Q8N6G6 (ATL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ADAMTS-like protein 1
Short name=ADAMTSL-1

Alternative name(s):
Punctin-1

Gene names

Name:	ADAMTSL1
Synonyms:	ADAMTSR1, C9orf94
ORF Names:	UNQ528/PRO1071

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1762 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Monomer. Ref.1
Subcellular location	Secreted › extracellular space › extracellular matrix Ref.1 Ref.8 Ref.9.
Tissue specificity	Expressed primarily in adult skeletal muscle. Ref.1
Post-translational modification	C-, N- and O-glycosylated. O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTSL1. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion. Ref.1 Ref.8 Ref.9 Disulfide bonds are present.
Sequence similarities	Contains 4 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 PLAC domain. Contains 9 TSP type-1 domains.
Caution	Although strongly similar to members of the ADAMTS family it lacks the metalloprotease and disintegrin-like domains which are typical of that family.
Mass spectrometry	Isoform 1: Molecular mass is 61935±595 Da from positions 28 - 525. Determined by MALDI. Ref.1
Sequence caution	The sequence AAI00789.1 differs from that shown. Reason: Frameshift at position 1312. The sequence AAI00791.1 differs from that shown. Reason: Frameshift at position 1312. The sequence AAK34948.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Extracellular matrix Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Repeat Signal
Molecular function	Hydrolase
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	metallopeptidase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 3 (identifier: Q8N6G6-3)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: Q8N6G6-1)

The sequence of this isoform differs from the canonical sequence as follows:
     526-1762: Missing.

Isoform 2 (identifier: Q8N6G6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     362-378: Missing.
     448-456: CTVTCGQGL → VTVPSFFVH
     457-1762: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q8N6G6-4)

The sequence of this isoform differs from the canonical sequence as follows:
     670-683: WEIGKWSPCSLTCG → SSIDSAWNACNVLC
     684-1762: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: Q8N6G6-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1299: Missing.
     1300-1311: QGVNVTINCQVA → MSGVFCFFFFFL
     1549-1557: WMVTSWSAC → AMGLASGLT
     1558-1762: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 6 (identifier: Q8N6G6-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1299: Missing.
     1300-1311: QGVNVTINCQVA → MSGVFCFFFFFL

