Q8N6C5 (IGSF1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Immunoglobulin superfamily member 1
Short name=IgSF1

Alternative name(s):
Immunoglobulin-like domain-containing protein 1
Inhibin-binding protein
Short name=InhBP
Pituitary gland-specific factor 2
p120

Gene names

Name:	IGSF1
Synonyms:	IGDC1, KIAA0364, PGSF2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1336 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor. Antagonizes activin A signaling in the presence or absence of inhibin B By similarity. Necessary to mediate a specific antagonistic effect of inhibin B on activin-stimulated transcription. Ref.7
Subunit structure	Interacts with INHA By similarity. In Ref.9 does not interact with INHA; standard receptor binding assay. Interacts with ACVR1B; the interaction appears to be ligand-dependent as it is diminished by inhibin B and activin A. Interacts with ACVR2A, ACVR2B, ACVRL1 and BMPR1B. Interacts with HECTD1. Ref.7 Ref.8 Ref.9
Subcellular location	Isoform 1: Membrane; Multi-pass membrane protein Potential. Isoform 2: Membrane; Multi-pass membrane protein Potential. Isoform 3: Secreted Potential.
Tissue specificity	Highly expressed in pancreas, testis and fetal liver. Moderately expressed in heart, prostate and small intestine. Expressed at very low levels in brain, thymus, ovary, colon, fetal lung and fetal kidney. Expressed in muscle. Isoform 3 is expressed in pituitary gland. Ref.2 Ref.3
Sequence similarities	Contains 12 Ig-like C2-type (immunoglobulin-like) domains.
Caution	It is uncertain whether Met-1 or Met-12 is the initiator.

Ontologies

Keywords
Cellular component	Membrane Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from direct assay Ref.7. Source: UniProtKB signal transduction Inferred from direct assay Ref.7. Source: UniProtKB
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	inhibin beta-A binding Inferred from direct assay Ref.7. Source: UniProtKB inhibin beta-B binding Inferred from direct assay Ref.7. Source: UniProtKB receptor activity Inferred from direct assay Ref.7. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q8N6C5-1)

Also known as: InhBP-L; long;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8N6C5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     24-33: RMSLGMTSIV → L

Isoform 3 (identifier: Q8N6C5-3)

Also known as: InhBP-S; short;

