIGSTIKTVQ
1310 1320 1330 1340 1350
GVNVTINCQV AGVPEAEVTW FRNKSKLGSP HHLHEGSLLL TNVSSSDQGL
1360 1370 1380 1390 1400
YSCRAANLHG ELTESTQLLI LDPPQVPTQL EDIRALLAAT GPNLPSVLTS
1410 1420 1430 1440 1450
PLGTQLVLDP GNSALLGCPI KGHPVPNITW FHGGQPIVTA TGLTHHILAA
1460 1470 1480 1490 1500
GQILQVANLS GGSQGEFSCL AQNEAGVLMQ KASLVIQDYW WSVDRLATCS
1510 1520 1530 1540 1550
ASCGNRGVQQ PRLRCLLNST EVNPAHCAGK VRPAVQPIAC NRRDCPSRWM
1560 1570 1580 1590 1600
VTSWSACTRS CGGGVQTRRV TCQKLKASGI STPVSNDMCT QVAKRPVDTQ
1610 1620 1630 1640 1650
ACNQQLCVEW AFSSWGQCNG PCIGPHLAVQ HRQVFCQTRD GITLPSEQCS
1660 1670 1680 1690 1700
ALPRPVSTQN CWSEACSVHW RVSLWTLCTA TCGNYGFQSR RVECVHARTN
1710 1720 1730 1740 1750
KAVPEHLCSW GPRPANWQRC NITPCENMEC RDTTRYCEKV KQLKLCQLSQ
1760
FKSRCCGTCG KA
Length:1,762
Mass (Da):193,409
Last modified:June 15, 2010 - v4
Checksum:i2822C0A367C2EF4E
GO
Isoform 1 (identifier: Q8N6G6-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     526-1762: Missing.

Show »
Length:525
Mass (Da):58,416
Checksum:i4D797F7ECBD4FC51
GO
Isoform 2 (identifier: Q8N6G6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     362-378: Missing.
     448-456: CTVTCGQGL → VTVPSFFVH
     457-1762: Missing.

Note: No experimental confirmation available.

Show »
Length:439
Mass (Da):48,764
Checksum:iB7155590915B3F3D
GO
Isoform 4 (identifier: Q8N6G6-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     670-683: WEIGKWSPCSLTCG → SSIDSAWNACNVLC
     684-1762: Missing.

Note: No experimental confirmation available.

Show »
Length:683
Mass (Da):75,523
Checksum:i49BFADA25E9EEBB5
GO
Isoform 5 (identifier: Q8N6G6-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1299: Missing.
     1300-1311: QGVNVTINCQVA → MSGVFCFFFFFL
     1549-1557: WMVTSWSAC → AMGLASGLT
     1558-1762: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:258
Mass (Da):27,468
Checksum:iD105728584BE2DE1
GO
Isoform 6 (identifier: Q8N6G6-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1299: Missing.
     1300-1311: QGVNVTINCQVA → MSGVFCFFFFFL

Show »
Length:463
Mass (Da):50,568
Checksum:i044EA30A0BD28A00
GO

Sequence cautioni

The sequence AAI00789.1 differs from that shown. Reason: Frameshift at position 1312.
The sequence AAI00791.1 differs from that shown. Reason: Frameshift at position 1312.
The sequence AAK34948.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti54 – 552SY → AN in AAK84170. (PubMed:11805097)Curated
Sequence conflicti208 – 2081I → L in AAQ88693. (PubMed:12975309)Curated
Sequence conflicti1409 – 14091D → G in BAC03925. (PubMed:14702039)Curated

Mass spectrometryi

Isoform 1 : Molecular mass is 61935±595 Da from positions 28 - 525. Determined by MALDI. 1 Publication

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti242 – 2421S → N.
Corresponds to variant rs776755 [ dbSNP | Ensembl ].
VAR_017174