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 28	28
	Chain	29 – 1762	1734	ADAMTS-like protein 1		PRO_0000035860
Regions
	Domain	33 – 82	50	TSP type-1 1
	Domain	376 – 424	49	TSP type-1 2
	Domain	436 – 493	58	TSP type-1 3
	Domain	522 – 584	63	TSP type-1 4
	Domain	607 – 665	59	TSP type-1 5
	Domain	666 – 729	64	TSP type-1 6
	Domain	788 – 850	63	TSP type-1 7
	Domain	861 – 963	103	Ig-like C2-type 1
	Domain	1164 – 1266	103	Ig-like C2-type 2
	Domain	1286 – 1369	84	Ig-like C2-type 3
	Domain	1395 – 1485	91	Ig-like C2-type 4
	Domain	1545 – 1608	64	TSP type-1 8
	Domain	1666 – 1726	61	TSP type-1 9
	Domain	1726 – 1762	37	PLAC
Sites
	Site	36	1	Not glycosylated
Amino acid modifications
	Glycosylation	39	1	C-linked (Man) Ref.9
	Glycosylation	42	1	C-linked (Man) Ref.9
	Glycosylation	48	1	O-linked (Fuc...) Ref.9
	Glycosylation	251	1	N-linked (GlcNAc...) Ref.8
	Glycosylation	312	1	O-linked (Fuc...) Ref.8
	Glycosylation	391	1	O-linked (Fuc...) Ref.8
	Glycosylation	451	1	O-linked (Fuc...) Ref.8
	Disulfide bond	45 ↔ 76		By similarity
	Disulfide bond	49 ↔ 81		By similarity
	Disulfide bond	60 ↔ 66		By similarity
	Disulfide bond	534 ↔ 578		By similarity
	Disulfide bond	538 ↔ 583		By similarity
	Disulfide bond	549 ↔ 567		By similarity
	Disulfide bond	678 ↔ 723		By similarity
	Disulfide bond	682 ↔ 728		By similarity
	Disulfide bond	693 ↔ 712		By similarity
	Disulfide bond	800 ↔ 844		By similarity
	Disulfide bond	804 ↔ 849		By similarity
	Disulfide bond	815 ↔ 832		By similarity
	Disulfide bond	899 ↔ 947		By similarity
	Disulfide bond	1202 ↔ 1250		By similarity
	Disulfide bond	1308 ↔ 1353		By similarity
	Disulfide bond	1418 ↔ 1469		By similarity
Natural variations
	Alternative sequence	1 – 1299	1299	Missing in isoform 5 and isoform 6.		VSP_039322
	Alternative sequence	362 – 378	17	Missing in isoform 2.		VSP_039323
	Alternative sequence	448 – 456	9	CTVTCGQGL → VTVPSFFVH in isoform 2.		VSP_039324
	Alternative sequence	457 – 1762	1306	Missing in isoform 2.		VSP_039325
	Alternative sequence	526 – 1762	1237	Missing in isoform 1.		VSP_039326
	Alternative sequence	670 – 683	14	WEIGK…SLTCG → SSIDSAWNACNVLC in isoform 4.		VSP_039327
	Alternative sequence	684 – 1762	1079	Missing in isoform 4.		VSP_039328
	Alternative sequence	1300 – 1311	12	QGVNV…NCQVA → MSGVFCFFFFFL in isoform 5 and isoform 6.		VSP_039329
	Alternative sequence	1549 – 1557	9	WMVTSWSAC → AMGLASGLT in isoform 5.		VSP_039330
	Alternative sequence	1558 – 1762	205	Missing in isoform 5.		VSP_039331
	Natural variant	242	1	S → N. Corresponds to variant rs776755 [ dbSNP | Ensembl ].		VAR_017174
Experimental info
	Mutagenesis	36	1	W → A: Small reduction in secretion of ADAMTSL1. Ref.9
	Mutagenesis	39	1	W → A: Significant reduction in secretion of ADAMTSL1. Ref.9
	Mutagenesis	39	1	W → F: Abolishes secretion of ADAMTSL1. Ref.9
	Mutagenesis	42	1	W → A: Modest reduction in secretion of ADAMTSL1. Ref.9
	Mutagenesis	42	1	W → F: Abolishes secretion of ADAMTSL1. Ref.9
	Mutagenesis	251	1	N → Q: Abolishes N-glycosylation. Reduces secretion of ADAMTSL1.