The sequence of this isoform differs from the canonical sequence as follows:
     224-242: LYPKPTLTAHPGPIMAPGE → GCGYGCWHLAIVVPGIMAG
     243-1336: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 28	28	Potential
	Chain	29 – 1336	1308	Immunoglobulin superfamily member 1		PRO_0000318512
Regions
	Topological domain	29 – 518	490	Extracellular Potential
	Transmembrane	519 – 539	21	Helical; Potential
	Topological domain	540 – 559	20	Cytoplasmic Potential
	Transmembrane	560 – 580	21	Helical; Potential
	Topological domain	581 – 1336	756	Extracellular Potential
	Domain	38 – 122	85	Ig-like C2-type 1
	Domain	137 – 222	86	Ig-like C2-type 2
	Domain	226 – 312	87	Ig-like C2-type 3
	Domain	321 – 408	88	Ig-like C2-type 4
	Domain	419 – 500	82	Ig-like C2-type 5
	Domain	589 – 677	89	Ig-like C2-type 6
	Domain	686 – 760	75	Ig-like C2-type 7
	Domain	777 – 869	93	Ig-like C2-type 8
	Domain	873 – 958	86	Ig-like C2-type 9
	Domain	965 – 1060	96	Ig-like C2-type 10
	Domain	1065 – 1150	86	Ig-like C2-type 11
	Domain	1161 – 1242	82	Ig-like C2-type 12
Amino acid modifications
	Glycosylation	53	1	N-linked (GlcNAc...) Potential
	Glycosylation	338	1	N-linked (GlcNAc...) Potential
	Glycosylation	374	1	N-linked (GlcNAc...) Potential
	Glycosylation	381	1	N-linked (GlcNAc...) Potential
	Glycosylation	607	1	N-linked (GlcNAc...) Potential
	Glycosylation	747	1	N-linked (GlcNAc...) Potential
	Glycosylation	798	1	N-linked (GlcNAc...) Potential
	Glycosylation	846	1	N-linked (GlcNAc...) Potential
	Glycosylation	939	1	N-linked (GlcNAc...) Potential
	Glycosylation	986	1	N-linked (GlcNAc...) Potential
	Glycosylation	1027	1	N-linked (GlcNAc...) Potential
	Glycosylation	1082	1	N-linked (GlcNAc...) Potential
	Glycosylation	1147	1	N-linked (GlcNAc...) Potential
	Glycosylation	1223	1	N-linked (GlcNAc...) Potential
	Disulfide bond	58 ↔ 106		By similarity
	Disulfide bond	248 ↔ 296		By similarity
	Disulfide bond	343 ↔ 392		By similarity
	Disulfide bond	441 ↔ 484		By similarity
	Disulfide bond	703 ↔ 750		By similarity
	Disulfide bond	799 ↔ 849		By similarity
	Disulfide bond	895 ↔ 942		By similarity
	Disulfide bond	1087 ↔ 1134		By similarity
	Disulfide bond	1183 ↔ 1226		By similarity
Natural variations
	Alternative sequence	24 – 33	10	RMSLGMTSIV → L in isoform 2.		VSP_031195
	Alternative sequence	224 – 242	19	LYPKP…MAPGE → GCGYGCWHLAIVVPGIMAG in isoform 3.		VSP_031196
	Alternative sequence	243 – 1336	1094	Missing in isoform 3.		VSP_031197
	Natural variant	381	1	N → H. Corresponds to variant rs6637826 [ dbSNP | Ensembl ].		VAR_054960
Experimental info
	Sequence conflict	462	1	K → R in CAA71535. Ref.1
	Sequence conflict	494	1	I → M in CAA71535. Ref.1
	Sequence conflict	757	1	R → L in CAA71535. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (InhBP-L) (long) [UniParc]. Last modified April 14, 2009. Version 3. Checksum: 7D0D2C36FD1CE8B8	FASTA	1,336	148,936
	10 20 30 40 50 60 MTLDRPGEGA TMLKTFTVLL FCIRMSLGMT SIVMDPQPEL WIESNYPQAP WENITLWCRS 70 80 90 100 110 120 PSRISSKFLL LKDKTQMTWI RPSHKTFQVS FLIGALTESN AGLYRCCYWK ETGWSKPSKV 130 140 150 160 170 180 LELEAPGQLP KPIFWIQAET PALPGCNVNI LCHGWLQDLV FMLFKEGYAE PVDYQVPTGT 190 200 210 220 230 240 MAIFSIDNLT PEDEGVYICR THIQMLPTLW SEPSNPLKLV VAGLYPKPTL TAHPGPIMAP 250 260 270 280 290 300 GESLNLRCQG PIYGMTFALM RVEDLEKSFY HKKTIKNEAN FFFQSLKIQD TGHYLCFYYD 310 320 330 340 350 360 ASYRGSLLSD VLKIWVTDTF PKTWLLARPS AVVQMGQNVS LRCRGPVDGV GLALYKKGED 370 380 390 400 410 420 KPLQFLDATS IDDNTSFFLN NVTYSDTGIY SCHYLLTWKT SIRMPSHNTV ELMVVDKPPK 430 440 450 460 470 480 PSLSAWPSTV FKLGKAITLQ CRVSHPVLEF SLEWEERETF QKFSVNGDFI ISNVDGKGTG 490 500 510 520 530 540 TYSCSYRVET HPNIWSHRSE PLKLMGPAGY LTWNYVLNEA IRLSLIMQLV ALLLVVLWIR 550 560 570 580 590 600 WKCRRLRIRE AWLLGTAQGV TMLFIVTALL CCGLCNGVLI EETEIVMPTP KPELWAETNF 610 620 630 640 650 660 PLAPWKNLTL WCRSPSGSTK EFVLLKDGTG WIATRPASEQ VRAAFPLGAL TQSHTGSYHC 670 680 690 700 710 720 HSWEEMAVSE PSEALELVGT DILPKPVISA SPTIRGQELQ LRCKGWLAGM GFALYKEGEQ 730 740 750 760 770 780 EPVQQLGAVG REAFFTIQRM EDKDEGNYSC RTHTEKRPFK WSEPSEPLEL VIKEMYPKPF 790 800 810 820 830 840 FKTWASPVVT PGARVTFNCS TPHQHMSFIL YKDGSEIASS DRSWASPGAS AAHFLIISVG 850 860 870 880 890 900 IGDGGNYSCR YYDFSIWSEP SDPVELVVTE FYPKPTLLAQ PGPVVFPGKS VILRCQGTFQ 910 920 930 940 950 960 GMRFALLQEG AHVPLQFRSV SGNSADFLLH TVGAEDSGNY SCIYYETTMS NRGSYLSMPL 970 980 990 1000 1010 1020 MIWVTDTFPK PWLFAEPSSV VPMGQNVTLW CRGPVHGVGY ILHKEGEATS MQLWGSTSND 1030 1040 1050 1060 1070 1080 GAFPITNISG TSMGRYSCCY HPDWTSSIKI QPSNTLELLV TGLLPKPSLL AQPGPMVAPG 1090 1100 1110 1120 1130 1140 ENMTLQCQGE LPDSTFVLLK EGAQEPLEQQ RPSGYRADFW MPAVRGEDSG IYSCVYYLDS 1150 1160 1170 1180 1190 1200 TPFAASNHSD SLEIWVTDKP PKPSLSAWPS TMFKLGKDIT LQCRGPLPGV EFVLEHDGEE 1210 1220 1230 1240 1250 1260 APQQFSEDGD FVINNVEGKG IGNYSCSYRL QAYPDIWSEP SDPLELVGAA GPVAQECTVG 1270 1280 1290 1300 1310 1320 NIVRSSLIVV VVVALGVVLA IEWKKWPRLR TRGSETDGRD QTIALEECNQ EGEPGTPANS 1330 PSSTSQRISV ELPVPI
	Isoform 2 [UniParc]. Checksum: 736C689FEC94D2E1	FASTA	1,327	147,973
	10 20 30 40 50 60 MTLDRPGEGA TMLKTFTVLL FCILMDPQPE LWIESNYPQA PWENITLWCR SPSRISSKFL 70 80 90 100 110 120 LLKDKTQMTW IRPSHKTFQV SFLIGALTES NAGLYRCCYW KETGWSKPSK VLELEAPGQL 130 140 150 160 170 180 PKPIFWIQAE TPALPGCNVN ILCHGWLQDL VFMLFKEGYA EPVDYQVPTG TMAIFSIDNL 190 200 210 220 230 240 TPEDEGVYIC RTHIQMLPTL WSEPSNPLKL VVAGLYPKPT LTAHPGPIMA PGESLNLRCQ 250 260 270 280 290 300 GPIYGMTFAL MRVEDLEKSF YHKKTIKNEA NFFFQSLKIQ DTGHYLCFYY DASYRGSLLS 310 320 330 340 350 360 DVLKIWVTDT FPKTWLLARP SAVVQMGQNV SLRCRGPVDG VGLALYKKGE DKPLQFLDAT 370 380 390 400 410 420 SIDDNTSFFL NNVTYSDTGI YSCHYLLTWK TSIRMPSHNT VELMVVDKPP KPSLSAWPST 430 440 450 460 470 480 VFKLGKAITL QCRVSHPVLE FSLEWEERET FQKFSVNGDF