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Q8N697

- S15A4_HUMAN

UniProt

Q8N697 - S15A4_HUMAN

Protein

Solute carrier family 15 member 4

Gene

SLC15A4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides.1 Publication

    GO - Molecular functioni

    1. L-histidine transmembrane transporter activity Source: Ensembl
    2. symporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. ion transport Source: Reactome
    2. oligopeptide transport Source: InterPro
    3. protein transport Source: UniProtKB-KW
    4. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Peptide transport, Protein transport, Symport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_19328. Proton/oligonucleotide cotransporters.

    Protein family/group databases

    TCDBi2.A.17.3.11. the proton-dependent oligopeptide transporter (pot/ptr) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 15 member 4
    Alternative name(s):
    Peptide transporter 4
    Peptide/histidine transporter 1
    Short name:
    hPHT1
    Gene namesi
    Name:SLC15A4
    Synonyms:PHT1, PTR4
    ORF Names:FP12591
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:23090. SLC15A4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. lysosomal membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134928948.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 577577Solute carrier family 15 member 4PRO_0000338599Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei279 – 2791PhosphoserineBy similarity
    Modified residuei298 – 2981PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8N697.
    PaxDbiQ8N697.
    PRIDEiQ8N697.

    PTM databases

    PhosphoSiteiQ8N697.

    Expressioni

    Tissue specificityi

    Highly expressed in skeletal muscle. Moderately expressed in kidney, liver, and heart. Weakly expressed in colon and brain. Expressed in low levels throughout the gastrointestinal tract and in Caco-2 cells. Expressed in retinal fragment epithelium (RPE) and neural retina. Expressed in small intestine, stomach, duodenum, jejunum, ileum and colon.3 Publications

    Gene expression databases

    ArrayExpressiQ8N697.
    BgeeiQ8N697.
    CleanExiHS_SLC15A4.
    GenevestigatoriQ8N697.

    Organism-specific databases

    HPAiHPA016713.

    Interactioni

    Protein-protein interaction databases

    BioGridi125714. 3 interactions.
    DIPiDIP-60839N.
    IntActiQ8N697. 1 interaction.
    STRINGi9606.ENSP00000266771.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N697.
    SMRiQ8N697. Positions 32-557.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei49 – 6921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei76 – 9621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei105 – 12521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei158 – 17821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei194 – 21421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei222 – 24221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei318 – 33821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei363 – 38321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei405 – 42521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei459 – 47921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei490 – 51021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei535 – 55521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi8 – 3932Ala-richAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG3104.
    HOGENOMiHOG000143436.
    HOVERGENiHBG108431.
    KOiK14638.
    OMAiATGFLVM.
    OrthoDBiEOG7FNC8C.
    PhylomeDBiQ8N697.
    TreeFamiTF330897.

    Family and domain databases

    InterProiIPR016196. MFS_dom_general_subst_transpt.
    IPR000109. POT_fam.
    IPR018456. PTR2_symporter_CS.
    [Graphical view]
    PANTHERiPTHR11654. PTHR11654. 1 hit.
    PfamiPF00854. PTR2. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 3 hits.
    PROSITEiPS01023. PTR2_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N697-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEGSGGGAGE RAPLLGARRA AAAAAAAGAF AGRRAACGAV LLTELLERAA    50
    FYGITSNLVL FLNGAPFCWE GAQASEALLL FMGLTYLGSP FGGWLADARL 100
    GRARAILLSL ALYLLGMLAF PLLAAPATRA ALCGSARLLN CTAPGPDAAA 150
    RCCSPATFAG LVLVGLGVAT VKANITPFGA DQVKDRGPEA TRRFFNWFYW 200
    SINLGAILSL GGIAYIQQNV SFVTGYAIPT VCVGLAFVVF LCGQSVFITK 250
    PPDGSAFTDM FKILTYSCCS QKRSGERQSN GEGIGVFQQS SKQSLFDSCK 300
    MSHGGPFTEE KVEDVKALVK IVPVFLALIP YWTVYFQMQT TYVLQSLHLR 350
    IPEISNITTT PHTLPAAWLT MFDAVLILLL IPLKDKLVDP ILRRHGLLPS 400
    SLKRIAVGMF FVMCSAFAAG ILESKRLNLV KEKTINQTIG NVVYHAADLS 450
    LWWQVPQYLL IGISEIFASI AGLEFAYSAA PKSMQSAIMG LFFFFSGVGS 500
    FVGSGLLALV SIKAIGWMSS HTDFGNINGC YLNYYFFLLA AIQGATLLLF 550
    LIISVKYDHH RDHQRSRANG VPTSRRA 577
    Length:577
    Mass (Da):62,034
    Last modified:October 1, 2002 - v1
    Checksum:i701111038C752E70
    GO
    Isoform 2 (identifier: Q8N697-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-337: Missing.

