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Q8N695

- SC5A8_HUMAN

UniProt

Q8N695 - SC5A8_HUMAN

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Protein

Sodium-coupled monocarboxylate transporter 1

Gene

SLC5A8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Acts as an electrogenic sodium (Na+) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na+:substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na+ gradient and hence contribute to the maintenance of the energy status and function of neurons.11 Publications

Kineticsi

  1. KM=1442 µM for beta-D-hydroxybutyate1 Publication
  2. KM=2327 µM for beta-L-hydroxybutyate1 Publication
  3. KM=1088 µM for D-lactate1 Publication
  4. KM=184 µM for L-lactate1 Publication
  5. KM=387 µM for pyruvate1 Publication
  6. KM=213 µM for acetoacetate1 Publication
  7. KM=209 µM for alpha-ketoisocaproate1 Publication

GO - Molecular functioni

  1. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. ion transport Source: Reactome
  3. sodium ion transport Source: UniProtKB-KW
  4. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_19372. Organic anion transporters.

Protein family/group databases

TCDBi2.A.21.5.3. the solute:sodium symporter (sss) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-coupled monocarboxylate transporter 1
Alternative name(s):
Apical iodide transporter
Electrogenic sodium monocarboxylate cotransporter
Sodium iodide-related cotransporter
Solute carrier family 5 member 8
Gene namesi
Name:SLC5A8Imported
Synonyms:AITImported, SMCT2 Publications, SMCT11 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12, UP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:19119. SLC5A8.

Subcellular locationi

Apical cell membrane 3 Publications; Multi-pass membrane protein 3 Publications
Note: Expressed at the apical membrane of normal tall thyrocytes and of colonic epithelial cells.3 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99ExtracellularSequence Analysis
Transmembranei10 – 3021HelicalSequence AnalysisAdd
BLAST
Topological domaini31 – 5121CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei52 – 7221HelicalSequence AnalysisAdd
BLAST
Topological domaini73 – 8311ExtracellularSequence AnalysisAdd
BLAST
Transmembranei84 – 10421HelicalSequence AnalysisAdd
BLAST
Topological domaini105 – 13228CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei133 – 15321HelicalSequence AnalysisAdd
BLAST
Topological domaini154 – 1618ExtracellularSequence Analysis
Transmembranei162 – 18221HelicalSequence AnalysisAdd
BLAST
Topological domaini183 – 1897CytoplasmicSequence Analysis
Transmembranei190 – 21021HelicalSequence AnalysisAdd
BLAST
Topological domaini211 – 23929ExtracellularSequence AnalysisAdd
BLAST
Transmembranei240 – 26021HelicalSequence AnalysisAdd
BLAST
Topological domaini261 – 27919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei280 – 30021HelicalSequence AnalysisAdd
BLAST
Topological domaini301 – 33636ExtracellularSequence AnalysisAdd
BLAST
Transmembranei337 – 35923HelicalSequence AnalysisAdd
BLAST
Topological domaini360 – 38930CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei390 – 41021HelicalSequence AnalysisAdd
BLAST
Topological domaini411 – 4155ExtracellularSequence Analysis
Transmembranei416 – 43621HelicalSequence AnalysisAdd
BLAST
Topological domaini437 – 4393CytoplasmicSequence Analysis
Transmembranei440 – 46021HelicalSequence AnalysisAdd
BLAST
Topological domaini461 – 51858ExtracellularSequence AnalysisAdd
BLAST
Transmembranei519 – 53921HelicalSequence AnalysisAdd
BLAST
Topological domaini540 – 61071CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

PharmGKBiPA134989874.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 610610Sodium-coupled monocarboxylate transporter 1PRO_0000334499Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi485 – 4851N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8N695.
PRIDEiQ8N695.

PTM databases

PhosphoSiteiQ8N695.

