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Q8N6G6 (ATL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ADAMTS-like protein 1

Short name=ADAMTSL-1
Alternative name(s):
Punctin-1
Gene names
Name:ADAMTSL1
Synonyms:ADAMTSR1, C9orf94
ORF Names:UNQ528/PRO1071
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1762 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Monomer. Ref.1

Subcellular location

Secretedextracellular spaceextracellular matrix Ref.1 Ref.8 Ref.9.

Tissue specificity

Expressed primarily in adult skeletal muscle. Ref.1

Post-translational modification

C-, N- and O-glycosylated. O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTSL1. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion. Ref.1 Ref.8 Ref.9

Disulfide bonds are present.

Sequence similarities

Contains 4 Ig-like C2-type (immunoglobulin-like) domains.

Contains 1 PLAC domain.

Contains 9 TSP type-1 domains.

Caution

Although strongly similar to members of the ADAMTS family it lacks the metalloprotease and disintegrin-like domains which are typical of that family.

Mass spectrometry

Isoform 1: Molecular mass is 61935±595 Da from positions 28 - 525. Determined by MALDI. Ref.1

Sequence caution

The sequence AAI00789.1 differs from that shown. Reason: Frameshift at position 1312.

The sequence AAI00791.1 differs from that shown. Reason: Frameshift at position 1312.

The sequence AAK34948.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]
Isoform 3 (identifier: Q8N6G6-3)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 1 (identifier: Q8N6G6-1)

The sequence of this isoform differs from the canonical sequence as follows:
     526-1762: Missing.
Isoform 2 (identifier: Q8N6G6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     362-378: Missing.
     448-456: CTVTCGQGL → VTVPSFFVH
     457-1762: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: Q8N6G6-4)

The sequence of this isoform differs from the canonical sequence as follows:
     670-683: WEIGKWSPCSLTCG → SSIDSAWNACNVLC
     684-1762: Missing.
Note: No experimental confirmation available.
Isoform 5 (identifier: Q8N6G6-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1299: Missing.
     1300-1311: QGVNVTINCQVA → MSGVFCFFFFFL
     1549-1557: WMVTSWSAC → AMGLASGLT
     1558-1762: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Isoform 6 (identifier: Q8N6G6-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1299: Missing.
     1300-1311: QGVNVTINCQVA → MSGVFCFFFFFL

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828
Chain29 – 17621734ADAMTS-like protein 1
PRO_0000035860

Regions

Domain33 – 8250TSP type-1 1
Domain376 – 42449TSP type-1 2
Domain436 – 49358TSP type-1 3
Domain522 – 58463TSP type-1 4
Domain607 – 66559TSP type-1 5
Domain666 – 72964TSP type-1 6
Domain788 – 85063TSP type-1 7
Domain861 – 963103Ig-like C2-type 1
Domain1164 – 1266103Ig-like C2-type 2
Domain1286 – 136984Ig-like C2-type 3
Domain1395 – 148591Ig-like C2-type 4
Domain1545 – 160864TSP type-1 8
Domain1666 – 172661TSP type-1 9
Domain1726 – 176237PLAC

Sites

Site361Not glycosylated

Amino acid modifications

Glycosylation391C-linked (Man) Ref.9
Glycosylation421C-linked (Man) Ref.9
Glycosylation481O-linked (Fuc...) Ref.9
Glycosylation2511N-linked (GlcNAc...) Ref.8
Glycosylation3121O-linked (Fuc...) Ref.8
Glycosylation3911O-linked (Fuc...) Ref.8
Glycosylation4511O-linked (Fuc...) Ref.8
Disulfide bond45 ↔ 76 By similarity
Disulfide bond49 ↔ 81 By similarity
Disulfide bond60 ↔ 66 By similarity
Disulfide bond534 ↔ 578 By similarity
Disulfide bond538 ↔ 583 By similarity
Disulfide bond549 ↔ 567 By similarity
Disulfide bond678 ↔ 723 By similarity
Disulfide bond682 ↔ 728 By similarity
Disulfide bond693 ↔ 712 By similarity
Disulfide bond800 ↔ 844 By similarity
Disulfide bond804 ↔ 849 By similarity
Disulfide bond815 ↔ 832 By similarity
Disulfide bond899 ↔ 947 By similarity
Disulfide bond1202 ↔ 1250 By similarity
Disulfide bond1308 ↔ 1353 By similarity
Disulfide bond1418 ↔ 1469 By similarity