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 12991299Missing in isoform 5 and isoform 6. 2 PublicationsVSP_039322Add
BLAST
Alternative sequencei362 – 37817Missing in isoform 2. 1 PublicationVSP_039323Add
BLAST
Alternative sequencei448 – 4569CTVTCGQGL → VTVPSFFVH in isoform 2. 1 PublicationVSP_039324
Alternative sequencei457 – 17621306Missing in isoform 2. 1 PublicationVSP_039325Add
BLAST
Alternative sequencei526 – 17621237Missing in isoform 1. 3 PublicationsVSP_039326Add
BLAST
Alternative sequencei670 – 68314WEIGK…SLTCG → SSIDSAWNACNVLC in isoform 4. 1 PublicationVSP_039327Add
BLAST
Alternative sequencei684 – 17621079Missing in isoform 4. 1 PublicationVSP_039328Add
BLAST
Alternative sequencei1300 – 131112QGVNV…NCQVA → MSGVFCFFFFFL in isoform 5 and isoform 6. 2 PublicationsVSP_039329Add
BLAST
Alternative sequencei1549 – 15579WMVTSWSAC → AMGLASGLT in isoform 5. 1 PublicationVSP_039330
Alternative sequencei1558 – 1762205Missing in isoform 5. 1 PublicationVSP_039331Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF176313 mRNA. Translation: AAK84170.1.
AY358327 mRNA. Translation: AAQ88693.1.
AK092602 mRNA. Translation: BAC03925.1.
AK291956 mRNA. Translation: BAF84645.1.
AL158150 Genomic DNA. Translation: CAO03592.1.
AL353895, AL442638, AL449963 Genomic DNA. Translation: CAI14851.1.
AL591423 Genomic DNA. No translation available.
CH471071 Genomic DNA. Translation: EAW58656.1.
BC030262 mRNA. Translation: AAH30262.1.
BC100788 mRNA. Translation: AAI00789.1. Frameshift.
BC100790 mRNA. Translation: AAI00791.1. Frameshift.
AF251058 mRNA. Translation: AAK34948.1. Different initiation.
CCDSiCCDS47954.1. [Q8N6G6-3]
CCDS6485.1. [Q8N6G6-1]
RefSeqiNP_001035362.3. NM_001040272.5. [Q8N6G6-3]
NP_443098.3. NM_052866.4. [Q8N6G6-1]
UniGeneiHs.741483.

Genome annotation databases

EnsembliENST00000276935; ENSP00000276935; ENSG00000178031. [Q8N6G6-4]
ENST00000327883; ENSP00000327887; ENSG00000178031. [Q8N6G6-1]
ENST00000380545; ENSP00000369918; ENSG00000178031. [Q8N6G6-6]
ENST00000380548; ENSP00000369921; ENSG00000178031. [Q8N6G6-3]
ENST00000380566; ENSP00000369940; ENSG00000178031. [Q8N6G6-2]
ENST00000542621; ENSP00000440472; ENSG00000178031. [Q8N6G6-5]
GeneIDi92949.
KEGGihsa:92949.
UCSCiuc003znb.3. human. [Q8N6G6-2]
uc003znc.4. human. [Q8N6G6-1]
uc003zne.4. human. [Q8N6G6-3]
uc003znf.4. human. [Q8N6G6-6]

Polymorphism databases

DMDMi298286924.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF176313 mRNA. Translation: AAK84170.1 .
AY358327 mRNA. Translation: AAQ88693.1 .
AK092602 mRNA. Translation: BAC03925.1 .
AK291956 mRNA. Translation: BAF84645.1 .
AL158150 Genomic DNA. Translation: CAO03592.1 .
AL353895 , AL442638 , AL449963 Genomic DNA. Translation: CAI14851.1 .
AL591423 Genomic DNA. No translation available.
CH471071 Genomic DNA. Translation: EAW58656.1 .
BC030262 mRNA. Translation: AAH30262.1 .
BC100788 mRNA. Translation: AAI00789.1 . Frameshift.
BC100790 mRNA. Translation: AAI00791.1 . Frameshift.
AF251058 mRNA. Translation: AAK34948.1 . Different initiation.
CCDSi CCDS47954.1. [Q8N6G6-3 ]
CCDS6485.1. [Q8N6G6-1 ]
RefSeqi NP_001035362.3. NM_001040272.5. [Q8N6G6-3 ]
NP_443098.3. NM_052866.4. [Q8N6G6-1 ]
UniGenei Hs.741483.

3D structure databases

ProteinModelPortali Q8N6G6.
SMRi Q8N6G6. Positions 34-296, 888-956, 1164-1532.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000369921.

PTM databases

PhosphoSitei Q8N6G6.

Polymorphism databases

DMDMi 298286924.

Proteomic databases

PaxDbi Q8N6G6.
PRIDEi Q8N6G6.