Expressioni

Tissue specificityi

Expressed in normal thyroid, localized at the apical pole of thyroid cells facing the colloid lumen, but expression profoundly decreased in thyroid carcinomas. Expressed in normal colon but absent in colon aberrant crypt foci and colon cancers. Present in normal kidney cortex, brain, prostate, gastric mucosa and breast tissue but was significantly down-regulated in primary gliomas, gastric cancer, prostate tumors and breast tumors.10 Publications

Inductioni

Down-regulated in some primary cancers; due to aberrant methylation in primary colon cancers, astrocytomas and oligodendrogliomas as well as in cancers of the colon, prostate and gastric regions, and glial cell lines. Expression reactivated on treatment with a demethylating drug, 5-azacytidine.4 Publications

Gene expression databases

BgeeiQ8N695.
CleanExiHS_SLC5A8.
GenevestigatoriQ8N695.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000299233.

Structurei

3D structure databases

ProteinModelPortaliQ8N695.
SMRiQ8N695. Positions 57-456.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi569 – 5724Poly-LysSequence Analysis

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0591.
GeneTreeiENSGT00760000118955.
HOGENOMiHOG000261662.
HOVERGENiHBG057280.
InParanoidiQ8N695.
KOiK14388.
OMAiWISQGMS.
OrthoDBiEOG70PBX7.
PhylomeDBiQ8N695.
TreeFamiTF316728.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR019900. Na/solute_symporter_subgr.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 1 hit.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N695-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDTPRGIGTF VVWDYVVFAG MLVISAAIGI YYAFAGGGQQ TSKDFLMGGR
60 70 80 90 100
RMTAVPVALS LTASFMSAVT VLGTPSEVYR FGAIFSIFAF TYFFVVVISA
110 120 130 140 150
EVFLPVFYKL GITSTYEYLE LRFNKCVRLC GTVLFIVQTI LYTGIVIYAP
160 170 180 190 200
ALALNQVTGF DLWGAVVATG VVCTFYCTLG GLKAVIWTDV FQVGIMVAGF
210 220 230 240 250
ASVIIQAVVM QGGISTILND AYDGGRLNFW NFNPNPLQRH TFWTIIIGGT
260 270 280 290 300
FTWTSIYGVN QSQVQRYISC KSRFQAKLSL YINLVGLWAI LTCSVFCGLA
310 320 330 340 350
LYSRYHDCDP WTAKKVSAPD QLMPYLVLDI LQDYPGLPGL FVACAYSGTL
360 370 380 390 400
STVSSSINAL AAVTVEDLIK PYFRSLSERS LSWISQGMSV VYGALCIGMA
410 420 430 440 450
ALASLMGALL QAALSVFGMV GGPLMGLFAL GILVPFANSI GALVGLMAGF
460 470 480 490 500
AISLWVGIGA QIYPPLPERT LPLHLDIQGC NSTYNETNLM TTTEMPFTTS
510 520 530 540 550
VFQIYNVQRT PLMDNWYSLS YLYFSTVGTL VTLLVGILVS LSTGGRKQNL
560 570 580 590 600
DPRYILTKED FLSNFDIFKK KKHVLSYKSH PVEDGGTDNP AFNHIELNSD
610
QSGKSNGTRL
Length:610
Mass (Da):66,578
Last modified:May 18, 2010 - v2
Checksum:i47FF410B895DB692
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti490 – 4901M → I in AAL88746. (PubMed:12107270)Curated
Sequence conflicti490 – 4901M → I in AAP46193. (PubMed:12829793)Curated
Sequence conflicti490 – 4901M → I in AAP46194. (PubMed:12829793)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti193 – 1931V → I.2 Publications
Corresponds to variant rs1709189 [ dbSNP | Ensembl ].
VAR_057336
Natural varianti251 – 2511F → V.1 Publication
Corresponds to variant rs11834933 [ dbSNP | Ensembl ].
VAR_057337

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY081220 mRNA. Translation: AAL88746.1.
AF536216 mRNA. Translation: AAP46193.1.
AF536217 Genomic DNA. Translation: AAP46194.1.
AC079953 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97649.1.
BC110492 mRNA. Translation: AAI10493.1.
CCDSiCCDS9080.1.
RefSeqiNP_666018.3. NM_145913.3.
UniGeneiHs.444536.

