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Protein

Homeobox protein ESX1

Gene

ESX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi139 – 198HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription by RNA polymerase II Source: NTNU_SB
  • regulation of cell cycle Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein ESX1
Alternative name(s):
Extraembryonic, spermatogenesis, homeobox 1
Cleaved into the following 2 chains:
Gene namesi
Name:ESX1
Synonyms:ESX1L, ESX1R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000123576.5
HGNCiHGNC:14865 ESX1
MIMi300154 gene
neXtProtiNX_Q8N693

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi80712
OpenTargetsiENSG00000123576
PharmGKBiPA27892

Polymorphism and mutation databases

BioMutaiESX1
DMDMi116241356

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000386626? – 406Homeobox protein ESX1-C
ChainiPRO_00000488761 – 406Homeobox protein ESX1Add BLAST406
ChainiPRO_00003866251 – ?Homeobox protein ESX1-N

Post-translational modificationi

Undergoes proteolytic cleavage; produces a 45 kDa N-terminal homeodomain-containing fragment (ESXR1-N) and a 20 kDa C-terminal fragment (ESXR1-C).1 Publication

Proteomic databases

EPDiQ8N693
PaxDbiQ8N693
PeptideAtlasiQ8N693
PRIDEiQ8N693

PTM databases

iPTMnetiQ8N693
PhosphoSitePlusiQ8N693

Expressioni

Tissue specificityi

Expressed in placenta and testis. Expressed in testicular germ cell tumors.2 Publications

Gene expression databases

BgeeiENSG00000123576
CleanExiHS_ESX1
GenevisibleiQ8N693 HS

Organism-specific databases

HPAiHPA051992

Interactioni

Protein-protein interaction databases

BioGridi123270, 2 interactors
IntActiQ8N693, 3 interactors
MINTiQ8N693
STRINGi9606.ENSP00000361669

Structurei

3D structure databases

ProteinModelPortaliQ8N693
SMRiQ8N693
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati244 – 25219
Repeati253 – 26129
Repeati262 – 27039
Repeati271 – 27949
Repeati280 – 28859
Repeati289 – 29769
Repeati298 – 30679
Repeati307 – 31589
Repeati316 – 32499
Repeati325 – 333109
Repeati334 – 342119
Repeati343 – 351129
Repeati352 – 360139
Repeati361 – 369149
Repeati370 – 378159

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni244 – 37815 X 9 AA tandem repeats of P-P-x-x-P-x-P-P-xAdd BLAST135

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi138 – 143Nuclear localization signalSequence analysis6

Keywords - Domaini

Homeobox, Repeat

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00820000127081
HOGENOMiHOG000198273
HOVERGENiHBG084082
InParanoidiQ8N693
KOiK18491
OMAiMAPVPPW
OrthoDBiEOG091G0L2D
PhylomeDBiQ8N693
TreeFamiTF315976

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR013847 POU
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00028 POUDOMAIN
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N693-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESLRGYTHS DIGYRSLAVG EDIEEVNDEK LTVTSLMARG GEDEENTRSK
60 70 80 90 100
PEYGTEAENN VGTEGSVPSD DQDREGGGGH EPEQQQEEPP LTKPEQQQEE
110 120 130 140 150
PPLLELKQEQ EEPPQTTVEG PQPAEGPQTA EGPQPPERKR RRRTAFTQFQ
160 170 180 190 200
LQELENFFDE SQYPDVVARE RLAARLNLTE DRVQVWFQNR RAKWKRNQRV
210 220 230 240 250
LMLRNTATAD LAHPLDMFLG GAYYAAPALD PALCVHLVPQ LPRPPVLPVP
260 270 280 290 300
PMPPRPPMVP MPPRPPIAPM PPMAPVPPGS RMAPVPPGPR MAPVPPWPPM
310 320 330 340 350
APVPPWPPMA PVPTGPPMAP VPPGPPMARV PPGPPMARVP PGPPMAPLPP
360 370 380 390 400
GPPMAPLPPG PPMAPLPPGP PMAPLPPRSH VPHTGLAPVH ITWAPVINSY

YACPFF
Length:406
Mass (Da):44,297
Last modified:October 17, 2006 - v3
Checksum:i7013E3986F1148FA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti320P → R in AAH42633 (PubMed:15489334).Curated1
Sequence conflicti320P → R in AAH53599 (PubMed:15489334).Curated1
Sequence conflicti338 – 339RV → PL in AAH42633 (PubMed:15489334).Curated2
Sequence conflicti338 – 339RV → PL in AAH53599 (PubMed:15489334).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059352314T → P. Corresponds to variant dbSNP:rs9697856Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY114148 mRNA Translation: AAM62141.1
AL049631 Genomic DNA No translation available.
CH471120 Genomic DNA Translation: EAX02755.1
BC042633 mRNA Translation: AAH42633.1
BC053599 mRNA Translation: AAH53599.1
CCDSiCCDS14516.1
RefSeqiNP_703149.1, NM_153448.3
UniGeneiHs.223782

Genome annotation databases

EnsembliENST00000372588; ENSP00000361669; ENSG00000123576
GeneIDi80712
KEGGihsa:80712
UCSCiuc004ely.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiESX1_HUMAN
AccessioniPrimary (citable) accession number: Q8N693
Secondary accession number(s): B0QYU3, Q7Z6K7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 17, 2006
Last modified: May 23, 2018
This is version 132 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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