Protocols and materials databases

DNASUi 92949.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000276935 ; ENSP00000276935 ; ENSG00000178031 . [Q8N6G6-4 ]
ENST00000327883 ; ENSP00000327887 ; ENSG00000178031 . [Q8N6G6-1 ]
ENST00000380545 ; ENSP00000369918 ; ENSG00000178031 . [Q8N6G6-6 ]
ENST00000380548 ; ENSP00000369921 ; ENSG00000178031 . [Q8N6G6-3 ]
ENST00000380566 ; ENSP00000369940 ; ENSG00000178031 . [Q8N6G6-2 ]
ENST00000542621 ; ENSP00000440472 ; ENSG00000178031 . [Q8N6G6-5 ]
GeneIDi 92949.
KEGGi hsa:92949.
UCSCi uc003znb.3. human. [Q8N6G6-2 ]
uc003znc.4. human. [Q8N6G6-1 ]
uc003zne.4. human. [Q8N6G6-3 ]
uc003znf.4. human. [Q8N6G6-6 ]

Organism-specific databases

CTDi 92949.
GeneCardsi GC09P018464.
H-InvDB HIX0007941.
HGNCi HGNC:14632. ADAMTSL1.
HPAi HPA048566.
HPA057437.
MIMi 609198. gene.
neXtProti NX_Q8N6G6.
PharmGKBi PA24554.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG272362.
GeneTreei ENSGT00760000118885.
HOVERGENi HBG068818.
InParanoidi Q8N6G6.
OMAi RWEIGKW.
OrthoDBi EOG7TXKFQ.
PhylomeDBi Q8N6G6.
TreeFami TF351125.

Enzyme and pathway databases

Reactomei REACT_200626. O-glycosylation of TSR domain-containing proteins.
SignaLinki Q8N6G6.

Miscellaneous databases

GeneWikii ADAMTSL1.
GenomeRNAii 92949.
NextBioi 77924.
PROi Q8N6G6.
SOURCEi Search...

Gene expression databases

Bgeei Q8N6G6.
CleanExi HS_ADAMTSL1.
ExpressionAtlasi Q8N6G6. baseline and differential.
Genevestigatori Q8N6G6.

Family and domain databases

Gene3Di 2.60.40.10. 4 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR010909. PLAC.
IPR000884. Thrombospondin_1_rpt.
[Graphical view ]
Pfami PF07679. I-set. 3 hits.
PF08686. PLAC. 1 hit.
PF00090. TSP_1. 8 hits.
[Graphical view ]
PRINTSi PR01857. ADAMTSFAMILY.
SMARTi SM00408. IGc2. 4 hits.
SM00209. TSP1. 13 hits.
[Graphical view ]
SUPFAMi SSF82895. SSF82895. 11 hits.
PROSITEi PS50835. IG_LIKE. 4 hits.
PS50900. PLAC. 1 hit.
PS50092. TSP1. 9 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Punctin, a novel ADAMTS-like molecule, ADAMTSL-1, in extracellular matrix."
    Hirohata S., Wang L.W., Miyagi M., Yan L., Seldin M.F., Keene D.R., Crabb J.W., Apte S.S.
    J. Biol. Chem. 277:12182-12189(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, GLYCOSYLATION, MASS SPECTROMETRY, DISULFIDE BONDS.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5).
    Tissue: Prostate.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 6).
    Tissue: Lung.
  7. Mao Y., Xie Y., Zhou Z., Zhao W., Zhao S., Wang W., Huang Y., Wang S., Tang R., Chen X., Wu C.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 214-1762 (ISOFORM 4).
  8. "O-fucosylation of thrombospondin type 1 repeats in ADAMTS-like-1/punctin-1 regulates secretion: implications for the ADAMTS superfamily."
    Wang L.W., Dlugosz M., Somerville R.P., Raed M., Haltiwanger R.S., Apte S.S.
    J. Biol. Chem. 282:17024-17031(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-251; THR-312; SER-391 AND THR-451, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
  9. "Post-translational modification of thrombospondin type-1 repeats in ADAMTS-like 1/punctin-1 by C-mannosylation of tryptophan."
    Wang L.W., Leonhard-Melief C., Haltiwanger R.S., Apte S.S.
    J. Biol. Chem. 284:30004-30015(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT TRP-39; TRP-42 AND THR-48, LACK OF GLYCOSYLATION AT TRP-36, SUBCELLULAR LOCATION, MUTAGENESIS OF TRP-36; TRP-39; TRP-42; TRP-385 AND TRP-445, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiATL1_HUMAN
AccessioniPrimary (citable) accession number: Q8N6G6
Secondary accession number(s): A6PVN1
, A8K7E1, Q496M6, Q496M8, Q5T708, Q5VZT8, Q8NAI9, Q96RW4, Q9BXY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: June 15, 2010
Last modified: October 29, 2014
This is version 114 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

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