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Protein

Leukocyte immunoglobulin-like receptor subfamily A member 3

Gene

LILRA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes.2 Publications

GO - Molecular functioni

  • antigen binding Source: ProtInc
  • receptor activity Source: ProtInc

GO - Biological processi

  • adaptive immune response Source: UniProtKB-KW
  • defense response Source: ProtInc
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Adaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte immunoglobulin-like receptor subfamily A member 3
Alternative name(s):
CD85 antigen-like family member E
Immunoglobulin-like transcript 6
Short name:
ILT-6
Leukocyte immunoglobulin-like receptor 4
Short name:
LIR-4
Monocyte inhibitory receptor HM43/HM31
CD_antigen: CD85e
Gene namesi
Name:LILRA3
Synonyms:ILT6, LIR4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6604. LILRA3.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB-SubCell
  • plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30378.

Polymorphism and mutation databases

BioMutaiLILRA3.
DMDMi92090611.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 PublicationAdd
BLAST
Chaini24 – 439416Leukocyte immunoglobulin-like receptor subfamily A member 3PRO_0000014818Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 98Combined sources1 Publication
Glycosylationi140 – 1401N-linked (GlcNAc...)1 Publication
Disulfide bondi145 ↔ 197PROSITE-ProRule annotation
Disulfide bondi157 ↔ 167PROSITE-ProRule annotation
Disulfide bondi246 ↔ 297PROSITE-ProRule annotation
Glycosylationi281 – 2811N-linked (GlcNAc...)1 Publication
Glycosylationi302 – 3021N-linked (GlcNAc...)1 Publication
Glycosylationi341 – 3411N-linked (GlcNAc...)1 Publication
Disulfide bondi346 ↔ 397PROSITE-ProRule annotation
Glycosylationi431 – 4311N-linked (GlcNAc...)1 Publication

Post-translational modificationi

N-glycosylation is required for ligand binding.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8N6C8.
PeptideAtlasiQ8N6C8.
PRIDEiQ8N6C8.

PTM databases

iPTMnetiQ8N6C8.
PhosphoSiteiQ8N6C8.

Expressioni

Tissue specificityi

Detected in B-cells, and at lower levels in natural killer (NK) cells. Detected in peripheral blood monocytes and lung.2 Publications

Gene expression databases

BgeeiENSG00000170866.

Interactioni

Protein-protein interaction databases

BioGridi116216. 7 interactions.
IntActiQ8N6C8. 1 interaction.
MINTiMINT-1482453.

Structurei

Secondary structure

1
439
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi30 – 356Combined sources
Beta strandi37 – 404Combined sources
Beta strandi45 – 506Combined sources
Beta strandi52 – 565Combined sources
Beta strandi58 – 658Combined sources
Helixi68 – 725Combined sources
Helixi75 – 795Combined sources
Beta strandi82 – 876Combined sources
Helixi90 – 923Combined sources
Beta strandi94 – 1029Combined sources
Turni103 – 1053Combined sources
Beta strandi106 – 1083Combined sources
Beta strandi114 – 1196Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3Q2CX-ray2.50A24-120[»]
ProteinModelPortaliQ8N6C8.
SMRiQ8N6C8. Positions 25-417.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 10882Ig-like C2-type 1Add
BLAST
Domaini119 – 224106Ig-like C2-type 2Add
BLAST
Domaini226 – 31590Ig-like C2-type 3Add
BLAST
Domaini326 – 41590Ig-like C2-type 4Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IKJD. Eukaryota.
ENOG41116BR. LUCA.
HOVERGENiHBG074353.
InParanoidiQ8N6C8.
KOiK06512.
PhylomeDBiQ8N6C8.
TreeFamiTF336644.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR016332. A1B_glyco/leuk_Ig-like_rcpt.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
[Graphical view]
PIRSFiPIRSF001979. Alpha_1B_glycoprot_prd. 1 hit.
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N6C8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTPILTVLIC LGLSLDPRTH VQAGPLPKPT LWAEPGSVIT QGSPVTLRCQ
60 70 80 90 100
GSLETQEYHL YREKKTALWI TRIPQELVKK GQFPILSITW EHAGRYCCIY
110 120 130 140 150
GSHTAGLSES SDPLELVVTG AYSKPTLSAL PSPVVTSGGN VTIQCDSQVA
160 170 180 190 200
FDGFILCKEG EDEHPQCLNS HSHARGSSRA IFSVGPVSPS RRWSYRCYGY
210 220 230 240 250
DSRAPYVWSL PSDLLGLLVP GVSKKPSLSV QPGPVVAPGE KLTFQCGSDA
260 270 280 290 300
GYDRFVLYKE WGRDFLQRPG RQPQAGLSQA NFTLGPVSRS YGGQYTCSGA
310 320 330 340 350
YNLSSEWSAP SDPLDILITG QIRARPFLSV RPGPTVASGE NVTLLCQSQG
360 370 380 390 400
GMHTFLLTKE GAADSPLRLK SKRQSHKYQA EFPMSPVTSA HAGTYRCYGS
410 420 430
LSSNPYLLTH PSDPLELVVS GAAETLSPPQ NKSDSKAGE
Length:439
Mass (Da):47,472
Last modified:April 4, 2006 - v3
Checksum:i3932C6DA202ED5F5
GO
Isoform 2 (identifier: Q8N6C8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     158-221: Missing.