Natural variations

Alternative sequence1 – 12991299Missing in isoform 5 and isoform 6.
VSP_039322
Alternative sequence362 – 37817Missing in isoform 2.
VSP_039323
Alternative sequence448 – 4569CTVTCGQGL → VTVPSFFVH in isoform 2.
VSP_039324
Alternative sequence457 – 17621306Missing in isoform 2.
VSP_039325
Alternative sequence526 – 17621237Missing in isoform 1.
VSP_039326
Alternative sequence670 – 68314WEIGK…SLTCG → SSIDSAWNACNVLC in isoform 4.
VSP_039327
Alternative sequence684 – 17621079Missing in isoform 4.
VSP_039328
Alternative sequence1300 – 131112QGVNV…NCQVA → MSGVFCFFFFFL in isoform 5 and isoform 6.
VSP_039329
Alternative sequence1549 – 15579WMVTSWSAC → AMGLASGLT in isoform 5.
VSP_039330
Alternative sequence1558 – 1762205Missing in isoform 5.
VSP_039331
Natural variant2421S → N.
Corresponds to variant rs776755 [ dbSNP | Ensembl ].
VAR_017174

Experimental info

Mutagenesis361W → A: Small reduction in secretion of ADAMTSL1. Ref.9
Mutagenesis391W → A: Significant reduction in secretion of ADAMTSL1. Ref.9
Mutagenesis391W → F: Abolishes secretion of ADAMTSL1. Ref.9
Mutagenesis421W → A: Modest reduction in secretion of ADAMTSL1. Ref.9
Mutagenesis421W → F: Abolishes secretion of ADAMTSL1. Ref.9
Mutagenesis2511N → Q: Abolishes N-glycosylation. Reduces secretion of ADAMTSL1.
Mutagenesis3121T → A: Small increase in secretion of ADAMTSL1. About 40% increase in secretion of ADAMTSL1; when associated with A-391. Dramatic increase in secretion of ADAMTSL1; when associated with A-391 and A-451.
Mutagenesis3851W → A: Significant reduction in secretion of ADAMTSL1. Ref.9
Mutagenesis3851W → F: No effect on secretion of ADAMTSL1. Ref.9
Mutagenesis3911S → A: Small increase in secretion of ADAMTSL1. About 40% increase in secretion of ADAMTSL1; when associated with A-312. Dramatic increase in secretion of ADAMTSL1; when associated with A-312 and A-451.
Mutagenesis4451W → A: Modest reduction in secretion of ADAMTSL1. Ref.9
Mutagenesis4511T → A: Small increase in secretion of ADAMTSL1. Dramatic increase in secretion of ADAMTSL1; when associated with A-312 and A-391.
Sequence conflict54 – 552SY → AN in AAK84170. Ref.1
Sequence conflict2081I → L in AAQ88693. Ref.2
Sequence conflict14091D → G in BAC03925. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 3 [UniParc].

