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Protein

Ankyrin repeat domain-containing protein 29

Gene

ANKRD29

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 29
Gene namesi
Name:ANKRD29
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:27110. ANKRD29.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134948058.

Polymorphism and mutation databases

BioMutaiANKRD29.
DMDMi109940219.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301Ankyrin repeat domain-containing protein 29PRO_0000243903Add
BLAST

Proteomic databases

PaxDbiQ8N6D5.
PRIDEiQ8N6D5.

PTM databases

iPTMnetiQ8N6D5.
PhosphoSiteiQ8N6D5.

Expressioni

Gene expression databases

BgeeiQ8N6D5.
CleanExiHS_ANKRD29.
ExpressionAtlasiQ8N6D5. baseline and differential.
GenevisibleiQ8N6D5. HS.

Organism-specific databases

HPAiHPA041272.
HPA049419.

Interactioni

Protein-protein interaction databases

BioGridi127061. 7 interactions.
STRINGi9606.ENSP00000468354.

Structurei

3D structure databases

ProteinModelPortaliQ8N6D5.
SMRiQ8N6D5. Positions 19-297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati11 – 4131ANK 1Add
BLAST
Repeati45 – 7430ANK 2Add
BLAST
Repeati78 – 10730ANK 3Add
BLAST
Repeati111 – 14030ANK 4Add
BLAST
Repeati144 – 17330ANK 5Add
BLAST
Repeati177 – 20630ANK 6Add
BLAST
Repeati210 – 23930ANK 7Add
BLAST
Repeati242 – 27130ANK 8Add
BLAST

Sequence similaritiesi

Contains 8 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129724.
HOGENOMiHOG000158359.
HOVERGENiHBG080846.
InParanoidiQ8N6D5.
OMAiVANGAWV.
OrthoDBiEOG7P02H2.
PhylomeDBiQ8N6D5.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 3 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 8 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N6D5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCRMSFKKET PLANAAFWAA RRGNLALLKL LLNSGRVDVD CRDSHGTTLL
60 70 80 90 100
MVAAYAGHID CVRELVLQGA DINLQRESGT TALFFAAQQG HNDVVRFLFG
110 120 130 140 150
FGASTEFRTK DGGTALLAAS QYGHMQVVET LLKHGANIHD QLYDGATALF
160 170 180 190 200
LAAQGGYLDV IRLLLASGAK VNQPRQDGTA PLWIASQMGH SEVVRVMLLR
210 220 230 240 250
GADRDAARND GTTALLKAAN KGYNDVIKEL LKFSPTLGIL KNGTSALHAA
260 270 280 290 300
VLSGNIKTVA LLLEAGADPS LRNKANELPA ELTKNERILR LLRSKEGPRK

S
Length:301
Mass (Da):32,442
Last modified:June 27, 2006 - v2
Checksum:i26B553175F6E2ED1
GO
Isoform 3 (identifier: Q8N6D5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     242-274: Missing.

Note: No experimental confirmation available.
Show »
Length:268
Mass (Da):29,158
Checksum:i5CBF876C344CF3F6
GO

Sequence cautioni

The sequence BAC85555.1 differs from that shown.Intron retention.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti95 – 951V → M in a breast cancer sample; somatic mutation. 1 Publication
VAR_035610
Natural varianti112 – 1121G → E.1 Publication
Corresponds to variant rs17855552 [ dbSNP | Ensembl ].
VAR_026869

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei242 – 27433Missing in isoform 3. 1 PublicationVSP_019488Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057782 mRNA. Translation: BAB71569.1.
AK123197 mRNA. Translation: BAC85555.1. Sequence problems.
AK313667 mRNA. Translation: BAG36419.1.
AC010853 Genomic DNA. No translation available.
CH471088 Genomic DNA. Translation: EAX01160.1.
BC030622 mRNA. Translation: AAH30622.1.
CCDSiCCDS11879.1. [Q8N6D5-1]
CCDS77164.1. [Q8N6D5-3]
RefSeqiNP_001295167.1. NM_001308238.1. [Q8N6D5-3]
NP_775776.2. NM_173505.3. [Q8N6D5-1]
UniGeneiHs.355689.
Hs.374774.

Genome annotation databases

EnsembliENST00000322980; ENSP00000323387; ENSG00000154065. [Q8N6D5-3]
ENST00000592179; ENSP00000468354; ENSG00000154065. [Q8N6D5-1]
GeneIDi147463.
KEGGihsa:147463.
UCSCiuc002kun.4. human. [Q8N6D5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057782 mRNA. Translation: BAB71569.1.
AK123197 mRNA. Translation: BAC85555.1. Sequence problems.
AK313667 mRNA. Translation: BAG36419.1.
AC010853 Genomic DNA. No translation available.
CH471088 Genomic DNA. Translation: EAX01160.1.
BC030622 mRNA. Translation: AAH30622.1.
CCDSiCCDS11879.1. [Q8N6D5-1]
CCDS77164.1. [Q8N6D5-3]
RefSeqiNP_001295167.1. NM_001308238.1. [Q8N6D5-3]
NP_775776.2. NM_173505.3. [Q8N6D5-1]
UniGeneiHs.355689.
Hs.374774.

3D structure databases

ProteinModelPortaliQ8N6D5.
SMRiQ8N6D5. Positions 19-297.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127061. 7 interactions.
STRINGi9606.ENSP00000468354.

PTM databases

iPTMnetiQ8N6D5.
PhosphoSiteiQ8N6D5.

Polymorphism and mutation databases

BioMutaiANKRD29.
DMDMi109940219.

Proteomic databases

PaxDbiQ8N6D5.
PRIDEiQ8N6D5.

Protocols and materials databases

DNASUi147463.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322980; ENSP00000323387; ENSG00000154065. [Q8N6D5-3]
ENST00000592179; ENSP00000468354; ENSG00000154065. [Q8N6D5-1]
GeneIDi147463.
KEGGihsa:147463.
UCSCiuc002kun.4. human. [Q8N6D5-1]

Organism-specific databases

CTDi147463.
GeneCardsiANKRD29.
HGNCiHGNC:27110. ANKRD29.
HPAiHPA041272.
HPA049419.
neXtProtiNX_Q8N6D5.
PharmGKBiPA134948058.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129724.
HOGENOMiHOG000158359.
HOVERGENiHBG080846.
InParanoidiQ8N6D5.
OMAiVANGAWV.
OrthoDBiEOG7P02H2.
PhylomeDBiQ8N6D5.

Miscellaneous databases

ChiTaRSiANKRD29. human.
GenomeRNAii147463.
PROiQ8N6D5.

Gene expression databases

BgeeiQ8N6D5.
CleanExiHS_ANKRD29.
ExpressionAtlasiQ8N6D5. baseline and differential.
GenevisibleiQ8N6D5. HS.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 3 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 8 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Brain and Cerebellum.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLU-112.
    Tissue: Brain.
  5. Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-95.

Entry informationi

Entry nameiANR29_HUMAN
AccessioniPrimary (citable) accession number: Q8N6D5
Secondary accession number(s): B2R972, Q6ZWE8, Q96LU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: June 8, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.