Show »
Length:375
Mass (Da):40,357
Checksum:iC827A5E1F4C0CC41
GO
Isoform 3 (identifier: Q8N6C8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MHRGLIHPQSSAVGGDAM

Note: No experimental confirmation available.
Show »
Length:456
Mass (Da):49,187
Checksum:i4CD52DE6205ED869
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti105 – 1051A → V in AAH28208 (PubMed:15489334).Curated
Sequence conflicti223 – 2231S → P in AAB68667 (PubMed:9278324).Curated
Sequence conflicti250 – 2501A → T in AAM18037 (PubMed:12750859).Curated
Sequence conflicti371 – 3711S → L in AAB68667 (PubMed:9278324).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti3 – 31P → S.3 Publications
Corresponds to variant rs11574606 [ dbSNP | Ensembl ].
VAR_016990
Natural varianti107 – 1071L → R.1 Publication
Corresponds to variant rs6509862 [ dbSNP | Ensembl ].
VAR_016991
Natural varianti301 – 3011Y → H.1 Publication
Corresponds to variant rs4473306 [ dbSNP | Ensembl ].
VAR_016992
Natural varianti307 – 3071W → C.
Corresponds to variant rs1128645 [ dbSNP | Ensembl ].
VAR_059397

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MHRGLIHPQSSAVGGDAM in isoform 3. CuratedVSP_045886
Alternative sequencei158 – 22164Missing in isoform 2. 1 PublicationVSP_045887Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91926 mRNA. Translation: AAB68666.1.
U91927 mRNA. Translation: AAB68667.1.
AF025527 mRNA. Translation: AAB87661.1.
AF014924 mRNA. Translation: AAC51886.1.
AC008984 Genomic DNA. No translation available.
AC010518 Genomic DNA. No translation available.
BC028208 mRNA. Translation: AAH28208.1.
AF482762 Genomic DNA. Translation: AAM18035.1.
AF482763 Genomic DNA. Translation: AAM18036.1.
AF482764 Genomic DNA. Translation: AAM18037.1.
AF482765 Genomic DNA. Translation: AAM18038.1.
AF482766 Genomic DNA. Translation: AAM18039.1.
AF482767 Genomic DNA. Translation: AAM18040.1.
AF482768 Genomic DNA. Translation: AAM18041.1.
AF482769 Genomic DNA. Translation: AAM18042.1.
RefSeqiNP_001166125.1. NM_001172654.2. [Q8N6C8-2]
NP_006856.3. NM_006865.4. [Q8N6C8-1]
UniGeneiHs.113277.
Hs.624711.