Last modified June 15, 2010. Version 4.
Checksum: 2822C0A367C2EF4E

FASTA1,762193,409
        10         20         30         40         50         60 
MECCRRATPG TLLLFLAFLL LSSRTARSEE DRDGLWDAWG PWSECSRTCG GGASYSLRRC 

        70         80         90        100        110        120 
LSSKSCEGRN IRYRTCSNVD CPPEAGDFRA QQCSAHNDVK HHGQFYEWLP VSNDPDNPCS 

       130        140        150        160        170        180 
LKCQAKGTTL VVELAPKVLD GTRCYTESLD MCISGLCQIV GCDHQLGSTV KEDNCGVCNG 

       190        200        210        220        230        240 
DGSTCRLVRG QYKSQLSATK SDDTVVAIPY GSRHIRLVLK GPDHLYLETK TLQGTKGENS 

       250        260        270        280        290        300 
LSSTGTFLVD NSSVDFQKFP DKEILRMAGP LTADFIVKIR NSGSADSTVQ FIFYQPIIHR 

       310        320        330        340        350        360 
WRETDFFPCS ATCGGGYQLT SAECYDLRSN RVVADQYCHY YPENIKPKPK LQECNLDPCP 

       370        380        390        400        410        420 
ASDGYKQIMP YDLYHPLPRW EATPWTACSS SCGGGIQSRA VSCVEEDIQG HVTSVEEWKC 

       430        440        450        460        470        480 
MYTPKMPIAQ PCNIFDCPKW LAQEWSPCTV TCGQGLRYRV VLCIDHRGMH TGGCSPKTKP 

       490        500        510        520        530        540 
HIKEECIVPT PCYKPKEKLP VEAKLPWFKQ AQELEEGAAV SEEPSFIPEA WSACTVTCGV 

       550        560        570        580        590        600 
GTQVRIVRCQ VLLSFSQSVA DLPIDECEGP KPASQRACYA GPCSGEIPEF NPDETDGLFG 

       610        620        630        640        650        660 
GLQDFDELYD WEYEGFTKCS ESCGGGVQEA VVSCLNKQTR EPAEENLCVT SRRPPQLLKS 

       670        680        690        700        710        720 
CNLDPCPARW EIGKWSPCSL TCGVGLQTRD VFCSHLLSRE MNETVILADE LCRQPKPSTV 

       730        740        750        760        770        780 
QACNRFNCPP AWYPAQWQPC SRTCGGGVQK REVLCKQRMA DGSFLELPET FCSASKPACQ 

       790        800        810        820        830        840 
QACKKDDCPS EWLLSDWTEC STSCGEGTQT RSAICRKMLK TGLSTVVNST LCPPLPFSSS 

       850        860        870        880        890        900 
IRPCMLATCA RPGRPSTKHS PHIAAARKVY IQTRRQRKLH FVVGGFAYLL PKTAVVLRCP 

       910        920        930        940        950        960 
ARRVRKPLIT WEKDGQHLIS STHVTVAPFG YLKIHRLKPS DAGVYTCSAG PAREHFVIKL 

       970        980        990       1000       1010       1020 
IGGNRKLVAR PLSPRSEEEV LAGRKGGPKE ALQTHKHQNG IFSNGSKAEK RGLAANPGSR 

      1030       1040       1050       1060       1070       1080 
YDDLVSRLLE QGGWPGELLA SWEAQDSAER NTTSEEDPGA EQVLLHLPFT MVTEQRRLDD 

      1090       1100       1110       1120       1130       1140 
ILGNLSQQPE ELRDLYSKHL VAQLAQEIFR SHLEHQDTLL KPSERRTSPV TLSPHKHVSG 

      1150       1160       1170       1180       1190       1200 
FSSSLRTSST GDAGGGSRRP HRKPTILRKI SAAQQLSASE VVTHLGQTVA LASGTLSVLL 

      1210       1220       1230       1240       1250       1260 
HCEAIGHPRP TISWARNGEE VQFSDRILLQ PDDSLQILAP VEADVGFYTC NATNALGYDS 

      1270       1280       1290       1300       1310       1320 
VSIAVTLAGK PLVKTSRMTV INTEKPAVTV DIGSTIKTVQ GVNVTINCQV AGVPEAEVTW 

      1330       1340       1350       1360       1370       1380 
FRNKSKLGSP HHLHEGSLLL TNVSSSDQGL YSCRAANLHG ELTESTQLLI LDPPQVPTQL 

