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Protein

Beta-defensin 125

Gene

DEFB125

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Has antibacterial activity.Curated

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiR-HSA-1461957. Beta defensins.
R-HSA-1461973. Defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 125
Alternative name(s):
Beta-defensin 25
Short name:
DEFB-25
Defensin, beta 125
Gene namesi
Name:DEFB125
Synonyms:DEFB25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:18105. DEFB125.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38501.

Polymorphism and mutation databases

BioMutaiDEFB125.
DMDMi152112501.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Peptidei21 – 6747Beta-defensin 125PRO_0000006996Add
BLAST
Propeptidei68 – 15689Sequence analysisPRO_0000006997Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 55By similarity
Disulfide bondi35 ↔ 49By similarity
Disulfide bondi39 ↔ 56By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ8N687.
PRIDEiQ8N687.

PTM databases

PhosphoSiteiQ8N687.

Expressioni

Gene expression databases

BgeeiQ8N687.
CleanExiHS_DEFB125.
GenevisibleiQ8N687. HS.

Organism-specific databases

HPAiHPA043095.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000371847.

Structurei

3D structure databases

ProteinModelPortaliQ8N687.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J47E. Eukaryota.
ENOG4111802. LUCA.
GeneTreeiENSGT00390000000604.
HOGENOMiHOG000115943.
HOVERGENiHBG051308.
InParanoidiQ8N687.
OMAiILLCRNK.
OrthoDBiEOG7WT43C.
PhylomeDBiQ8N687.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]
ProDomiPD866254. PD866254. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N687-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNILMLTFII CGLLTRVTKG SFEPQKCWKN NVGHCRRRCL DTERYILLCR
60 70 80 90 100
NKLSCCISII SHEYTRRPAF PVIHLEDITL DYSDVDSFTG SPVSMLNDLI
110 120 130 140 150
TFDTTKFGET MTPETNTPET TMPPSEATTP ETTMPPSETA TSETMPPPSQ

TALTHN
Length:156
Mass (Da):17,537
Last modified:May 29, 2007 - v2
Checksum:i4B72FD99B1F00FCD
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti62 – 621H → Y.
Corresponds to variant rs41276376 [ dbSNP | Ensembl ].
VAR_061134

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525927 mRNA. Translation: AAP47220.1.
AL360078 Genomic DNA. Translation: CAI15186.2.
CH471133 Genomic DNA. Translation: EAX10689.1.
BC128195 mRNA. Translation: AAI28196.1.
BC128196 mRNA. Translation: AAI28197.1.
AY122477 mRNA. Translation: AAM93918.1.
CCDSiCCDS12989.2.
RefSeqiNP_697020.2. NM_153325.3.
UniGeneiHs.380220.

Genome annotation databases

EnsembliENST00000382410; ENSP00000371847; ENSG00000178591.
GeneIDi245938.
KEGGihsa:245938.
UCSCiuc002wcw.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525927 mRNA. Translation: AAP47220.1.
AL360078 Genomic DNA. Translation: CAI15186.2.
CH471133 Genomic DNA. Translation: EAX10689.1.
BC128195 mRNA. Translation: AAI28196.1.
BC128196 mRNA. Translation: AAI28197.1.
AY122477 mRNA. Translation: AAM93918.1.
CCDSiCCDS12989.2.
RefSeqiNP_697020.2. NM_153325.3.
UniGeneiHs.380220.

3D structure databases

ProteinModelPortaliQ8N687.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000371847.

PTM databases

PhosphoSiteiQ8N687.

Polymorphism and mutation databases

BioMutaiDEFB125.
DMDMi152112501.

Proteomic databases

PaxDbiQ8N687.
PRIDEiQ8N687.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382410; ENSP00000371847; ENSG00000178591.
GeneIDi245938.
KEGGihsa:245938.
UCSCiuc002wcw.4. human.

Organism-specific databases

CTDi245938.
GeneCardsiDEFB125.
HGNCiHGNC:18105. DEFB125.
HPAiHPA043095.
neXtProtiNX_Q8N687.
PharmGKBiPA38501.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J47E. Eukaryota.
ENOG4111802. LUCA.
GeneTreeiENSGT00390000000604.
HOGENOMiHOG000115943.
HOVERGENiHBG051308.
InParanoidiQ8N687.
OMAiILLCRNK.
OrthoDBiEOG7WT43C.
PhylomeDBiQ8N687.

Enzyme and pathway databases

ReactomeiR-HSA-1461957. Beta defensins.
R-HSA-1461973. Defensins.

Miscellaneous databases

ChiTaRSiDEFB125. human.
GenomeRNAii245938.
NextBioi91816.
PROiQ8N687.

Gene expression databases

BgeeiQ8N687.
CleanExiHS_DEFB125.
GenevisibleiQ8N687. HS.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]
ProDomiPD866254. PD866254. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis."
    Rodriguez-Jimenez F.-J., Krause A., Schulz S., Forssmann W.-G., Conejo-Garcia J.-R., Schreeb R., Motzkus D.
    Genomics 81:175-183(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Discovery of five conserved beta-defensin gene clusters using a computational search strategy."
    Schutte B.C., Mitros J.P., Bartlett J.A., Walters J.D., Jia H.P., Welsh M.J., Casavant T.L., McCray P.B. Jr.
    Proc. Natl. Acad. Sci. U.S.A. 99:2129-2133(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-156, IDENTIFICATION.
    Tissue: B-cell, Fetal lung and Testis.

Entry informationi

Entry nameiDB125_HUMAN
AccessioniPrimary (citable) accession number: Q8N687
Secondary accession number(s): A1A502, Q7Z7B9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: May 29, 2007
Last modified: May 11, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.