Genome annotation databases

EnsembliENST00000612127; ENSP00000484119; ENSG00000278046. [Q8N6C8-1]
ENST00000615652; ENSP00000482971; ENSG00000273884. [Q8N6C8-1]
ENST00000617541; ENSP00000477708; ENSG00000275841. [Q8N6C8-2]
ENST00000619638; ENSP00000481818; ENSG00000275841. [Q8N6C8-1]
ENST00000620589; ENSP00000480386; ENSG00000276175. [Q8N6C8-1]
GeneIDi11026.
KEGGihsa:11026.
UCSCiuc032ini.2. human. [Q8N6C8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91926 mRNA. Translation: AAB68666.1.
U91927 mRNA. Translation: AAB68667.1.
AF025527 mRNA. Translation: AAB87661.1.
AF014924 mRNA. Translation: AAC51886.1.
AC008984 Genomic DNA. No translation available.
AC010518 Genomic DNA. No translation available.
BC028208 mRNA. Translation: AAH28208.1.
AF482762 Genomic DNA. Translation: AAM18035.1.
AF482763 Genomic DNA. Translation: AAM18036.1.
AF482764 Genomic DNA. Translation: AAM18037.1.
AF482765 Genomic DNA. Translation: AAM18038.1.
AF482766 Genomic DNA. Translation: AAM18039.1.
AF482767 Genomic DNA. Translation: AAM18040.1.
AF482768 Genomic DNA. Translation: AAM18041.1.
AF482769 Genomic DNA. Translation: AAM18042.1.
RefSeqiNP_001166125.1. NM_001172654.2. [Q8N6C8-2]
NP_006856.3. NM_006865.4. [Q8N6C8-1]
UniGeneiHs.113277.
Hs.624711.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3Q2CX-ray2.50A24-120[»]
ProteinModelPortaliQ8N6C8.
SMRiQ8N6C8. Positions 25-417.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116216. 7 interactions.
IntActiQ8N6C8. 1 interaction.
MINTiMINT-1482453.

PTM databases

iPTMnetiQ8N6C8.
PhosphoSiteiQ8N6C8.

Polymorphism and mutation databases

BioMutaiLILRA3.
DMDMi92090611.

Proteomic databases

PaxDbiQ8N6C8.
PeptideAtlasiQ8N6C8.
PRIDEiQ8N6C8.

Protocols and materials databases

DNASUi11026.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000612127; ENSP00000484119; ENSG00000278046. [Q8N6C8-1]
ENST00000615652; ENSP00000482971; ENSG00000273884. [Q8N6C8-1]
ENST00000617541; ENSP00000477708; ENSG00000275841. [Q8N6C8-2]
ENST00000619638; ENSP00000481818; ENSG00000275841. [Q8N6C8-1]
ENST00000620589; ENSP00000480386; ENSG00000276175. [Q8N6C8-1]
GeneIDi11026.
KEGGihsa:11026.
UCSCiuc032ini.2. human. [Q8N6C8-1]

Organism-specific databases

CTDi11026.
GeneCardsiLILRA3.
HGNCiHGNC:6604. LILRA3.
MIMi604818. gene.
neXtProtiNX_Q8N6C8.
PharmGKBiPA30378.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKJD. Eukaryota.
ENOG41116BR. LUCA.
HOVERGENiHBG074353.
InParanoidiQ8N6C8.
KOiK06512.
PhylomeDBiQ8N6C8.
TreeFamiTF336644.

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

GeneWikiiLILRA3.
GenomeRNAii11026.
PROiQ8N6C8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170866.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR016332. A1B_glyco/leuk_Ig-like_rcpt.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
[Graphical view]
PIRSFiPIRSF001979. Alpha_1B_glycoprot_prd. 1 hit.
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLIRA3_HUMAN
AccessioniPrimary (citable) accession number: Q8N6C8
Secondary accession number(s): J3KPM2
, O15469, O15470, O75016, Q8N151, Q8N154, Q8NHJ1, Q8NHJ2, Q8NHJ3, Q8NHJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: April 4, 2006
Last modified: September 7, 2016
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.