    Show »
    Length:240
    Mass (Da):26,606
    Checksum:i2896131C1AB96FB0
    GO

    Sequence cautioni

    The sequence AAI46804.1 differs from that shown. Reason: Frameshift at position 342.
    The sequence AAK95565.1 differs from that shown. Reason: Frameshift at position 572.
    The sequence AAQ04807.1 differs from that shown. Reason: Frameshift at position 497.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti24 – 241A → T in AAI46804. (PubMed:15489334)Curated
    Sequence conflicti34 – 352RA → LL in AAK95565. 1 PublicationCurated
    Sequence conflicti44 – 441E → G in AAI46804. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti239 – 2391V → A.
    Corresponds to variant rs33990080 [ dbSNP | Ensembl ].
    VAR_051611

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 337337Missing in isoform 2. 2 PublicationsVSP_034052Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY050629 mRNA. Translation: AAK95565.1. Frameshift.
    AY038999 mRNA. Translation: AAK72099.1.
    AF461893 mRNA. Translation: AAQ04807.1. Frameshift.
    AK095717 mRNA. Translation: BAG53113.1.
    CH471054 Genomic DNA. Translation: EAW98494.1.
    BC028394 mRNA. Translation: AAH28394.2.
    BC146803 mRNA. Translation: AAI46804.1. Frameshift.
    CCDSiCCDS9264.1. [Q8N697-1]
    RefSeqiNP_663623.1. NM_145648.3. [Q8N697-1]
    UniGeneiHs.507260.

    Genome annotation databases

    EnsembliENST00000266771; ENSP00000266771; ENSG00000139370. [Q8N697-1]
    GeneIDi121260.
    KEGGihsa:121260.
    UCSCiuc001uhu.2. human. [Q8N697-1]

    Polymorphism databases

    DMDMi74751048.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY050629 mRNA. Translation: AAK95565.1 . Frameshift.
    AY038999 mRNA. Translation: AAK72099.1 .
    AF461893 mRNA. Translation: AAQ04807.1 . Frameshift.
    AK095717 mRNA. Translation: BAG53113.1 .
    CH471054 Genomic DNA. Translation: EAW98494.1 .
    BC028394 mRNA. Translation: AAH28394.2 .
    BC146803 mRNA. Translation: AAI46804.1 . Frameshift.
    CCDSi CCDS9264.1. [Q8N697-1 ]
    RefSeqi NP_663623.1. NM_145648.3. [Q8N697-1 ]
    UniGenei Hs.507260.

    3D structure databases

    ProteinModelPortali Q8N697.
    SMRi Q8N697. Positions 32-557.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125714. 3 interactions.
    DIPi DIP-60839N.
    IntActi Q8N697. 1 interaction.
    STRINGi 9606.ENSP00000266771.

    Chemistry

    GuidetoPHARMACOLOGYi 987.

    Protein family/group databases

    TCDBi 2.A.17.3.11. the proton-dependent oligopeptide transporter (pot/ptr) family.

    PTM databases

    PhosphoSitei Q8N697.

    Polymorphism databases

    DMDMi 74751048.

    Proteomic databases

    MaxQBi Q8N697.
    PaxDbi Q8N697.
    PRIDEi Q8N697.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000266771 ; ENSP00000266771 ; ENSG00000139370 . [Q8N697-1 ]
    GeneIDi 121260.
    KEGGi hsa:121260.
    UCSCi uc001uhu.2. human. [Q8N697-1 ]

    Organism-specific databases

    CTDi 121260.
    GeneCardsi GC12M129277.
    HGNCi HGNC:23090. SLC15A4.
    HPAi HPA016713.
    MIMi 615806. gene.
    neXtProti NX_Q8N697.
    PharmGKBi PA134928948.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG3104.
    HOGENOMi HOG000143436.
    HOVERGENi HBG108431.
    KOi K14638.
    OMAi ATGFLVM.
    OrthoDBi EOG7FNC8C.
    PhylomeDBi Q8N697.
    TreeFami TF330897.

    Enzyme and pathway databases

    Reactomei REACT_19328. Proton/oligonucleotide cotransporters.

    Miscellaneous databases

    ChiTaRSi SLC15A4. human.
    GenomeRNAii 121260.
    NextBioi 80688.
    PROi Q8N697.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8N697.
    Bgeei Q8N697.
    CleanExi HS_SLC15A4.
    Genevestigatori Q8N697.

    Family and domain databases

    InterProi IPR016196. MFS_dom_general_subst_transpt.
    IPR000109. POT_fam.
    IPR018456. PTR2_symporter_CS.
    [Graphical view ]
    PANTHERi PTHR11654. PTHR11654. 1 hit.
    Pfami PF00854. PTR2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 3 hits.
    PROSITEi PS01023. PTR2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a human novel gene with product of peptide/histidine."
      Guo J.H., Yu L.
      Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Molecular cloning of a human brain peptide/histidine transporter, PTR4."
      Mondon P., Bouayadi K., Fournier J., Saubusse P., Lablie C.
      Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    7. "Human proton/oligopeptide transporter (POT) genes: identification of putative human genes using bioinformatics."
      Botka C.W., Wittig T.W., Graul R.C., Nielsen C.U., Higaki K., Amidon G.L., Sadee W.
      AAPS PharmSci 2:E16-E16(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    8. "Spatial expression patterns of peptide transporters in the human and rat gastrointestinal tracts, Caco-2 in vitro cell culture model, and multiple human tissues."
      Herrera-Ruiz D., Wang Q., Gudmundsson O.S., Cook T.J., Smith R.L., Faria T.N., Knipp G.T.
      AAPS PharmSci 3:E9-E9(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    9. "The functional evaluation of human peptide/histidine transporter 1 (hPHT1) in transiently transfected COS-7 cells."
      Bhardwaj R.K., Herrera-Ruiz D., Eltoukhy N., Saad M., Knipp G.T.
      Eur. J. Pharm. Sci. 27:533-542(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiS15A4_HUMAN
    AccessioniPrimary (citable) accession number: Q8N697
    Secondary accession number(s): A6H8Y9
    , B3KTK1, Q71M34, Q7Z5F8, Q8TAH0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3