Genome annotation databases

EnsembliENST00000536262; ENSP00000445340; ENSG00000256870.
ENST00000572861; ENSP00000461697; ENSG00000262217.
GeneIDi160728.
KEGGihsa:160728.
UCSCiuc001thz.4. human.

Polymorphism databases

DMDMi296452898.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY081220 mRNA. Translation: AAL88746.1 .
AF536216 mRNA. Translation: AAP46193.1 .
AF536217 Genomic DNA. Translation: AAP46194.1 .
AC079953 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97649.1 .
BC110492 mRNA. Translation: AAI10493.1 .
CCDSi CCDS9080.1.
RefSeqi NP_666018.3. NM_145913.3.
UniGenei Hs.444536.

3D structure databases

ProteinModelPortali Q8N695.
SMRi Q8N695. Positions 57-456.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000299233.

Chemistry

DrugBanki DB08872. gabapentin enacarbil.
DB00627. Niacin.
GuidetoPHARMACOLOGYi 922.

Protein family/group databases

TCDBi 2.A.21.5.3. the solute:sodium symporter (sss) family.

PTM databases

PhosphoSitei Q8N695.

Polymorphism databases

DMDMi 296452898.

Proteomic databases

PaxDbi Q8N695.
PRIDEi Q8N695.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000536262 ; ENSP00000445340 ; ENSG00000256870 .
ENST00000572861 ; ENSP00000461697 ; ENSG00000262217 .
GeneIDi 160728.
KEGGi hsa:160728.
UCSCi uc001thz.4. human.

Organism-specific databases

CTDi 160728.
GeneCardsi GC12M101549.
H-InvDB HIX0036731.
HGNCi HGNC:19119. SLC5A8.
MIMi 608044. gene.
neXtProti NX_Q8N695.
PharmGKBi PA134989874.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0591.
GeneTreei ENSGT00760000118955.
HOGENOMi HOG000261662.
HOVERGENi HBG057280.
InParanoidi Q8N695.
KOi K14388.
OMAi WISQGMS.
OrthoDBi EOG70PBX7.
PhylomeDBi Q8N695.
TreeFami TF316728.

Enzyme and pathway databases

Reactomei REACT_19372. Organic anion transporters.

Miscellaneous databases

GeneWikii SLC5A8.
GenomeRNAii 160728.
NextBioi 87983.
PROi Q8N695.
SOURCEi Search...

Gene expression databases

Bgeei Q8N695.
CleanExi HS_SLC5A8.
Genevestigatori Q8N695.

