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Protein

Myc target protein 1

Gene

MYCT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator. Does not seem to significantly affect growth cell capacity. Overexpression seems to mediate many of the known phenotypic features associated with MYC, including promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation (By similarity).By similarity

Enzyme and pathway databases

BioCyciZFISH:ENSG00000120279-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Myc target protein 1
Alternative name(s):
Myc target in myeloid cells protein 1
Gene namesi
Name:MYCT1
Synonyms:MTLC, MTMC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:23172. MYCT1.

Subcellular locationi

  • Nucleus 1 Publication

  • Note: Expressed in nuclei of hepatocellular carcinoma cell line BEL-7402 cells.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi80177.
OpenTargetsiENSG00000120279.
PharmGKBiPA134908917.

Polymorphism and mutation databases

BioMutaiMYCT1.
DMDMi74751049.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003109591 – 235Myc target protein 1Add BLAST235

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei135PhosphoserineBy similarity1
Modified residuei138PhosphoserineBy similarity1
Modified residuei141PhosphoserineBy similarity1
Modified residuei149PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8N699.
PeptideAtlasiQ8N699.
PRIDEiQ8N699.

PTM databases

iPTMnetiQ8N699.
PhosphoSitePlusiQ8N699.
SwissPalmiQ8N699.

Expressioni

Tissue specificityi

Down-regulated in gastric cancer tissues.

Gene expression databases

BgeeiENSG00000120279.
CleanExiHS_MYCT1.
ExpressionAtlasiQ8N699. baseline and differential.
GenevisibleiQ8N699. HS.

Organism-specific databases

HPAiHPA047992.

Interactioni

Protein-protein interaction databases

IntActiQ8N699. 2 interactors.
STRINGi9606.ENSP00000356214.

Structurei

3D structure databases

ProteinModelPortaliQ8N699.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi95 – 113Bipartite nuclear localization signalSequence analysisAdd BLAST19

Sequence similaritiesi

Belongs to the MYCT1 family.Curated

Phylogenomic databases

eggNOGiENOG410IE0H. Eukaryota.
ENOG4111XBR. LUCA.
GeneTreeiENSGT00390000011642.
HOGENOMiHOG000113704.
HOVERGENiHBG057854.
InParanoidiQ8N699.
OMAiFLQCPPL.
OrthoDBiEOG091G0P71.
PhylomeDBiQ8N699.
TreeFamiTF333196.

Family and domain databases

InterProiIPR029180. Myc_target_1.
[Graphical view]
PANTHERiPTHR14869. PTHR14869. 1 hit.
PfamiPF15179. Myc_target_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N699-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTQVYEGLC KNYFSLAVLQ RDRIKLLFFD ILVFLSVFLL FLLFLVDIMA
60 70 80 90 100
NNTTSLGSPW PENFWEDLIM SFTVSMAIGL VLGGFIWAVF ICLSRRRRAS
110 120 130 140 150
APISQWSSSR RSRSSYTHGL NRTGFYRHSG CERRSNLSLA SLTFQRQASL
160 170 180 190 200
EQANSFPRKS SFRASTFHPF LQCPPLPVET ESQLVTLPSS NISPTISTSH
210 220 230
SLSRPDYWSS NSLRVGLSTP PPPAYESIIK AFPDS
Length:235
Mass (Da):26,593
Last modified:October 1, 2002 - v1
Checksum:i880ADD4C9598F53F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti147Q → R in BAB15035 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037115119G → S.Corresponds to variant rs17710008dbSNPEnsembl.1
Natural variantiVAR_037116127R → G.1 PublicationCorresponds to variant rs17852097dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF527367 mRNA. Translation: AAM88866.1.
AK024922 mRNA. Translation: BAB15035.1.
AL390960 Genomic DNA. Translation: CAI23573.1.
CH471051 Genomic DNA. Translation: EAW47726.1.
BC022556 mRNA. Translation: AAH22556.2.
BC128463 mRNA. Translation: AAI28464.1.
BC128464 mRNA. Translation: AAI28465.1.
AL834500 mRNA. Translation: CAD39158.3.
CCDSiCCDS5239.1.
RefSeqiNP_079383.2. NM_025107.2.
XP_011534451.1. XM_011536149.2.
XP_011534452.1. XM_011536150.2.
XP_011534453.1. XM_011536151.2.
XP_011534454.1. XM_011536152.2.
XP_016866808.1. XM_017011319.1.
UniGeneiHs.18160.

Genome annotation databases

EnsembliENST00000367245; ENSP00000356214; ENSG00000120279.
GeneIDi80177.
KEGGihsa:80177.
UCSCiuc003qpc.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF527367 mRNA. Translation: AAM88866.1.
AK024922 mRNA. Translation: BAB15035.1.
AL390960 Genomic DNA. Translation: CAI23573.1.
CH471051 Genomic DNA. Translation: EAW47726.1.
BC022556 mRNA. Translation: AAH22556.2.
BC128463 mRNA. Translation: AAI28464.1.
BC128464 mRNA. Translation: AAI28465.1.
AL834500 mRNA. Translation: CAD39158.3.
CCDSiCCDS5239.1.
RefSeqiNP_079383.2. NM_025107.2.
XP_011534451.1. XM_011536149.2.
XP_011534452.1. XM_011536150.2.
XP_011534453.1. XM_011536151.2.
XP_011534454.1. XM_011536152.2.
XP_016866808.1. XM_017011319.1.
UniGeneiHs.18160.

3D structure databases

ProteinModelPortaliQ8N699.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8N699. 2 interactors.
STRINGi9606.ENSP00000356214.

PTM databases

iPTMnetiQ8N699.
PhosphoSitePlusiQ8N699.
SwissPalmiQ8N699.

Polymorphism and mutation databases

BioMutaiMYCT1.
DMDMi74751049.

Proteomic databases

PaxDbiQ8N699.
PeptideAtlasiQ8N699.
PRIDEiQ8N699.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367245; ENSP00000356214; ENSG00000120279.
GeneIDi80177.
KEGGihsa:80177.
UCSCiuc003qpc.5. human.

Organism-specific databases

CTDi80177.
DisGeNETi80177.
GeneCardsiMYCT1.
H-InvDBHIX0006305.
HGNCiHGNC:23172. MYCT1.
HPAiHPA047992.
neXtProtiNX_Q8N699.
OpenTargetsiENSG00000120279.
PharmGKBiPA134908917.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE0H. Eukaryota.
ENOG4111XBR. LUCA.
GeneTreeiENSGT00390000011642.
HOGENOMiHOG000113704.
HOVERGENiHBG057854.
InParanoidiQ8N699.
OMAiFLQCPPL.
OrthoDBiEOG091G0P71.
PhylomeDBiQ8N699.
TreeFamiTF333196.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000120279-MONOMER.

Miscellaneous databases

GenomeRNAii80177.
PROiQ8N699.

Gene expression databases

BgeeiENSG00000120279.
CleanExiHS_MYCT1.
ExpressionAtlasiQ8N699. baseline and differential.
GenevisibleiQ8N699. HS.

Family and domain databases

InterProiIPR029180. Myc_target_1.
[Graphical view]
PANTHERiPTHR14869. PTHR14869. 1 hit.
PfamiPF15179. Myc_target_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYCT1_HUMAN
AccessioniPrimary (citable) accession number: Q8N699
Secondary accession number(s): Q8N396, Q8TBE8, Q9H763
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-49 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.