      1390       1400       1410       1420       1430       1440 
EDIRALLAAT GPNLPSVLTS PLGTQLVLDP GNSALLGCPI KGHPVPNITW FHGGQPIVTA 

      1450       1460       1470       1480       1490       1500 
TGLTHHILAA GQILQVANLS GGSQGEFSCL AQNEAGVLMQ KASLVIQDYW WSVDRLATCS 

      1510       1520       1530       1540       1550       1560 
ASCGNRGVQQ PRLRCLLNST EVNPAHCAGK VRPAVQPIAC NRRDCPSRWM VTSWSACTRS 

      1570       1580       1590       1600       1610       1620 
CGGGVQTRRV TCQKLKASGI STPVSNDMCT QVAKRPVDTQ ACNQQLCVEW AFSSWGQCNG 

      1630       1640       1650       1660       1670       1680 
PCIGPHLAVQ HRQVFCQTRD GITLPSEQCS ALPRPVSTQN CWSEACSVHW RVSLWTLCTA 

      1690       1700       1710       1720       1730       1740 
TCGNYGFQSR RVECVHARTN KAVPEHLCSW GPRPANWQRC NITPCENMEC RDTTRYCEKV 

      1750       1760 
KQLKLCQLSQ FKSRCCGTCG KA 

« Hide

Isoform 1 [UniParc].

Checksum: 4D797F7ECBD4FC51
Show »

FASTA52558,416
Isoform 2 [UniParc].

Checksum: B7155590915B3F3D
Show »

FASTA43948,764
Isoform 4 [UniParc].

Checksum: 49BFADA25E9EEBB5
Show »

FASTA68375,523
Isoform 5 [UniParc].

Checksum: D105728584BE2DE1
Show »

FASTA25827,468
Isoform 6 [UniParc].

Checksum: 044EA30A0BD28A00
Show »

FASTA46350,568

References

« Hide 'large scale' references
[1]"Punctin, a novel ADAMTS-like molecule, ADAMTSL-1, in extracellular matrix."
Hirohata S., Wang L.W., Miyagi M., Yan L., Seldin M.F., Keene D.R., Crabb J.W., Apte S.S.
J. Biol. Chem. 277:12182-12189(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, GLYCOSYLATION, MASS SPECTROMETRY, DISULFIDE BONDS.
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5).
Tissue: Prostate.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 6).
Tissue: Lung.
[7]Mao Y., Xie Y., Zhou Z., Zhao W., Zhao S., Wang W., Huang Y., Wang S., Tang R., Chen X., Wu C.
Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 214-1762 (ISOFORM 4).
[8]"O-fucosylation of thrombospondin type 1 repeats in ADAMTS-like-1/punctin-1 regulates secretion: implications for the ADAMTS superfamily."
Wang L.W., Dlugosz M., Somerville R.P., Raed M., Haltiwanger R.S., Apte S.S.
J. Biol. Chem. 282:17024-17031(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION AT ASN-251; THR-312; SER-391 AND THR-451, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
[9]"Post-translational modification of thrombospondin type-1 repeats in ADAMTS-like 1/punctin-1 by C-mannosylation of tryptophan."
Wang L.W., Leonhard-Melief C., Haltiwanger R.S., Apte S.S.
J. Biol. Chem. 284:30004-30015(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION AT TRP-39; TRP-42 AND THR-48, LACK OF GLYCOSYLATION AT TRP-36, SUBCELLULAR LOCATION, MUTAGENESIS OF TRP-36; TRP-39; TRP-42; TRP-385 AND TRP-445, IDENTIFICATION BY MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF176313 mRNA. Translation: AAK84170.1.
AY358327 mRNA. Translation: AAQ88693.1.
AK092602 mRNA. Translation: BAC03925.1.
AK291956 mRNA. Translation: BAF84645.1.
AL158150 Genomic DNA. Translation: CAO03592.1.
AL353895, AL442638, AL449963 Genomic DNA. Translation: CAI14851.1.
AL591423 Genomic DNA. No translation available.
CH471071 Genomic DNA. Translation: EAW58656.1.
BC030262 mRNA. Translation: AAH30262.1.
BC100788 mRNA. Translation: AAI00789.1. Frameshift.
BC100790 mRNA. Translation: AAI00791.1. Frameshift.
AF251058 mRNA. Translation: AAK34948.1. Different initiation.
CCDSCCDS47954.1. [Q8N6G6-3]
CCDS6485.1. [Q8N6G6-1]
RefSeqNP_001035362.3. NM_001040272.5. [Q8N6G6-3]
NP_443098.3. NM_052866.4. [Q8N6G6-1]
UniGeneHs.741483.