Family and domain databases

InterProi IPR001734. Na/solute_symporter.
IPR019900. Na/solute_symporter_subgr.
[Graphical view ]
PANTHERi PTHR11819. PTHR11819. 1 hit.
Pfami PF00474. SSF. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00813. sss. 1 hit.
PROSITEi PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of a putative human iodide transporter located at the apical membrane of thyrocytes."
    Rodriguez A.-M., Perron B., Lacroix L., Caillou B., Leblanc G., Schlumberger M., Bidart J.-M., Pourcher T.
    J. Clin. Endocrinol. Metab. 87:3500-3503(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INHIBITION.
    Tissue: KidneyImported.
  2. "SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers."
    Li H., Myeroff L., Smiraglia D., Romero M.F., Pretlow T.P., Kasturi L., Lutterbaugh J., Rerko R.M., Casey G., Issa J.-P., Willis J., Willson J.K., Plass C., Markowitz S.D.
    Proc. Natl. Acad. Sci. U.S.A. 100:8412-8417(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT ILE-193, FUNCTION, INDUCTION, TISSUE SPECIFICITY.
    Tissue: Colon1 Publication.
  3. "Functional identification of SLC5A8, a tumor suppressor down-regulated in colon cancer, as a Na(+)-coupled transporter for short-chain fatty acids."
    Miyauchi S., Gopal E., Fei Y.-J., Ganapathy V.
    J. Biol. Chem. 279:13293-13296(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, STOICHIOMETRY, VARIANTS ILE-193 AND VAL-251.
    Tissue: Intestine1 Publication.
  4. "The human tumour suppressor gene SLC5A8 expresses a Na+-monocarboxylate cotransporter."
    Coady M.J., Chang M.-H., Charron F.M., Plata C., Wallendorff B., Sah J.F., Markowitz S.D., Romero M.F., Lapointe J.-Y.
    J. Physiol. (Lond.) 557:719-731(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, STOICHIOMETRY, INHIBITION.
    Tissue: Kidney cortex1 Publication.
  5. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  8. "Expression of the apical iodide transporter in human thyroid tissues: a comparison study with other iodide transporters."
    Lacroix L., Pourcher T., Magnon C., Bellon N., Talbot M., Intaraphairot T., Caillou B., Schlumberger M., Bidart J.-M.
    J. Clin. Endocrinol. Metab. 89:1423-1428(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  9. "Aberrant methylation and histone deacetylation associated with silencing of SLC5A8 in gastric cancer."
    Ueno M., Toyota M., Akino K., Suzuki H., Kusano M., Satoh A., Mita H., Sasaki Y., Nojima M., Yanagihara K., Hinoda Y., Tokino T., Imai K.
    Tumor Biol. 25:134-140(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, INDUCTION.
  10. "Shared epigenetic mechanisms in human and mouse gliomas inactivate expression of the growth suppressor SLC5A8."
    Hong C., Maunakea A., Jun P., Bollen A.W., Hodgson J.G., Goldenberg D.D., Weiss W.A., Costello J.F.
    Cancer Res. 65:3617-3623(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, INDUCTION.
  11. "SLC5A8 triggers tumor cell apoptosis through pyruvate-dependent inhibition of histone deacetylases."
    Thangaraju M., Gopal E., Martin P.M., Ananth S., Smith S.B., Prasad P.D., Sterneck E., Ganapathy V.
    Cancer Res. 66:11560-11564(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  12. "Identity of SMCT1 (SLC5A8) as a neuron-specific Na+-coupled transporter for active uptake of L-lactate and ketone bodies in the brain."
    Martin P.M., Gopal E., Ananth S., Zhuang L., Itagaki S., Prasad B.M., Smith S.B., Prasad P.D., Ganapathy V.
    J. Neurochem. 98:279-288(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.
  13. "Interaction of ibuprofen and other structurally related NSAIDs with the sodium-coupled monocarboxylate transporter SMCT1 (SLC5A8)."
    Itagaki S., Gopal E., Zhuang L., Fei Y.-J., Miyauchi S., Prasad P.D., Ganapathy V.
    Pharm. Res. 23:1209-1216(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INHIBITION.
  14. "Candidate tumor suppressor gene SLC5A8 is frequently down-regulated by promoter hypermethylation in prostate tumor."
    Park J.Y., Zheng W., Kim D., Cheng J.Q., Kumar N., Ahmad N., Pow-Sang J.
    Cancer Detect. Prev. 31:359-365(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, INDUCTION.
  15. "Transport of nicotinate and structurally related compounds by human SMCT1 (SLC5A8) and its relevance to drug transport in the mammalian intestinal tract."
    Gopal E., Miyauchi S., Martin P.M., Ananth S., Roon P., Smith S.B., Ganapathy V.
    Pharm. Res. 24:575-584(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, STOICHIOMETRY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiSC5A8_HUMAN
AccessioniPrimary (citable) accession number: Q8N695
Secondary accession number(s): Q2TB99, Q7Z2H9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Increase of iodide influx inhibited by addition of perchlorate (NaClO4), a competitive inhibitor of iodide uptake catalyzed by sodium iodide symporter (NIS). Cotransport of monocarboxylates and nicotinate strongly inhibited by probenecid, nonsteroid anti-inflammatory drugs (ibuprofen, fenoprofen, ketprofen, naproxen) in a Na+-dependent manner or by prolonged exposure to external concentrations of monocarboxylates.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3