	Mutagenesis	312	1	T → A: Small increase in secretion of ADAMTSL1. About 40% increase in secretion of ADAMTSL1; when associated with A-391. Dramatic increase in secretion of ADAMTSL1; when associated with A-391 and A-451.
	Mutagenesis	385	1	W → A: Significant reduction in secretion of ADAMTSL1. Ref.9
	Mutagenesis	385	1	W → F: No effect on secretion of ADAMTSL1. Ref.9
	Mutagenesis	391	1	S → A: Small increase in secretion of ADAMTSL1. About 40% increase in secretion of ADAMTSL1; when associated with A-312. Dramatic increase in secretion of ADAMTSL1; when associated with A-312 and A-451.
	Mutagenesis	445	1	W → A: Modest reduction in secretion of ADAMTSL1. Ref.9
	Mutagenesis	451	1	T → A: Small increase in secretion of ADAMTSL1. Dramatic increase in secretion of ADAMTSL1; when associated with A-312 and A-391.
	Sequence conflict	54 – 55	2	SY → AN in AAK84170. Ref.1
	Sequence conflict	208	1	I → L in AAQ88693. Ref.2
	Sequence conflict	1409	1	D → G in BAC03925. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 3 [UniParc]. Last modified June 15, 2010. Version 4. Checksum: 2822C0A367C2EF4E	FASTA	1,762	193,409
	10 20 30 40 50 60 MECCRRATPG TLLLFLAFLL LSSRTARSEE DRDGLWDAWG PWSECSRTCG GGASYSLRRC 70 80 90 100 110 120 LSSKSCEGRN IRYRTCSNVD CPPEAGDFRA QQCSAHNDVK HHGQFYEWLP VSNDPDNPCS 130 140 150 160 170 180 LKCQAKGTTL VVELAPKVLD GTRCYTESLD MCISGLCQIV GCDHQLGSTV KEDNCGVCNG 190 200 210 220 230 240 DGSTCRLVRG QYKSQLSATK SDDTVVAIPY GSRHIRLVLK GPDHLYLETK TLQGTKGENS 250 260 270 280 290 300 LSSTGTFLVD NSSVDFQKFP DKEILRMAGP LTADFIVKIR NSGSADSTVQ FIFYQPIIHR 310 320 330 340 350 360 WRETDFFPCS ATCGGGYQLT SAECYDLRSN RVVADQYCHY YPENIKPKPK LQECNLDPCP 370 380 390 400 410 420 ASDGYKQIMP YDLYHPLPRW EATPWTACSS SCGGGIQSRA VSCVEEDIQG HVTSVEEWKC 430 440 450 460 470 480 MYTPKMPIAQ PCNIFDCPKW LAQEWSPCTV TCGQGLRYRV VLCIDHRGMH TGGCSPKTKP 490 500 510 520 530 540 HIKEECIVPT PCYKPKEKLP VEAKLPWFKQ AQELEEGAAV SEEPSFIPEA WSACTVTCGV 550 560 570 580 590 600 GTQVRIVRCQ VLLSFSQSVA DLPIDECEGP KPASQRACYA GPCSGEIPEF NPDETDGLFG 610 620 630 640 650 660 GLQDFDELYD WEYEGFTKCS ESCGGGVQEA VVSCLNKQTR EPAEENLCVT SRRPPQLLKS 670 680 690 700 710 720 CNLDPCPARW EIGKWSPCSL TCGVGLQTRD VFCSHLLSRE MNETVILADE LCRQPKPSTV 730 740 750 760 770 780 QACNRFNCPP AWYPAQWQPC SRTCGGGVQK REVLCKQRMA DGSFLELPET FCSASKPACQ 790 800 810 820 830 840 QACKKDDCPS EWLLSDWTEC STSCGEGTQT RSAICRKMLK TGLSTVVNST LCPPLPFSSS 850 860 870 880 890 900 IRPCMLATCA RPGRPSTKHS PHIAAARKVY IQTRRQRKLH FVVGGFAYLL PKTAVVLRCP 910 920 930 940 950 960 ARRVRKPLIT WEKDGQHLIS STHVTVAPFG YLKIHRLKPS DAGVYTCSAG PAREHFVIKL 970 980 990 1000 1010 1020 IGGNRKLVAR PLSPRSEEEV LAGRKGGPKE ALQTHKHQNG IFSNGSKAEK RGLAANPGSR 1030 1040 1050 1060 1070 1080 YDDLVSRLLE QGGWPGELLA SWEAQDSAER NTTSEEDPGA EQVLLHLPFT MVTEQRRLDD 1090 1100 1110 1120 1130 1140 ILGNLSQQPE ELRDLYSKHL VAQLAQEIFR SHLEHQDTLL KPSERRTSPV TLSPHKHVSG 1150 1160 1170 1180 1190 1200 FSSSLRTSST GDAGGGSRRP HRKPTILRKI SAAQQLSASE VVTHLGQTVA LASGTLSVLL 1210 1220 1230 1240 1250 1260 HCEAIGHPRP TISWARNGEE VQFSDRILLQ PDDSLQILAP VEADVGFYTC NATNALGYDS 1270 1280 1290 1300 1310 1320 VSIAVTLAGK PLVKTSRMTV INTEKPAVTV DIGSTIKTVQ GVNVTINCQV AGVPEAEVTW 1330 1340 1350 1360 1370 1380 FRNKSKLGSP HHLHEGSLLL TNVSSSDQGL YSCRAANLHG ELTESTQLLI LDPPQVPTQL 1390 1400 1410 1420 1430 1440 EDIRALLAAT GPNLPSVLTS PLGTQLVLDP GNSALLGCPI KGHPVPNITW FHGGQPIVTA 1450 1460 1470 1480 1490 1500 TGLTHHILAA GQILQVANLS GGSQGEFSCL AQNEAGVLMQ KASLVIQDYW WSVDRLATCS 1510 1520 1530 1540 1550 1560 ASCGNRGVQQ PRLRCLLNST EVNPAHCAGK VRPAVQPIAC NRRDCPSRWM VTSWSACTRS 1570 1580 1590 1600 1610 1620 CGGGVQTRRV TCQKLKASGI STPVSNDMCT QVAKRPVDTQ ACNQQLCVEW AFSSWGQCNG 1630 1640 1650 1660 1670 1680 PCIGPHLAVQ HRQVFCQTRD GITLPSEQCS ALPRPVSTQN CWSEACSVHW RVSLWTLCTA 1690 1700 1710 1720 1730 1740 TCGNYGFQSR RVECVHARTN KAVPEHLCSW GPRPANWQRC NITPCENMEC RDTTRYCEKV 1750 1760 KQLKLCQLSQ FKSRCCGTCG KA
	Isoform 1 [UniParc]. Checksum: 4D797F7ECBD4FC51	FASTA	525	58,416
	10 20 30 40 50 60 MECCRRATPG TLLLFLAFLL LSSRTARSEE DRDGLWDAWG PWSECSRTCG GGASYSLRRC 70 80 90 100 110 120 LSSKSCEGRN IRYRTCSNVD CPPEAGDFRA QQCSAHNDVK HHGQFYEWLP VSNDPDNPCS 130 140 150 160 170 180 LKCQAKGTTL VVELAPKVLD GTRCYTESLD MCISGLCQIV GCDHQLGSTV KEDNCGVCNG 190 200 210 220 230 240 DGSTCRLVRG QYKSQLSATK SDDTVVAIPY GSRHIRLVLK GPDHLYLETK TLQGTKGENS 250 260 270 280 290 300 LSSTGTFLVD NSSVDFQKFP DKEILRMAGP LTADFIVKIR NSGSADSTVQ FIFYQPIIHR 310 320 330 340 350 360 WRETDFFPCS ATCGGGYQLT SAECYDLRSN RVVADQYCHY YPENIKPKPK LQECNLDPCP 370 380 390 400 410 420 ASDGYKQIMP YDLYHPLPRW EATPWTACSS SCGGGIQSRA VSCVEEDIQG HVTSVEEWKC 430 440 450 460 470 480 MYTPKMPIAQ PCNIFDCPKW LAQEWSPCTV TCGQGLRYRV VLCIDHRGMH TGGCSPKTKP 490 500 510 520 HIKEECIVPT PCYKPKEKLP VEAKLPWFKQ AQELEEGAAV SEEPS
	Isoform 2 [UniParc]. Checksum: B7155590915B3F3D	FASTA	439	48,764
	10 20 30 40 50 60 MECCRRATPG TLLLFLAFLL LSSRTARSEE DRDGLWDAWG PWSECSRTCG GGASYSLRRC 70 80 90 100 110 120 LSSKSCEGRN IRYRTCSNVD CPPEAGDFRA QQCSAHNDVK HHGQFYEWLP VSNDPDNPCS 130 140 150 160 170 180 LKCQAKGTTL VVELAPKVLD GTRCYTESLD MCISGLCQIV GCDHQLGSTV KEDNCGVCNG 190 200 210 220 230 240 DGSTCRLVRG QYKSQLSATK SDDTVVAIPY GSRHIRLVLK GPDHLYLETK TLQGTKGENS 250 260 270 280 290 300 LSSTGTFLVD NSSVDFQKFP DKEILRMAGP LTADFIVKIR NSGSADSTVQ FIFYQPIIHR 310 320 330 340 350 360 WRETDFFPCS ATCGGGYQLT SAECYDLRSN RVVADQYCHY YPENIKPKPK LQECNLDPCP 370 380 390 400 410 420 ARWEATPWTA CSSSCGGGIQ SRAVSCVEED IQGHVTSVEE WKCMYTPKMP IAQPCNIFDC 430 PKWLAQEWSP VTVPSFFVH
	Isoform 4 [UniParc]. Checksum: 49BFADA25E9EEBB5	FASTA	683	75,523
	10 20 30 40 50 60 MECCRRATPG TLLLFLAFLL LSSRTARSEE DRDGLWDAWG PWSECSRTCG GGASYSLRRC 70 80 90 100 110 120 LSSKSCEGRN IRYRTCSNVD CPPEAGDFRA QQCSAHNDVK HHGQFYEWLP VSNDPDNPCS 130 140 150 160 170 180 LKCQAKGTTL VVELAPKVLD GTRCYTESLD MCISGLCQIV GCDHQLGSTV KEDNCGVCNG 190 200 210 220 230 240 DGSTCRLVRG QYKSQLSATK SDDTVVAIPY GSRHIRLVLK GPDHLYLETK TLQGTKGENS 250 260 270 280 290 300 LSSTGTFLVD NSSVDFQKFP DKEILRMAGP LTADFIVKIR NSGSADSTVQ FIFYQPIIHR 310 320 330 340 350 360 WRETDFFPCS ATCGGGYQLT SAECYDLRSN RVVADQYCHY YPENIKPKPK LQECNLDPCP 370 380 390 400 410 420 ASDGYKQIMP YDLYHPLPRW EATPWTACSS SCGGGIQSRA VSCVEEDIQG HVTSVEEWKC 430 440 450 460 470 480 MYTPKMPIAQ PCNIFDCPKW LAQEWSPCTV TCGQGLRYRV VLCIDHRGMH TGGCSPKTKP 490 500 510 520 530 540 HIKEECIVPT PCYKPKEKLP VEAKLPWFKQ AQELEEGAAV SEEPSFIPEA WSACTVTCGV 550 560 570 580 590 600 GTQVRIVRCQ VLLSFSQSVA DLPIDECEGP KPASQRACYA GPCSGEIPEF NPDETDGLFG 610 620 630 640 650 660 GLQDFDELYD WEYEGFTKCS ESCGGGVQEA VVSCLNKQTR EPAEENLCVT SRRPPQLLKS 670 680 CNLDPCPARS SIDSAWNACN VLC
	Isoform 5 [UniParc]. Checksum: D105728584BE2DE1	FASTA	258	27,468
	10 20 30 40 50 60 MSGVFCFFFF FLGVPEAEVT WFRNKSKLGS PHHLHEGSLL LTNVSSSDQG LYSCRAANLH 70 80 90 100 110 120 GELTESTQLL ILDPPQVPTQ LEDIRALLAA TGPNLPSVLT SPLGTQLVLD PGNSALLGCP 130 140 150 160 170 180 IKGHPVPNIT WFHGGQPIVT ATGLTHHILA AGQILQVANL SGGSQGEFSC LAQNEAGVLM 190 200 210 220 230 240 QKASLVIQDY WWSVDRLATC SASCGNRGVQ QPRLRCLLNS TEVNPAHCAG KVRPAVQPIA 250 CNRRDCPSRA MGLASGLT
	Isoform 6 [UniParc]. Checksum: 044EA30A0BD28A00	FASTA	463	50,568
	10 20 30 40 50 60 MSGVFCFFFF FLGVPEAEVT WFRNKSKLGS PHHLHEGSLL LTNVSSSDQG LYSCRAANLH 70 80 90 100 110 120 GELTESTQLL ILDPPQVPTQ LEDIRALLAA TGPNLPSVLT SPLGTQLVLD PGNSALLGCP 130 140 150 160 170 180 IKGHPVPNIT WFHGGQPIVT ATGLTHHILA AGQILQVANL SGGSQGEFSC LAQNEAGVLM 190 200 210 220 230 240 QKASLVIQDY WWSVDRLATC SASCGNRGVQ QPRLRCLLNS TEVNPAHCAG KVRPAVQPIA 250 260 270 280 290 300 CNRRDCPSRW MVTSWSACTR SCGGGVQTRR VTCQKLKASG ISTPVSNDMC TQVAKRPVDT 310 320 330 340 350 360 QACNQQLCVE WAFSSWGQCN GPCIGPHLAV QHRQVFCQTR DGITLPSEQC SALPRPVSTQ 370 380 390 400 410 420 NCWSEACSVH WRVSLWTLCT ATCGNYGFQS RRVECVHART NKAVPEHLCS WGPRPANWQR 430 440 450 460 CNITPCENME CRDTTRYCEK VKQLKLCQLS QFKSRCCGTC GKA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Punctin, a novel ADAMTS-like molecule, ADAMTSL-1, in extracellular matrix." Hirohata S., Wang L.W., Miyagi M., Yan L., Seldin M.F., Keene D.R., Crabb J.W., Apte S.S. J. Biol. Chem. 277:12182-12189(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, GLYCOSYLATION, MASS SPECTROMETRY, DISULFIDE BONDS.
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5). Tissue: Prostate.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 6). Tissue: Lung.
[7]	Mao Y., Xie Y., Zhou Z., Zhao W., Zhao S., Wang W., Huang Y., Wang S., Tang R., Chen X., Wu C. Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 214-1762 (ISOFORM 4).
[8]	"O-fucosylation of thrombospondin type 1 repeats in ADAMTS-like-1/punctin-1 regulates secretion: implications for the ADAMTS superfamily." Wang L.W., Dlugosz M., Somerville R.P., Raed M., Haltiwanger R.S., Apte S.S. J. Biol. Chem. 282:17024-17031(2007) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION AT ASN-251; THR-312; SER-391 AND THR-451, SUBCELLULAR LOCATION, MASS SPECTROMETRY.
[9]	"Post-translational modification of thrombospondin type-1 repeats in ADAMTS-like 1/punctin-1 by C-mannosylation of tryptophan." Wang L.W., Leonhard-Melief C., Haltiwanger R.S., Apte S.S. J. Biol. Chem. 284:30004-30015(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION AT TRP-39; TRP-42 AND THR-48, LACK OF GLYCOSYLATION AT TRP-36, SUBCELLULAR LOCATION, MASS SPECTROMETRY, MUTAGENESIS OF TRP-36; TRP-39; TRP-42; TRP-385 AND TRP-445.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF176313 mRNA. Translation: AAK84170.1. AY358327 mRNA. Translation: AAQ88693.1. AK092602 mRNA. Translation: BAC03925.1. AK291956 mRNA. Translation: BAF84645.1. AL158150 Genomic DNA. Translation: CAO03592.1. AL353895, AL442638, AL449963 Genomic DNA. Translation: CAI14851.1. AL591423 Genomic DNA. No translation available. CH471071 Genomic DNA. Translation: EAW58656.1. BC030262 mRNA. Translation: AAH30262.1. BC100788 mRNA. Translation: AAI00789.1. Frameshift. BC100790 mRNA. Translation: AAI00791.1. Frameshift. AF251058 mRNA. Translation: AAK34948.1. Different initiation.
IPI	IPI00157513. IPI00377098. IPI00414931. IPI00953341. IPI00967648. IPI00973465.
RefSeq	NP_001035362.3. NM_001040272.5. NP_443098.3. NM_052866.4.
UniGene	Hs.741483.
3D structure databases
ProteinModelPortal	Q8N6G6.
SMR	Q8N6G6. Positions 34-296, 1165-1532.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000369921.
PTM databases
PhosphoSite	Q8N6G6.
Polymorphism databases
DMDM	298286924.
Proteomic databases
PaxDb	Q8N6G6.
PRIDE	Q8N6G6.
Protocols and materials databases
DNASU	92949.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000276935; ENSP00000276935; ENSG00000178031. ENST00000327883; ENSP00000327887; ENSG00000178031. ENST00000380545; ENSP00000369918; ENSG00000178031. ENST00000380548; ENSP00000369921; ENSG00000178031. ENST00000380566; ENSP00000369940; ENSG00000178031. ENST00000542621; ENSP00000440472; ENSG00000178031.
GeneID	92949.
KEGG	hsa:92949.
UCSC	uc003znb.3. human. uc003znc.4. human. uc003zne.4. human. uc003znf.4. human.
Organism-specific databases
CTD	92949.
GeneCards	GC09P018464.
H-InvDB	HIX0007941.
HGNC	HGNC:14632. ADAMTSL1.
MIM	609198. gene.
neXtProt	NX_Q8N6G6.
PharmGKB	PA24554.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG272362.
HOVERGEN	HBG068818.
InParanoid	Q8N6G6.
OMA	LTCGVGL.
Enzyme and pathway databases
SignaLink	Q8N6G6.
Gene expression databases
ArrayExpress	Q8N6G6.
Bgee	Q8N6G6.
CleanEx	HS_ADAMTSL1.
Genevestigator	Q8N6G6.
GermOnline	ENSG00000147892. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 4 hits.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003598. Ig_sub2. IPR013273. Peptidase_M12B_ADAM-TS. IPR010909. PLAC. IPR000884. Thrombospondin_1_rpt. [Graphical view]
Pfam	PF07679. I-set. 4 hits. PF08686. PLAC. 1 hit. PF00090. TSP_1. 8 hits. [Graphical view]
PRINTS	PR01857. ADAMTSFAMILY.
SMART	SM00408. IGc2. 4 hits. SM00209. TSP1. 13 hits. [Graphical view]
SUPFAM	SSF82895. TSP1. 13 hits.
PROSITE	PS50835. IG_LIKE. 4 hits. PS50900. PLAC. 1 hit. PS50092. TSP1. 9 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	92949.
NextBio	77924.
SOURCE	Search...

Entry information

Entry name

ATL1_HUMAN

Accession

Primary (citable) accession number: Q8N6G6
Secondary accession number(s): A6PVN1 , A8K7E1, Q496M6, Q496M8, Q5T708, Q5VZT8, Q8NAI9, Q96RW4, Q9BXY3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2003
Last sequence update:	June 15, 2010
Last modified:	May 29, 2013
This is version 100 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.