3D structure databases

ProteinModelPortalQ8N6G6.
SMRQ8N6G6. Positions 34-296, 888-959, 1191-1532.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000369921.

PTM databases

PhosphoSiteQ8N6G6.

Polymorphism databases

DMDM298286924.

Proteomic databases

PaxDbQ8N6G6.
PRIDEQ8N6G6.

Protocols and materials databases

DNASU92949.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000276935; ENSP00000276935; ENSG00000178031. [Q8N6G6-4]
ENST00000327883; ENSP00000327887; ENSG00000178031. [Q8N6G6-1]
ENST00000380545; ENSP00000369918; ENSG00000178031. [Q8N6G6-6]
ENST00000380548; ENSP00000369921; ENSG00000178031. [Q8N6G6-3]
ENST00000380566; ENSP00000369940; ENSG00000178031. [Q8N6G6-2]
ENST00000542621; ENSP00000440472; ENSG00000178031. [Q8N6G6-5]
GeneID92949.
KEGGhsa:92949.
UCSCuc003znb.3. human. [Q8N6G6-2]
uc003znc.4. human. [Q8N6G6-1]
uc003zne.4. human. [Q8N6G6-3]
uc003znf.4. human. [Q8N6G6-6]

Organism-specific databases

CTD92949.
GeneCardsGC09P018464.
H-InvDBHIX0007941.
HGNCHGNC:14632. ADAMTSL1.
HPAHPA048566.
HPA057437.
MIM609198. gene.
neXtProtNX_Q8N6G6.
PharmGKBPA24554.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG272362.
HOVERGENHBG068818.
InParanoidQ8N6G6.
OMARWEIGKW.
OrthoDBEOG7TXKFQ.
PhylomeDBQ8N6G6.
TreeFamTF351125.

Enzyme and pathway databases

ReactomeREACT_17015. Metabolism of proteins.
SignaLinkQ8N6G6.

Gene expression databases

ArrayExpressQ8N6G6.
BgeeQ8N6G6.
CleanExHS_ADAMTSL1.
GenevestigatorQ8N6G6.

Family and domain databases

Gene3D2.60.40.10. 4 hits.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR010909. PLAC.
IPR000884. Thrombospondin_1_rpt.
[Graphical view]
PfamPF07679. I-set. 3 hits.
PF08686. PLAC. 1 hit.
PF00090. TSP_1. 8 hits.
[Graphical view]
PRINTSPR01857. ADAMTSFAMILY.
SMARTSM00408. IGc2. 4 hits.
SM00209. TSP1. 13 hits.
[Graphical view]
SUPFAMSSF82895. SSF82895. 11 hits.
PROSITEPS50835. IG_LIKE. 4 hits.
PS50900. PLAC. 1 hit.
PS50092. TSP1. 9 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiADAMTSL1.
GenomeRNAi92949.
NextBio77924.
PROQ8N6G6.
SOURCESearch...

Entry information

Entry nameATL1_HUMAN
AccessionPrimary (citable) accession number: Q8N6G6
Secondary accession number(s): A6PVN1 expand/collapse secondary AC list , A8K7E1, Q496M6, Q496M8, Q5T708, Q5VZT8, Q8NAI9, Q96RW4, Q9BXY3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: June 15, 2010
Last modified: July 9, 2014
This is version 111 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM