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Q8N697

- S15A4_HUMAN

UniProt

Q8N697 - S15A4_HUMAN

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Protein

Solute carrier family 15 member 4

Gene

SLC15A4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides.1 Publication

GO - Molecular functioni

  1. L-histidine transmembrane transporter activity Source: Ensembl
  2. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. ion transport Source: Reactome
  2. oligopeptide transport Source: InterPro
  3. protein transport Source: UniProtKB-KW
  4. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Peptide transport, Protein transport, Symport, Transport

Enzyme and pathway databases

ReactomeiREACT_19328. Proton/oligonucleotide cotransporters.

Protein family/group databases

TCDBi2.A.17.3.11. the proton-dependent oligopeptide transporter (pot/ptr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 15 member 4
Alternative name(s):
Peptide transporter 4
Peptide/histidine transporter 1
Short name:
hPHT1
Gene namesi
Name:SLC15A4
Synonyms:PHT1, PTR4
ORF Names:FP12591
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:23090. SLC15A4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei49 – 6921HelicalSequence AnalysisAdd
BLAST
Transmembranei76 – 9621HelicalSequence AnalysisAdd
BLAST
Transmembranei105 – 12521HelicalSequence AnalysisAdd
BLAST
Transmembranei158 – 17821HelicalSequence AnalysisAdd
BLAST
Transmembranei194 – 21421HelicalSequence AnalysisAdd
BLAST
Transmembranei222 – 24221HelicalSequence AnalysisAdd
BLAST
Transmembranei318 – 33821HelicalSequence AnalysisAdd
BLAST
Transmembranei363 – 38321HelicalSequence AnalysisAdd
BLAST
Transmembranei405 – 42521HelicalSequence AnalysisAdd
BLAST
Transmembranei459 – 47921HelicalSequence AnalysisAdd
BLAST
Transmembranei490 – 51021HelicalSequence AnalysisAdd
BLAST
Transmembranei535 – 55521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. lysosomal membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134928948.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 577577Solute carrier family 15 member 4PRO_0000338599Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei279 – 2791PhosphoserineBy similarity
Modified residuei298 – 2981PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8N697.
PaxDbiQ8N697.
PRIDEiQ8N697.

PTM databases

PhosphoSiteiQ8N697.

Expressioni

Tissue specificityi

Highly expressed in skeletal muscle. Moderately expressed in kidney, liver, and heart. Weakly expressed in colon and brain. Expressed in low levels throughout the gastrointestinal tract and in Caco-2 cells. Expressed in retinal fragment epithelium (RPE) and neural retina. Expressed in small intestine, stomach, duodenum, jejunum, ileum and colon.3 Publications

Gene expression databases

BgeeiQ8N697.
CleanExiHS_SLC15A4.
ExpressionAtlasiQ8N697. baseline and differential.
GenevestigatoriQ8N697.

Organism-specific databases

HPAiHPA016713.

Interactioni

Protein-protein interaction databases

BioGridi125714. 6 interactions.
DIPiDIP-60839N.
IntActiQ8N697. 1 interaction.
STRINGi9606.ENSP00000266771.

Structurei

3D structure databases

ProteinModelPortaliQ8N697.
SMRiQ8N697. Positions 32-557.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi8 – 3932Ala-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG3104.
GeneTreeiENSGT00530000062961.
HOGENOMiHOG000143436.
HOVERGENiHBG108431.
InParanoidiQ8N697.
KOiK14638.
OMAiATGFLVM.
OrthoDBiEOG7FNC8C.
PhylomeDBiQ8N697.
TreeFamiTF330897.