IISNVDGKGT GTYSCSYRVE 490 500 510 520 530 540 THPNIWSHRS EPLKLMGPAG YLTWNYVLNE AIRLSLIMQL VALLLVVLWI RWKCRRLRIR 550 560 570 580 590 600 EAWLLGTAQG VTMLFIVTAL LCCGLCNGVL IEETEIVMPT PKPELWAETN FPLAPWKNLT 610 620 630 640 650 660 LWCRSPSGST KEFVLLKDGT GWIATRPASE QVRAAFPLGA LTQSHTGSYH CHSWEEMAVS 670 680 690 700 710 720 EPSEALELVG TDILPKPVIS ASPTIRGQEL QLRCKGWLAG MGFALYKEGE QEPVQQLGAV 730 740 750 760 770 780 GREAFFTIQR MEDKDEGNYS CRTHTEKRPF KWSEPSEPLE LVIKEMYPKP FFKTWASPVV 790 800 810 820 830 840 TPGARVTFNC STPHQHMSFI LYKDGSEIAS SDRSWASPGA SAAHFLIISV GIGDGGNYSC 850 860 870 880 890 900 RYYDFSIWSE PSDPVELVVT EFYPKPTLLA QPGPVVFPGK SVILRCQGTF QGMRFALLQE 910 920 930 940 950 960 GAHVPLQFRS VSGNSADFLL HTVGAEDSGN YSCIYYETTM SNRGSYLSMP LMIWVTDTFP 970 980 990 1000 1010 1020 KPWLFAEPSS VVPMGQNVTL WCRGPVHGVG YILHKEGEAT SMQLWGSTSN DGAFPITNIS 1030 1040 1050 1060 1070 1080 GTSMGRYSCC YHPDWTSSIK IQPSNTLELL VTGLLPKPSL LAQPGPMVAP GENMTLQCQG 1090 1100 1110 1120 1130 1140 ELPDSTFVLL KEGAQEPLEQ QRPSGYRADF WMPAVRGEDS GIYSCVYYLD STPFAASNHS 1150 1160 1170 1180 1190 1200 DSLEIWVTDK PPKPSLSAWP STMFKLGKDI TLQCRGPLPG VEFVLEHDGE EAPQQFSEDG 1210 1220 1230 1240 1250 1260 DFVINNVEGK GIGNYSCSYR LQAYPDIWSE PSDPLELVGA AGPVAQECTV GNIVRSSLIV 1270 1280 1290 1300 1310 1320 VVVVALGVVL AIEWKKWPRL RTRGSETDGR DQTIALEECN QEGEPGTPAN SPSSTSQRIS VELPVPI
	Isoform 3 (InhBP-S) (short) [UniParc]. Checksum: 1F8A2B1484A754EB	FASTA	242	27,206
	10 20 30 40 50 60 MTLDRPGEGA TMLKTFTVLL FCIRMSLGMT SIVMDPQPEL WIESNYPQAP WENITLWCRS 70 80 90 100 110 120 PSRISSKFLL LKDKTQMTWI RPSHKTFQVS FLIGALTESN AGLYRCCYWK ETGWSKPSKV 130 140 150 160 170 180 LELEAPGQLP KPIFWIQAET PALPGCNVNI LCHGWLQDLV FMLFKEGYAE PVDYQVPTGT 190 200 210 220 230 240 MAIFSIDNLT PEDEGVYICR THIQMLPTLW SEPSNPLKLV VAGGCGYGCW HLAIVVPGIM AG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and genomic organization of a gene coding for a new member of the cell adhesion molecule family mapping to Xq25." Frattini A., Faranda S., Redolfi E., Allavena P., Vezzoni P. Gene 214:1-6(1998) [PubMed: 9729118] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Cloning and expression of an immunoglobulin superfamily gene (IGSF1) in Xq25." Mazzarella R., Pengue G., Jones J., Jones C., Schlessinger D. Genomics 48:157-162(1998) [PubMed: 9521868] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
[3]	"Expression profile of active genes in the human pituitary gland." Tanaka S., Tatsumi K., Okubo K., Itoh K., Kawamoto S., Matsubara K., Amino N. J. Mol. Endocrinol. 28:33-44(2002) [PubMed: 11854097] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY. Tissue: Pituitary.
[4]	"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 4:141-150(1997) [PubMed: 9205841] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[5]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1153-1336. Tissue: Testis.
