Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Myc target protein 1

Gene

MYCT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator. Does not seem to significantly affect growth cell capacity. Overexpression seems to mediate many of the known phenotypic features associated with MYC, including promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation (By similarity).By similarity

Caution

It is uncertain whether Met-1 or Met-49 is the initiator.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
Myc target protein 1
Alternative name(s):
Myc target in myeloid cells protein 1
Gene namesi
Name:MYCT1
Synonyms:MTLC, MTMC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000120279.6
HGNCiHGNC:23172 MYCT1
neXtProtiNX_Q8N699

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi80177
OpenTargetsiENSG00000120279
PharmGKBiPA134908917

Polymorphism and mutation databases

BioMutaiMYCT1
DMDMi74751049

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003109591 – 235Myc target protein 1Add BLAST235

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei135PhosphoserineBy similarity1
Modified residuei138PhosphoserineBy similarity1
Modified residuei141PhosphoserineBy similarity1
Modified residuei149PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8N699
PeptideAtlasiQ8N699
PRIDEiQ8N699
ProteomicsDBi72150

PTM databases

iPTMnetiQ8N699
PhosphoSitePlusiQ8N699
SwissPalmiQ8N699

Expressioni

Tissue specificityi

Down-regulated in gastric cancer tissues.

Gene expression databases

BgeeiENSG00000120279
CleanExiHS_MYCT1
ExpressionAtlasiQ8N699 baseline and differential
GenevisibleiQ8N699 HS

Organism-specific databases

HPAiHPA047992

Interactioni

Protein-protein interaction databases

BioGridi123159, 2 interactors
IntActiQ8N699, 3 interactors
MINTiQ8N699
STRINGi9606.ENSP00000356214

Structurei

3D structure databases

ProteinModelPortaliQ8N699
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi95 – 113Bipartite nuclear localization signalSequence analysisAdd BLAST19

Sequence similaritiesi

Belongs to the MYCT1 family.Curated

Phylogenomic databases

eggNOGiENOG410IE0H Eukaryota
ENOG4111XBR LUCA
GeneTreeiENSGT00390000011642
HOGENOMiHOG000113704
HOVERGENiHBG057854
InParanoidiQ8N699
OMAiFLQCPPL
OrthoDBiEOG091G0P71
PhylomeDBiQ8N699
TreeFamiTF333196

Family and domain databases

InterProiView protein in InterPro
IPR029180 Myc_target_1
PANTHERiPTHR14869 PTHR14869, 1 hit
PfamiView protein in Pfam
PF15179 Myc_target_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q8N699-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTQVYEGLC KNYFSLAVLQ RDRIKLLFFD ILVFLSVFLL FLLFLVDIMA
60 70 80 90 100
NNTTSLGSPW PENFWEDLIM SFTVSMAIGL VLGGFIWAVF ICLSRRRRAS
110 120 130 140 150
APISQWSSSR RSRSSYTHGL NRTGFYRHSG CERRSNLSLA SLTFQRQASL
160 170 180 190 200
EQANSFPRKS SFRASTFHPF LQCPPLPVET ESQLVTLPSS NISPTISTSH
210 220 230
SLSRPDYWSS NSLRVGLSTP PPPAYESIIK AFPDS
Length:235
Mass (Da):26,593
Last modified:October 1, 2002 - v1
Checksum:i880ADD4C9598F53F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti147Q → R in BAB15035 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037115119G → S. Corresponds to variant dbSNP:rs17710008Ensembl.1
Natural variantiVAR_037116127R → G1 PublicationCorresponds to variant dbSNP:rs17852097Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF527367 mRNA Translation: AAM88866.1
AK024922 mRNA Translation: BAB15035.1
AL390960 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47726.1
BC022556 mRNA Translation: AAH22556.2
BC128463 mRNA Translation: AAI28464.1
BC128464 mRNA Translation: AAI28465.1
AL834500 mRNA Translation: CAD39158.3
CCDSiCCDS5239.1
RefSeqiNP_079383.2, NM_025107.2
XP_011534451.1, XM_011536149.2
XP_011534452.1, XM_011536150.2
XP_011534453.1, XM_011536151.2
XP_011534454.1, XM_011536152.2
XP_016866808.1, XM_017011319.1
UniGeneiHs.18160

Genome annotation databases

EnsembliENST00000367245; ENSP00000356214; ENSG00000120279
GeneIDi80177
KEGGihsa:80177
UCSCiuc003qpc.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMYCT1_HUMAN
AccessioniPrimary (citable) accession number: Q8N699
Secondary accession number(s): Q8N396, Q8TBE8, Q9H763
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health