Family and domain databases

InterProiIPR016196. MFS_dom_general_subst_transpt.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 1 hit.
PfamiPF00854. PTR2. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
PROSITEiPS01023. PTR2_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N697-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGSGGGAGE RAPLLGARRA AAAAAAAGAF AGRRAACGAV LLTELLERAA
60 70 80 90 100
FYGITSNLVL FLNGAPFCWE GAQASEALLL FMGLTYLGSP FGGWLADARL
110 120 130 140 150
GRARAILLSL ALYLLGMLAF PLLAAPATRA ALCGSARLLN CTAPGPDAAA
160 170 180 190 200
RCCSPATFAG LVLVGLGVAT VKANITPFGA DQVKDRGPEA TRRFFNWFYW
210 220 230 240 250
SINLGAILSL GGIAYIQQNV SFVTGYAIPT VCVGLAFVVF LCGQSVFITK
260 270 280 290 300
PPDGSAFTDM FKILTYSCCS QKRSGERQSN GEGIGVFQQS SKQSLFDSCK
310 320 330 340 350
MSHGGPFTEE KVEDVKALVK IVPVFLALIP YWTVYFQMQT TYVLQSLHLR
360 370 380 390 400
IPEISNITTT PHTLPAAWLT MFDAVLILLL IPLKDKLVDP ILRRHGLLPS
410 420 430 440 450
SLKRIAVGMF FVMCSAFAAG ILESKRLNLV KEKTINQTIG NVVYHAADLS
460 470 480 490 500
LWWQVPQYLL IGISEIFASI AGLEFAYSAA PKSMQSAIMG LFFFFSGVGS
510 520 530 540 550
FVGSGLLALV SIKAIGWMSS HTDFGNINGC YLNYYFFLLA AIQGATLLLF
560 570
LIISVKYDHH RDHQRSRANG VPTSRRA
Length:577
Mass (Da):62,034
Last modified:October 1, 2002 - v1
Checksum:i701111038C752E70
GO
Isoform 2 (identifier: Q8N697-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-337: Missing.

Show »
Length:240
Mass (Da):26,606
Checksum:i2896131C1AB96FB0
GO

Sequence cautioni

The sequence AAI46804.1 differs from that shown. Reason: Frameshift at position 342. Curated
The sequence AAK95565.1 differs from that shown. Reason: Frameshift at position 572. Curated
The sequence AAQ04807.1 differs from that shown. Reason: Frameshift at position 497. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 241A → T in AAI46804. (PubMed:15489334)Curated
Sequence conflicti34 – 352RA → LL in AAK95565. 1 PublicationCurated
Sequence conflicti44 – 441E → G in AAI46804. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti239 – 2391V → A.
Corresponds to variant rs33990080 [ dbSNP | Ensembl ].
VAR_051611

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 337337Missing in isoform 2. 2 PublicationsVSP_034052Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY050629 mRNA. Translation: AAK95565.1. Frameshift.
AY038999 mRNA. Translation: AAK72099.1.
AF461893 mRNA. Translation: AAQ04807.1. Frameshift.
AK095717 mRNA. Translation: BAG53113.1.
CH471054 Genomic DNA. Translation: EAW98494.1.
BC028394 mRNA. Translation: AAH28394.2.
BC146803 mRNA. Translation: AAI46804.1. Frameshift.
CCDSiCCDS9264.1. [Q8N697-1]
RefSeqiNP_663623.1. NM_145648.3. [Q8N697-1]
UniGeneiHs.507260.

Genome annotation databases

EnsembliENST00000266771; ENSP00000266771; ENSG00000139370. [Q8N697-1]
GeneIDi121260.
KEGGihsa:121260.
UCSCiuc001uhu.2. human. [Q8N697-1]

Polymorphism databases

DMDMi74751048.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY050629 mRNA. Translation: AAK95565.1 . Frameshift.
AY038999 mRNA. Translation: AAK72099.1 .
AF461893 mRNA. Translation: AAQ04807.1 . Frameshift.
AK095717 mRNA. Translation: BAG53113.1 .
CH471054 Genomic DNA. Translation: EAW98494.1 .
BC028394 mRNA. Translation: AAH28394.2 .
BC146803 mRNA. Translation: AAI46804.1 . Frameshift.
CCDSi CCDS9264.1. [Q8N697-1 ]
RefSeqi NP_663623.1. NM_145648.3. [Q8N697-1 ]
UniGenei Hs.507260.