[7]	"Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP)." Chapman S.C., Woodruff T.K. Mol. Endocrinol. 15:668-679(2001) [PubMed: 11266516] [Abstract] Cited for: FUNCTION, INTERACTION WITH ACVR1B; ACVR2A; ACVR2B; ACVRL1 AND BMPR1B.
[8]	"Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs." Nakayama M., Kikuno R., Ohara O. Genome Res. 12:1773-1784(2002) [PubMed: 12421765] [Abstract] Cited for: INTERACTION WITH HECTD1.
[9]	"Properties of inhibin binding to betaglycan, InhBP/p120 and the activin type II receptors." Chapman S.C., Bernard D.J., Jelen J., Woodruff T.K. Mol. Cell. Endocrinol. 196:79-93(2002) [PubMed: 12385827] [Abstract] Cited for: NEGATIVE INTERACTION WITH INHA.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y10523 mRNA. Translation: CAA71535.1. AF034198 mRNA. Translation: AAC52057.1. AB058894 mRNA. Translation: BAB40235.1. AB002362 mRNA. Translation: BAA20819.2. AL590806 Genomic DNA. No translation available. AL137369 mRNA. Translation: CAB70713.1.
IPI	IPI00043215. IPI00166985. IPI00515081.
RefSeq	NP_001164433.1. NM_001170962.1. NP_001164434.1. NM_001170963.1. NP_001546.2. NM_001555.4. NP_991402.1. NM_205833.3.
UniGene	Hs.22111.
3D structure databases
HSSP	HSSP built from PDB template 1OVZ based on UniProtKB P24071.
ProteinModelPortal	Q8N6C5.
SMR	Q8N6C5. Positions 36-1319.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8N6C5. 2 interactions.
STRING	Q8N6C5.
PTM databases
PhosphoSite	Q8N6C5.
Polymorphism databases
DMDM	226694182.
Proteomic databases
PRIDE	Q8N6C5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000361420; ENSP00000355010; ENSG00000147255.
GeneID	3547.
KEGG	hsa:3547.
UCSC	uc004ewd.1. human. uc004ewf.1. human. uc004ewg.1. human.
Organism-specific databases
CTD	3547.
GeneCards	GC0XM130407.
H-InvDB	HIX0017051.
HGNC	HGNC:5948. IGSF1.
MIM	300137. gene.
neXtProt	NX_Q8N6C5.
PharmGKB	PA29761.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG07894.
GeneTree	ENSGT00570000078816.
HOGENOM	HBG507240.
OMA	CSYRLQA.
Gene expression databases
ArrayExpress	Q8N6C5.
Bgee	Q8N6C5.
CleanEx	HS_IGSF1.
Genevestigator	Q8N6C5.
Family and domain databases
InterPro	IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR003598. Ig_sub2. IPR013151. Immunoglobulin. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 12 hits.
Pfam	PF00047. ig. 1 hit. [Graphical view]
SMART	SM00409. IG. 6 hits. SM00408. IGc2. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 6 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	13848.
SOURCE	Search...

Entry information

Entry name

IGSF1_HUMAN

Accession

Primary (citable) accession number: Q8N6C5
Secondary accession number(s): B5MEG2, O15070, Q9NTC8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	April 14, 2009
Last modified:	January 25, 2012
This is version 81 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.