Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Myc target protein 1

Gene

MYCT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator. Does not seem to significantly affect growth cell capacity. Overexpression seems to mediate many of the known phenotypic features associated with MYC, including promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Myc target protein 1
Alternative name(s):
Myc target in myeloid cells protein 1
Gene namesi
Name:MYCT1
Synonyms:MTLC, MTMC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:23172. MYCT1.

Subcellular locationi

  • Nucleus 1 Publication

  • Note: Expressed in nuclei of hepatocellular carcinoma cell line BEL-7402 cells.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134908917.

Polymorphism and mutation databases

BioMutaiMYCT1.
DMDMi74751049.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 235235Myc target protein 1PRO_0000310959Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei135 – 1351PhosphoserineBy similarity
Modified residuei138 – 1381PhosphoserineBy similarity
Modified residuei141 – 1411PhosphoserineBy similarity
Modified residuei149 – 1491PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8N699.
PRIDEiQ8N699.

PTM databases

iPTMnetiQ8N699.
PhosphoSiteiQ8N699.
SwissPalmiQ8N699.

Expressioni

Tissue specificityi

Down-regulated in gastric cancer tissues.

Gene expression databases

BgeeiQ8N699.
CleanExiHS_MYCT1.
ExpressionAtlasiQ8N699. baseline and differential.
GenevisibleiQ8N699. HS.

Organism-specific databases

HPAiHPA047992.

Interactioni

Protein-protein interaction databases

IntActiQ8N699. 2 interactions.
STRINGi9606.ENSP00000356214.

Structurei

3D structure databases

ProteinModelPortaliQ8N699.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi95 – 11319Bipartite nuclear localization signalSequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the MYCT1 family.Curated

Phylogenomic databases

eggNOGiENOG410IE0H. Eukaryota.
ENOG4111XBR. LUCA.
GeneTreeiENSGT00390000011642.
HOGENOMiHOG000113704.
HOVERGENiHBG057854.
InParanoidiQ8N699.
OMAiFLQCPPL.
OrthoDBiEOG7VDXQG.
PhylomeDBiQ8N699.
TreeFamiTF333196.

Family and domain databases

InterProiIPR029180. Myc_target_1.
[Graphical view]
PANTHERiPTHR14869. PTHR14869. 1 hit.
PfamiPF15179. Myc_target_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N699-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTQVYEGLC KNYFSLAVLQ RDRIKLLFFD ILVFLSVFLL FLLFLVDIMA
60 70 80 90 100
NNTTSLGSPW PENFWEDLIM SFTVSMAIGL VLGGFIWAVF ICLSRRRRAS
110 120 130 140 150
APISQWSSSR RSRSSYTHGL NRTGFYRHSG CERRSNLSLA SLTFQRQASL
160 170 180 190 200
EQANSFPRKS SFRASTFHPF LQCPPLPVET ESQLVTLPSS NISPTISTSH
210 220 230
SLSRPDYWSS NSLRVGLSTP PPPAYESIIK AFPDS
Length:235
Mass (Da):26,593
Last modified:October 1, 2002 - v1
Checksum:i880ADD4C9598F53F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti147 – 1471Q → R in BAB15035 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti119 – 1191G → S.
Corresponds to variant rs17710008 [ dbSNP | Ensembl ].
VAR_037115
Natural varianti127 – 1271R → G.1 Publication
Corresponds to variant rs17852097 [ dbSNP | Ensembl ].
VAR_037116

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF527367 mRNA. Translation: AAM88866.1.
AK024922 mRNA. Translation: BAB15035.1.
AL390960 Genomic DNA. Translation: CAI23573.1.
CH471051 Genomic DNA. Translation: EAW47726.1.
BC022556 mRNA. Translation: AAH22556.2.
BC128463 mRNA. Translation: AAI28464.1.
BC128464 mRNA. Translation: AAI28465.1.
AL834500 mRNA. Translation: CAD39158.3.
CCDSiCCDS5239.1.
RefSeqiNP_079383.2. NM_025107.2.
XP_011534451.1. XM_011536149.1.
XP_011534452.1. XM_011536150.1.
XP_011534453.1. XM_011536151.1.
XP_011534454.1. XM_011536152.1.
UniGeneiHs.18160.

Genome annotation databases

EnsembliENST00000367245; ENSP00000356214; ENSG00000120279.
GeneIDi80177.
KEGGihsa:80177.
UCSCiuc003qpc.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF527367 mRNA. Translation: AAM88866.1.
AK024922 mRNA. Translation: BAB15035.1.
AL390960 Genomic DNA. Translation: CAI23573.1.
CH471051 Genomic DNA. Translation: EAW47726.1.
BC022556 mRNA. Translation: AAH22556.2.
BC128463 mRNA. Translation: AAI28464.1.
BC128464 mRNA. Translation: AAI28465.1.
AL834500 mRNA. Translation: CAD39158.3.
CCDSiCCDS5239.1.
RefSeqiNP_079383.2. NM_025107.2.
XP_011534451.1. XM_011536149.1.
XP_011534452.1. XM_011536150.1.
XP_011534453.1. XM_011536151.1.
XP_011534454.1. XM_011536152.1.
UniGeneiHs.18160.

3D structure databases

ProteinModelPortaliQ8N699.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8N699. 2 interactions.
STRINGi9606.ENSP00000356214.

PTM databases

iPTMnetiQ8N699.
PhosphoSiteiQ8N699.
SwissPalmiQ8N699.

Polymorphism and mutation databases

BioMutaiMYCT1.
DMDMi74751049.

Proteomic databases

PaxDbiQ8N699.
PRIDEiQ8N699.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367245; ENSP00000356214; ENSG00000120279.
GeneIDi80177.
KEGGihsa:80177.
UCSCiuc003qpc.5. human.

Organism-specific databases

CTDi80177.
GeneCardsiMYCT1.
H-InvDBHIX0006305.
HGNCiHGNC:23172. MYCT1.
HPAiHPA047992.
neXtProtiNX_Q8N699.
PharmGKBiPA134908917.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE0H. Eukaryota.
ENOG4111XBR. LUCA.
GeneTreeiENSGT00390000011642.
HOGENOMiHOG000113704.
HOVERGENiHBG057854.
InParanoidiQ8N699.
OMAiFLQCPPL.
OrthoDBiEOG7VDXQG.
PhylomeDBiQ8N699.
TreeFamiTF333196.

Miscellaneous databases

GenomeRNAii80177.
PROiQ8N699.

Gene expression databases

BgeeiQ8N699.
CleanExiHS_MYCT1.
ExpressionAtlasiQ8N699. baseline and differential.
GenevisibleiQ8N699. HS.

Family and domain databases

InterProiIPR029180. Myc_target_1.
[Graphical view]
PANTHERiPTHR14869. PTHR14869. 1 hit.
PfamiPF15179. Myc_target_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of MTLC, a novel gene in 6q25."
    Qiu G.-B., Qiu G., Xu Z., Huang D., Gong L.-G., Li C., Sun X., Sun K.-L.
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 20:94-97(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
    Tissue: Laryngeal carcinoma.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-127.
    Tissue: Brain.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 32-235.
    Tissue: Amygdala.
  7. "Expression of MTLC gene in gastric carcinoma."
    Qiu G.-B., Gong L.-G., Hao D.-M., Zhen Z.-H., Sun K.-L.
    World J. Gastroenterol. 9:2160-2163(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: EXPRESSION IN GASTRIC CARCINOMA.
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiMYCT1_HUMAN
AccessioniPrimary (citable) accession number: Q8N699
Secondary accession number(s): Q8N396, Q8TBE8, Q9H763
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-49 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.