3D structure databases

ProteinModelPortali Q8N697.
SMRi Q8N697. Positions 32-557.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125714. 6 interactions.
DIPi DIP-60839N.
IntActi Q8N697. 1 interaction.
STRINGi 9606.ENSP00000266771.

Chemistry

GuidetoPHARMACOLOGYi 987.

Protein family/group databases

TCDBi 2.A.17.3.11. the proton-dependent oligopeptide transporter (pot/ptr) family.

PTM databases

PhosphoSitei Q8N697.

Polymorphism databases

DMDMi 74751048.

Proteomic databases

MaxQBi Q8N697.
PaxDbi Q8N697.
PRIDEi Q8N697.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000266771 ; ENSP00000266771 ; ENSG00000139370 . [Q8N697-1 ]
GeneIDi 121260.
KEGGi hsa:121260.
UCSCi uc001uhu.2. human. [Q8N697-1 ]

Organism-specific databases

CTDi 121260.
GeneCardsi GC12M129277.
HGNCi HGNC:23090. SLC15A4.
HPAi HPA016713.
MIMi 615806. gene.
neXtProti NX_Q8N697.
PharmGKBi PA134928948.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG3104.
GeneTreei ENSGT00530000062961.
HOGENOMi HOG000143436.
HOVERGENi HBG108431.
InParanoidi Q8N697.
KOi K14638.
OMAi ATGFLVM.
OrthoDBi EOG7FNC8C.
PhylomeDBi Q8N697.
TreeFami TF330897.

Enzyme and pathway databases

Reactomei REACT_19328. Proton/oligonucleotide cotransporters.

Miscellaneous databases

ChiTaRSi SLC15A4. human.
GenomeRNAii 121260.
NextBioi 80688.
PROi Q8N697.
SOURCEi Search...

Gene expression databases

Bgeei Q8N697.
CleanExi HS_SLC15A4.
ExpressionAtlasi Q8N697. baseline and differential.
Genevestigatori Q8N697.

Family and domain databases

InterProi IPR016196. MFS_dom_general_subst_transpt.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view ]
PANTHERi PTHR11654. PTHR11654. 1 hit.
Pfami PF00854. PTR2. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 3 hits.
PROSITEi PS01023. PTR2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a human novel gene with product of peptide/histidine."
    Guo J.H., Yu L.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Molecular cloning of a human brain peptide/histidine transporter, PTR4."
    Mondon P., Bouayadi K., Fournier J., Saubusse P., Lablie C.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  7. "Human proton/oligopeptide transporter (POT) genes: identification of putative human genes using bioinformatics."
    Botka C.W., Wittig T.W., Graul R.C., Nielsen C.U., Higaki K., Amidon G.L., Sadee W.
    AAPS PharmSci 2:E16-E16(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  8. "Spatial expression patterns of peptide transporters in the human and rat gastrointestinal tracts, Caco-2 in vitro cell culture model, and multiple human tissues."
    Herrera-Ruiz D., Wang Q., Gudmundsson O.S., Cook T.J., Smith R.L., Faria T.N., Knipp G.T.
    AAPS PharmSci 3:E9-E9(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  9. "The functional evaluation of human peptide/histidine transporter 1 (hPHT1) in transiently transfected COS-7 cells."
    Bhardwaj R.K., Herrera-Ruiz D., Eltoukhy N., Saad M., Knipp G.T.
    Eur. J. Pharm. Sci. 27:533-542(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiS15A4_HUMAN
AccessioniPrimary (citable) accession number: Q8N697
Secondary accession number(s): A6H8Y9
, B3KTK1, Q71M34, Q7Z5F8, Q8TAH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3